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All Journal Indonesian Journal for Health Sciences (IJHS) Indonesian Journal of Global Health Research
Diah Andini
Universitas Sriwijaya
Nursing Public Health

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GENETICS OF DEMENTIA: THE CANDIDATE GENES AND AVAILABLE GENETIC TESTINGS Ziske Maritska; Diah Andini; Febryana Ramadhani Machyar; Rachmat Taufan; Try Merdeka Puri; Tryvanie R Putra; Uswati Uswati; Bintang Arroyantri Prananjaya; Rini Nindela; Nita Parisa
Indonesian Journal for Health Sciences Vol 7, No 2 (2023): September
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v7i2.6353

Abstract

When dementia is present, a person's memory, reasoning, behavior, and even their capacity to carry out day-to-day chores can all become distorted. This syndrome remains present and actually worsens as time passes. It's possible that synapse loss, death and dysfunction of brain cells, gliosis, and inflammation are all factors in the progression of dementia. The clinical syndrome, age, and a history of the ailment in the patient's family should dictate the choices made about counseling and testing. Dementia is known as a multifactorial condition, brought on by the combination of strong genetic factors and environmental factors. There are several candidate genes  associated with Dementia; APP, PSEN1, and PSEN2 genes, in addition to the GRN and MAPT genes. This literatura review provide insight on the genetic of Dementia, particularly in the genetic causes and testings
Comparison of Combined Perineural Injection and Oral Mecobalamin with Oral Mecobalamin Therapy on Sensory Symptom Improvement in Patients with Carpal Tunnel Syndrome Diah Andini; Masita Masita; Henry Sugiharto; Erial Bahar
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1526

Abstract

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, predominantly presenting with sensory symptoms such as numbness and tingling. Conservative therapy with oral mecobalamin is widely used; however, the onset of improvement is often slow. Perineural injection of mecobalamin may provide a faster local effect, but clinical evidence remains limited. This study aimed to evaluate the effectiveness of combined perineural injection and oral mecobalamin compared with oral mecobalamin alone on sensory symptom improvement in CTS patients. This was a comparative interventional study conducted in patients with mild to moderate CTS at Dr. Mohammad Hoesin General Hospital, Palembang. Subjects were divided into two groups: a combination therapy group (perineural injection plus oral mecobalamin) and an oral mecobalamin group. Sensory symptoms were assessed using the Visual Analog Scale (VAS) at baseline, week 2, and week 4. Between-group and within-group comparisons were analyzed using t-tests, while mixed ANOVA was used to evaluate the effects of time and treatment group. Multivariate analysis was performed to identify factors independently associated with sensory symptom improvement. A total of 30 CTS patients were included in this study. There were no significant differences in baseline demographic and clinical characteristics between groups. Mixed ANOVA analysis demonstrated a significant time effect (p < 0.001) and a significant time group interaction, indicating a faster pattern of sensory symptom improvement (VAS score reduction) in the combination group. Multivariate analysis showed that combination therapy, sex, and occupation were independently associated with sensory symptom improvement, with occupation being the most dominant factor. The combination of perineural injection and oral mecobalamin is more effective in accelerating and enhancing sensory symptom improvement compared with oral mecobalamin therapy alone in patients with mild to moderate CTS.
Co-Authors Bintang Arroyantri Prananjaya Erial Bahar Febryana Ramadhani Machyar Masita Masita Nita Parisa Rachmat Taufan Rini Nindela Sugiharto, Henry Try Merdeka Puri Tryvanie R Putra Uswati Uswati Ziske Maritska