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Antibacterial activity of mexican sunflower leaf Tithonia diversifolia (Hemsl.) A.Gray Aqueous extract against methicillin-resistant Staphylococcus aureus Misrahanum Misrahanum; Zahratul Safarah; Yulia Sari Ismail
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The research of antibacterial activity of Mexican sunflower leaf Tithonia diversifolia (Hemsl.) A.Gray aqueous extract against Methicillin-Resistant Staphylococcus aureus (MRSA) was carried out. The research aimed to observe the antibacterial activity of Mexican sunflower leaves aqueous extract to inhibit the growth of MRSA with concentrations of 10, 20, 30, 40, and 50%. The extracts were obtained by the maceration method, and the antibacterial activity was tested using the agar well diffusion method. Characterization of Mexican sunflower leaves simplicia were obtained with water level 9%, water-soluble level 21,6%, ethanol-soluble level 10,3%, and total ash level 14,36%. Characterization of Mexican sunflower leaves aqueous extracts were obtained with water level 26,36%, water-soluble level 53,13%, ethanol-soluble level 26,36%, and total ash level 19,98%. Phytochemical screening revealed that aqueous extract of Mexican sunflower leaves contained secondary metabolites of alkaloids, flavonoids, tannins, and saponins. The largest inhibitory zone was shown at a 50% extract concentration with a diameter of 12,40 mm. The aqueous extract of Mexican sunflower leaves was capable to form the inhibition zone on the MRSA growth.

PENGARUH MARINASI MADU TERHADAP KUALITAS MIKROBIOLOGIS DAGING SAPI (Boss sp.) Yulia Sari Ismail; Cut Yulvizar; Sugiarti Sugiarti; Misrahanum Misrahanum
Prosiding Seminar Nasional Biotik Vol 3, No 1 (2015): PROSIDING SEMINAR NASIONAL BIOTIK III 2015
Publisher : Prosiding Seminar Nasional Biotik

Penelitian ini menggunakan madu sebagai pengawet daging sapi (Boss sp.). Tujuannya adalah untuk mengukur dan mengamati pengaruh marinasi madu terhadap total pertumbuhan bakteri Escherichia coli pada daging sapi (Boss sp.). Penelitian ini dilaksanakan di Laboratorium Mikrobiologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Syiah Kuala dari bulan Agustus sampai bulan Desember 2014. Metode yang digunakan adalah eksperimental laboratorium. Data dianalisis menggunakan Analisis Varian dengan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 4 ulangan. Hasil Penelitian menunjukkan perlakuan terhadap lamanya marinasi pada waktu 5, 10, 15 dan 20 menit berpengaruh nyata (p

ACTIVITY TEST OF Abrus precatorius L. LEAF EXTRACT AGAINST CLINICAL Streptococcus pneumonia GROWTH* Misrahanum Misrahanum; Cut Intan Annisa Puteri; Cut Yulvizar
Jurnal Natural Volume 17, Number 1, March 2017
Publisher : Universitas Syiah Kuala

Abstract. Saga (Abrus precatorius L.) have been used by Indonesian community as a traditional medicine. The research aims to determine the activity of the methanol extract of saga leaves to inhibit the growth of clinical Streptococcus pneumoniae growth. Inhibition tests was done with casting cup method. The results showed that the methanol extract of saga leaves at a concentration of 37,5; 50; 62,5; 75 and 87,5 mg/mL formed growth inhibition zone of clinical S. pneumoniae with consecutive average of 0,5; 1,75; 2,82; 4,00; and 4,82 mm. Based on the results of the research can be concluded that the methanol extract of saga leaves had activity in inhibiting the growth of clinical S. pneumoniae isolates with low category. Key words: Abrus precatorius L., Clinical Streptococcus pneumoniae, Methanol extract*Judul ini telah dipresentasikan pada Seminar Nasional: Indonesian Students Conference on Science and Mathematics(ISCSM) 11-12 November 2015, Banda Aceh Indonesia

FORMULATION DOSAGE FORM OF TABLET CONTAINING KEPEL LEAF EXTRACT (Stelechocarpus burahol (Blume) Hook.f & Thomson) AS AN ANTIMICROBIAL AGENTS Hilda Maysarah; Meutia Faradilla; Tedy Kurniawan Bakri; Misrahanum Misrahanum
Jurnal Natural Volume 19 Number 2, June 2019
Publisher : Universitas Syiah Kuala

Pharmaceutical dosage form that contains herbal materials has been developed in order to make it easy to consume. Tablet is one of pharmaceutical dosage form that generally used. A formulation and antimicrobial test of tablet containing extract of Kepel leaf with different concentration of diluents, binders, and disintegrants has been studied. The evaluation test showed that formulation consist of 25 % of Kepel leaf extract, 64.5 % of avicel PH 102, 2 % of PVP, 7 % of amprotab, 0.5 % of aerosil, and 1 % of talcum are better than the others. The experimental method used in this study was wet granulation. From the result of the mass granulation evaluation, it was obtain that speed flow without vibration was 2.53 second, with vibration was 2.83 second, bulk density was 0.329 g/mL, taped density was 0.376 g/mL and compressibility was 12.65 %. The result of tablet evaluation obtained that the average weight was 498 mg, with the average hardness was 4 kg/cm2 and disintegration time was 2.36 minutes. Antimicrobial test showed that in the concentration of 50 mg/mL, had average inhibitory diameter against S. aureus of 12.96 mm, P. aeruginosa 12.7 mm, and against B. subtilis was 12.53 mm. Whereas, concentration of 62.5 mg/mL had average inhibitory diameter against S. aureus was 13.5 mm, P. aeruginosa was 13.56 mm, and against B. subtilis was 13.43 mm. Both concentrations did not have antimicrobial activity against E.coli.

GAS CROMATOGRAPHIC ANALYSIS OF ORGANOPHOSPATE AND PYRETROID COMPOUNDS IN MOSQUITO COILS Sadli Sadli; Misrahanum Misrahanum
Jurnal Natural Volume 11, Number 2, September 2011
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.066 KB)

Mosquito coils contain active compounds such as chlorpyriphos, dichlorphos, and d-alletrhrin which may be hazardous to the health. As majority of pesticides are stable heat, they can be changed into stable vapor state by column. a gas chromatographic method of analysis was developed. Gas chromatography for organophosphate compounds, namely chlorpyriphos and dichlorphos, with a OV-17 packed column, and a flame photometry detector equipped by filter for phosphor, which detecs phosphor containing compounds exclusively, avoiding any interference of other non phosphor compounds present in the sample matrix. Gas chromatography for a pyrethoid compound, d-allethrin, utilizes a HP-1 capilarry column with a flame ionization detector, and detect, any ionizable compound. The research was initiated by adjustment of the condition of gas chromatography system to obtain an appropiate separation of compounds a good shape of chromatogram and a tolerable retention time. With a flow rate of nitrogen 55 ml/min, column temperatures of 210oC, a detector and injector temperature of 230oC, the method gave a retention times chlorpyriphos of 6,47 minute and that of dichlorphos of 0,73 minute . The difference in retention time of chlorpyriphos and that of dichlorphos was caused by the difference in molecular weight of both compounds, thin dichlorphos with a smaller molecular weight (220, 98) was eluted faster than chlorpyriphos (350,6). For d-allethrin whit a flow rate of nitrogen gas of 40 ml/min, a column temperature of 180oC, a detector and injector temperature of 210oC, a retention time of d-allethrin of 3,28 minutes was obtained. The mosquito coils tested did not contain any chlorpyriphos nor dichlorphos, and some contained d-allethrin. The d-allethrin content obtained in one of the sample was beyond the tolerated limit.

ACTIVITY TEST OF Abrus precatorius L. LEAF EXTRACT AGAINST CLINICAL Streptococcus pneumonia GROWTH* Misrahanum Misrahanum; Cut Intan Annisa Puteri; Cut Yulvizar
Jurnal Natural Volume 17, Number 1, March 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v17i1.7260

Abstract. Saga (Abrus precatorius L.) have been used by Indonesian community as a traditional medicine. The research aims to determine the activity of the methanol extract of saga leaves to inhibit the growth of clinical Streptococcus pneumoniae growth. Inhibition tests was done with casting cup method. The results showed that the methanol extract of saga leaves at a concentration of 37,5; 50; 62,5; 75 and 87,5 mg/mL formed growth inhibition zone of clinical S. pneumoniae with consecutive average of 0,5; 1,75; 2,82; 4,00; and 4,82 mm. Based on the results of the research can be concluded that the methanol extract of saga leaves had activity in inhibiting the growth of clinical S. pneumoniae isolates with low category. Key words: Abrus precatorius L., Clinical Streptococcus pneumoniae, Methanol extract*Judul ini telah dipresentasikan pada Seminar Nasional: Indonesian Students Conference on Science and Mathematics(ISCSM) 11-12 November 2015, Banda Aceh Indonesia

FORMULATION DOSAGE FORM OF TABLET CONTAINING KEPEL LEAF EXTRACT (Stelechocarpus burahol (Blume) Hook.f & Thomson) AS AN ANTIMICROBIAL AGENTS Hilda Maysarah; Meutia Faradilla; Tedy Kurniawan Bakri; Misrahanum Misrahanum
Jurnal Natural Volume 19 Number 2, June 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i2.12151

Pharmaceutical dosage form that contains herbal materials has been developed in order to make it easy to consume. Tablet is one of pharmaceutical dosage form that generally used. A formulation and antimicrobial test of tablet containing extract of Kepel leaf with different concentration of diluents, binders, and disintegrants has been studied. The evaluation test showed that formulation consist of 25 % of Kepel leaf extract, 64.5 % of avicel PH 102, 2 % of PVP, 7 % of amprotab, 0.5 % of aerosil, and 1 % of talcum are better than the others. The experimental method used in this study was wet granulation. From the result of the mass granulation evaluation, it was obtain that speed flow without vibration was 2.53 second, with vibration was 2.83 second, bulk density was 0.329 g/mL, taped density was 0.376 g/mL and compressibility was 12.65 %. The result of tablet evaluation obtained that the average weight was 498 mg, with the average hardness was 4 kg/cm2 and disintegration time was 2.36 minutes. Antimicrobial test showed that in the concentration of 50 mg/mL, had average inhibitory diameter against S. aureus of 12.96 mm, P. aeruginosa 12.7 mm, and against B. subtilis was 12.53 mm. Whereas, concentration of 62.5 mg/mL had average inhibitory diameter against S. aureus was 13.5 mm, P. aeruginosa was 13.56 mm, and against B. subtilis was 13.43 mm. Both concentrations did not have antimicrobial activity against E.coli.

Theoretical Evaluation of Michelia Species’ Bioactive Compounds and Theraupetic Potential: A Literature Review Oktaviana, Nurul; Isnaini, Nadia; Harnelly, Essy; Zulkarnain, Zulkarnain; Muhammad, Syaifullah; Misrahanum, Misrahanum
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.12

Michelia alba is a multifunctional plant found in Indonesia and is also called magnolia. Michelia alba is a tree known for its essential oil, which has long been used as a fragrance ingredient in perfumes and cosmetics. The potential of M. alba is immense for use in the prevention and treatment of disease as well as the management of human health and wellness. To date, there have been few publications regarding the biological activities of M. alba, focusing on tyrosinase inhibitory, antibacterial, antidiabetic, anti-inflammatory and antioxidant activities. However, M. alba may have additional undiscovered biological activities associated with its bioactive compounds. The purpose of this literature review research is to find out the bioactive compounds and therapeutic potential of the M. alba plant through literature searches that can be a reference for further research. The literature review method is carried out by searching and collecting data from literature sources obtained from several national and international journals that review bioactive compounds and the therapeutic potential of M. alba plants. Based on the literature review, it was found that M. alba has bioactive compounds namely linalool (72.8 flower oil and 80.1% leaf oil), α-terpineol (6.04% flower oil), phenylethyl alcohol (2.58% flower oil), β-pinene (2.39% flower oil) and geraniol (1, 23%) which have therapeutic activities such as mental health disorders, anticancer, anti-inflammatory, antihypertensive, antidiabetic, antihyperlipidemia, antimaagic, antidiarrheal, anti-asthma, and antihyperpigmentation. In traditional medicine it is used to treat fever, syphilis, gonorrhea and malaria, bronchitis, prostatitis, cancer, headache, sinusitis, cough, inflammation of the respiratory tract, chest fullness, flatulence, nausea, body and underarm odor, and vaginal discharge.

Edukasi dan Inovasi Gampong Ramah Lingkungan di Ulee Lueng Aceh Besar Misrahanum, Misrahanum; Sadli, Sadli; Murniana, Murniana; Arpini, Mifta; Humaira, Cut Jessica
Reswara: Jurnal Pengabdian Kepada Masyarakat Vol 6, No 1 (2025)
Publisher : Universitas Dharmawangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46576/rjpkm.v6i1.5111

Kualitas lingkungan hidup yang menurun akan menyebabkan kualitas hidup manusia juga mengalami penurunan. Hal ini dipengaruhi oleh aktivitas konsumtif dan minimnya kesadaran masyarakat akan pentingnya keberlanjutan lingkungan. Oleh karena itu, untuk mencegah dan mengatasi permasalahan tersebut diperlukan kegiatan edukasi ramah lingkungan untuk mendukung tujuan Pembangunan Berkelanjutan. Berdasarkan observasi yang dilakukan di Gampong Ulee Lueng, Kecamatan Darul Imarah, Aceh Besar menunjukkan masih rendahnya upaya pengelolaan sampah rumah tangga, baik organik maupun anorganik oleh masyarakat sehingga berpotensi mencemari lingkungan. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan masyarakat khususnya ibu rumah tangga yang juga terlibat langsung dalam kegiatan PKK agar dapat mengelola sampah dengan baik. Kegiatan dilakukan secara bertahap mulai bulan Juni sampai Agustus 2024. Tahap pertama berupa edukasi dengan presentasi,tanya jawab dan diskusi materi terkait pemilahan dan pengelolaan sampah rumah tangga. Pembagian leaflet secara door-to-door juga dilakukan untuk memperluas cakupan edukasi. Tahap kedua demonstrasi pembuatan produk olahan sampah rumah tangga berupa sabun cuci dari minyak jelantah, eco-enzyme, kompos biopori dan eco-brick yang melibatkan 21 peserta. Tahap ketiga monitoring dan evaluasi kegiatan terkait pengetahuan dan sikap serta pengaplikasian produk hasil olahan sampah. Hasil kegiatan edukasi dan demonstrasi yang dilakukan dapat meningkatkan pengetahuan dan keterampilan peserta, dengan perubahan sikap sebesar 92,38%-99,04%. Keberhasilan program ini diharapkan dapat diaplikasikan secara berkelanjutan dalam kegiatan Gampong, sehingga dapat menjadi contoh bagi Gampong lain di sekitarnya

POTENSI KITOSAN SEBAGAI PENGAWET PRODUK HASIL PERIKANAN DI DESA PULOT KABUPATEN ACEH BESAR Yulvizar, Cut; Zaidiyah, Zaidiyah; Fahmi, Chairul; Amalia, Amalia; Masykur, Masykur; Misrahanum, Misrahanum; Irhamni, Irhamni
JURNAL PENGABDIAN MAHAKARYA MASYARAKAT INDONESIA Vol 3, No 1 (2025): JURNAL PENGABDIAN MAHAKARYA MASYARAKAT INDONESIA
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/pemasi.v3i1.45735

The processing activities of salted fish and peda, carried out by the Setia Bakti Women's Cooperative and the Kamboja Group, demonstrate considerable potential for further development. This potential is supported by the abundance of marine resources, the simplicity of the processing technology, the increased demand for salted fish and peda during the month of Ramadan, and the presence of numerous community-based traditional fish processors. It is imperative to ensure the shelf life of salted fish and peda, in order to maintain product quality during distribution and consumption. Salted fish has been shown to have a longer shelf life, remaining stable for up to two weeks without significant changes, whereas peda has been found to deteriorate within 25 days. This limitation can be addressed through the improvement of raw material quality, processing methods, packaging, and storage practices. The enhancement of product quality, the achievement of a more appealing flavour profile, the assurance of hygienic packaging, the provision of competitive pricing, and the elimination of the use of hazardous food additives are of paramount importance. A promising approach involves the use of natural preservatives such as chitosan, derived from shrimp, crab, and squid shells, which has the potential to extend shelf life and broaden market reach. Furthermore, the advancement of conventional fish processing can be further facilitated through structured interventions, encompassing research, training, the provision of infrastructure, and community empowerment. These interventions are designed to enhance business performance and improve the socio-economic conditions of local processors.

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