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Rika Valensia
Universitas Singaperbangsa Karawang, Jl. HS. Ronggo Waluyo, Telukjambe Timur, Karawang, Jawa Barat, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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ANALISIS BERBAGAI METODE IDENTIFIKASI ISOFLAVON: LITERATUR REVIEW Vriezka Mierza; Fitri Aida; Hajar Hartati; Herdiana Verliani; Nisa Alifia Zahra; Rika Valensia
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.22 KB) | DOI: 10.36490/journal-jps.com.v6i1.28

Abstract

Isoflavone is included in the phytoestrogens, a natural plant substance with a structure similar to 17-β-estradiol. It can bind to estrogen receptors so that isoflavones can prevent or slow down forms of cancer related to Alzheimer's hormones, osteoporosis, and others. Isoflavones are also included in the flavonoids found in fruits such as berries, grapes and are most abundant in soybeans and other nuts. From the literature study that has been conducted, it was found that there are several methods for identifying isoflavone compounds, including HPLC/HPLC, TLC, UV-Vis Spectrophotometry, Mass Spectrophotometry, and others. Of the many types of isoflavones that exist, the most commonly identified isoflavones are genistein and daidzein, which can be found in samples of soybeans, soy milk, and processed tempeh. The isoflavone content identified by each researcher differs in terms of the quantity and type of isoflavone content. This is because in identifying isoflavones, there are factors that influence them. The duration of fermentation has an effect because it is related to the presence of dissolved compounds during the fermentation process, which results in differences in the quantity of isoflavones, besides that the reactive and easily oxidized nature of isoflavones causes isoflavones to bind to other compounds to form new unknown compounds so that isoflavones are no longer identified.
Potensi Beberapa Senyawa Turunan dan Tumbuhan sebagai Antidepresan dengan metode skrining Komputasi : Literature Review Vina Luthfiana Hasna; Erlangga Muhamad Prayuda; Rika Valensia; Aditya Putra Tama; Khamairah Azzahrawaani Hermawan; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (401.308 KB) | DOI: 10.36490/journal-jps.com.v6i1.29

Abstract

Depression is a severe mental illness that is usually characterized by feelings of sadness or anxiety. Data reports that some 800,000 cases of suicide are the result of depression. Meanwhile, in Indonesia, individuals with depression are in the range of 6% of the total population. Another finding was by the Central Statistics Agency (2014) that at least 3.4 million youth aged 10-19 experienced mental disorders in 2013. This review article aims to provide readers with information regarding compounds that have the potential as antidepressants. The method used in this literature review is to search for reference sources in the form of scientific journals or scientific articles, both on a national and international scale, related to in silico testing of antidepressant compounds. Several compounds can be used as antidepressants. The most common receptors used to test antidepressant activity are 5-HT1A (5-hydroxytryptophan) and MAOA (Monoamine Oxidase A). Compounds that have potential as antidepressants include safrole from nutmeg, Curcuma longa active compounds, curcumin derivatives, Angelica archagelica extracts, Gingerol and shogaol in Zingiber officinale Constituents, Dehydrozingerone Compounds from Zingiber officinale extract, eicosanal and acetate phytol from Elatostem papillosum, L. -17, 1MeTIQ, and Aegeline in Aegle marmelos fruit extract,
Co-Authors Aditya Putra Tama Erlangga Muhamad Prayuda Fitri Aida Hajar Hartati Herdiana Verliani Khamairah Azzahrawaani Hermawan Lina Nurfadhila Nisa Alifia Zahra Vina Luthfiana Hasna Vriezka Mierza