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All Journal Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia
Kurnia Sari Setio Putri, Kurnia Sari Setio
Fakultas Farmasi Universitas Indonesia
Medicine & Pharmacology

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Kompleks Polielektrolit Kitosan-Xanthan sebagai Matriks Sediaan Mukoadhesif Setio Putri, Kurnia Sari; Sulistomo, Bambang; Surini, Silvia
Pharmaceutical Sciences and Research Vol. 4, No. 1
Publisher : UI Scholars Hub

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Abstract

Mucoadhesive dosage form is a pharmaceutical dosage form with prolonged gastric residence time which can increase bioavailability of drugs. An excipient with suitable swelling and bioadhesive characteristics plays important role to obtain good mucoadhesive dosage form. Our pre-eliminary study showed that chitosan-xanthan gum polyelectrolyte complex (CXPC) in ratio 1:1 exhibit suitable swelling index to be developed as mucoadhesive dosage forms. This research was performed to study CXPC characteristics as matrix for mucoadhesive granules dosage form matrix. In this study CXPC 1:1 was utilized as the matrix in the mucoadhesive granules with drug-CXPC ratio of 1:1, 1:2, and 1:3, using diltiazem HCl as a drug model. The granules were prepared by wet granulation method, and the in vitro bioadhesive properties of the granules, as well as the drug release profile, were evaluated. The results showed that formula containing diltiazem HCl and CXPC in ratio of 1:2 possessed a good bioadhesive ability up to 8-12 hours and showed controlled drug release profile up to 8 hours. The results can be concluded that the CXPC is a suitable excipient as a mucoadhesive matrix.
Challenge and Development Strategy for Colon-Targeted Drug Delivery System Iswandana, Raditya; Putri, Kurnia Sari Setio; Putri, Fathia Amalia; Gunawan, Maxius; Larasati, Sekar Arum
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

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Colon-Targeted Drug Delivery System (CTDDS) is able to improve local therapeutic effects in the treatment of colon-specific diseases, such as Crohn’s disease, Ulcerative Colitis (UC), and Irritable Bowel Syndrome (IBS). A colon can also be a suitable site for systemic delivery of drugs susceptible to extreme gastric pH, such as peptides and protein therapeutics. The physiological conditions of the gastrointestinal tract and the physicochemical properties of drugs are being considered to develop strategies and approaches to overcome emerging challenges. This review will discuss factors, challenges, strategies, and approaches to developing a colon-targeted drug delivery system.
Challenges and Future Perspective of Gastroretentive Mucoadhesive Dosage Forms Akbar, Rayhan; Setiawan, Heri; Maggadani, Baitha Palanggatan; Iswandana, Raditya; Setio Putri, Kurnia Sari
Pharmaceutical Sciences and Research Vol. 11, No. 2
Publisher : UI Scholars Hub

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Gastroretentive Mucoadhesive Dosage Form (GMDF) is one type of Gastroretentive Drug Delivery System (GRDDS) technology designed to exploit the adhesiveness of dosage forms in the gastric mucosa. This aims to increase drug residence time, enhance drug solubility and absorption, and ultimately improve drug bioavailability and therapeutic effect. Various studies have explored the use of different polymers to develop GMDF systems and dosage forms. However, despite extensive research in this field, there are still limited GMDF products approved by the US FDA and INA FDA. Therefore, this review addresses the challenges in developing GMDF, its current state, and potential future opportunities. This literature review is performed by searching Google Scholar, PubMed, and ScienceDirect and Google Patents using the terms “gastroretentive”, “mucoadhesive”, “challenge”, “strategy”, and “patent.” Additionally, searches were conducted in the US FDA and INA FDA Drug Approval Databases. Based on our study, we identified numerous challenges in developing GMDF, including patient physiological challenges, drug formulas, production processes, product analysis, and clinical trials. To address these challenges, multiple strategies should be developed to optimize the formulation, production process, and product analysis of GMDF, ultimately leading to successful clinical trials and regulatory approval of this product.
Formulasi Sabun Cair Perak Nanopartikel dengan Penstabil Polyvinil Alcohol : Sabun Cair Perak Nanopartikel Sutriyo; Hanandi, Sharon; Putri, Kurnia Sari Setio; Poetri, Okti Nadia; Annisa, Syifa; Rahmasari, Ratika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (608.928 KB) | DOI: 10.35617/jfionline.v13i1.115

Abstract

According to Global Burden of Disease reported on 2019, about 1.53 million deaths caused by infectious diseases such as pneumonia and diarrhea. Triclosan is one of the active ingredient commonly used in antibacterial soap as one way to prevent the spread of infectious disease.. However, bacteria resistance against triclosan has been reported. Silver nanoparticles (AgNP) is an alternative antibacterial that potential to be used in liquid hand wash. However AgNp tend to aggregate during storage, thus stabilizer is needed This study aims to synthesize AgNP, formulate the liquid hand wash contain AgNP with polyvinil alcohol as stabilizer, and evaluate its effectiveness against Escherichia coli, Staphylococcus aureus, and Salmonella thypi. AgNP was prepared using the chemical reduction method between silver nitrate and sodium borohydride, followed by its characterization using UV-Vis spectrophotometer, TEM, PSA, and AAS. The physical characteristic of AgNp-liquid hand wash were also evaluated. Further, the antibacterial activity of AgNP-handwash was evaluated by phenol coefficient method. The peak of UV absorption spectrum of colloidal was found at 404.2 nm indicated the presence of AgNP. Ag content in AgNP colloidal was 38.405 mg/Kg ± 0,008. The spherical shape of AgNP was observed. The AgNP size was 65.1 nm with polydispersity index value of 0.543, and zeta potential value was -22.25 mV. The obtained AgNP-hand wash met the Indonesian standard criteria and was stable for 28 days. The best phenol coefficient value was obtained at formulation with addition of 30% AgNP (0.1 for S. typhi, 0.4 for E. coli, and 0.01 for S. aureus).
Co-Authors AA Sudharmawan, AA Akbar, Rayhan Annisa, Syifa Baitha Palanggatan Maggadani, Baitha Palanggatan Bambang Sulistomo Bambang Sulistomo, Bambang gunawan, maxius Hanandi, Sharon Larasati, Sekar Arum Okti Nadia Poetri Putri, Fathia Amalia Raditya Iswandana Rahmasari, Ratika Silvia Surini Silvia Surini Sutriyo