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All Journal Lansau: Jurnal Ilmu Kefarmasian MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Parawansah
Halu Oleo University
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Aktivitas Antihiperglikemik Ekstrak Daun Gedi Merah (Abelmoschus manihot L.Medik) pada Tikus Model Diabetes Melitus Tipe II: Antihyperglycemic activity of Red Gedi Leaf Extract (Abelmoschus manihot L.Medik) in Type II Diabetes Mellitus Model Rats Nuralifah; Parawansah; La Ode Muhammad Fitrawan; Irvan Anwar; Alya Zuhriyah
Lansau: Jurnal Ilmu Kefarmasian Vol. 1 No. 1 (2023): Lansau: Edisi April 2023
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/lansau.v1i1.5

Abstract

Type II diabetes mellitus is a metabolic disorder characterized by increased blood glucose levels due to damage to pancreatic β cells which causes reduced insulin production or abnormal insulin action. The leaves of Abelmoschus manihot L.Medik as an antidiabetic have been used empirically by the community. This study aims to determine the activity of the ethanol extract of Abelmoschus manihot L.Medik leaves as an antihyperglycemic agent in male rats fed a high-fat diet and experiencing type 2 DM induced by streptozotocin. The test animals were divided into six groups: the normal control group (KN) without treatment; the negative control group (K-), which was treated with 0.5% NaCMC, the positive control group (K+), which was treated with metformin 9 mg and the test group of extracts. With doses varying from 75 mg/kg, 150 mg/kg, and 300 mg/kg, rats were first given a high-fat diet, then induced by streptozotocin at a 30 mg/kg dose extract was given for seven days. The results of the phytochemical screening showed that the ethanol extract of red gedi leaves contained alkaloids, flavonoids, tannins, saponins, and steroids. The measurement results showed that administering ethanol extract of red gedi leaves (Abelmoschus manihot L.Medik) doses of 75 mg/kg, 150 mg/kg, and 300 mg/kg affected reducing blood glucose levels in male rats of the Wistar strain type II diabetes mellitus model. Significant based on the One-way ANOVA test and the Least Significance Difference (LSD) post hoc test.
Ethanol Extract Activity of Teak Leaves (Tectona grandis L) Against Histopotological Appearance of Pancreatic Organs in Rats (Rattus norvegicus) Model Type II DM Nuralifah; Parawansah; Ruslin; Rachma Malina; Emma Haerunnita
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background: Diabetes mellitus is a disease characterized by increased blood glucose levels and changes in the histopathological structure of the islets of Langerhans of the pancreas. One of the plants used empirically as an antidiabetic is the teak plant (Tectona grandis Linn). The content compounds that are thought to act as antidiabetics are flavonoids. Purpose: The purposes of this study is to determine the activity of the ethanol extract of Tectona grandis L leaves which has antihyperglycemic activity as seen from the histopathology of the pancreas of white rats (Rattus norvegicus). Methods: Modeling diabetes mellitus in test animals was carried out by inducing 40 mg/kg BW streptozotocin intraperitoneally. There were 6 treatment groups, namely the normal control group, the positive control group, the negative control group, and the teak leaf ethanol extract group at doses of 100, 200, and 300 mg/kg. Results: The ethanol extract of Tectona grandis leaves has repair activity for regenerating endocrine cells in the islets of Langerhans with an average number of endocrine cells in the normal control group of 483 cells, positive control group 474 cells, negative control 318 cells, dose 100 mg/kg body weight 450 cells, a dose of 200 mg/KBB 462 cells and a dose of 300 mg/KBB 469 cells and it can regenerate endocrine cells. Conclusion: the ethanol extract of Tectona grandis L leaves at a dose of 300 mg/kg BW has activity in repairing endocrine cells with cell morphology almost resembling normal cells.
Correlation Of Age And BMI With The Incident Of Nausea And Vomiting In Patients Post Sectio Caesarian Operation With Spinal Anesthesia In Aliyah Hospital 2 Agussalim Ali; Parawansah; Sulastrianah
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 3 (2023): Suplemen
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background. Postoperative nausea and vomiting are one of the complications experienced by patients with anesthesia and surgery. There are many factors that influence this occurrence, including age and BMI, where young age and obese BMI tend to experience postoperative nausea and vomiting. This is based on the fact that older age is easier to control nausea and vomiting than young people and obese BMI has more fat tissue to store anesthetic drugs so that the side effects of drugs can last longer. Method. This study used an observational analytic method with a cross sectional approach carried out at Aliyah Hospital 2. The number of samples in this study were 38 people who were taken using total sampling technique. Data collection was obtained from filling in the observation sheet and then the data was analyzed using the Fisher's Exact Test statistical test. The dependent variable in this study was postoperative nausea and vomiting and the independent variables were age and BMI. Results. The results of this study found that age did not have a significant relationship with the incidence of postoperative nausea and vomiting at Aliyah Hospital 2 (p = 0.298) and BMI had a significant relationship with the incidence of postoperative nausea and vomiting at Aliyah Hospital 2 (p = 0.019). Conclusion. From this study it can be concluded that the incidence of postoperative nausea and vomiting after spinal anesthesia is higher in patients with older age and excessive BMI.
The Impact of the Ethyl Acetate Fraction of Bitter Melon Fruit (Momordica charantia l.) on Insulin Hormone Levels of Diabetic Rats (Rattus norvegicus) Using the Enzyme-Linked Immunosorbent Assay Method Parawansah; Tien; Amiruddin Eso; Muhammad Junaid Azis; Nuralifah
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 3 (2023): Suplemen
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background: The World Health Organization (WHO) has forecast a rise in the prevalence of diabetes mellitus from 2.8% in 2000 to 4.4% in 2030. Numerous investigations have been undertaken to identify alternate avenues for antidiabetic treatment. Momordica charantia, sometimes referred to as bitter melon, is recognized for its possession of mimic insulin components. The ethanol extracts derived from Momordica charantia have been found to exhibit favorable outcomes in the reduction of blood glucose levels and the stimulation of pancreatic beta cells for the secretion of insulin hormone. Purpose: The purpose of this research is to investigate the impact of bitter melon extract on insulin levels in rats induced with streptozotosin. Method: The present study employed various methodologies to investigate the research question. The present investigation comprised three distinct sets of tests, specifically streptozotosin-induced rats, streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract, and non-induced streptozotosin rats. The measurement of insulin levels is conducted using the enzyme-linked immunosorbent assay (ELISA) technique. If the p-value was more than 0.05, an unpaired T-test was employed for data analysis. Result: The research findings indicate that there is no statistically significant distinction in the insulin levels between streptozotosin-induced rats and streptozotosin-induced rats administered with the ethyl acetate fraction of the Momordica charantia extract group (p = 0.081). The insulin levels of streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract were found to be statistically similar to those of non-induced streptozotosin rats (p = 0.505). Conclusion: There is no discernible distinction in the insulin levels among streptozotosin-induced rats, streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract, and non-induced streptozotosin rats.
Co-Authors Agussalim Ali Alya Zuhriyah Amiruddin Eso Anwar, Irvan Emma Haerunnita La Ode Muhammad Fitrawan Muhammad Junaid Azis Nuralifah Nuralifah Nuralifah, Nuralifah Rachma Malina Ruslin Sulastrianah Tien