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All Journal MPI (Media Pharmaceutica Indonesiana) Pharmaceutical Sciences and Research (PSR)
Endang Wahyu Fitriani, Endang Wahyu
Universitas Surabaya
Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Karakterisasi dan Stabilitas Fisik Mikroemulsi Tipe A/M dengan Berbagai Fase Minyak Fitriani, Endang Wahyu; Imelda, Erlina; Kornelis, Christina; Avanti, Christina
Pharmaceutical Sciences and Research Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

This research consists of formulation, characterization and physical stability of the microemulsion of water-in-oil type. On the microemulsion, VCO, palm oil, olive oil and soybean oil were used as oil phase, aqua demineralisata used as the aqueous phase, a combination of Span® 80 and Tween® 80 as a surfactant and propanol as cosurfactant. Each formula was three times replication done and determined the physical characteristics including organoleptic observations, measurements of density, droplet, viscosity, flow properties, and pH. Determination of physical characteristics was done at the beginning of the microemulsion formed and after 5 weeks storage at room temperature. The physical stability test including the centrifugation test at 10,000 rpm for 30 minutes, the freeze-thaw test for 6 cycles, and heating stability with the oven temperature of 60ºC, 70ºC, 80ºC, 90ºC and 100ºC for 5 hours were done. The data obtained were analyzed using t-Test and one-way ANOVA. Based on the characteristic and physical stability tests, it was showed that microemulsion with VCO, palm oil and soybean oil had better physical characteristics and stability compared to the microemulsion with olive oil.
Development of A Self Nanoemulsifying Drug Delivery System for Atenolol using Soybean Oil, Olive Oil and Virgin Coconut Oil Fitriani, Endang Wahyu; Malini, Helma; Rosita, Vestiana; Handika, Yella
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 1 (2025): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i1.7440

Abstract

Oral formulations remain the primary method of drug delivery, however, the solubility and lipophilicity of compounds such as atenolol present significant obstacles. Atenolol, a β1-selective antihypertensive agent, exhibits limited solubility in both aqueous and gastrointestinal environments. Atenolol is developed in a lipid-based delivery system, specifically the Self-Nanoemulsifying Drug Delivery System (SNEDDS), to enhance its bioavailability and resolve this issue. SNEDDS can improve drug solubility by generating spontaneous nanoemulsions in the gastrointestinal tract. This study aims to evaluate and improve the main components of SNEDDS, specifically oil, surfactant, and co-surfactant, according to the parameters of % transmittance, polydispersity index (PI), and zeta potential. The research findings suggest that the nine formulas have not yet achieved the optimal attributes concerning clarity and durability against dilution. Differences in oil types and amounts of surfactants and cosurfactants influence droplet size, polydispersity index, and zeta potential. Formulas 2 (soybean oil), 7, and 9 (olive oil) exhibit physicochemical parameters that meets the criteria and possess potential for further advancement. Submitted: 10-04-2025, Revised: 22-04-2025, Accepted: 07-05-2025, Published regularly: June 2025
Co-Authors Avanti, Christina Christina Kornelis, Christina Erlina Imelda, Erlina Handika, Yella Helma Malini, Helma Rosita, Vestiana