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All Journal Journal of Health Management and Pharmacy Exploration (JOHMPE)
Risky Juliansyah Putri
Universitas Mandala Waluya, Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Effect of nephroprotectors of javanese bark extract (Lannea coromandelica) on aspirin-induced rat serum creatinine levels Jastria Pusmarani; Mus Ifaya; Risky Juliansyah Putri; Ade Safitri
Journal of Health Management and Pharmacy Exploration Vol. 1 No. 1 (2023): February 2023
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v1i1.138

Abstract

Kidney disease is a global health problem based on the increase of incidence, prevalence, and morbidity rate. According to RISKESDAS 2018, the prevalence of chronic kidney disease (CKD) was increased significantly. Lannea coromandelica stem bark contains flavonoid was exhibited antioxidant that could be potential as nephroprotector. This study aimed to find out the nephroprotector effect of ethanolic extract of Lannea coromandelica stem bark by measurement serum creatinine levels at rats (Rattus novergicus). This study was used experimental laboratory method. In this study used 25 rats were divided into 5 groups. Group 1 was administered Na CMC 1 % as negative control group. Group 2 was administered aspirin 600 mg/kg body weight as induced control group. Group 3, 4, and 5 were administered Lannea coromandelica stem bark ethanolic extract with the doses 400 mg/kg body weight, 800 mg/kg body weight, and 1200 mg/kg body weight, respectively. The extract of lannea coromandelica stem bark groups were given for 4 days orally. Blood of rats were collected from the orbital sinus eye to be measured creatinine serum level at 5th day. The data was analyzed statistically with one way ANOVA and Paired samples test. The result of this study exhibited that there was a differences of creatinine levels between pre and post treatment with p-value=0.033< 0.05. In conclusion, this study presented that ethanolic extract of Lannea coromandelica stem bark was decreased serum creatinine levels at doses 800 and 1200 mg/kg body weight against the aspirin induced on rats.
Antibacterial nardus grass kombucha (cymbopogon nardus (l.) rendle) against staphylococcus epidermidis and propionibacterium acnes Risky Juliansyah Putri; Agista Amelya; Nur Hatidjah Awaliyah Halid; Dian Rahmaniar Trisnaputri; Wa Ode Ida Fitriah; Himaniarwati
Journal of Health Management and Pharmacy Exploration Vol. 4 No. 1 (2026): February 2026
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v4i1.668

Abstract

The bacteria Propionibacterium acnes (PA) and Staphylococcus epidermidis (SE) cause acne vulgaris, an infection marked by inflammation in the sebaceous glands, as well as obstruction and accumulation of keratinous components. Kombucha contains antimicrobial chemicals, among other components. The active components' antibacterial properties should be strengthened by the addition of Nardus grass. Finding the most ideal concentration and the efficiency of Nardus grass kombucha in suppressing PA and SE bacteria were the goals of this investigation. The Kirby-Bauer antibacterial testing method was used to test Nardus grass kombucha against PA and SE bacteria after it had fermented for 14 days at concentrations of 70%, 80%, and 90%. ANOVA and SPSS software were used to analyze the data. According to the test results, the development of clean zones demonstrated that Nardus grass kombucha at all concentrations may stop bacterial growth. At 70%, 80%, and 90% concentrations, the inhibition zones' average diameters against PA bacteria were 16.60 mm, 18.53 mm, and 20.96 mm, respectively. At the same doses, the inhibition zones for SE bacteria were 15.40 mm, 16.30 mm, and 17.53 mm. The results of the study showed that nardus grass kombucha can inhibit PA and SE bacteria, with 90% being the ideal concentration.
Co-Authors Ade Safitri Agista Amelya Dian Rahmaniar Trisnaputri Himaniarwati Jastria Pusmarani Mus Ifaya Nur Hatidjah Awaliyah Halid Wa Ode Ida Fitriah