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All Journal KOLONI JIPI (Jurnal IPA dan Pembelajaran IPA)
Abdul Wahab
Universitas Abulyatama
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Education Environmental Science Law, Crime, Criminology & Criminal Justice Physics Public Health Social Sciences Other

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Potensi Pendekatan in Silico Sebagai Penghambat Aktivitas Protein Protease Utama SARS-CoV-2 dari Tiga Senyawa Tanaman Obat Jahe Merah Cut Annisa Thahara; Rizarullah Rizarullah*; Ratih Ayu Atika; Abdul Wahab
JIPI (Jurnal IPA dan Pembelajaran IPA) Vol 6, No 3 (2022): SEPTEMBER 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jipi.v6i3.24914

Abstract

Corona Virus Disease (COVID-19) is a pneumonia outbreak that has been worldwide to date. This outbreak was caused by a Coronavirus originating from Hubei province that first occurred in Wuhan in December 2019. COVID-19 is caused by SARS-CoV-2. SARS-CoV-2 which causes corona has important proteins that are used to infect and replicate, one of which is the main protease protein (Mpro). Red ginger (Zingiber officinale var.Rubrum) is one of the spices that has properties to cure various diseases such as flu, cough and diarrhea. Ginger contains compounds that are antioxidants. The purpose of this study was to examine the potential biological activity of red ginger compounds, namely Gingerol 10, Shogaol 6, and Shogaol 8 as inhibitors of the main protease (MPro) protein activity of SARS-CoV-2. This research was conducted using the In Silico method and AutoDock Vina software was used for the tethering process. The results of gridbox optimization by redocking control ligands obtained RMSD results of 1,100 Å. The results of the tethering showed Gibbs free energy (ΔG) Test Ligand 1 (-5.5 kcal/mol), Test Ligand 2 (-6.0 kcal/mol), and Test Ligand 3 (-5.6 kcal/mol) which showed red ginger compounds have potential as inhibitor of the main protease (MPro) protein activity of SARS-CoV-2.
Karakteristik Pasien Epilepsi Di Poliklinik Saraf Rumah Sakit Pertamedika Ummi Rosnati Izza Zuhra; Rizkidawati Rizkidawati; Abdul Wahab
KOLONI Vol. 5 No. 3 (2026): SEPTEMBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i3.1325

Abstract

Epilepsy is a chronic neurological disorder characterized by recurrent seizures due to abnormal electrical activity in the brain. This disease is still a health problem because it can affect the quality of life and activities of the sufferer. Identification of epilepsy patient characteristics based on age, sex, seizure type, family history, and therapy used is needed to provide a picture of the patient's profile and support more optimal health services. This study aims to determine the characteristics of epilepsy patients at the Neural Polyclinic of Pertamedika Ummi Rosnati Hospital, Banda Aceh in 2025. This type of research is descriptive with a design cross sectional. The sampling technique in this study is simple random sampling with a sample of 64 people who meet the inclusion criteria. The research was conducted from January to July 2026. The research instrument was in the form of patient medical record data, while data analysis was carried out univariately. The results showed that most of the patients were in the age group of 19–59 years as many as 55 people (85.9%), female as many as 34 people (53.1%), had general seizures as many as 46 people (71.9%), underwent polytherapy therapy as many as 34 people (53.1%), and had no family history of epilepsy as many as 50 people (78.1%). The most widely used antiepileptic drug therapy was the combination of phenytoin and divalproex in 15 people (23.4%).It can be concluded that epilepsy patients at the Neural Polyclinic of Pertamedika Ummi Rosnati Hospital Banda Aceh in 2025 are dominated by adulthood, female, general seizures, polytherapy use, and no family history of epilepsy.
Co-Authors Cut Annisa Thahara Izza Zuhra Ratih Ayu Atika Rizarullah, Rizarullah Rizkidawati Rizkidawati