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All Journal International Journal of Cell and Biomedical Science Sustainable Society Journal
Risky Chandra Satria Irawan
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Effect of Time Transport on Mesenchymal Stem Cell Surface Markers: Unveiling the Influence of Cellular Translocation on Cellular Phenotype Wicaksono, Hendi; Prasetio, Ardi; Risky Chandra Satria Irawan; Naufal Ardjivani Arifin
International Journal of Cell and Biomedical Science Vol 2 No 4 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v2i4.29

Abstract

Mesenchymal stem cells (MSCs) hold great promise in regenerative medicine due to their ability to differentiate into multiple cell types and promote tissue repair. However, the effect of transportation time on the surface markers of MSCs remains understudied. This study investigated the impact of transportation time on MSC surface markers, specifically CD73, CD90, CD105, and hematopoietic lineage markers. MSCs were isolated from human umbilical cords and cultured. Flow cytometry analysis confirmed the expression of MSC surface markers. The MSCs were then subjected to simulated transportation for different time periods ranging from 0 to 24 hours at 2-8oC. After transportation, flow cytometry was used to analyze the expression of surface markers. The results showed that prolonged transportation time led to a decrease in the expression levels of CD73, CD90, and CD105, which are important markers for maintaining MSC functionality. Additionally, there was an increase in hematopoietic lineage marker expression. These findings suggest that transportation time can compromise the therapeutic potential of MSCs. Further investigation is needed to understand the underlying mechanisms responsible for the observed changes in surface marker expression. Optimization strategies, such as improved temperature control and protective agents, should be considered to mitigate the negative effects of prolonged transportation time. In conclusion, this study highlights the importance of considering transportation time and its impact on MSC surface markers in cellular therapy protocols. Understanding and addressing these effects are crucial for ensuring the quality and effectiveness of MSC-based therapies.
Peningkatan Literasi Kesehatan Masyarakat melalui Skrining Kesehatan dan Edukasi Sains Bioteknologi dan Biomedis di Posyandu Nongkosawit, Semarang Nurul Hidayah; Naufal Sebastian Anggoro; Dendi Krisna Nugaraha; Risky Chandra Satria Irawan; Salindri Prawitasari; Nadya Audina Nurkhafiya Sadikin; Dini Cahyani; Fauziah Novita Putri Rifai; Dian Respati Ayu; Rita Agustina
Sustainable Society Journal Vol. 1 No. 2 (2026)
Publisher : Agung Putra University

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Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan mendeskripsikan hasil skrining kesehatan dasar dan mengevaluasi perubahan pengetahuan peserta setelah edukasi kesehatan berbasis komunitas di Posyandu Nongkosawit, Semarang, pada 14 Februari 2026. Kegiatan menggunakan pendekatan deskriptif dengan evaluasi pre-test dan post-test. Pemeriksaan meliputi tekanan darah, glukosa darah sewaktu, asam urat, dan kolesterol total sesuai ketersediaan data. Data skrining diperoleh dari 27 peserta, sedangkan evaluasi perubahan pengetahuan melibatkan 24 peserta dengan data pre-test dan post-test lengkap. Data dianalisis secara deskriptif, dan perubahan skor pengetahuan diuji menggunakan Wilcoxon signed-rank. Hasil menunjukkan rerata tekanan darah sistolik sebesar 140,74 ± 19,65 mmHg dan diastolik sebesar 82,44 ± 12,18 mmHg, sedangkan rerata glukosa darah sewaktu mencapai 159,19 ± 95,96 mg/dL. Rerata skor pengetahuan meningkat dari 6,29 ± 3,21 pada pre-test menjadi 8,71 ± 1,20 pada post-test, dengan kenaikan sebesar 2,42 poin yang signifikan secara statistik (p = 0,0014). Temuan ini menunjukkan peningkatan skor pengetahuan segera setelah edukasi. Namun, desain tanpa kelompok pembanding dan pengukuran tindak lanjut membatasi penarikan kesimpulan mengenai efektivitas kausal, perubahan perilaku, maupun dampak kesehatan jangka panjang. Integrasi skrining dan edukasi kesehatan berbasis komunitas berpotensi mendukung upaya promotif dan preventif, tetapi perlu disertai tindak lanjut hasil skrining serta evaluasi berkelanjutan.
Co-Authors Dendi Krisna Nugaraha Dian Respati Ayu Dini Cahyani Fauziah Novita Putri Rifai Hendi Wicaksono Nadya Audina Nurkhafiya Sadikin Naufal Ardjivani Arifin Naufal Sebastian Anggoro Nurul Hidayah Prasetio, Ardi Rita Agustina Salindri Prawitasari