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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Window of Health : Jurnal Kesehatan Indonesian Community Journal Pharmaceutical Reports
Muzakkir Baits, Muzakkir
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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 1 
TOXICITY TEST DIETHYL ETHER EKSTRACT OXALIS CORNICULATA L. HERB ON BRINE SHRIMP LETHALITY TEST METHOD Herwin, Herwin; Kosman, Rachmat; Baits, Muzakkir
Jurnal Ilmiah As-Syifaa Vol 6, No 2 (2014): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.895 KB)

Abstract

Recearch toxicity effect of  standar dietil eter ekstract Oxalis corniculata L. herb at Artemia salina Leach with purpose  to determine toxicity potencial and LC50 value Oxalis corniculata L. herb on  brine shrimp lethality test method. The result of this research shows that diethyl ether ekstract Oxalis corniculata L. herb at concentration  100, 50, 5, 1, 0.5, 0.1, 0.05, 0.01 µg/ml and controler is diethyl ether. Presentation data of Artemia salina Leach larvae was analyzed with probit analysis to count LC50. Ekstract is toxic if LC50 value < 1000 µg/ml. So obtained that diethyl ether ekstrak Oxalis corniculata L. herb is toxit to Artemia salina Leach larvae with LC50 4,17± 2,59 µg/ml. Key words : Oxalis corniculata L, Toxicity, Brine Shrimp Lethality Test.
AKTIVITAS ANTIBAKTERI FRAKSI-FRAKSI DAUN Colocacia esculenta L. TERHADAP Salmonella thypi Dan Staphylococcus aureus SECARA BIOAUTOGRAPHY-TLC Baits, Muzakkir; Herwin, Herwin; Ririn, Ririn
Jurnal Ilmiah As-Syifaa Vol 8, No 2 (2016): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (45.568 KB) | DOI: 10.33096/jifa.v8i2.224

Abstract

Antibacterial activity test has been done on Colocacia esculenta L leaves fractions. The aim of the research was to determine the antibacterial activity of Colocacia esculenta L leaves fractions delivered from Pare-Pare District of South Sulawesi on Salmonella thypii and Staphyllococcus aureus by means of vacuum liquid chromatography and Bioautographic-TLC. Results of fractionations of the ethanol extract by the former method using eluent of 100 mL n-hexane, n-hexane:ethyl acetate (10:1; 1:1), 100 mL ethyl acetate, ethyl acetate:methanol (10:1; 1:1) and 100 mL methanol were obtained 7 fractions. Bioautographic-TLC assay then carried out on the obtained fractions they were fraction 3,4,5,6 and 7 respectively and obtained Rf value 0.80 was possessed antibacterial activity on both tested bacteria.
PRODUKSI BIOETANOL DARI BIJI BUAH NANGKA (Artocarpus heterophyllus) MELALUI PROSES HIDROLISIS ASAM SULFAT DAN FERMENTASI Naid, Tadjuddin; Baits, Muzakkir; Triana, Yenni
Jurnal Ilmiah As-Syifaa Vol 4, No 2 (2012): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (41.116 KB) | DOI: 10.33096/jifa.v4i2.76

Abstract

Fermentation  from jackfruit seeds (Artocarpus heterophyllus) through the Process Using Acid Hydrolysis. Bioethanol is ethanol fermentation process biomass results with the help of microorganisms. Raw materials for bioethanol is sugary materials, starchy and fibrous. This study tries  to make bioethanol from jackfruit seeds (Artocarpus heterophyllus) which is a starchy material. during these jackfruit seeds into consumption only partly public and partly not used. The purpose of this study was to determine the optimum concentration of H2SO4on the hydrolysis process and determine the optimum fermentation time in the fermentation process. The process of making ethanol in two steps, namely acid hydrolysis and fermentation. Cassava peel hydrolyzed by using a solution of H2SO4 in a variety of variable concentrations (0.1, 0.5 and 1 M) at a temperature of 100oC for 1 hour. Then a solution of the hydrolysis fermented with various variables days (1, 2, 3, 4, 5, 6 and 7 days). The result showed that the optimum concentration of H2SO4 solution for the hydrolysis reaction is 1 M at a temperature of 100oC for 1 hour and the optimum fermentation time in the fermentation process is on day 4 where the produced ethanol at 13,19% v/v. Key words : Fermentation, Artocarpus heterophyllus, Hydrolysis
ANALISIS KOMPONEN KIMIA AKTIF ISOLAT DAUN Colocacia esculenta L. IDTK01 SECARA SPEKTROFOTOMETER INRA MERAH Herwin, Herwin; Baits, Muzakkir; Ririn, Ririn; Harly Nurung, Ayyub
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.746

Abstract

The objective of this research is to analysis chemical coumpounds active isolate of Colocacia esculenta L.’s leaves IDTK01 using infra red spectrophotometer. The fractionation of the ethanolic extract of Colocasia esculenta L’s leaves using liquid vacuum chromatography obtained 7 fractions. Active fraction was B fraction isolated from the active coumpound by TLC-preparative from 3 different isolate, IDTK01, IDTK02 dan IDTK03. IDTK01 isolate was tested its antibacterial activity using TLC-bioautography with eluen n-hexane:ethyl acetate (10:1) and its active against Salmonella thypi with Rf value 0.98. Active isolate IDTK01 was analyze its active bacterial coumpound using infrared spectrophotometer and the results is hydrogen bond, hydroxyl functional group (OH), aryl/ aromatic (C=C), aliphatic (CH2), Ether aldehyde (C-O), and pyridine.
Hydroquinone Levels in Whitening Body Lotion Circulating in Makassar City by the UV-Vis Spectrophotometry Method Rezky M, Mega; Suhaenah, Asriani; Baits, Muzakkir
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.272

Abstract

Hydroquinone is an active compound that is able to control pigment production to inhibit melanin formation and has activity as a skin whitening agent, so hydroquinone is widely used in cosmetic products. Hydroquinone has adverse side effects if used for a long time. BPOM RI has issued a regulation on the prohibition on the use of hydroquinone as a bleach in cosmetics. The purpose of this study was to identify the hydroquinone content in whitening handbody samples circulating in Makassar City and to find out the level of hydroquinone contained in the sample. Qualitative analysis is carried out using FeCl₃ reagents and quantitative analysis using the UV-VIS spectrophotometry method. The number of samples used in this study was as many as 4 samples that did not have a registration number from BPOM RI. The results showed that the 4 samples studied positively contained hydroquinone. The results of the sample test measured at a maximum wavelength of 292 nm, obtained hydroquinone levels at the sample code HB1 = 1.267%; sample code HB2 = 0.912%; sample code HB3 = 0.379% and sample code HB4 = 0.449%.
Kersen (Cherry) (Muntingia calabura L) Leaves as an Alternative Plant Free Radical Scavenger in Improving the Immune System St. Maryam; Baits, Muzakkir; Tahir, Masdiana
Window of Health : Jurnal Kesehatan Vol 6 No 4 (October 2023)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.vi.703

Abstract

Kersen (Cherry) (Muntingia calabura L) leaves are empirically used to treat various diseases because they contain flavonoid and tannin compounds. Based on previous research, it was reported that phenolic compounds, tannins, and flavonoids can potentially counteract free radicals so that they can improve the body's immune system. The purpose of this study was to determine the antioxidant activity of extracts of methanol, ethyl acetate, and n-hexane from cherry leaves (Muntingia calabura L.). The DPPH free radical scavenging method is based on the reduction of the colored DPPH free radical methanol solution by free radical inhibition. The extraction process of a compound is carried out to separate the material from the mixture using a suitable solvent. The existence of a level of polarity of a solvent used to attract the components of active compounds in plants is a guide for the search for new compounds in a plant. The potential of a compound to counteract free radicals can be determined by calculating the IC50. The results showed that the extract of methanol, ethyl acetate, and n-hexane of the cherry leaf (Muntingia calabura L.) had inhibitory activity against DPPH free radicals with IC50 values of 8.67; 9,097, and 18.17 g/mL. Meanwhile, gallic acid has inhibitory activity with an IC50 value of 1.77 g/mL. Methanol and ethyl acetate extracts of cherry leaves were able to inhibit DPPH activity in a very strong category, which was almost comparable to gallic acid, while n-hexane extract had antioxidant activity in a strong category.
Antioxidant Activity and Total Carotenoids Level of Litopenaeus vannamei Fawwaz, Muammar; Baits, Muzakkir; Pratama, Mamat; Abidin, Zainal
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.41481

Abstract

Udang putih (Litopenaeus vannamei) merupakan salah satu spesies Crustacea yang cangkangnya mengandung senyawa karotenoid. Senyawa ini merupakan antioksidan alami yang berpotensi tinggi. Penelitian ini bertujuan untuk mengetahui karotenoid total pada ekstrak cangkang L. vannamei dan mengevaluasi aktivitas antioksidannya secara in vitro. Ekstrak diperoleh dengan cara maserasi menggunakan n-heksan. Tingkat total karotenoid dalam ekstrak ditentukan setara dengan β-karoten. Spektrofotometer UV-Visible mengukur ekstrak dan larutan standar referensi pada panjang gelombang maksimum β-karoten (462 nm). Dua metode berbeda digunakan dalam menentukan aktivitas antioksidan ekstrak; metode peredaman radikal 1,1-diphenyl-2-picryl-hydrazyl (DPPH) dan metode ferric reducing antioxidant power (FRAP). Hasil penelitian menunjukkan bahwa karotenoid total dalam ekstrak cangkang L. vannamei adalah 5,87 mg/g, setara dengan β-karoten. Konsentrasi hambat setengah (IC50) ekstrak dengan metode DPPH adalah 27,59 µg/mL menunjukkan potensi sedang sebagai antioksidan dibandingkan dengan kuersetin standar sebesar 1,28 µg/mL. Kapasitas antioksidan ekstrak dengan metode FRAP dinyatakan dalam mg setara kuersetin (QE) per g ekstrak (mgQE/g), dan hasilnya menunjukkan potensi penghambatan sebesar 1,65 mgQE/g ekstrak. Dengan demikian, dapat disimpulkan bahwa ekstrak cangkang udang vannamei sangat potensial sebagai sumber karotenoid alami dengan efek antioksidan yang memadai.
Pemberdayaan Majelis Taklim Al-Urwah Tamalate Melalui Pelatihan Pembuatan Perjahe Suplemen Peningkat Imunitas Rendah Kalori Baits, Muzakkir; Syarif, Rezki; Faradiba; Dahlia, Andi; Malik, Abdul; Anggrayni, Anggi; Praditha, Elyana; Amalia, Alifya; Yusuf, Rudy
I-Com: Indonesian Community Journal Vol 5 No 1 (2025): I-Com: Indonesian Community Journal (Maret 2025)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70609/icom.v5i1.6084

Abstract

Majelis taklim Al-Urwah merupakan mitra kegiatan pengabdian yang terdiri dari ibu-ibu rumah tangga yang belum produktif secara finansial ,salah satu program kerjanya yaitu membina dan memperdayakan anggotanya dengan memberikan keterampilan melalui pelatihan. Kegiatan pengabdian kepada masyarakat ini bertujuan memberikan  memberikan keterampilan  mengolah jahe menjadi permen melalui pelatihan partisipatif.  Kegiatan  dilaksanakan diawali dengan penyuluhan materi pelatihan  kemudian pelatihan secara langsung pembuatan permen  jahe dan pelatihan pengemasan produk secara higienis dan menarik.  selanjutnya  dilakukan diskusi dan  diberikan kuesioner terkait produk permen dengan lima parameter. Hasil kegiatan ini dengan peningkatan keterampilan cara pembuatan permen jahe dan pengemasan produk yang menarik dan higiensi dan terdapat produk permen jahe yang siap untuk  dikomersilkan dan diaplikasikan oleh ibu-ibu majelis taklim Al-Urwah.
In vitro, efek antidiabetes dan antikolestrol kopasanda (Chromolaena odorata L.) Rahmawati, Rahmawati; Baits, Muzakkir; Putri, Hemalia; Nurhikmah, Nurhikmah
Jurnal Fitofarmaka Indonesia Vol 12, No 1 (2025): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v12i1.1330

Abstract

The leaves of the kopasanda plant (Chromolaena odorata L.) contain alkaloids, flavonoids, saponins, terpenoids and tannins which have the potential to be anti-diabetic and anti-cholesterol. In vitro research has been carried out on the ethanol extract of kopasanda leaves (Chromolaena odorata L.) to determine the potential of α-glucosidase enzyme inhibitor compounds as antidiabetic by determining the IC50 value and the potential to reduce cholesterol levels as an anticholesterol by determining the EC50 value. Testing for the inhibitory activity of the α-glucosidase enzyme used the spectrophotometer method with a microplate reader at a wavelength of 405 nm, with acarbose as a comparison. The results showed that the activity of the ethanol extract of kopasanda leaves (Chromolaena odorata L.) as an inhibitor of the α-glucosidase enzyme obtained an IC50 value of 444.019 µg/mL in the very weak category. In testing the anti-cholesterol potential using a UV-Vis spectrophotometer with measurements at a wavelength of 672 nm, the calculation results obtained an EC50 value of 1,017.118 µg/L. This shows that the activity of the ethanol extract of kopasanda leaves (Chromolaena odorata L.) has the potential to inhibit cholesterol.
Co-Authors Abdul Malik Amalia, Alifya Anggrayni, Anggi Asriani Suhaenah Dahlia, Andi Faradiba Herwin Herwin, Herwin Mamat Pratama, Mamat Masdiana Tahir, Masdiana Mochammad Imron Awalludin Muammar Fawwaz Nurhikmah Nurhikmah Nurung, Ayyub Harly Praditha, Elyana putri, Hemalia Rachmat Kosman, Rachmat Rahmawati, Rahmawati Rezky M, Mega Ririn Ririn Syarif, Rezki Tadjuddin Naid Yenni Triana, Yenni Yusuf, Rudy Zainal Abidin