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All Journal e-GIGI Indonesian Journal of Cancer Chemoprevention IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Journal of Indonesian Dental Association Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Indonesian Journal of Pharmaceutical Education Jurnal AKAL: Abdimas dan Kearifan Lokal Jurnal Abdimas Kesehatan Terpadu
Anggraeni, Rezky
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Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Transportation

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Penyuluhan Tatalaksana Awal Trauma Gigi pada Anak-anak Guru dan Wali Murid RA Al-Muttaqin Jeddy; Dwimega, Arianne; Tegar Badruzzaman, Idham; Erfan, Erni; Ihsan Rizal, Muhammad; Anggraeni, Rezky
JURNAL ABDIMAS KESEHATAN TERPADU Vol. 2 No. 2 (2023): Jurnal Abdimas Kesehatan Terpadu
Publisher : Fakultas Kedokteran Gigi, Universitas Trisakti bekerjasama dengan Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/jakt.v2i2.18791

Abstract

Anterior tooth trauma often occurs in children because children are more active than adults and their coordination and assessment of conditions are not good enough, so they often fall while learning to walk, run, play and exercise. Trauma that occurs to a child's teeth can interfere speech, chewing, aesthetics and the eruption of permanent teeth, thereby disrupting the growth and development of the teeth and jaw. Therefore, it is important to pay attention to the approach regarding the first treatment of trauma to primary teeth for parents and children. The choice of Community Service target at RA Al-Muttaqin was due to a request from the school principal as community leader. Education and training activities were carried out on July 27 2023 for a total of 20 teachers and parents. The aim of this activity is to increase knowledge and motivate changes in attitudes and behavior in maintaining oral health and regarding first care for primary tooth trauma. The initial assessment of knowledge and attitudes regarding primary care for trauma to primary teeth and the mouth of teachers was carried out through a pre-test. Counseling on how to maintain healthy teeth and mouth, including dental and oral health problems, prevention methods, as well as first care for primary tooth trauma by the presenter as well as educational videos. As an evaluation, a post test was carried out. The evaluation of the post test results showed an increase in scores. Recommendations for continuing this training activity in other elementary schools, especially for teachers in the school environment.
The Effect of Hexane Fractionation of Plectranthus amboinicus Leaf Extract on the Formation of Fusobacterium nucleatum Inhibition Zone Anggraeni, Rezky
Journal of Indonesian Dental Association Vol 7 No 2 (2024): October
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v7i2.1210

Abstract

Introduction – Pendahuluan: Periodontitis is an inflammatory disease in the oral cavity commonly experienced by the Indonesian population. In addition to therapeutic periodontal therapy, preventive care is also needed, such as plaque control by brushing teeth and using mouthwash. Plectranthus amboinicus leaves are a plant used by some Indonesian communities as herbal medicine. Plectranthus amboinicus is one of the plants that is known to have antibacterial activity. Objective – Tujuan: To determine the inhibitory activity of hexane fraction extract of P. amboinicus leaves against F. nucleatum bacteria. Methods – Metode: Fusobacterium nucleatum bacteria were treated with hexane fraction extract of P. amboinicus leaves at concentrations of 25%, 50%, and 75% for 24 hours to measure the diameter of the inhibition zone, followed by statistical tests, namely Post Hoc Test to see differences in each treatment group. Results – Hasil: Phytochemical testing results showed that the hexane fraction extract of P. amboinicus leaves contained active compounds such as phenols, steroids, tannins, and alkaloids. Among the three concentrations of hexane fraction used, the 75% concentration exhibited the greatest inhibitory activity against F. nucleatum. Conclusion – Kesimpulan: Hexane fraction extract of P. amboinicus leaves possesses inhibitory activity against F. nucleatum bacteria.
PENYULUHAN DAN PELATIHAN PEMELIHARAAN KESEHATAN GIGI DAN MULUT MASYARAKAT RW 005 KELURAHAN TANJUNG DUREN SELATAN Anggraeni, Rezky; Soulissa, Abdul Gani; Adrian, Nova; Stefanie, Rosita; Raiyon, Maria Leny; Bougenville, Vell; Cendana, Aurellia Nadia; Aurili, Rifaty
Jurnal AKAL: Abdimas dan Kearifan Lokal Vol. 6 No. 1 (2025): Jurnal AKAL : Abdimas dan Kearifan Lokal
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/akal.v6i1.20546

Abstract

Kesehatan gigi dan mulut merupakan hal yang peting dan perlu diperhatikan. Perilaku menjaga kesehatan gigi dan mulut didukung oleh pengetahuan. Hingga saat ini, pengeratuah mengenai kesehatan gigi dan mulut masih minim terutama, pada masyarakat wilayah RW 005, Kelurahan Tanjung Duren Selatan. Berdasarkan permasalahn tersebut, maka akan diadakan Pengabdian Kesehatan Masyarakat di wilayah RW 005, Tanjung Duren Selatan. Tujuan: PkM ini bertujuan untuk meningkatkan kesadaran dan pengetahuan masyarakat di wilayah RW 005, Kelurahan Tanjung Duren Selatan. Metode yang digunakan adalah metode observasional deskriptif. Hasil kegiatan PkM ini, setelah dilakukan penyuluhan dan pengetahuan masyarakat RW 005, Kelurahan Tanjung Duren Selatan mengalami peningkatan. Kesimpulannya adalah pengetahuan masyarakat RW 005 mengenai karies dan penyebabnya, frekuensi menyikat gigi, dan cara mencegah karies mengalami peningkatan pasca penyuluhan kesehatan gigi dan mulut.
Antibacterial Efficacy of AgNO₃ Combined with Cymbopogon citratus Extract and Chitosan Nanocomposite Against Pseudomonas aeruginosa Azrianty, Annisa; Komariah, Komariah; Ranggaini, Monica Dewi; Anggraeni, Rezky; Halim, Johni; Nugroho, Didi
Indonesian Journal of Pharmaceutical Education Vol 5, No 2 (2025): May–August 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i2.30641

Abstract

Infections caused by pathogenic bacteria such as Pseudomonas aeruginosa present significant challenges in clinical practice, particularly due to rising resistance to conventional antibiotics. The development of environmentally friendly, nanotechnology-based antibacterial agents is considered a promising alternative. This study aimed to evaluate the antibacterial activity of a nanocomposite comprising silver nitrate (AgNO₃), Cymbopogon citratus leaf extract, and chitosan against P. aeruginosa. The nanocomposite was synthesized using a green synthesis method, with plant extract serving as a natural reducing agent and chitosan as a nanoparticle stabilizer. Antibacterial activity was assessed via disk diffusion against five concentrations (6.25, 12.5, 15, 25, and 50 mg/mL), and compared to positive (chlorhexidine) and negative (acetic acid) controls. The results showed that the 6.25 mg/mL concentration produced the largest inhibition zone (average 11 mm), although it did not surpass the effectiveness of chlorhexidine. The inhibition zones remained stable for up to 72 hours, indicating sustained antibacterial activity. A decline in efficacy at 50 mg/mL was observed, likely due to nanoparticle aggregation and biological saturation. These findings support the potential of AgNO₃–C. citratus–chitosan nanocomposite as a natural-based alternative antibacterial agent. Further studies are recommended to characterize its physicochemical properties, elucidate its mechanism of action, and evaluate its toxicity and applicability in pharmaceutical and biomedical contexts.
Effects of Clinacanthus nutans and Aloe vera Extracts on bFGF Synthesis in Fibroblasts Anggraeni, Rezky; Roeslan, Moehamad Orliando
Journal of Indonesian Dental Association Vol 5 No 1 (2022): April
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Wound healing is an important but complicated process, containing a multifaceted process. The growth factor involved in the wound healing process is basic fibroblast growth factor (bFGF). Clinacanthus nutans (C. nutans) and A. vera are traditional plants that have the ability to induce fibroblast migration. However, no study has yet compared the effects of C. nutans and A. vera on bFGF protein synthesis associated with wound healing. Objective: The aim of this study was to evaluate the effect of extracts of C. nutans and A. vera on the fibroblast synthesis of bFGF in fibroblasts. Method: Clinacanthus nutans leaf powder was extracted using a solution of hexane and chloroform sequentially. While the A. vera gel is taken. Fibroblasts were treated with several concentrations (10, 50, and 100 µg/mL) within 24 hours. Synthesis of bFGF protein was tested using enzyme linked immunoabsorbent assay (ELISA). Result: The chloroform extract of C. nutans and A. vera up regulated the synthesis of bFGF. Concentration of 10 µg/mL C. nutans showed the highest bFGF protein synthesis compared to other treatment groups. Conclusion: Chloroform extract of C. nutans and A. vera can up regulated the synthesis of bFGF in fibroblasts. ABSTRAK Pendahuluan: Penyembuhan luka adalah proses penting namun rumit, yang terdiri dari beberapa fase penyembuhan. Faktor pertumbuhan yang berhubungan dengan proses penyembuhan luka adalah, basic fibroblast growth factor (bFGF). Clinacanthus nutans (C. nutans) dan Aloe vera (A. vera) adalah tumbuhan tradisional yang memiliki kemampuan untuk menginduksi migrasi fibroblas. Namun, belum ada penelitian yang telah membandingkan efek C. nutans dan A. vera terhadap sintesis protein bFGF yang berhubungan dengan luka penyembuhan. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui efek ekstrak C. nutans dan A. vera terhadap sintesis bFGF pada fibroblas. Metode: Bubuk daun C. nutans di ektraksi menggunakan larutan heksana dan kloroform secara berurutan. Sedangkan A. vera diambil gel nya. Fibroblas diberi perlakuan dengan beberapa konsentrasi (10, 50, dan 100 µg/mL) dalam waktu 24 jam. Sintesis protein bFGF diuji menggunakan enzym linked immunoabsorbent assay (ELISA). Hasil: Ekstrak kloroform C. nutans dan A. vera dapat meningkatkan sintesis protein bFGF lebih tinggi dibandingkan dengan kontrol negatif pada uji ELISA. C. nutans konsentrasi 10 µg/mL menunjukkan sintesis protein bFGF tertinggi dibandingkan dengan kelompok perlakuan lain. Kesimpulan: Ekstrak kloroform C. nutans dan A. vera dapat meningkatkan sintesis protein bFGF pada fibroblas.
Bone Resorption in Ameloblastoma and Its Underlying Mechanism Jackson, Jackson; Halim, Johni; Anggraeni, Rezky; Sandra, Ferry
Indonesian Journal of Cancer Chemoprevention Vol 12, No 1 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss1pp57-66

Abstract

Ameloblastoma, a tumor located in the jaw, grows slowly but locally invasive. Ameloblastoma expands in the jaw based on a mechanism resorbing the surrounding bone. To date, the bone resorption mechanisms of ameloblastoma are associated with the expression of receptor activator of nuclear factor (NF)-κB (RANK) ligand (RANKL), matrix metalloproteinases (MMPs), and tumor necrosis factor (TNF)-α. RANKL plays an important role in generating osteoclastogenesis. MMPs degrade the extracellular matrix. TNF-α can induce the formation of osteoclast and modulate the MMPs. In this review the bone resorption mechanism of ameloblastoma as well its signaling pathway will be disclosed.Keywords: Ameloblastoma, RANKL, MMPs, TNF-α.
Antibacterial Activity of Nanocomposite Chitosan-Silver Nanoparticle with Cymbopogon citratus Extract as a Bioreductor Against Staphylococcus aureus Anggraeni, Rezky; Melyda, Ananda Shelly; Pakpahan, Alfred; Ranggaini, Dewi; Halim, Johni; Komariah, Komariah
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 2 (2025): June 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v10.i2.112

Abstract

Nanocomposites are materials formed by combining two components, one or both of which are on the nanometer scale. The nanocomposite in this study is a combination of chitosan and silver nanoparticles produced through the synthesis of silver nitrate using Cymbopogon citratus extract. Silver nanoparticles have antibacterial abilities that can be utilized to overcome various diseases. However, their antibacterial properties may be reduced due to the tendency of silver nanoparticles to agglomerate. This can be overcome by the addition of chitosan as a stabilizing agent to prevent agglomeration and maintain the antibacterial effectiveness of silver nanoparticles. This study aims to evaluate the antibacterial activity of a nanocomposite formed by combining chitosan and silver nanoparticles synthesized using Cymbopogon citratus extract against Staphylococcus aureus through the diffusion method. The samples used included nanocomposites at concentrations of 6.25 mg/mL, 12.5 mg/mL, 15 mg/mL, 25 mg/mL, and 50 mg/mL, amoxicillin as a positive control, Acetic acid, and distilled water as negative controls. The results of antibacterial activity testing showed that all nanocomposite test concentrations had the ability to inhibit the growth of Staphylococcus aureus as evidenced by the formation of an inhibition zone around the disc paper. However, the highest antibacterial activity shown by the nanocomposites was still lower compared to the antibacterial activity of amoxicillin Keywords: Antibacterial activity, Chitosan, Cymbopogon citratus, Silver nanoparticles, Staphylococcus aureus
Large radicular cyst compressing the mandibular canal: a case report Andika, Steve Yosua; Yunizar, Vania Rizky; Audry Arifin, Sariyani Pancasari; Anggraeni, Rezky
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 9 No 2 (2025): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v9i2.1388

Abstract

Objectives: To describe radicular cysts and differentiate them from radiographically similar cysts such as odontogenic keratocysts. Case Report: A 21-year-old female patient presented to the Dental and Oral Hospital with a primary complaint of residual root fragments in the left mandibular region, for which she requested extraction. Extraoral clinical examination revealed no facial asymmetry, swelling, or tenderness, and the region was asymptomatic upon palpation. The patient reported no relevant systemic medical history. Panoramic radiographic examination demonstrated a well-defined unilocular radiolucent lesion extending from the apical third of tooth 36 to the periapical areas of teeth 35, 37, and 38. Given the limitations in diagnostic detail offered by conventional periapical radiography, a Cone-Beam Computed Tomography (CBCT) scan was subsequently performed. Multiplanar reconstruction images from the CBCT revealed a radiolucent lesion extending from the periapical area of tooth 35, with evidence of compression on the mandibular canal. Conclusion: Radicular cysts are the most common type of odontogenic cyst and are associated with dental inflammation. Radicular cysts and OKCs have a similar radiographic appearance, leading to confusion between the two. Cone Beam Computed Tomography (CBCT) offers three-dimensional imaging that allows a comprehensive assessment of the lesion's size, extent, and relationship to adjacent anatomic structures, allowing the characteristics of both radicular lesions and OKCs to be clearly demonstrated. The characteristics of each lesion can be clearly described, making CBCT a very helpful modality in these cases. Keywords: Cone Beam Computed Tomography, odontogenic cyst, radicular cyst
Efektivitas Antibakteri Nanokomposit AgNP Cymbopogon citratus dengan Penstabil Kitosan terhadap Streptococcus viridans Halim, Johni; Siahaya, Aleceandra A. S.; Komariah, Komariah; Ranggaini, Dewi; Anggraeni, Rezky
e-GiGi Vol. 14 No. 1 (2026): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v14i1.64572

Abstract

Abstract: Nanocomposite is a synthesis of silver nanoparticles (AgNP) with lemongrass leaves (Cymbopogon citratus) stabilized with chitosan. The combination of nanocomposites has synergy in inhibiting bacteria, one of which is Streptococcus viridans that causes abscesses in the oral cavity. This study aimed to determine the effectiveness of nanocomposite chitosan AgCh with C. citratus in inhibiting the growth of S. viridans. This was an in vitro experimental laboratory study with a post-test group control design using disc diffusion for antibacterial test. Samples were divided into eight groups, with several concentrations 6.25 mg/mL, 12.5 mg/mL, 15 mg/mL, 25 mg/mL, and 50 mg/mL, positive control (clindamycin), and negative control (aquadest and acetic acid). Normality test showed a p-value of >0.05, which meant data were normally distributed. One-way ANOVA test showed a p-value <0.05, indicating there was a difference in each treatment. Therefore, further testing was carried out using the Tukey's post hoc. In conclusion, chitosan nanocomposite, AgCh, with C. citratus can inhibit the growth of S. viridans with the formation of the best inhibition zone at a concentration of 50 mg/mL, followed by concentrations (25, 12.5, 15, and 6.25) mg/mL. Keywords: nanocomposite; silver nanoparticles; Cymbopogon citratus; chitosan; Streptococcus viridans; abscess    Abstrak: Nanokomposit ialah sintesis nanopartikel perak (AgNP) dengan daun serai dapur (Cymbopogon citratus) yang distabilkan dengan kitosan. Gabungan nanokomposit memiliki sinergitas dalam menghambat pertumbuhan bakteri, salah satunya Streptococcus viridans yang menyebabkan abses dalam rongga mulut. Penelitian ini bertujuan untuk mengetahui efektivitas nanokomposit kitosan AgCh dengan C. citratus dalam menghambat pertumbuhan S. viridans. Jenis penelitian ialah eksperimental laboratorik in vitro dengan post test group control design. Pengujian antibakteri menggunakan metode difusi cakram. Sampel dibagi dalam delapan kelompok, masing-masing pada konsentrasi 6,25 mg/mL, 12,5 mg/mL, 15 mg/mL, 25 mg/mL, 50 mg/mL, kontrol positif (clindamycin), dan kontrol negatif (akuades dan asam asetat). Hasil uji normalitas menunjukkan p>0,05 yang berarti data terdistribusi normal. Uji oneway ANOVA menunjukkan nilai p<0,05 yang berarti terdapat perbedaan pada setiap perlakuan, sehingga dilakukan uji lanjut dengan menggunakan post hoc tukey. Simpulan penelitian ini ialah nanokomposit kitosan, AgCh, dengan C. citratus dapat menghambat pertumbuhan S. viridans dengan pembentukan zona hambat terbaik pada konsentrasi 50 mg/mL, diikuti oleh konsentrasi (25, 12,5, 15, dan 6,25) mg/mL. Kata kunci: nanokomposit; nanopartikel perak; Cymbopogon citratus; kitosan; Streptococcus viridans; abses
Co-Authors Adrian, Nova Alfred Pakpahan, Alfred Andika, Steve Yosua Arianne Dwimega Audry Arifin, Sariyani Pancasari Aurili, Rifaty Azrianty, Annisa Bougenville, Vell Cendana, Aurellia Nadia Erni Erfan, Erni Ferry Sandra Halim, Johni Ihsan Rizal, Muhammad Jackson Jackson, Jackson Jeddy Komariah Komariah Maria Leny Raiyon, Maria Leny Melyda, Ananda Shelly Nugroho, Didi Ranggaini, Dewi Ranggaini, Monica Dewi Roeslan, Moehamad Orliando Siahaya, Aleceandra A. S. Soulissa, Abdul Gani Stefanie, Rosita Tegar Badruzzaman, Idham Yunizar, Vania Rizky