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Nemay A Ndaong
Universitas Nusa Cendana
Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Public Health Veterinary

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GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus) JANTAN YANG DIBERI INFUSA PARE LOKAL PULAU TIMOR Maria Asti S.R Rafe; Cynthia D Gaina; Nemay A Ndaong
Jurnal Veteriner Nusantara Vol 3 No 1 (2020): Februari 2020
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn/vol3iss1pp61-73

Abstract

Some of the chemical compounds in bitter melon fruit that acts as infertility for males, namely saponins, tannins, alkaloids, flavonoids and triterpenoids were able to reduce the number of spermatogenic cells. Renal excretory function in carrying out this gets tough task, because almost 25% of all blood flow to the two kidneys. The amount of blood flow to the kidney causes renal exposure to the material circulating in the circulation system is quite high, so that the toxic material will easily cause damage to the kidney tissue. This study aimed to determine the effect of dose delivery infusion of local bitter melon fruit on the island of Timor, East Nusa Tenggara against renal histopathology description of male white rat (Rattus norvegicus). The study was conducted in the 2 treatment groups, namely (P1) bitter melon infusion at a dose of 1250 mg/kgBB/day and (P2) bitter melon infusion at a dose of 2500 mg/kgBB/day. Each treatment group consisted of 6 rats administered for 48 days. Microscopic changes that occur in the kidneys of mice include glomerular congestion, atrophy of the glomerulus, tubular hemorrhage, necrosis of the tubules are composed of cells piknosis, Karyorrhexis cells, karyolysis cells and tubular protein deposits. The average glomerular damage and kidney tubules was higher in treatment P2 than P1 which indicates the ravages caused by high dose bitter melon infusion given to the treatment group P1 and P2 so that the chemical substances to be excessive and toxic, accumulate in the kidneys and cause damage to the kidneys
GAMBARAN HISTOPATOLOGI HEPAR TIKUS PUTIH (Rattus norvegicus) JANTAN PASCA PEMBERIAN EKSTRAK INFUSA BUAH PARE (Momordica charantia L.) LOKAL NTT Agnes Y Taek; Nemay A Ndaong; Cynthia D Gaina
Jurnal Veteriner Nusantara Vol 3 No 2 (2020): Agustus 2020
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v3i2.3412

Abstract

Hepatic is the largest gland in the body. Hepatic function in the metabolism and detoxification of a wide variety of compounds into the body. Infusion extract of bitter melon (M. charantia L.) fruit is a herbal preparation containing chemical compounds such as flavonoids, glycosides, triterpenoids, polyphenols, alkaloids, saponins, and tannins. Excessive drug dosing in a long period of time, can make liver damage acute, subacute or chronic. Toxic effects of drugs often seen in the tissues, especially the liver and kidneys are on histology, appearing as inflammatory cell infiltration, hidropic degeneration, fatty degeneration and necrosis. The purpose of this study is to determine the effect of variations in dose infusion extract of bitter melon fruit (M. charantia L.) locally NTT against white picture rat liver histopathology (R. norvegicus) male and determine the effective dose infusion extract of bitter melon fruit (M. charantia L.) NTT local who gave a response, or effects on fertility drugs white rat (R. norvegicus) male. The method used in this study is completely randomized design method namely by dividing the mice randomized into two treatment groups with different doses variations. Analysis of the data used is descriptive. The results obtained showed that the average infiltration in P1 was 5.8 ± 6.7, while the P2 is 3.7 ± 5.5. Hydropic degeneration in P1 was 17.3 ± 10.7 and in P2 was 63.5 ±32.7. fatty degeneration in P1 was 2.3 ± 4.4 and 10.2 ± At P2 is 9.5. Necrosis of P1 was 0.5 ± 0.8, while the P2 is 4.2 ± 2.9.
UJI AKTIVITAS EKSTRAK ETANOL DAUN KETAPANG (Terminaliacatappa) SEBAGAI ANTIBAKTERI TERHADAP PERTUMBUHAN Escherichia coli DAN Staphylococcus aureus SECARA IN VITRO Leonardo A. Seme; Elisabet Tangkonda; Nemay A Ndaong
Jurnal Veteriner Nusantara Vol 3 No 2 (2020): Agustus 2020
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v3i2.3419

Abstract

Collibacilocis is a disease which is caused by Escherichia coli. Staphylococcus aureus is one of bacterial species which is cause mastitis. Antibiotic can be use to treat a disease which is caused by Escherichia coli dan Staphylococcus aureus infection. Antibiotic can cause a side effect such as bacteria resistance and reside to from animal. Cattapa leaves contain flavonoid, alkaloid, tannin, triterpenoid, resin, and saponin compound which is have function as antibacterial. The aim of this study is to know the effects of cattapa leaves ethanol extract for growth of Escherichia coli and Staphylococcus aureus. This study use bacterial from envirionment that isolated from pig with diarrhea sample and Staphylococcus aureus from cow that show mastitis symptoms. This study consist two group are treatment group and comparator group. Treatment group are cattapa leaves ethanol extract that given of 20%, 40%, 60%,80%, and 100%. The comparator group are antibiotic group that consist of ciprofloksasin, tetracycline, cefoxitin, amoxicilin, and ampicilin. The study result show cattapa leaves ethanol extract do not have effect to inhibite growth of Escherichia coli and Staphylococcus aureus. The conclusion is cattapa leaves do not have effect to inhibits the growth of Escherichia coli dan Staphylococcus aureus.
Co-Authors Agnes Y Taek Cynthia D Gaina cynthia D Gaina Elisabet Tangkonda Leonardo A. Seme Maria Asti S.R Rafe