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All Journal Jurnal Engine: Energi, Manufaktur, dan Material Jurnal Ilmiah Wahana Pendidikan Journal of Islamic Scriptures in Non-Arabic Societies
Siti Nur Istiqomah
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Religion Control & Systems Engineering Education Energy Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Social Sciences Other

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TINJAUAN LITERATUR TOKSISITAS METOTREKSAT SEBAGAI ANTIRHEUMATOID ARTHRITIS Nanda Diva Meilani; Munir Alinu Mulki; Elzandra Imola Vioniken; Siska Bela Safitri; Siti Nur Istiqomah; Meliana Sari; Syelziva Yonda Atwita
Jurnal Ilmiah Wahana Pendidikan Vol 9 No 14 (2023): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.8176493

Abstract

Rheumatoid Arthritis (RA) adalah penyakit autoimun dengan peradangan kronis pada sendi yang menyebabkan kerusakan sendi dan deformitas. Pengobatan RA melibatkan penggunaan obat-obatan seperti metotreksat (MTX), yang memiliki efek anti-inflamasi dan anti-proliferatif. Namun, penggunaan MTX dapat menyebabkan toksisitas dan efek samping yang dapat mempengaruhi keberhasilan terapi. Penelitian ini bertujuan untuk melakukan tinjauan literatur tentang toksisitas MTX sebagai pengobatan RA. Pencarian studi literatur dilakukan menggunakan Google Scholar melalui software Publish or Perish versi 8 dengan kata kunci "toksisitas metotreksat," "rheumatoid arthritis," dan "antirheumatoid arthritis." Studi literatur yang relevan dipilih berdasarkan judul dan metode yang digunakan dengan kriteria inklusi dan eksklusi pada jenis studi literatur, tahun terbit dan bidangnya. Studi literatur menunjukkan bahwa penggunaan MTX dalam pengobatan RA dapat menghasilkan efek terapeutik yang signifikan, tetapi juga dapat menyebabkan toksisitas. Toksisitas yang dapat terjadi termasuk supresi sumsum tulang, toksisitas paru, toksisitas ginjal, toksisitas hematologis, dan meningkatkan risiko infeksi. Hepatotoksisitas juga merupakan efek samping umum yang terkait dengan penggunaan MTX. Penggunaan MTX sebagai pengobatan RA efektif dalam mengurangi gejala dan mencegah kerusakan sendi. Namun, toksisitas dan efek sampingnya harus dipantau dengan baik. Pengetahuan tentang toksisitas MTX membantu dalam pemantauan dan manajemen yang tepat selama pengobatan RA.
Perancangan Mesin Pengering Kopi Otomatis dengan Arduino Uno Deni Hidayat; Siti Nur Istiqomah
Jurnal Engine: Energi, Manufaktur, dan Material Vol. 9 No. 1 (2025)
Publisher : Proklamasi 45 University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30588/jeemm.v9i1.2159

Abstract

Processing of agricultural products, especially coffee, has an important role in the economy of rural communities. One of the main stages in coffee processing is the drying process, which aims to reduce the water content to an optimal level in order to maintain the quality of the coffee beans. In Mekar Buana Village, Tegalwaru District, Karawang, the drying process is still done manually, so it takes a long time and produces non-uniform quality. To overcome this problem, this research designed an automatic coffee drying machine based on Arduino Uno with the support of Internet of Things (IoT) technology. This machine allows automatic temperature and humidity settings and can be monitored remotely. Design analysis and static load stress testing were carried out using SolidWorks software to ensure the resistance of the machine structure to operational loads. The research results show that the designed machine is able to work optimally, increase the efficiency of drying time, and maintain the quality of coffee beans better than traditional methods. It is hoped that the implementation of this machine can increase the productivity of coffee farmers and support technological innovation in the agricultural sector.
Pandangan Al-Qur’an Terhadap Hoaks Persepektif Tafsir Maqāṣidī (Studi Q.S. Al-Ḥujurāt: 6 dan al-Nūr: 15) Siti Nur Istiqomah; Muhammad Nur Amin; Muhammad Ikhwanudin
Journal of Islamic Scriptures in Non-Arabic Societies Vol. 2 No. 1 (2025): Journal of Islamic Scriptures in Non-Arabic Societies (JISNAS)
Publisher : Kuras Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51214/jisnas.v2i1.949

Abstract

The phenomenon of hoax dissemination in the digital era has become a serious challenge with far-reaching impacts on social stability, political dynamics, and religious life among Muslim communities. The Qur’an, as the holy scripture of Islam, offers fundamental principles for responding to information, particularly through verses that emphasize verification and caution, such as Q.S. al-Ḥujurāt [49]:6 and Q.S. al-Nūr [24]:15. This study aims to analyze the content of these two verses using the maqāṣidī tafsir approach as developed by Abdul Mustaqim, in order to uncover the substantial and contextual values of Islamic law. This research employs a qualitative method with a descriptive-analytical approach based on literature review from primary and secondary authoritative tafsir sources. The findings reveal that these verses encompass core values of maqāṣid al-sharī‘ah, including: ḥifẓ al-nafs (protection of life), ḥifẓ al-‘aql (protection of intellect), ḥifẓ al-dīn (protection of religion), ḥifẓ al-dawlah (protection of the state), and ḥurriyyah al-mas’ūliyyah (responsible freedom). These values are not only normative but also practical in addressing the challenges of modern disinformation. Thus, the maqāṣidī approach presents a relevant and solution-oriented methodology for shaping ethical media engagement and fostering responsible Islamic digital literacy in contemporary society.
Co-Authors Deni Hidayat Elzandra Imola Vioniken Meliana Sari Muhammad Ikhwanudin Muhammad Nur Amin Munir Alinu Mulki Nanda Diva Meilani Siska Bela Safitri Syelziva Yonda Atwita