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All Journal Indonesian Journal of Global Health research Riset Informasi Kesehatan
Humaryanto Humaryanto
Universitas Jambi
Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Antimicrobial effect of areca nut ethanol extract against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) Hanina Hanina; Humaryanto Humaryanto; Lipinwati Lipinwati
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.730

Abstract

Background: Developing herbal medicines for antibacterial activity has been challenging in Indonesia. Of the alternative antimicrobials, areca nut (Areca catechu L) has antimicrobial activity since it contains flavonoids, tannins, phenols, alkaloids, saponins, terpenoids, and glycosides. The use of antibiotics in underdeveloped and developing countries is still irrational, and bacterial infection in Indonesia is still a problem to resolve, so searching for new herbal medicines is very important. Staphylococcus aureus is the most common normal flora that causes infection. The two types of Staphylococcus aureus are Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-sensitive Staphylococcus aureus (MSSA). The study aimed to determine the efficacy of the antibacterial activity of areca nut ethanol extract against MRSA and MSSA isolates. Methods: The research was conducted at the Biomedical Laboratory, Faculty of Medicine and Health Sciences, University of Jambi. Young and old areca nut ethanol extracts were macerated using 96% ethanol. The antibacterial activity test of the ethanol extract was carried out using the Kirby-Bauer disc diffusion method against the isolates of MRSA (clinical isolates) and MSSA (SA 25923/K+, SA 29213/K-). Results: The results showed that the phytochemicals of young areca nut extracts contained alkaloids, flavonoids, phenols, and steroids, and old areca nut extracts contained alkaloids, flavonoids, and phenols. The MRSA isolates did not show the activity of the two areca nut ethanol extracts and were also resistant to Ceftadizime, Gentamicin, Ceftriaxone, and Cefoxitin. The MSSA isolates showed strong activity against old areca nut ethanol extract, moderate activity against young areca nut ethanol extract, and resistance to gentamicin. Conclusion: MRSA bacteria are resistant to the ethanol extract of young and old areca nuts, while the ethanol extract of old areca nuts has strong antibacterial activity against MSSA. Keywords: antibacterial, areca seed ethanol extract, MRSA, MSSA
Correlation Clinicopathological and Immunohistochemical Expression of Interleukin-6 (IL-6) in Keloid Fairuz Fairuz; Erisca Utami; Hasna Dewi; Fitriyanti Fitriyanti; Miftahurrahma Miftahurrahma; Budi Justitia; Mara Imam Taufiq Siregar; Humaryanto Humaryanto
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.5844

Abstract

IL-6 has been shown to enhance collagen synthesis and prolong the fibroblast proliferative phase, potentially contributing to uncontrolled keloid growth. However, despite its frequent mention in the literature as a crucial factor in keloid formation, studies specifically exploring the molecular mechanisms of IL-6 in fibroblast regulation and its interaction with other cytokines within keloid tissue remain limited. This study aims to further investigate the role of IL-6 in keloid matrix formation. This study is an analytical study conducted cross-sectionally. The samples used were patients diagnosed with keloids histopathologically based on microscopic criteria. Clinical data were taken from medical records and microscopic and immunohistochemical assessments using paraffin blocks available in the anatomical pathology laboratory of hospitals in Jambi city. There were 36 cases of keloids, aged between 12 and 42 years, mostly in women (66.7%), occurring in the trunk area (77.8%) 30 cases of recurrence (83.3%). We found 24 cases (77.8%) with strong IL-6 immunoexpression. There were 3 cases (8.3%) with no immunoexpression. There was a strong correlation between IL-6 immunoexpression and gender (p=0.03), age(0.04) and recurrence (p=0.02). The role of fibroblast cells is very important for the process of collagen formation in wound healing. The role of fibroblast cells is very important for the process of collagen formation in wound healing, where interleukin-6 in various theories and studies supports the process of collagen formation.
Co-Authors Budi Justitia dewi, hasna Erisca Utami Fairuz Quzwain Fitriyanti Fitriyanti Hanina, Hanina Lipinwati Lipinwati Mara Imam Taufiq Siregar Miftahurrahma Miftahurrahma