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All Journal Sumatera Medical Journal Jurnal Penyakit Dalam Indonesia
Habibah Hanum Nasution, Habibah Hanum
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Immunology & microbiology Medicine & Pharmacology

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Correlation of Depression Symptoms and Interleukin-6 in Chronic Renal Disease with Regular Hemodialysis Patients Damayanti, Indah; Nasution, Habibah Hanum; Lubis, Wika Hanida
Sumatera Medical Journal Vol. 1 No. 1 (2018): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5235.571 KB) | DOI: 10.32734/sumej.v1i1.442

Abstract

Depression is psychosomatic disorder are common in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). Correlated with morbidity and mortality associated with chronic inflammation in patients, that characterized by elevated levels of plasma cytokines, especially interleukin (IL)-6. Objective: To investigate the correlation of depressive symptoms with IL-6 levels in patients with CKD who underwent regular HD. Methods: One hundred and 29 CKD patients were enrolled in this cross- sectional study. All eligible patients were screened for IL-6 level. Beck Depression Inventory (BDI) II questioner were then given to determine the presence of depression. Level of IL-6 was then correlated with BDI score using Spearman test. Result: The mean BDI score was 19,32 ± 6,18 indicating the level of mild depression symptoms, and the mean IL-6 level (8,697 ± 6,947 pg/mL) was still within normal range. There was a moderate positive correlation (r = 0.417) between the level of depressive symptoms and IL- 6 levels. Conclusion: There was a moderate positive correlation (r = 0.417) between IL-6 levels and depressive symptoms in patient with HD. However, mean IL-6 levels in depressive patients are still within normal limits indicating that the cause of depression is multifactorial.
Correlation between Spiritual Aspect and Serum Interleukin-6Level in Chronic Hemodialysis Patients Hanida, Wika; Mudjaddid, E; Nasution, Habibah Hanum; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. Holistic approach in psychosomatic focus on spirituality factor and spiritual support is expected to improve services and psychological condition of the patients. Inflammatory response during hemodialisis procedure hence increased with the evidence of increasing level of serum interleukin-6 (IL-6). Further research is still needed to see the spiritual factors that can decrease the inflammatory factors. Methods. Cross sectional study on 51 chronic hemodialisis patients at RSUP. H. Adam Malik and RSU dr. Pirngadi Medan between July-August 2014. Serum IL-6 was measured using quantitative enzyme-linked immune sorbent assay (ELISA) methods. Blood samples and spiritual aspect assessment by handing out FACIT Sp-12 questionnaire to patients were taken in the morning, 30 minutes before hemodialisis. Results. Subscale meaning 10.67 (SB 2.66), peace 9.63 (SB 2.19) and faith 11.47 (SB 2.91). Median serum IL-6 level is 5,63 (1,48- 28,88) pg/mL. Median FACIT Sp-12 is 30,00 (18-48). Correlation test between serum IL-6 level and spiritual aspect have shown statistically weak negative correlation (correlation coefficient -0,330, p=0.018). Conclusions: spirituality level in chronic hemodialisis patients are higher. Weak negative correlation between serum IL-6 level and spiritual level on chronic hemodialisis patients was found in this study.
Co-Authors E Mudjaddid, E E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Indah Damayanti, Indah Lubis, Wika Hanida Wika Hanida, Wika