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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) As-syifaa Jurnal Farmasi Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Jurnal Kesehatan Kusuma Husada Jurnal Ilmiah Farmasi Simplisia
Devina Ingrid Anggraini
Prodi D3 Farmasi, Sekolah Tinggi Ilmu Kesehatan Nasional
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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Pengaruh Konsentrasi Pelarut Ekstrak Etanol Bawang Daun (Allium Fistulosum L.) Sebagai Antikolesterol Secara Spektrofotometri Visibel Devina Ingrid Anggraini; Libna Dima Pratama
JIFS: JURNAL ILMIAH FARMASI SIMPLISIA Vol. 3 No. 1 (2023): Juni 2023
Publisher : Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Aceh

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Abstract

Kolesterol yaitu senyawa kompleks hasil produksi tubuh. Kelebihan kolesterol didalam tubuh akan menyebabkan masalah hiperkolesterolemia. Masyarakat menggunakan obat penurun kolesterol berbahan sintetis seperti obat golongan statin. Obat golongan statin menimbulkan efek samping seperti miopati dan rhabdomiolisis. Bawang daun mengandung senyawa tanin, saponin, flavonoid, dan alkaloid. Flavonoid merupakan senyawa yang berperan sebagai antikolesterol. Tujuan dari penelitian yaitu untuk mengetahui pengaruh perbedaan konsentrasi pelarut ekstrak yang digunakan saat ekstraksi bawang daun dalam menurunkan koleserol. Penggunaan konsentrasi pelarut yang berbeda saat ekstraksi dapat berpengaruh terhadap penurunan kolesterol. Penentuan aktivitas antikolesterol dilakukan dengan menggunakan metode Lieberman-Burchard yang dianalisis pada daerah visibel dengan panjang gelombang maksimal 669 nm. Konsentrasi yang digunakan pada ekstrak etanol 70% bawang daun yaitu 20 ppm, 30 ppm, 40 ppm, 50 ppm, dan 60 ppm. Konsentrasi pada ekstrak etanol 96% bawang daun yaitu 40 ppm, 50 ppm, 60 ppm, 70 ppm, dan 80 ppm. Hasil penelitian ini dapat ditarik kesimpulannya bahwa ekstrak etanol 70% bawang daun memiliki kemampuan menurunkan kolesterol dengan nilai EC50 45,439 ppm lebih besar dibadingkan dengan ekstrak etanol 96% bawang daun memiliki kemampuan menurunkan kolesterol dengan nilai EC50 67, 211 ppm.
ANALISIS KOMPARATIF KADAR ION MAGNESIUM EKSTRAK ETANOL BUAH JAMBU BIJI (Psidium Guajava L.) DENGAN VARIASI METODE EKSTRAKSI Devina Ingrid Anggraini
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 9 No. 1 (2026): Jurnal Farmasi Medika/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v9i1.67491

Abstract

Red guava fruit (Psidium guajava L.) is rich in minerals, one of which is magnesium, which has the potential as a natural active ingredient in cosmetic formulations. To ensure the effectiveness and stability of this compound, a study of various extraction methods is needed to determine the most optimal technique in producing the highest magnesium ion levels. This study aims to compare the magnesium ion levels in 70% ethanol extracts of red guava fruit extracted using maceration and ultrasonic methods. An experimental approach was used to determine which method is more effective in producing optimal magnesium levels. Identification of magnesium ions was carried out qualitatively using the titan yellow test and the NaOH test. Quantitatively, the determination of magnesium ion levels was analyzed using UV-Vis spectrophotometry at a wavelength of 527.5 nm with the EBT color complex. To evaluate the effectiveness of the extraction method, a t-test was conducted on the magnesium content data to prove the significant effect of the different extraction techniques used. The results showed that both extracts contained magnesium ions. Analysis of magnesium ion levels in the ultrasonic method (260.47 mg/100 g) was proven to be higher than that in the maceration method (199.46 mg/100 g). The independent t-statistical test strengthens the research results by showing a significant difference between the two extraction methods (sig 0.000), so that ultrasonic is considered more effective in producing higher levels of magnesium ions. Keywords: ethanol extract, magnesium ions, red guava, UV–Vis spectrophotometry
Co-Authors Atur Semartini Desty Putri Pancawati Dwi Damayanti Eka Wisnu Kusuma Endang Tri Wahyuni I Pujilestari Libna Dima Pratama Lily Fathrah Nabillah Mudasir Mudasir Reggy Andani Siska Andriani Susilowati Susilowati Vita Anggun Cahyani