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Basaruddin Ahmad, Basaruddin

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Author-ID : 631609

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Serum interleukin-17 (IL-17) in chronic periodontitis patients Arief, Erry Mochamad; Mubin, Marina binti; Zainuddin, Siti Lailatul Akmar; Abdullah, Nurul Asma; Ahmad, Basaruddin
Padjadjaran Journal of Dentistry Vol 29, No 3 (2017): November
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Introduction: Explorations into the periodontal medicine relationship have discovered interleukin-17 (IL-17) cytokine as one of the pro-inflammatory mediators that play a crucial role in the initiation and progression of the chronic periodontal disease. This case and control study aimed to compare the serum IL-17 concentration between chronic periodontitis and healthy subjects and to assess the relationship between the IL-17 serum and the clinical periodontal parameters in chronic periodontitis patients. Methods: This study was a case-control study. The subjects were selected using purposive sampling method. The periodontal screening assessment in the Family Treatment Center and Postgraduate Dental Clinic, Universiti Sains Malaysia Hospital. A total of 55 samples who fit with the inclusion and exclusion study criteria of full-mouth clinical periodontal records together with blood serums were obtained from 28 chronic periodontitis patients and from 27 healthy subjects. The concentration of IL-17 cytokine in serum was measured using ELISA test. Results: Subjects with periodontal disease presented significantly worse clinical parameters (p<0.001) compared to control. The level of serum IL-17 concentration was significantly higher (p=0.026) in chronic periodontitis subjects 3.6 (1.03) pg/mL compared to the control 3.1 (0.70) pg/mL. Conclusions: There was no correlation between the level of IL-17 concentration in the serum and clinical periodontal parameters.

Development and Validation of the Human Aspects Influencing the Oral Healthcare Data Quality (HAI-DQ) Questionnaire among Primary Oral Healthcare Workers in Malaysia Mohd Zuhudi, Alwani; Mohd Salleh, Syirahaniza; Sinor, Mohd Zulkarnain; Mat Nor, Mohd Zarawi; Ahmad, Basaruddin; Sanusi, Sarliza Yasmin
Journal of Dentistry Indonesia Vol. 31, No. 1
Publisher : UI Scholars Hub

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Resolving substandard oral healthcare data quality requires identifying the influencing factors. However, no known instrument for such assessment can be used locally. Objective: To develop and validate the HAI-DQ questionnaire for assessing human factors that influence oral healthcare data quality among primary oral healthcare workers in Malaysia. Methods: The HAI-DQ questionnaire was developed based on literature reviews, focus group discussions, and focus observations. Six experts assessed its content validity using the Content Validity Index (CVI), and the Face Validity Index (FVI) was used to establish its face validity through a pre-test involving 30 primary dental personnel. Results: Four domains with 57 items were derived during the HAI-DQ development. The I-CVI values between 0.83 to 1.00 and the S-CVI value of 0.97 indicated acceptable content validity. Excellent face validity was denoted by the I-FVI values of 0.93 to 1.00 and an S-FVI value of 0.99. Conclusion: HAI-DQ is relevant and comprehensible for assessing human aspects that influence data quality, indicating its potential to be used as an investigation tool in future research related to oral healthcare data quality. Nevertheless, other psychometric assessments are required to further support the instrument’s validity.

Serum interleukin-17 (IL-17) in chronic periodontitis patients Arief, Erry Mochamad; Mubin, Marina binti; Zainuddin, Siti Lailatul Akmar; Abdullah, Nurul Asma; Ahmad, Basaruddin
Padjadjaran Journal of Dentistry Vol 29, No 3 (2017): November 2017
Publisher : Universitas Padjadjaran

Introduction: Explorations into the periodontal medicine relationship have discovered interleukin-17 (IL-17) cytokine as one of the pro-inflammatory mediators that play a crucial role in the initiation and progression of the chronic periodontal disease. This case and control study aimed to compare the serum IL-17 concentration between chronic periodontitis and healthy subjects and to assess the relationship between the IL-17 serum and the clinical periodontal parameters in chronic periodontitis patients. Methods: This study was a case-control study. The subjects were selected using purposive sampling method. The periodontal screening assessment in the Family Treatment Center and Postgraduate Dental Clinic, Universiti Sains Malaysia Hospital. A total of 55 samples who fit with the inclusion and exclusion study criteria of full-mouth clinical periodontal records together with blood serums were obtained from 28 chronic periodontitis patients and from 27 healthy subjects. The concentration of IL-17 cytokine in serum was measured using ELISA test. Results: Subjects with periodontal disease presented significantly worse clinical parameters (p<0.001) compared to control. The level of serum IL-17 concentration was significantly higher (p=0.026) in chronic periodontitis subjects 3.6 (1.03) pg/mL compared to the control 3.1 (0.70) pg/mL. Conclusions: There was no correlation between the level of IL-17 concentration in the serum and clinical periodontal parameters.

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