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FRENGKI FRENGKI
Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Immunology & microbiology Neuroscience Physics Veterinary

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The potential of the metabolites active from Moringa leaves (Moringa oleifera, Lam) on sensitivity of doxorubicin towards breast cancer: in silico studies FRENGKI FRENGKI; KMS M AMIN ALQADRI; SITI AISYAH; HENNIVANDA HENNIVANDA
Jurnal Natural Volume 23 Number 2, June 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v23i2.31142

Abstract

Breast cancer is one type of cancer with the highest incidence suffered by women. Doxorubicin is a chemotherapy that is often used as the main chemotherapy and combination chemotherapy, but the use of doxorubicin is often complained of side effects that cause auto resistance. Combination with chemopreventives from natural ingredients has become an option to increase therapeutic response and to minimize side effects and resistance to chemotherapy use. This study aims to screen several active compounds of the phenolic-flavonoid group contained in Moringa leaves (Moringa oleifera, Lam) against NFκβ receptors in silico using a molecular docking technique. The material in the form of “Canonical smiles” data is quercetin, quercetin-3 glycoside (Q3G), rutin, kaempferol, myricetin, isorhamnetin, deoxyelephantopin and doxorubicin which were downloaded from www.pubchem.org and converted to 3D structures using MOE software. While the 3D structure of the receptor (1VKX) was downloaded from www.rscb.org. The results of the docking of the active compounds contained in Moringa leaves (Moringa oleifera, Lam) showed a fairly strong affinity by releasing energy when forming a ligand-receptor complex. Quercetin 3-glycoside has the best potential as an NF inhibitor with an affinity of -14.23 kcal/mol. Quercetin 3-glycoside also has a good pharmacokinetic profile with low toxicity. While the phenolic-flavonoid compounds contained in other Moringa leaves are only able to reduce the affinity of doxorubicin for the NF receptor by changing the "site binding" conformation of the receptor. In conclusion, quercetin 3-glycoside deserves to be a drug candidate or a companion to the chemotherapy of doxorubicin.
Black Cumin Seed Extract Decrease Motility and Shortening Mortality Time of Ascaridia galli Worm In Vitro Henni Vanda; Ahmad Khairi Abadi; Muhammad Hambal; Farida Athaillah; Wahyu Eka Sari; Frengki Frengki; Daniel Daniel
Jurnal Veteriner Vol 24 No 1 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.1.63

Abstract

Ascaridiasis caused by roundworm Ascaridia galli is one of important diseases in poultry industry in Indonesia. This disease can affect economic losses in the form of death, growth retardation, reduced egg production as well as trigger for secondary viral or bacteria infections. Control of this nematode requires a good strategy to avoid the risk of anthelmintic resistance, one of which is the use of herbal medicine such as black cumin seed (Nigella sativa). This study was aimed to determine the level of motility and mortality time of A. galli after treated with black cumin seed extract in vitro. In this study, black cumin seed was extracted using ethanol 96%, and then diluted to 15% (P1), 25% (P2), and 45% (P3) concentration. Pyrantel pamoate preparation was used as positive control (C1), and carboxymethyl cellulose (CMC) solution as negative control (C0). Observations were carried out every 15 minutes until all the treatment worms died. The results revealed that the motility and mortality time of A. galli were significantly different in some treatment groups. The mortality time of group C0, C1 , P1, P2, and P3 were 2592, 801, 1557, 1350, and 612 minutes, respectively. 45% of black cumin seed extract had the ability to decrease worm motility, and it showed the shortest mortality time compared to other treatment groups. It can be concluded that ethanolic extract of black cumin seeds had potential anthelmintics property on A. galli worms
The potential of the metabolites active from Moringa leaves (Moringa oleifera, Lam) on sensitivity of doxorubicin towards breast cancer: in silico studies FRENGKI FRENGKI; KMS M AMIN ALQADRI; SITI AISYAH; HENNIVANDA HENNIVANDA
Jurnal Natural Volume 23 Number 2, June 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v23i2.31142

Abstract

Breast cancer is one type of cancer with the highest incidence suffered by women. Doxorubicin is a chemotherapy that is often used as the main chemotherapy and combination chemotherapy, but the use of doxorubicin is often complained of side effects that cause auto resistance. Combination with chemopreventives from natural ingredients has become an option to increase therapeutic response and to minimize side effects and resistance to chemotherapy use. This study aims to screen several active compounds of the phenolic-flavonoid group contained in Moringa leaves (Moringa oleifera, Lam) against NFκβ receptors in silico using a molecular docking technique. The material in the form of “Canonical smiles” data is quercetin, quercetin-3 glycoside (Q3G), rutin, kaempferol, myricetin, isorhamnetin, deoxyelephantopin and doxorubicin which were downloaded from www.pubchem.org and converted to 3D structures using MOE software. While the 3D structure of the receptor (1VKX) was downloaded from www.rscb.org. The results of the docking of the active compounds contained in Moringa leaves (Moringa oleifera, Lam) showed a fairly strong affinity by releasing energy when forming a ligand-receptor complex. Quercetin 3-glycoside has the best potential as an NF inhibitor with an affinity of -14.23 kcal/mol. Quercetin 3-glycoside also has a good pharmacokinetic profile with low toxicity. While the phenolic-flavonoid compounds contained in other Moringa leaves are only able to reduce the affinity of doxorubicin for the NF receptor by changing the "site binding" conformation of the receptor. In conclusion, quercetin 3-glycoside deserves to be a drug candidate or a companion to the chemotherapy of doxorubicin.
Co-Authors Ahmad Khairi Abadi Daniel Daniel Farida Athaillah Henni Vanda HENNIVANDA HENNIVANDA KMS M AMIN ALQADRI Muhammad Hambal SITI AISYAH