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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan MEDIC MEdical Dedication Riset Informasi Kesehatan Journal of Medical Studies
Lipinwati Lipinwati
Universitas Jambi
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Other

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Antimicrobial effect of areca nut ethanol extract against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) Hanina Hanina; Humaryanto Humaryanto; Lipinwati Lipinwati
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.730

Abstract

Background: Developing herbal medicines for antibacterial activity has been challenging in Indonesia. Of the alternative antimicrobials, areca nut (Areca catechu L) has antimicrobial activity since it contains flavonoids, tannins, phenols, alkaloids, saponins, terpenoids, and glycosides. The use of antibiotics in underdeveloped and developing countries is still irrational, and bacterial infection in Indonesia is still a problem to resolve, so searching for new herbal medicines is very important. Staphylococcus aureus is the most common normal flora that causes infection. The two types of Staphylococcus aureus are Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA). The study aimed to determine the efficacy of the antibacterial activity of areca nut ethanol extract against MRSA and MSSA isolates. Methods: The research was conducted at the Biomedical Laboratory, Faculty of Medicine and Health Sciences, University of Jambi. Young and old areca nut ethanol extracts were macerated using 96% ethanol. The antibacterial activity test of the ethanol extract was carried out using the Kirby-Bauer disc diffusion method against the isolates of MRSA (clinical isolates) and MSSA (SA 25923/K+, SA 29213/K-). Results: The results showed that the phytochemicals of young areca nut extracts contained alkaloids, flavonoids, phenols, and steroids, and old areca nut extracts contained alkaloids, flavonoids, and phenols. The MRSA isolates did not show the activity of the two areca nut ethanol extracts and were also resistant to Ceftadizime, Gentamicin, Ceftriaxone, and Cefoxitin. The MSSA isolates showed strong activity against old areca nut ethanol extract, moderate activity against young areca nut ethanol extract, and resistance to gentamicin. Conclusion: MRSA bacteria are resistant to the ethanol extract of young and old areca nuts, while the ethanol extract of old areca nuts has strong antibacterial activity against MSSA. Keywords: antibacterial, areca seed ethanol extract, MRSA, MSSA
Gambaran Kadar C-Reactive Protein (CRP) pada Osteomyelitis Dini Pasla Ramadhanti; Budi Justitia; Hanina Hanina; Lipinwati Lipinwati
Journal of Medical Studies Vol. 3 No. 3 (2023): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v3i3.28439

Abstract

ABSTRACT Background: Osteomyelitis is an infection of the bone. Osteomyelitis is most often caused by bacteria. Osteomyelitis can be measured use C-Reactive Protein (CRP). CRP is a parameter infection that has a good level of sensitivity and specificity. Aims of this study is to describe the level of CRP in Osteomyelitis Methods: This study was a descriptive method, conducted in July-December 2022, with data collection using total sampling. Samples of this study used blood osteomyelitis patients with inclusion and exclusion criteria. The data is presented in the table. Results: That of 14 osteomyelitis patients, in the male sex group, 10 people (71.4%). 26-35 years 4 people (28.6%). There were 3 patients (21.4%) with acute osteomyelitis and 11 patients (78.6%) with chronic osteomyelitis. There were 11 patients (78.6%) who had traumatic osteomyelitis and 3 patients (21.4%) who had non-traumatic osteomyelitis. There were 11 patients (78.6%) with abnormal CRP levels. Conclusion: The conclusion of osteomyelitis patients is male gender, age group 26-35 years, patients with chronic osteomyelitis, patients with traumatic osteomyelitis, and the CRP levels of osteomyelitis patients are abnormal. Keywords: Osteomyelitis, CRP ABSTRAK Latar Belakang: Osteomyelitis adalah infeksi mikroorganisme yang menyebabkan kerusakan tulang. Osteomyelitis paling sering disebabkan oleh bakteri. Osteomyelitis dapat diukur dengan menggunakan C-Reactive Protein (CRP) yang merupakan parameter yang memiliki tingkat sensitivitas dan spesifisitas yang baik. Tujuan Penelitian ini adalah untuk menggambarkan kadar CRP pada osteomyelitis. Metode: Penelitian ini menggunakan metode deskriptif untuk mengetahui gambaran kadar CRP pada pasien osteomyelitis. Sampel berupa pasien yang terdiagnosa osteomyelitis. Hasil: Pada hasil penelitian ini, dari 14 pasien osteomyelitis yang berada pada kelompok berjenis kelamin laki-laki sebanyak 10 orang (71,4%). Berusia 26-35 tahun sebanyak 4 orang (28,6%). Pasien yang mengalami osteomyelitis akut sebanyak 3 orang (21,4%) dan osteomyelitis kronik sebanyak 11 orang (78,6%). Pasien yang mengalami osteomyelitis trauma sebanyak 11 orang (78,6%) dan osteomyelitis non trauma sebanyak 3 orang (21,4%). Terdapat kadar CRP tidak normal sebanyak 11 orang (78,6%). Kesimpulan: Gambaran osteomyelitis banyak dijumpai yang berjenis kelamin laki-laki, kelompok usia 26-35 tahun, pasien dengan osteomyelitis kronik, pasien dengan osteomyelitis trauma, dan pasien dengan kadar CRP tidak normal. Kata kunci: Osteomyelitis, CRP
Dextran Sulfate Sodium Effectiveness As Inflammatory Bowel Disease Inducer In BALB/c Mice Hanina Hanina; Lipinwati Lipinwati; Tia Wida Ekaputri Hz; Hasna Dewi
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 11 No. 4 (2023): JAMBI MEDICAL JOURNAL Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v11i4.22941

Abstract

ABSTRACT Background: Inflamatory Bowel Disease (IBD) in animal model could be induced by chemical agents such as dextran sulfate sodium (DSS),  trinitrobenzene sulfanic acid and oxazolone. The inflammation induced by DSS gave many clinical symptoms and immnulogic reactions like in human. In the recent study, the disease activity index has been assessed on the BALB/c mice that induced by DSS 2% and 3%, the result was no significant result. Therefore, DAI score was not necessarily describe the intestinal tissue real condition, so the researcher want to continue assessing DSS influence to the microscopic features of BALB/c mice intestine and colon. Methods: Nine male BALB/c mice 6-8 weeks, weight 25-40 g divided in 3 groups. Group I as control, while group II and III induced by  2 cycles of 2% DSS for 5 days followed by drinking water for 10 days and 3 cycles of 3% DSS for 7 days followed by drinking water for 7 days. Assesment of DSS effectiveness by microscopic examination of intestine and colon to observe inflammatory features. Results: . The microscopic features of group II and group III mice intestine and colon has no inflammatory features as control group. Oral admission DSS 2% and DSS 3% did not establish microscopic changes in BALB/c mice intestine and colon, so it was not effective as mice IBD inducer.  
EDUKASI DAN SOSIALISASI TUBERKULOSIS LUAR PARU DI DESA MARO SEBO KECAMATAN JAMBI LUAR KOTA KABUPATEN MUARO JAMBI Hanina Hanina; Fairuz Fairuz; Hasna Dewi; Lipinwati Lipinwati; Mirna Marhami Iskandar
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 6 No. 2 (2023): MEDIC. Medical dedication
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/medicaldedication.v6i2.28780

Abstract

ABSTRACTMycobacterium tuberculosis (MTBC), apart from causing TB in the lungs, can also cause extra-pulmonary tuberculosis or extrapulmonary tuberculosis (EPTB). Extrapulmonary tuberculosis (EPTB) accounts for approximately 20-30% of all active TB cases and primarily affects children and adults with weakened immune systems. Tuberculosis is a health problem in the community and environment in Maro Sebo Village, Jambi Luar Kota District, Muaro Jambi Regency, Jambi Province. In this village, which is one of the village areas supported by Jambi University, 47 cases of TB were found in 2022, with a low level of treatment compliance. This indicates that many carrier patients will become a source of contact for those around them as one of the implementations of the tri dharma of higher education, community service regarding tuberculosis detection is expected to be able to implement the vision and mission of this community service well, namely by providing education and outreach regarding tuberculosis, so that it is hoped that the community will gain an increased understanding of tuberculosis outside the lungs and can increase self-awareness and family and the surrounding environment. This counselling included 73 respondents who were residents of Maro Sebo Village. The counselling methods used were interactive discussions and giving leaflets. Respondents filled out questionnaires before and after counselling. As a result, there was an increase in the average questionnaire results from 47.7 to 70.1. It can be concluded that the counselling method using interactive discussions and leaflets is quite effective in increasing the knowledge of the Maro Sebo Village community regarding extrapulmonary tuberculosis.Keywords: Maro Sebo Village, Extrapulmonary, Tuberculosis ABSTRAKMycobacterium tuberculosis (MTBC) selain menyebabkan penyakit di paru-paru juga dapat menyebabkan penyakit esktra paru. Penyakit tuberkulosis ekstra paru (extrapulmonary tuberculosis/EPTB) menyumbang sekitar 20-30% darisemua kasus TB aktif dan mempengaruhi terutama anak-anak dan orang dewasa dengan sistem kekebalan tubuh yang lemah. Tuberkulosis merupakan salah satu masalah kesehatan dalam bidang komunitas dan lingkungan, salah satunya di Desa Maro Sebo Kecamatan Jambi Luar Kota Kabupaten Muaro Jambi Provinsi Jambi. Di desa yang merupakan salah satu wilavah desa binaan Universitas Jambi ini, ditemukan 47kasusTBpadatahun2022 dengan tingkat kepatuhan pengobatan yang rendah. Hal ini mengindikasikan banvak pasien karier yang akan menjadi sumber kontak untuk sekitarnya. Sebagai salah satu pelaksanaan tri dharma perguruan tinggi, pengabdian masyarakat tentang deteksi tuberkulosis diharapkan dapat melaksanakan visi misi layanankomunitas ini dengan baik, yaitu dengan melakukan edukasi dan sosialisasi mengenai tuberkulosis, sehingga diharapkan masyarakat mendapatkan peningkatan pemahaman tentang tuberkulosis di luar paru dan dapat meningkatkan kewaspadaan diri dan keluargaserta lingkungan disekitarnya. Penyuluhan ini mengikutsertakan 73 orang responden yang merupakan masyarakat Desa Maro Sebo. Metode penyuluhan yang dilakukan adalah diskusi interaktif dan pemberian leaflet. Responden mengisi kueisioner sebelum dan sesudah penyuluhan (metode pretes -postes). Hasilnya terdapat peningkatan rata-rata hasil kueisioner dari 47.7 menjadi 70.1. Dapat disimpulkan bahwa metode penyuluhan dengan diskusi interaktif dan leaflet cukup efektif untuk meningkatkan pengetahuan masyarakat Desa Maro Sebo mengenai tuberkulosis luar paru.Kata kunci: Desa Maro Sebo, Ekstra paru, Tuberkulosis
Uji Beda Leukosit dan NLR (Neutrophil Lymphocyte-Ratio) terhadap Luaran Pasien Sepsis Rawat ICU (Intensive Care Unit) RSUD Raden Mattaher Jambi 2019 - Oktober 2022 Aidil Rahmat Ilham; Lipinwati Lipinwati; Ahmad Syauqy; Samsirun Halim; Sotianingsih Sotianingsih; Tia Wida Ekaputri
Journal of Medical Studies Vol. 4 No. 1 (2024): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v4i1.31935

Abstract

ABSTRACT Background: Sepsis is a clinical syndrome caused by an overreaction of the body's immune response stimulated by microbes or bacteria inside and outside the body. There is visible organ dysfunction. Of an increase of 2 or more scoresSequential Organ Failure Assessment (SOFA). Early diagnosis and treatment by assessing inflammatory factors such as leukocytes and NLR (Neutrophil-to-lymphocyte ratio). This study aims to determine the difference between leukocyte levels and NLR values based on the outcome of septic patients. Method: This study used an analytic observational cohort method with a retrospective and prospective approach involving 54 research subjects, using consecutive sampling. Sampling was done by calculating leukocyte levels and NLR values at 0, 24, 72, and 144 hours in septic patients. Results: The patients who died for more than 24 hours were 36 patients. The highest average results were measured at 24 hours, with leukocytes 17.48 ± 8.49 and NLR 24.96 ± 22.17. The mean leukocyte and NLR levels were higher in the death group. The analysis found no significant difference between the leukocyte and NLR with the outcomes in septic patients (p >0.05). Conclusion: There was no significant difference between leukocytes and NLR with the outcome of septic patients. Keywords: Biomarkers, Leukocytes, Mortality, NLR, Sepsis   ABSTRAK Latar Belakang: Sepsis adalah suatu sindrom klinik oleh karena reaksi yang berlebihan dari respon imun tubuh yang distimulasi mikroba atau bakteri dari dalam dan luar tubuh. Terdapat disfungsi organ yang terlihat. dari peningkatan 2 atau lebih skor Sequential Organ Failure Assessment (SOFA). Diagnosis dan penanganan lebih awal dengan menilai faktor inflamasi seperti leukosit dan NLR (Neutrophil-to-lymphocyte rasio). Penelitian ini bertujuan untuk mengetahui perbedaan antara kadar leukosit dan nilai NLR berdasarkan luaran pasien sepsis. Metode: Penelitian ini menggunakan metode analitik observasional kohort, dengan pendekatan retrospektif dan prospektif yang melibatkan 54 subjek penelitian, menggunakan teknik consecutive sampling. Pengambilan sampel dilakukan dengan cara menghitung kadar leukosit dan nilai NLR pada jam ke-0, 24, 72, dan 144 pada pasien sepsis. Hasil: Dari 54 sampel, hasil luaran pasien meninggal lebih banyak pada jam 24 sebanyak 36 pasien. Rerata hasil tertinggi pada pada pengukuran jam 24 dengan Leukosit 17,48±8,49 dan NLR 24,96±22,17. Rerata kadar leukosit dan nilai NLR lebih tinggi pada kelompok luaran meninggal. Hasil analisis tidak terdapat perbedaan yang signifikan antara Leukosit dan NLR dengan luaran pasien sepsis (p >0,05). Kesimpulan: Tidak terdapat perbedaan yang signifikan antara Leukosit dan NLR terhadap luaran pasien sepsis. Kata Kunci: Biomarker, Leukosit, Mortalitas, NLR, Sepsis
Co-Authors Ahmad Syauqy Aidil Rahmat Ilham Budi Justitia dewi, hasna Dini Pasla Ramadhanti Fairuz Quzwain Hanina, Hanina Humaryanto Humaryanto Iskandar, Mirna Marhami Samsirun Halim Sotianingsih Sotianingsih Tia Wida Ekaputri