Article Per Year (5 Year)
p-Index From 2020 - 2025
2.488
P-Index
This Author published in this journals
All Journal SEL Jurnal Penelitian Kesehatan Journal of Science and Applicative Technology Jurnal Medika Malahayati Jurnal Eduscience (JES) Jurnal Sains Riset Proceedings of International Conference on Multidiciplinary Research Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik) International Journal of Health Science (IJHS) Chimica Didactica Acta : Journal of Chemistry and Chemistry Education JIPI (Jurnal IPA dan Pembelajaran IPA)
Rizarullah, Rizarullah
Fakultas Kedokteran Universitas Abulyatama Aceh
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
HUBUNGAN STATUS GIZI SISWI SMP DI PEDESAAN DAN PERKOTAAN TERHADAP POLA SIKLUS MENSTRUASI Anggi Nadra Hanum Siregar; Dewi Karlina Rusly; Rizarullah Rizarullah
JURNAL EDUSCIENCE (JES) Vol 6, No 2 (2019): Jurnal Eduscience (JES)
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.42 KB) | DOI: 10.36987/jes.v6i2.1421

Abstract

Masa remaja merupakan masa transisi atau peralihan dari masa anak-anak menuju dewasa yang ditandai adanya perubahan fisik, psikis dan psikososial. Pada remaja putri, pubertas ditandai dengan permulaan menstruasi (menarche). Pada remaja putri dibutuhkan status gizi yang baik dalam membantu pertumbuhan remaja termasuk keteraturan siklus menstruasi. Remaja putri yang mengalami asupan gizi kurang atau lebih dapat menyebabkan gangguan fungsi reproduksi dan berdampak pada gangguan menstruasi. Tujuan penelitian untuk mengetahui hubungan status gizi dengan siklus menstruasi pada remaja putri di SMP perkotaan dan pedesaan. Desain penelitian yaitu metode koleratif dengan rancangan cross sectional, populasi yaitu semua remaja putri yang memenuhi kriteria inklusi. Sampel penelitian ini 120 responden termasuk 60 responden daerah pedesaan dan 60 responden dari daerah perkotaan yang didapat dengan menggunakan teknik purposive sampling. Instrumen yang digunakan yaitu kuesioner siklus menstruasi dan lembar obeservasi hasil pengukuran berat badan dan tinggi badan yang dilakukan. Hasil uji statistik menggunakan uji Chi Square pada tingkat kemaknaan 95% (α ≤ 0,05), kemudian diperoleh dipedesaan dengan nilai p = 0.401 sedangkan diperkotaan dengan nilai p = 0.203. Ini berarti bahwa nilai p >α (0,05). Dengan demikian bahwa tidak terdapat hubungan yang bermakna antara status gizi dengan siklus menstruasi pada remaja putri di remaja putri di SMP perkotaan dan pedesaan. Dan juga tidak ada perbedaan secara signifikan semua variabel. Saran untuk remaja putri agar lebih menjaga status gizi dan memelihara kesehatan reproduksi mereka agar siklus menstruasi mereka menjadi teratur.
SIMULASI DOCKING SENYAWA AKTIF DAUN BINAHONG SEBAGAI INHIBITOR ENZYME ALDOSE REDUCTASE Andrio Suhadi; Rizarullah Rizarullah; Feriyani Feriyani
Sel Jurnal Penelitian Kesehatan Vol 6 No 2 (2019): SEL Jurnal Penelitian Kesehatan
Publisher : Balai Penelitian dan Pengembangan Kesehatan Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1002.615 KB) | DOI: 10.22435/sel.v6i2.1651

Abstract

Sindroma metabolik merupakan masalah dunia yang disebabkan salah satunya oleh diabetes mellitus. Daun binahong merupakan tanaman yang sering digunakan untuk mengobati berbagai penyakit. Penelitian ini bertujuan untuk melihat aktivitas inhibisi senyawa daun binahong untuk menghambat aldose reductase yang berperan mengubah glukosa menjadi sorbitol dengan cara simulasi docking. Senyawa dari daun binahong adalah asam ursolat, vitexin dan oleonalat (ligan uji). Senyawa tersebut di ambil melalui situs pubchem, sedangkan enzyme aldose reductase (reseptor) didapat dari bank protein dunia dengan kode PDB 2HV5. Penelitian ini menggunakan teknik In Sillico dengan menggunakan perangkat lunak AutoDock Vina dan Discovery Studio serta Ligplot sebagai visualisasinya. Hasil optimasi gridbox dengan melakukan penambatan ulang ligan pembanding dan diperoleh RMSD sebesar 0,7 Å. Hasil docking menunjukkan energi bebas gibbs (∆G) Aldose Reductase (-11,7), Vitexin (-8,3), Asam Ursolat (-7,7) dan Oleonalat (-8,6) yang menunjukan adanya reaksi inhibisi yang stabil dari senyawa daun binahong dan ligan pembanding. Berdasarkan aturan dari Lipinski’s Rule menunjukan senyawa dari daun binahong memenuhi dari aturan Lipinski’s Rule yang berarti dapat digunakan secara oral kecuali Vitexin dan ligan pembanding zopolrestat melebihi dari jumlah atom. The metabolic syndrome is the cause of death around the world caused by diabetic mellitus. Binahong leaf is a kind of plant that is widely used to treat various diseases. This study aims to investigate the inhibitory activity of binahong leaves compound in inhibiting the aldose reductase which has role of converting glucose into sorbitol by docking simulation. The compound of binahong leaves consists of ursolic acid, vitexin, and oleonolic acid (ligand testing). These compound were taken from PubChem site, while aldose reductase enzyme (receptor) was obtained from the world protein bank with PDB 2HV5 code. This study incorporated in silica technique by using Auto dock vina software, Discovery Studio and Ligplot as visualization. The result of grid box optimization by redocking comparative ligand was 0.7Å RMSD. The docking result showed that the free Gibbs energy (∆G) of aldose reductase was (-11.7), Vitexin (-8.3), Ursolic acid (-7.7) and Oleonolic acid (-8.6). These value suggested that there was a stable inhibition reaction from the binahong leaves compound and the comparative ligand. Based on the Lipinski Rule, the composition of binahong leaves compound meets the Lipinski Rule criteria which means this medicine can be used orally except for vitexin and comparative ligands of zopolrestate which exceed the number of the atom.
PERBEDAAN PROFIL LIPID PASIEN STROKE ISKEMIK DAN STROKE HEMORAGIK DI RSUD MEURAXA KOTA BANDA ACEH Selvirawati Selvirawati; Abdul Wahab; Rizarullah Rizarullah
Jurnal Medika Malahayati Vol 4, No 3 (2020): Volume 4 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.709 KB) | DOI: 10.33024/jmm.v4i3.3149

Abstract

Stroke termasuk penyakit serebrovaskular yang ditandai dengan kematian jaringan otak (infark serebral) yang terjadi karena berkurangnya aliran darah ke otak. Serangan stroke umumnya menyebakan kerusakan yang serius atau nekrosis pada jaringan otak. Salah satu faktor risiko stroke adalah dislipidemia. Penelitian ini bertujuan untuk mengetahui perbedaan profil lipid pada pasien stroke iskemik dan stroke hemoragik. Desain yang digunakan dalam peneitian ini adalah studi potong lintang (Cross Sectional) yang menggunakan data sekunder pasien stroke dari catatan rekam medik RSUD Meuraxa Banda Aceh. Analisis data menggunakan Uji T-test sampel tidak berpasangan (Independent sample t test) dan uji non-parametrik Mann-Whitney U test. Pengujian normalitas data dilakukan dengan metode Shapiro-Wilk test. Penelitian ini berfokus pada pasien stroke iskemik dan stroke hemoragik rentang usia 50-70 tahun periode Januari-Desember 2019. Jumlah sampel yang digunakan 56 pasien stroke yang terdiri dari 30 pasien stroke iskemik dan 26 pasien stroke hemoragik. Hasil penelitian ini menunjukan nilai p untuk kolesterol total, LDL, HDL, dan trigliserida, berturut-turut 0,013, 0,271, 0,040, dan 0,421. Terdapat perbedaan profil lipid pada pasien stroke iskemik dan stroke hemoragik.
POTENSI ANTIDIABETES BENZYL BETA D GLUCOPYRANOSIDE DARI DAUN YACON SEBAGAI INHIBITOR ENZIM DPP-4: METODE IN SILICO Mangatur Riverson; Rizarullah Rizarullah
Prosiding Seminar Nasional Biotik Vol 8, No 1 (2020): PROSIDING SEMINAR NASIONAL BIOTIK VIII 2020
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh, Aceh, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (679.319 KB) | DOI: 10.22373/pbio.v8i2.9653

Abstract

Diabetes mellitus (DM) merupakan suatu kelompok penyakit metabolisme yang ditandai dengan peningkatan kadar gula darah. Daun yacon merupakan tanaman herbal yang sering digunakan sebagai obat herbal. Tujuan dari penelitian ini menganalisis potensi senyawa benzyl beta d glucopyranoside dari daun yacon sebagai obat antidiabetes. Penelitian ini menggunakan metode in silico dengan menggunakan perangkat lunak AutoDock Vina. Hasil penelitian menunjukkan energy bebas Gibbs (ΔG) benzyl beta d glucopyranoside (-6.8 kkal/mol), Nilai RMSD (1.101 Å), dan ikatan hidrogen pada asam amino Arg125, Asn710, Ser630, Tyr631. Berdasarkan aturan Lipinski senyawa benzyl beta d glukopyranoside dapat digunakan sebagai obat oral.
PENDEKATAN IN SILICO POTENSI PENGHAMBAT AKTIVITAS PROTEIN MAIN PROTEASE (Mpro) SARS-CoV- 2 DARI TIGA SENYAWA TANAMAN OBAT JAHE MERAH Rizarullah Rizarullah; Cut Annisa Thahara
Jurnal Sains Riset Vol 11, No 3 (2021): Edisi Khusus Dies Natalis Universitas Abulyatama
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Jabal Ghafur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47647/jsr.v11i3.825

Abstract

Corona Virus Disease (COVID-19) is a pneumonia outbreak that has been worldwide to date. This outbreak was caused by a Coronavirus originating from Hubei province that first occurred in Wuhan in December 2019. COVID-19 is caused by SARS-CoV-2. SARS-CoV-2 which causes corona has important proteins that are used to infect and replicate, one of which is the main protease protein (Mpro). Red ginger (Zingiber officinale var.Rubrum) is one of the spices that has properties to cure various diseases such as flu, cough and diarrhea. Ginger contains compounds that are antioxidants. The purpose of this study was to examine the potential biological activity of red ginger compounds, namely Gingerol 10, Shogaol 6, and Shogaol 8 as inhibitors of the main protease (MPro) protein activity of SARS-CoV-2. This research was conducted using the In Silico method and AutoDock Vina software was used for the tethering process. The results of gridbox optimization by redocking control ligands obtained RMSD results of 1,100 Å. The results of the tethering showed Gibbs free energy (ΔG) Test Ligand 1 (-5.5 kcal/mol), Test Ligand 2 (-6.0 kcal/mol), and Test Ligand 3 (-5.6 kcal/mol) which showed red ginger compounds have potential as inhibitor of the main protease (MPro) protein activity of SARS-CoV-2.Keywords: Main Protease (MPro), Gingerol 10, Shogaol 6, dan Shogaol 8
GAMBARAN SIKAP DAN PERILAKU TENAGA KESEHATAN DALAM PENGELOLAAN LIMBAH MEDIS DI RSUD ACEH BESAR Rizarullah Rizarullah; Satria Safirza
Jurnal Sains Riset Vol 11, No 2 (2021): September 2021
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Jabal Ghafur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47647/jsr.v11i2.743

Abstract

Background: Hospitals as a unit providing health services to the community not only have a positive impact but also the negative impact that medical waste generated by hospitals if not processed according to the procedure will have adverse health and environmental impacts. Research Objectives: To see the description of attitudes and behavior of health personnel in the treatment of medical waste because the problem there is still found mixed medical and non medical waste. Research Method: This research is descriptive research with research designusing cross sectional approach. In this research data collected through questionnaire method to 114 respondents namely health workers at RSUD Aceh Besar by using simple random sampling technique to know the description of attitude and behavior in medical waste processing. Result: Univariate analysis showed that most respondents had good attitude about medical waste treatment at RSUD Aceh Besar that is 73 people (64%) while respondents who have bad attitude counted 41 people (64%). Then most respondents have good behavior in medical waste processing at RSUD Aceh Besar that is 62 people (54,4%) whereas respondents who have bad behavior as much 52 people (45,6%). Most of the respondents stated that the medical waste treatment in RSUD Aceh Besar was good as many as 66 people (57.9%) while the respondents stated that the medical waste treatment in RSUD Aceh Besar was badas much as 52 people (45,6%).Keywords: Attitude, Behavior, Health Worker, Medical Waste Treatment
UJI AKTIVITAS ANTI BAKTERI EKSTRAK ETANOL DAUN BINAHONG (Andera Cordifolia) TERHADAP BAKTERI Stahpylococcus Aureus Isfanda Isfanda; Rizarullah Rizarullah
Jurnal Sains Riset Vol 11, No 2 (2021): September 2021
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Jabal Ghafur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47647/jsr.v11i2.733

Abstract

Antibacterial is a compound that can be used for the treatment of infections caused by bacteria. Traditionally Binahong plants (Anredera cordifolia) are plants known to the public to handle various diseases. Binahong leaf that has antibacterial natural compounds such as oleanolic acid, ursolic acid and apigenin. This study aims to examine the antibacterial activity of ethanol extract of binahong leaves against staphylococcus aureus bacteria. This research is using experimental method. Leaves binahong obtained from Sawang Aceh Utara. The maceration stage is done by using ethanol 96% for 3 days and then in doing phytochemical test to find out secondary metabolic content. Antibacterial testing using discs. The results of phytochemical tests found secondary metabolic compounds class of alkaloids, polyphenols, saponins, quinones, and triterpenoids. Antibacterial test using 25%, 50%, 75% concentration, negative control (Aquadest), and Positive control (Amoxicillin) obtained the results are 6mm, 6mm, 6.67mm, 0mm, 30,67 mm. Based on the research of ethanol extract of binahong leaf has an inhibitory power to the growth of Staphylococcus Aureus bacteria at 75% concentration. At concentrations of 25% and 50% there was no inhibition zone of Staphylococcus aureus bacteria growth.Keywords: Antibacterial, daun binahong, staphylococcus aureus
Analysis of Anti-Bacterial Acetivity Test of Binahong Leaves Ethanol Extract Agains Bacteria T. Khairol Razi; Khiisfanda Khiisfanda; Rizarullah Rizarullah
International Conference on Multidisciplinary Research Vol 5, No 2 (2022): ICMR
Publisher : Universitas Serambi Mekkah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32672/pic-mr.v5i2.5429

Abstract

Antibacterial is a compound that can be used for the treatment of infections caused by bacteria. Traditionally Binahong plants (Anredera cordifolia) are plants known to the public to handle various diseases. Binahong leaf that has antibacterial natural compounds such as oleanolic acid, ursolic acid and apigenin. This study aims to examine the antibacterial activity of ethanol extract of binahong leaves against staphylococcus aureus bacteria. This research is using experimental method. Leaves binahong obtained from Sawang Aceh Utara. The maceration stage is done by using ethanol 96% for 3 days and then in doing phytochemical test to find out secondary metabolic content. Antibacterial testing using discs. The results of phytochemical tests found secondary metabolic compounds class of alkaloids, polyphenols, saponins, quinones, and triterpenoids. Antibacterial test using 25%, 50%, 75% concentration, negative control (Aquadest), and Positive control (Amoxicillin) obtained the results are 6mm, 6mm, 6.67mm, 0mm, 30,67 mm. Based on the research of ethanol extract of binahong leaf has an inhibitory power to the growth of Staphylococcus Aureus bacteria at 75% concentration. At concentrations of 25% and 50% there was no inhibition zone of Staphylococcus aureus bacteria growth. Keywords: Ektrak Etanol, Antibacterial, Daun Binahong, Staphylococcus Aureus
Predicting Multi-Epitope Peptide Cancer Vaccine from Novel TAA Topo48 Tirta Setiawan; Rizarullah Rizarullah
Journal of Science and Applicative Technology Vol 5 No 1 (2021): Journal of Science and Applicative Technology June Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/jsat.v5i1.349

Abstract

Cancer is one of the most lethal diseases. Recently, cancer immunotherapy has a tremendous achievement in cancer treatment. A certain number of cancer based epitope vaccines with different moiety have been discovered. In japan, several clinical tests of cancer based epitope vaccine derived from tumor associated antigens (TAAs) are now ongoing or have recently been completed. a novel of TAAs potentially as cancer vaccine have been retrieved from a fragment weighed 48kDa derived from human DNA-topoisomerase 1 (TOP1) called Topo48. Therefore, it is still critical to discover a derived Topo48 epitope based cancer vaccine. Immuno-informatics considered as a methods noted to have better accuracy to design promising vaccine candidates. Here, continuous and discontinuous B-cell epitopes following with CTL epitopes and their docking interaction to major histocompatibility complex (MHC) class I Human Leukocyte Antigens (HLA)- A0201 were predicted. Kolaskar-Tongaonkar’s, Emini’s, Karpus-Schulz’s, and Parker’s methods were used to predict continuous B-cell epitopes while ElliPro was used for prediction of discontinued B-cell epitopes. Those considered methods marked to have better accuracy to design promising vaccine candidates. Similarly, CTL epitopes was also predicted by using NetCTL server and the best candidates were further investigated their binding affinity by mean of PEP-FOLD3, PatchDock rigid-body docking server, and FireDock server. Total 27 continuous epitopes and 7 discontinuous B-cell epitopes were predicted. In the other hand, 9 peptides were predicted as CTL epitopes. Whereas, three predicted CTL epitope in range 263MLDHEYTTK27, 755AIDMADEDY763, 715ALGTSKLNY724) exhibited good interactions to HLA-A0201. Moreover, we also found residues His266, Thr270, Ala755, Tyr723, Thr718, Ser719, Lys720 from Topo48 and residues Thr163, Asp757, His70, Glu63 from HLA- A0201 were indicated to be antigenic. Ultimately, our proposed continuous/discontinuous B-cell epitopes, and also CTL epitopes can be potential vaccines for cancer immunotherapy.
IDENTIFICATION OF POTENTIAL ANTIVIRUS FROM Moringa oleifera LEAF AS MPRO SARS-COV-2 INHIBITOR: STUDY OF MOLECULAR DOCKING Zaimi Afandi; Yuni Rahmayanti; Rizarullah Rizarullah
Chimica Didactica Acta Vol 10, No 1: June 2022
Publisher : FKIP USK

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.302 KB) | DOI: 10.24815/jcd.v10i1.24565

Abstract

Corona virus disease/COVID-19 is an acute respiratory infection caused by SARS-CoV-2 and has become a pandemic. COVID-19 can be prevented by efforts such as physical distancing, washing hands, using masks and self-isolation as well as regional isolation. Moringa is a plant that can be used both as food and medicine. The purpose of this study was to observe the activity of Moringa leaf compounds in inhibiting Mpro (main protease) SARS-CoV-2. Moringa leaf compounds tested were Gamma tocopherol, Benzyl glucosinolate and Chlorogenic acid. The compound was taken from pubchem, while Mpro SARS-CoV-2 (receptor) was obtained from the world protein bank with the PDB code 6W63. This research was conducted using the In Silico method and AutoDock Vina software was used for the tethering process. The results of gridbox optimization by re-tethering control ligands obtained RMSD results of 0.122 . The results showed free energy Gibbs (ΔG) Gamma tocopherol (-6.8 kcal/mol), Benzyl glucosinolat (-6.6 kcal/mol), and Chlorogenic acid (-7.0 kcal/mol) which indicated a stable inhibitory reaction of Moringa leaf compounds against Mpro SARS-CoV-2. Based on Lipinski's rules, the compounds from Moringa leaves tested were qualified to be used as herbal medicines to be used orally.  
Co-Authors Abdul Wahab Abdul Wahab Andrio Suhadi Anggi Nadra Hanum Siregar Awlanur, Cut Cut Annisa Thahara Cut Annisa Thahara Dewi Karlina Rusly Erlidawati*, Erlidawati Fazli, Rahmad Rizki Feriyani Feriyani Isfanda, Isfanda Khiisfanda Khiisfanda M Rizki Fakhrurrazi Mangatur Riverson Mangatur Riverson Sinurat Mustika, Chessy Rima Ratih Ayu Atika Saaid, Mardiana Satria Safirza Selvirawati Selvirawati T. Khairol Razi Tirta Setiawan Yuni Rahmayanti Zaimi Afandi