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Serum interleukin-17 (IL-17) in chronic periodontitis patients Arief, Erry Mochamad; Mubin, Marina binti; Zainuddin, Siti Lailatul Akmar; Abdullah, Nurul Asma; Ahmad, Basaruddin
Padjadjaran Journal of Dentistry Vol 29, No 3 (2017): November
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Introduction: Explorations into the periodontal medicine relationship have discovered interleukin-17 (IL-17) cytokine as one of the pro-inflammatory mediators that play a crucial role in the initiation and progression of the chronic periodontal disease. This case and control study aimed to compare the serum IL-17 concentration between chronic periodontitis and healthy subjects and to assess the relationship between the IL-17 serum and the clinical periodontal parameters in chronic periodontitis patients. Methods: This study was a case-control study. The subjects were selected using purposive sampling method. The periodontal screening assessment in the Family Treatment Center and Postgraduate Dental Clinic, Universiti Sains Malaysia Hospital. A total of 55 samples who fit with the inclusion and exclusion study criteria of full-mouth clinical periodontal records together with blood serums were obtained from 28 chronic periodontitis patients and from 27 healthy subjects. The concentration of IL-17 cytokine in serum was measured using ELISA test. Results: Subjects with periodontal disease presented significantly worse clinical parameters (p<0.001) compared to control. The level of serum IL-17 concentration was significantly higher (p=0.026) in chronic periodontitis subjects 3.6 (1.03) pg/mL compared to the control 3.1 (0.70) pg/mL. Conclusions: There was no correlation between the level of IL-17 concentration in the serum and clinical periodontal parameters.

Periodontal Parameters and Anti-Cardiolipin Antibodies Following Periodontal Therapy in Chronic Periodontitis Wan Mohamad, Wan Majdiah; Saad, Noor Rashidah; Zainuddin, Siti Lailatul Akmar; Taib, Haslina
Journal of Dentistry Indonesia Vol. 28, No. 1
Publisher : UI Scholars Hub

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Anti-cardiolipin (anti-CL) antibodies are autoantibodies which are directed against cell membrane phospholipids. A significant number of periodontitis patients showed positive for anti-CL antibody. Objective: This study aimed to determine the periodontal parameters and anti-CL antibodies levels before and after non-surgical periodontal therapy in chronic periodontitis. Methods: This cross-sectional study had been carried out at Periodontal Clinic, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Thirty five chronic periodontitis (CP) and 39 non-periodontitis (NP) patients underwent clinical periodontal examination at baseline. Plaque index (PI), gingival index (GI), periodontal pocket depth (PPD), and clinical attachment loss (CAL) were measured. Scaling and polishing was performed and blood samples were taken for IgG and IgM anti-CL antibodies analysis. Re-evaluationwas performed four weeks after initial therapy. CP patients were re-examined, all periodontal parameters were recorded and blood samples were taken for reassessment of IgG and IgM anti-CL antibodies. Results: Significant difference means of PI(p=0.001), GI (p=0.000), PPD (p=0.000) and, CAL (p=0.000) were found between CP and NP groups. All periodontal parameters were significantly reduced (p≤0.05) after four weeks of therapy. The mean levels of IgG and IgM anti-CL antibodies at baseline were significantly higher in CP than NP group (IgG=4.46 vs 3.22, p=0.002; IgM=3.28 vs 2.57, p=0.019). No significant difference of the median levels of IgG (p=0.82) and IgM anti-CL antibodies (p=0.35) following therapy. Conclusion: All periodontal parameters were significantly reduced following periodontal therapy. Higher level of Anti-CL antibodies in CP indicates stimulation of autoantibodies production by periodontal infection. Nonetheless no significant changes of this anti-CL antibodies levels despite significant reduction of the clinical parameters after periodontal therapy.

Salivary IgA Depression in Drug-Influenced Gingival Enlargement among Hypertensive Patients Sabarudin, Muhammad Annurdin; Taib, Haslina; Wan Mohamad, Wan Majdiah; Zainuddin, Siti Lailatul Akmar; Wan Ghazali, Wan Syamimee; Misran, Ahmad Azhar
Journal of Dentistry Indonesia Vol. 29, No. 1
Publisher : UI Scholars Hub

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Drug-influenced gingival enlargement (DIGE) among hypertensive patients is commonly associated with antihypertensive drugs such as calcium channel blockers (CCBs). Immune response alteration is one of the proposed mechanisms for DIGE. Immunoglobulin A (IgA) in saliva which involves in defense mechanism was shown to be affected in patients with DIGE. Objective: This study aimed to determine the association of salivary IgA level with DIGE. Methods: This cross-sectional study comprised 47 hypertensive patients who had consumed antihypertensive drugs for at least 3 months. Twenty-one (44.7%) males and 26 (55.3%) females had participated in this study. Data was analyzed using SPSS version 26.0. The p-value of less than 0.05 at a 95% confidence interval is considered statistically significant. Results: Eighty-three percent and 17.0% of hypertensive patients were on CCBs and non- CCBs respectively. Amlodipine was found to be the most common (55.3%) antihypertensive drug consumed. Twenty- one (44.7%) patients presented with DIGE. The salivary IgA level was significantly decreased (p=0.03) among hypertensive patients with DIGE [Median 4.9 ng/mL (IQR 5.268)] compared to those without DIGE [median 15.03 ng/mL (IQR 32.246)]. Conclusion: This data indicates the level of salivary IgA was significantly affected in patients with DIGE which may compromise the defense mechanism of saliva.

Knowledge, Attitude, Oral Hygiene Practice and Self-Perception on Periodontal Health among Older Adult Population in Malaysia Edwin Thomas, Annabel Shanta; Taib, Haslina; Berahim, Zurairah; Zainuddin, Siti Lailatul Akmar; Mohd Adnan, Munirah
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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Objective: This study aimed to assess the knowledge, attitude, oral hygiene practice, and self-perception of periodontal health among the older adult population in Malaysia and its association with demographic factors. Methods: An online questionnaire assessing their knowledge, attitude, oral hygiene practices, and self-perception of periodontal disease was distributed to adults aged 50 years and above. Results: 397 respondents participated. The mean knowledge score was 1.36 (SD 0.92), significantly associated with gender, ethnicity, education, and occupation. About 63% of respondents know that poor oral hygiene is related to general health and is significantly associated with ethnicity (p = 0.016) and occupation (p = 0.009). Most respondents showed good oral hygiene practice but visited the dentist only when necessary (45%). Many of them have positive perceptions of their gum health status (81.6%) and are significantly associated with ethnicity (p = 0.007), education level, and occupations. Conclusion: This study showed inadequate knowledge about periodontal health among older adults. The attitude, practices, and self-perception of periodontal disease are mainly associated with ethnicity, educational levels, and occupations. Awareness of periodontal disease should be reinforced among older adults for better quality of life.

Prevalence of Peri-implantitis and Assessment of Oral Health-related Quality of Life Among Patients with Dental Implants at Hospital Universiti Sains Malaysia Ang, Esther Li-Ching; Berahim, Zurairah; Abd Rahman, Normastura; Hassan, Akram; Zainuddin, Siti Lailatul Akmar
Journal of Dentistry Indonesia
Publisher : UI Scholars Hub

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Patient-reported outcomes about peri-implantitis are lacking among the Asian population, impacting decision-making in dental implant therapy. Objectives: This study aimed to assess the prevalence of peri-implantitis among Malaysian adults, and its impact on oral health-related quality of life (OHRQoL). Methods: Randomly selected 105 participants (adults aged 18 and above) having 265 implants were examined and diagnosed as with or without peri-implantitis (PI). Clinical examinations, including peri-implant probing depth, bleeding, and suppuration on probing with radiographic bone loss, were used to determine peri-implant status. OHRQoL of all participants were recorded using the short version of the Malaysian Oral Health Impact Profile [S-OHIP(M)] and reported as prevalence and severity of impact scores. Results: Prevalence of PI was 20.95% (95%CI 13.17-28.74) at the patient level and 11.7% (95%CI 7.83-15.57) at the implant level. Participants with PI had significantly greater percentages (p < 0.05) reporting impacts ‘fairly often’ or ‘very often’ in the dimensions ‘functional limitation’ and ‘handicap’ with their respective sub-items ‘difficulty chewing’ and ‘spending money.’ Both groups showed no significant difference in impact severity across items and domains. Although total S-OHIP(M) scores were higher in the PI group, the difference was not significant (p = 0.105). Conclusion: Peri-implantitis is relatively prevalent at 20%, but its impact on OHRQoL is minimal.

Serum interleukin-17 (IL-17) in chronic periodontitis patients Arief, Erry Mochamad; Mubin, Marina binti; Zainuddin, Siti Lailatul Akmar; Abdullah, Nurul Asma; Ahmad, Basaruddin
Padjadjaran Journal of Dentistry Vol 29, No 3 (2017): November 2017
Publisher : Faculty of Dentistry Universitas Padjadjaran

Introduction: Explorations into the periodontal medicine relationship have discovered interleukin-17 (IL-17) cytokine as one of the pro-inflammatory mediators that play a crucial role in the initiation and progression of the chronic periodontal disease. This case and control study aimed to compare the serum IL-17 concentration between chronic periodontitis and healthy subjects and to assess the relationship between the IL-17 serum and the clinical periodontal parameters in chronic periodontitis patients. Methods: This study was a case-control study. The subjects were selected using purposive sampling method. The periodontal screening assessment in the Family Treatment Center and Postgraduate Dental Clinic, Universiti Sains Malaysia Hospital. A total of 55 samples who fit with the inclusion and exclusion study criteria of full-mouth clinical periodontal records together with blood serums were obtained from 28 chronic periodontitis patients and from 27 healthy subjects. The concentration of IL-17 cytokine in serum was measured using ELISA test. Results: Subjects with periodontal disease presented significantly worse clinical parameters (p<0.001) compared to control. The level of serum IL-17 concentration was significantly higher (p=0.026) in chronic periodontitis subjects 3.6 (1.03) pg/mL compared to the control 3.1 (0.70) pg/mL. Conclusions: There was no correlation between the level of IL-17 concentration in the serum and clinical periodontal parameters.

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