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All Journal Jurnal Kimia Riset JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)
Dian Marlina
1Faculty Of Pharmacy, Setia Budi University
Chemistry Health Professions Medicine & Pharmacology Public Health

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SCREENING OF PIROXICAM SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) USING FRACTIONAL FACTORIAL DESIGN Septiawan Adi Nugroho; Ilham Kuncahyo; Dian Marlina
Jurnal Kimia Riset Vol. 8 No. 1 (2023): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v8i1.43803

Abstract

Piroxicam belongs to BCS class II and has low solubility. Self-nanoemulsifying drug delivery systems (SNEDDS) are considered a potential approach for increasing the solubility and release of piroxicam. This study aimed to select the components and component ratios of piroxicam SNEDDS using fractional factorial design 26-2 (FFD). The variables used in the DFT development of piroxicam SNEDDS are the type and concentration of oil (triacetin and oleic acid), surfactant (kolliphor EL and Tween 60), and co-surfactants (Transcutol and PEG 400). The FFD results showed 16 runs with different proportions of the piroxicam SNEDDS components, which were then characterized by critical parameters including emulsification time, %transmittance, droplet size, and drug loading. The components and component ratios of the PKM SNEDDS were determined using single-factor plot analysis. The results showed that triacetin (oil), kolliphor EL (surfactant), Transcutol (co-surfactant) had the greatest contribution to the formation of piroxicam SNEDDS with an oil ratio range of 11.11–28.57%, surfactant 44.44–77.78%, co-surfactant 11.11–44.44 %.
Tinjauan Sistematis dan Meta-Analisis: Analisis Dampak Intervensi Apoteker terhadap Clinical Outcome Pasien Epilepsi Najmah Salsabila; Jason Merari Peranginangin; Dian Marlina
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.82901

Abstract

People with epilepsy generally experience impaired social contact and decreased health. The role of pharmacists in the implementation of therapy for epilepsy patients is very important in providing pharmaceutical services. This research was conducted to examine the impact of pharmacist intervention on the clinical outcome of epilepsy patients. The research method was a systematic review and meta-analysis with a randomized controlled trial study design. Articles were obtained through electronic databases such as PubMed, Directory of Open Access Journals (DOAJ), SpringerLink, ScienceDirect, and Wiley. Items were selected using the PRISMA flowchart. Articles were analyzed using Review Manager 5.3. The results obtained were 10 articles from various countries, namely England, Singapore, China, Thailand, Colombia, America, and Nigeria. The data obtained showed that the pharmacist's intervention had a positive impact by increasing the clinical outcome of epilepsy patients compared to the absence of a pharmacist (SMD = 0.56; 95% CI = 0.03 to 1.10; p = 0.04). Then there was high heterogeneity (I2) between experiments (I2 = 96%; p <0.001), this was due to the different population variations. Furthermore, from the results of merging these 10 articles, it was found that there was publication bias as seen from the funnel plot graph which looked asymmetrical between the right and left plots. The interventions provided by pharmacists, namely consultation and counseling proved to have a positive impact on the clinical outcome of epilepsy patients in the form of increasing quality of life by decreasing seizure frequency and increasing knowledge of epilepsy patients.
Co-Authors Ilham Kuncahyo, Ilham Jason Merari Peranginangin Najmah Salsabila Septiawan Adi Nugroho