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All Journal Indonesian Journal of Pharmaceutical and Clinical Research Narra J Pharmaceutical Sciences and Research (PSR) Jurnal Natural
Meutia Faradilla, Meutia
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health

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Peran Tenaga Kefarmasian dalam Penanggulangan Bencana Role of Pharmacist in Disaster Management Faradilla, Meutia
Pharmaceutical Sciences and Research Vol. 5, No. 1
Publisher : UI Scholars Hub

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Abstract

Indonesia is a country that has high potency to be affected by disaster, either by natural or man-made disaster. After the 2004 tsunami, Indonesian government has improved its disaster prevention policy and program. In disaster management study, health management in disaster setting is aimed to assure the implementation of health service toward victims accordingly. As integrated part of the healthcare team in disaster management, pharmacists have to understand the importance of pharmaceutical care in pre-disaster, disaster, and post-disaster phase. This article aims to provide an overview on pharmacists’ role in disaster management from preparing and distributing medicine and medical devices to its role in therapy management, counselling, and patient education. This article also proposes to stakeholders in pharmacist professional organization to arrange plan and policy to increase and improve pharmacists’ involvement in disaster management.
Respon Bioakumulator Eceng Gondok (Eichhornia crassipes) Terhadap Logam Berat Pb dan Cd di Sungai Pegangsaan Dua Rahayu, Sri Teguh; Faradilla, Meutia; Verawati, Ester Yani; Triana, Muchrip
Pharmaceutical Sciences and Research Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

Eichhornia crassipes is one of Indonesia’s wild plant that considered as weed. Its presence can disrupt ecosystems in the river. However, it is proven to absorb Pb and Fe. It is also believed that E.crassipes can absorb other metals such as Hg , Zn , Cu and Cd which were belong to the same group as Pb and Fe. In addition to heavy metal sequestration, Eichhornia crassipes can also absorb pesticide residues. This descriptive research was done to determine the bioaccumulator response to Pb and Cd in Pegangsaan Dua river using Inductively Coupled Plasma method. Bioaccumulator response of Eichhornia crassipes were analyzed from the stem. The results of the study also showed that the Eichhornia crassipes plants were able to accumulate heavy metals of Pb and Cd. The organs most potential to absorb Cd and Pb were stem organ with average point 1 of Cd : 0,056 ppm and Pb : 0,5002 ppm, then the average point 2 of Cd : 0,0328 ppm and Pb : 0,0215 ppm , and the average point 3 of Cd : 0.0143 ppm and Pb : 1,293 ppm . In this end, it is suggested that the stem organ could be developed as bioaccumulation agent.
Antiseptic activity assay of ethanolic extract of Acehs rambutan rind (Nephelium lappaceum L.) against Staphylococcus aureus and its formulation as hand sanitizer gel SARI, IRMA; FARADILLA, MEUTIA; PUTRI, RISKA ANANDA
Jurnal Natural Volume 23 Number 1, February 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v23i1.20412

Abstract

The hands are one of the most susceptible parts of the human body to bacterial infection. One way to maintain health is to maintain hand hygiene. Ethanolic rambutan rind extract from Aceh province has been studied in order to determine if it can inhibit bacterial growth. This research was conducted to determine the antiseptic activity of the ethanol extract of rambutan rind against Stahpylococcus aureus by determining the phenol coefficient and determining whether the ethanolic extract of Acehs rambutan rind can be formulated into a hand sanitizer gel. Antiseptic activity testing was performed using the Rideal-Walker method which was carried out in 5 dilutions (1:100, 1:150, 1:200, 1:250 and 1:300). The absorbance measurement showed that the extract could act as an antiseptic, at a concentration of 1% and at a dilution of 1:200 which has phenol coefficient of 1.67. The ethanolic extract of Acehs rambutan rind can be formulated in the form of a hand sanitizer gel using 1% Carbopol as gelling agent. The results showed that the gel was brown with a distinctive menthol odor and changed into a dark brown color after a cycling test. The evaluation results of all formulas appropriated the requirements except for adhesion parameter. The results of the irritation test showed that the volunteers did not experience any signs of irritation. The results of the preference test showed that the respondents liked the shape and aroma parameters but not the color parameter.
Antioxidant and immunomodulatory activities of ethanol extracts from Syzygium cumini L. Skeels and Pogostemon cablin Benth Faradilla, Meutia; Fidrianny, Irda; Iwo, Maria I.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.918

Abstract

Syzygium cumini and Pogostemon cablin are mostly cultivated in tropical climates for culinary and perfumery purposes, yet their potential medicinal properties remain underreported. The aim of this study was to examine the antioxidant and immunomodulatory activities of ethanol extracts from S. cumini (EESC) and P. cablin (EEPC). Reflux extraction was carried out using 96% ethanol on the collected plant specimens to produce EESC and EEPC. Secondary metabolites of each extract were identified using gas chromatography-mass spectrometry (GC-MS). The extracts were measured for total phenol and flavonoid levels and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. The immunomodulatory activity test was carried out in vivo by assessing several parameters, including the phagocytic index via the carbon clearance method, organ indices, antibody titers, and delayed-type hypersensitivity (DTH) response, using sheep red blood cells (SRBC) as antigens. The extracts were also examined for their anti-inflammatory activity in acute and chronic inflammation models. In the DPPH antioxidant test, EESC and EEPC had IC50 values of 12.33 µg/mL and 182.17 µg/mL, respectively. Both extracts showed immunosuppressant activity, marked by a phagocytic index of <1. EESC yielded lower organ indices for the liver (p=0.025 at 200 mg/kg BW), spleen (p=0.028 at 100 mg/kg BW), and thymus (p=0.032 at 200 mg/kg BW) compared to the control group. For EEPC, lower organ indices were observed in the liver at 100 mg/kg BW (p=0.005) and 200 mg/kg BW (p=0.031). In the primary antibody titer and DTH tests, both EESC and EEPC showed immunosuppressant activity at 200 and 400 mg/kg BW (p<0.05). The extracts suppressed both the innate and adaptive immune systems. Both EEPC (p=0.004) and EESC at 100 mg/kg BW (p=0.03) significantly reduced serum TNF-α levels. In conclusion, EESC and EEPC have the potential as immunosuppressive and anti-inflammatory agents.
Antibacterial Activity of Citronella Essential Oil from Cymbopogon nardus (L.) Rendle) Against Methicillin-Resistant Staphylococcus aureus Sari, Irma; Misrahanum, Misrahanum; Faradilla, Meutia; Ayuningsih, Cut Mutia; Hilda Maysarah
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 1 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i1.8302

Abstract

Irrational antibiotic use in the treatment of infectious diseases can result in the emergence of antibiotic-resistant bacterial strains, such as Methicillin Resistant Staphylococcus aureus (MRSA). The purpose of this study is to determine the physical properties of citronella essential oil (Cymbopogon nardus (L.) Rendle) and to assess its antibacterial activity against MRSA. Citronella essential oil was extracted using a water-steam distillation method, yielding 0.5 percent. Citronella essential oil has a specific gravity of 0.904, a refractive index of 1.470, and is slightly soluble in 80 percent ethanol. All of these parameters were in accordance with the Indonesian Standard Requirement (SNI) for Citronella essential oil. The disc diffusion assay was used to test the antibacterial activity of this Citronella essential oil. The result indicated that Citronella essential oil has an activity to inhibit MRSA invitro.
Co-Authors Ayuningsih, Cut Mutia Ester Yani Verawati, Ester Yani Hilda Maysarah Irda Fidrianny Irma Sari Iwo, Maria I. Misrahanum Misrahanum Muchrip Triana, Muchrip Putri, Riska Ananda Sri Teguh Rahayu, Sri Teguh