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Oral erythema multiforme: Laboratory findings in monitoring Herpes simplex virus involvement (A case report) Raiyon, Maria Leny; Subita, Gus Permana
Padjadjaran Journal of Dentistry Vol 20, No 3 (2008): November
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Erythema Multiforme is polymorphous recurrent eruptions on the skin and oral mucosa. This case is describing a progression of a case of Erythema Multiforme in the oral mucosa of a 33-year-old man suggesting of herpes viral involvement. In the absence of identified inducing drugs, past medical history of clinical manifestation on Herpes Simplex Viral (HSV) but positive serum antibody against HSV-1 is suggesting of Herpes Associated Erythema Multiforme. This became the basis of the patient management. Several episodes of recurrences and relapses occurred during our treatment period in oral isolated sites which were later progressed with skin eruption of bullae. The later clinical presentation challenges the on going working diagnosis. It also necessitated a skin biopsy to rule out another possibility of bullous lesion diseases. The latter blood test showed seroconverted of HSV-2 antibody accompanying previous detected HSV-1 antibody. Both biopsy and peripheral blood sera test consistent with Herpes Simplex Virus involvement. The patient is on a scheduled antiviral prophylaxis. This case showed that Herpes Associated Erythema Multiforme (HAEM) does present initially as an isolated oral lesions and a serological test could be used to monitor seroconverting of HSV.

PENYULUHAN DAN PELATIHAN PEMELIHARAAN KESEHATAN GIGI DAN MULUT MASYARAKAT RW 005 KELURAHAN TANJUNG DUREN SELATAN Anggraeni, Rezky; Soulissa, Abdul Gani; Adrian, Nova; Stefanie, Rosita; Raiyon, Maria Leny; Bougenville, Vell; Cendana, Aurellia Nadia; Aurili, Rifaty
Jurnal AKAL: Abdimas dan Kearifan Lokal Vol. 6 No. 1 (2025): Jurnal AKAL : Abdimas dan Kearifan Lokal
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/akal.v6i1.20546

Kesehatan gigi dan mulut merupakan hal yang peting dan perlu diperhatikan. Perilaku menjaga kesehatan gigi dan mulut didukung oleh pengetahuan. Hingga saat ini, pengeratuah mengenai kesehatan gigi dan mulut masih minim terutama, pada masyarakat wilayah RW 005, Kelurahan Tanjung Duren Selatan. Berdasarkan permasalahn tersebut, maka akan diadakan Pengabdian Kesehatan Masyarakat di wilayah RW 005, Tanjung Duren Selatan. Tujuan: PkM ini bertujuan untuk meningkatkan kesadaran dan pengetahuan masyarakat di wilayah RW 005, Kelurahan Tanjung Duren Selatan. Metode yang digunakan adalah metode observasional deskriptif. Hasil kegiatan PkM ini, setelah dilakukan penyuluhan dan pengetahuan masyarakat RW 005, Kelurahan Tanjung Duren Selatan mengalami peningkatan. Kesimpulannya adalah pengetahuan masyarakat RW 005 mengenai karies dan penyebabnya, frekuensi menyikat gigi, dan cara mencegah karies mengalami peningkatan pasca penyuluhan kesehatan gigi dan mulut.

Penyuluhan dan Pemeriksaan Kesehatan Gigi dan Mulut pada Komunitas Mutiara Senja - Gereja Santo Andreas Louisa, Marie; Damayanti Marpaung, Carolina; Leny Raiyon, Maria; Tjandrawinata, Rosalina; Juslily, Marta
JURNAL ABDIMAS KESEHATAN TERPADU Vol. 4 No. 1 (2025): Jurnal Abdimas Kesehatan Terpadu
Publisher : Fakultas Kedokteran Gigi, Universitas Trisakti bekerjasama dengan Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jakt.v4i1.23059

Oral health can affect general health and quality of life; therefore it is very important for the elderly to understand the importance of oral health. Physical decline in the elderly can be seen through sagging skin, hair discoloration, and loss of vision and teeth. This condition can be exacerbated by poor oral hygiene. Based on previous research, it has been found that of the 71% of elderly who brush their teeth every day, only 2.9% brush their teeth at the right time. Therefore, the counseling activity was carried out on Saturday, May 17, 2025 at the Mutiara Senja Elderly Community, Santo Andreas Church. The method used in the counseling was the lecture method and providing education through PowerPoint media. Evaluation of participant knowledge was carried out before and after the counseling by providing multiple-choice assessment sheets to determine the level of knowledge. Based on the evaluation results, it was found that there was an increase in the level of knowledge of the counseling participants. This can be seen in the average post-test score which increased compared to the pre-test score

Oral erythema multiforme: Laboratory findings in monitoring Herpes simplex virus involvement (A case report) Raiyon, Maria Leny; Subita, Gus Permana
Padjadjaran Journal of Dentistry Vol 20, No 3 (2008): November 2008
Publisher : Universitas Padjadjaran

Erythema Multiforme is polymorphous recurrent eruptions on the skin and oral mucosa. This case is describing a progression of a case of Erythema Multiforme in the oral mucosa of a 33-year-old man suggesting of herpes viral involvement. In the absence of identified inducing drugs, past medical history of clinical manifestation on Herpes Simplex Viral (HSV) but positive serum antibody against HSV-1 is suggesting of Herpes Associated Erythema Multiforme. This became the basis of the patient management. Several episodes of recurrences and relapses occurred during our treatment period in oral isolated sites which were later progressed with skin eruption of bullae. The later clinical presentation challenges the on going working diagnosis. It also necessitated a skin biopsy to rule out another possibility of bullous lesion diseases. The latter blood test showed seroconverted of HSV-2 antibody accompanying previous detected HSV-1 antibody. Both biopsy and peripheral blood sera test consistent with Herpes Simplex Virus involvement. The patient is on a scheduled antiviral prophylaxis. This case showed that Herpes Associated Erythema Multiforme (HAEM) does present initially as an isolated oral lesions and a serological test could be used to monitor seroconverting of HSV.

SIBLINGS WITH ALLERGIC ANGIOEDEMA: A CASE SERIES ON ORAL ALLERGIC SYNDROME AND FAMILIAL ATOPY Firstine Kelsi Hartanto; Jeff Jeff Tjokro; Vivi Angelina; Maria Leny Raiyon
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22212

Background: Oral Allergy Syndrome (OAS) is a localized IgE-mediated food allergy triggered by certain fruits and vegetables in patients with atopic history. This case report describes two siblings with Oral Allergy Syndrome (OAS) presenting as allergic angioedema triggered by specific food allergens. Case Presentation: Case 1 involves a 25-year-old female who developed lip swelling, a burning sensation, numbness, multiple oral ulcers on the lower lip, and surrounding redness 30 minutes after consuming mint sauce in an Indian dish. Case 2 details a 21-year-old male who experienced immediate lip and soft palate swelling with numbness after eating Chinese food suspected to contain nuts. Discussion: Both siblings share a history of childhood atopy, predisposing them to IgE-mediated reactions. Their symptoms were characteristic of localized allergic responses in the oral mucosa, consistent with OAS. Case Management: Management involved a combined therapeutic approach: topical corticosteroids were applied to the affected oral areas to reduce local inflammation and promote healing of the mucosal lesions, while oral corticosteroids provided systemic anti-inflammatory effects. Additionally, cetirizine, an H1 receptor antagonist, was administered to block histamine-mediated symptoms such as swelling and itching. Patients were also advised to avoid mint-containing and peanut-containing foods as predisposing factors. Conclusion: This report highlights not only the clinical presentation and successful management of OAS in individuals with familial atopy but also underscores the potential genetic predisposition contributing to food-induced allergic reactions.

Theaflavin as Potential Multi-Target Anti-Inflammatory Agent in Periodontitis: An in silico Approach Ferry Sandra; Trijani Suwandi; Ricky Anggara Putranto; Maria Leny Raiyon; Albert Albert; Visi Endah Pratitis
The Indonesian Biomedical Journal Vol 18, No 3 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i3.4255

BACKGROUND: Periodontitis is a chronic inflammatory disease characterized by progressive periodontal tissue destruction and dysregulated inflammatory responses. Current therapies mainly target bacterial infection but are often less effective in controlling inflammation. Tea (Camellia sinensis) contains bioactive polyphenols with antimicrobial and anti-inflammatory properties, making it a promising alternative therapeutic candidate. However, molecular interactions of tea-derived compounds with inflammation-related proteins through molecular docking remain unclear. This study evaluate the binding affinity and interaction profiles of tea-derived compounds with inflammation-related to periodontitis protein targets using molecular docking.METHODS: Ligand and protein structures were retrieved from public databases and prepared using standard optimization protocols. Toxicity and pharmacokinetic properties were predicted using ProTox-3.0 and SwissADME, respectively. Molecular docking was performed using CB-Dock 2.0 with AutoDock Vina, and ligand-protein interactions were analyzed using Discovery Studio.RESULTS: All tested compounds, including catechin, epigallocatechin gallate (EGCG), theaflavin, and thearubigin showed low predicted toxicity. Theaflavin showed the strongest binding affinity across multiple targets, particularly against IRAK-4 (−9.8 kcal/mol), TLR4 (−9.2 kcal/mol), and IKK-β (−9.5 kcal/mol), supported by stable hydrogen bonds and hydrophobic interactions.CONCLUSION: Among all compounds, theaflavin exhibit strong multi-target binding potential against key inflammatory proteins in periodontitis, followed by EGCG and thearubigin. These findings support their potential as alternative or adjunctive anti-inflammatory agents, although further in vitro and in vivo validation are required.KEYWORDS: periodontitis, tea polyphenols, theaflavin, molecular docking, inflammation, NF-κB pathway

Peningkatan Pengetahuan dan Pelatihan Pembuatan Spray Saliva Herbal “Maloemia” untuk Mengatasi Xerostomia Pada Komunitas Lansia Adiyuswa Gereja HSPMTB Kota Tangerang Maria Leny Raiyon; Rahmi Amtha; Sri Ratna Laksmiastuti; Rosita Stefani; Adrianus Surya Wira Rajasa; Vanessa Adora; Maria Septiana Karta; Tasya Zakiyah Karim; Tania Arnelita Santoso
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 9, No 9 (2026): Volume 9 Nomor 9 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v9i9.26462

ABSTRAK Xerostomia atau mulut kering merupakan keluhan yang sering dialami lansia akibat proses degeneratif, penyakit sistemik, serta penggunaan obat-obatan jangka panjang. Kondisi ini dapat menurunkan kualitas hidup karena menyebabkan kesulitan makan, berbicara, dan meningkatkan risiko karies serta infeksi rongga mulut. Komunitas Lansia Adiyuswa Gereja HSPMTB Kota Tangerang secara rutin menjalankan pemeriksaan kesehatan umum, namun edukasi mengenai kesehatan gigi dan mulut, khususnya xerostomia, belum pernah dilakukan secara khusus. Tujuan kegiatan pengabdian kepada masyarakat ini untuk meningkatkan pengetahuan komunitas lansia mengenai xerostomia dan kesehatan rongga mulut lansia serta memberikan keterampilan pembuatan spray saliva herbal alami “Maloemia” (Madu Aloe vera untuk Xerostomia). Kegiatan dilaksanakan melalui penyuluhan, demonstrasi cara menjaga oral hygiene, dan pelatihan hands-on pembuatan spray saliva herbal berbahan alami kepada komunitas lansia ini. Evaluasi dilakukan menggunakan pre-test dan post-test terhadap materi edukasi yang diberikan. Hasil kegiatan menunjukkan peningkatan pemahaman peserta mengenai xerostomia, dampak penggunaan obat jangka panjang terhadap rongga mulut, terlihat dari adanya peningkatan pengetahuan melalui pre dan post test sebesar 28.9% (p=0,00). Peserta juga mampu mempraktikkan pembuatan spray saliva herbal “Maloemia” secara mandiri menggunakan bahan sederhana yang mudah diperoleh. Penyuluhan dan pelatihan pembuatan spray saliva herbal “Maloemia” terbukti efektif meningkatkan pengetahuan dan keterampilan anggota Komunitas Lansia Adiyuswa dalam upaya promotif dan preventif kesehatan rongga mulut lansia. Kata Kunci: Saliva Buatan, Aloe Vera, Madu, Lansia, Xerostomia. ABSTRACT Xerostomia or dry mouth is a common complaint among older adults caused by degenerative processes, systemic diseases, and long-term medication use. This condition may reduce quality of life by causing difficulties in eating and speaking, as well as increasing the risk of dental caries and oral infections. The Adiyuswa Elderly Community of HSPMTB Church Tangerang routinely conducts general health check-ups; however, oral health education, particularly regarding xerostomia, has never been specifically adressed. The objective of this community service activity is to improve the knowledge of this community members regarding xerostomia and oral health in older adults, as well as to provide practical training in preparing a natural herbal saliva spray “Maloemia” (Honey Aloe vera for Xerostomia). This programme was conducted through educational counseling, good oral hygiene procedure demonstrations, and hands-on training in preparing a natural herbal saliva spray for the elderly community. Evaluation of this programme was carried out by conducting pre-test and post-test questionnaires on the educational materials provided. The evaluation showed that this programme improved the participants’ understanding regarding oral health, the effects of long-term medication use on oral health, and xerostomia. This reflected by an increase in knowledge scores of pre-test to post-test by 28.9%. Participants were also able to independently prepare the “Maloemia” herbal saliva spray using simple and easily accessible ingredients. In addition to improving oral health knowledge, the activity also provided opportunities for community-based creative economic empowerment. Educational counseling and hands-on training in the preparation of the “Maloemia” herbal saliva spray effectively improved the knowledge and skills of Adiyuswa Elderly Community Tangerang in promotive and preventive oral healthcare for older adults. Keywords: Saliva Substitute, Aloe Vera, Honey, Elderly, Xerostomia.

Potential Interaction of Propyl Gallate and Butylated Hydroxyanisole with EGFR–PI3K–Akt–mTOR Proteins in Oral and Gastrointestinal Carcinogenic Signaling Pathway: An in silico Molecular Docking Study Ferry Sandra; Visi Endah Pratitis; Dewi Priandini; Andrian Nova Fitri; Maria Leny Raiyon; Kyung Hoon Lee
The Indonesian Biomedical Journal Vol 18, No 4 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i4.4329

BACKGROUND: Synthetic food preservatives are widely used to improve food stability and shelf life, but prolonged exposure may contribute to oral and gastrointestinal carcinogenesis. Epidermal growth factor receptor (EGFR)–phosphoinositide 3-kinase (PI3K)–protein kinase B (Akt)–mammalian target of rapamycin (mTOR) axis plays a pivotal role in regulating tumor initiation and progression; however, the potential interactions with cancer-related signaling proteins remain poorly understood. This study computationally evaluated the predicted binding interactions of commonly used synthetic food preservatives with proteins using molecular docking.METHODS: Propyl gallate (PG), butylated hydroxyanisole (BHA), tertiary-butylhydroquinone (TBHQ), potassium sorbate (PS), sodium benzoate (SB), and sodium metabisulfite (SMB) were evaluated for physicochemical properties using SwissADME. Molecular docking with EGFR, PI3K, Akt-1, and mTOR was performed using CB-Dock 2.0. Predicted ligand–protein interactions were analyzed using BIOVIA Discovery Studio 2016 and root mean square fluctuation (RMSF) was evaluated using CABS-flex 3.0.RESULTS: PG and BHA exhibited the most predicted binding affinities among the investigated preservatives. PG showed the strongest interactions with EGFR (−6.1 kcal/mol), PI3K (−6.8 kcal/mol), and mTOR (−6.7 kcal/mol), whereas BHA demonstrated the highest affinity toward PI3K (−6.8 kcal/mol) and Akt-1 (−6.5 kcal/mol). These interactions were supported by multiple hydrogen bonds, hydrophobic interactions, and van der Waals contacts.CONCLUSION: PG and BHA exhibited the highest binding affinity toward proteins of the EGFR–PI3K–Akt–mTOR associated with oral and gastrointestinal carcinogenesis. These computational findings provide a basis for future experimental studies to determine the biological relevance of the predicted protein–ligand interactions under long-term dietary exposure.KEYWORDS: synthetic food preservatives, molecular docking, oral carcinogenesis, gastrointestinal carcinogenesis

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