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Ikmal Hafizi
Department of Dentistry, Faculty of Dentistry, Universitas Muhammadiyah Surakarta, Jawa Tengah, Indonesia
Health Professions Public Health Veterinary

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Effect Of Coenzyme Q10 On Osteoblasts Cells Number In Male Wistar Rats Gingiva Undergoing Periodontitis Ferren Natasya Sushera; Aprilia Yuanita Anwaristi; Ikmal Hafizi; Nur Ariska Nugrahani
Jurnal EduHealth Vol. 14 No. 03 (2023): Jurnal EduHealt, Edition September 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54209/jurnaleduhealth.v14i3.2521

Abstract

Inflammatory conditions in periodontitis can lead to increased production of free radicals. This study aims to determine the effect of coenzyme Q10 on the number of osteoblast cells in the gingiva of male wistar rats with periodontitis. The method used in this research is true experimental laboratory with posttest only control group design. 24 male wistar rats were divided into 4 groups, negative control group and treatment group on days 7 and 14 with each group of 6 rats. Induction of periodontitis by tying using silk ligature in the subgingival area and induced Porphyromonas gingivalis bacteria around the mandibular incisors teeth given every 2 days for 7 days. The treatment group was applied coenzyme Q10 0.1ml twice a day. 6 rats from each group were decapitated on day 7 and 14 then processed into histological preparations and then measured the number of osteoblasts. Data were analyzed using one-way ANOVA and LSD test. Conclusion: Application of coenzyme Q10 has an effect on increasing the number of osteoblast cells in the gingiva of male wistar rats with periodontitis
Effect Of Application Of Mineral Trioide Aggregate (Mta) And Nanohydroxyapatite In Duck Egg Shell On Macrophages In Reversible Pulpitis Shinta Marliana; Cahyani Cahyani; Ikmal Hafizi; Nur Ariska Nugrahani
Jurnal EduHealth Vol. 14 No. 03 (2023): Jurnal EduHealt, Edition September 2023
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54209/jurnaleduhealth.v14i3.2544

Abstract

Pulp disease is caused by bacteria that cause tooth decay in the form of caries. These bacteria can penetrate the pulp through the gaps in the dentine, and develop in the dentinal tubules so that the permeability of the dentinal tubules decreases. Reversible pulpitis is a type of pulp disease, which if left untreated will develop into irreversible pulpitis. Pulp capping treatment as a treatment for non medicament aims to maintain the pulp to remain vital by reducing the inflammatory process. Macrophages as a marker that can be used as a sign when inflammation occurs. Pulp capping treatment usually use calcium hydroxide and Mineral Trioxide Aggregate (MTA) as material agent. Duck egg shells contain calcium carbonate and Mineral Trioxide Aggregate has an effectiveness over calcium hydroxide. the purpose of this study is to determine the difference in the number of macrophages in reversible pulpitis using duck egg nanohydroxyapatite (NHA) and MTA. this research is an in vivo laboratory experimental post test only control design with 27 research samples which one control group and two experiment group. The independent variables are duck egg nanohydroxyapatite and MTA, and the dependent variable is differences in the number of macrophages. there were significant differences in the three groups, where the average value of macrophage formation was lowest in the group of rats that were applied to MTA and followed by the NHA group. Meanwhile, the control group, the reversible pulpitis rat group without medicament application, had the highest average score. The application of MTA as a pulp capping medicament can reduce macrophages in reversible pulpitis using rats Sprague Dawley.
Co-Authors Aprilia Yuanita Anwaristi Cahyani Cahyani Ferren Natasya Sushera Nur Ariska Nugrahani Shinta Marliana