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R. D. Gupta, R. D.
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Medicine & Pharmacology

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Subduing the nail barrier with novel herbal penetration enhancers for transungual delivery system Singh, Vikram; Gupta, R. D.; Teotia, U. V. S.
Journal of Applied Pharmaceutical Research Vol 3 No 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Nail fungal infections are very common and also very difficult to treat because of nail morphology, deep penetrability of infectious agent inside nail plate and poor permeability of the nail plate. Transungual delivery shall be the first choice for treatment of nail infection if we get the effective penetration enhancers without causing the serious problem. In this study we tried to scanning some extracts penetration potency through the human cadaver nail plate. 
Investigation of novel penetration enhancer lawsonia inermis for drug delivery through nail plate Singh, Vikram; Gupta, R. D.; Teotia, U. V. S.
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

Nail fungus infections may be very painful and can seriously harm through systemic circulation if untreated. In this study we try to find out and formulate the natural penetration enhancer(PEs). Lawsonia Inermis leafs were used as a penetration enhancer. To extract the penetration enhancer extraction was done with methanol and dried, which shows hundred percent penetrations across the nail plate. Human cadaver nail plate (dry weight 45.8 mg, thickness 220 µm) defatted with chloroform: methanol (2:1) was used for penetration study. Diffusion study with the help of franz diffusion cell with phosphate buffer saline. The transungual film F32 evaluated for the physical properties – %Drug Content 97.1±0.03, Weight variation 180±2.10, Thickness 0.21±0.01, Flatness 99%, Folding endurance 180±3, WVTR 3.143±0.436, %Moisture content3.823±0.23. The drug moved across the nail plate in near to first order manner and support by the pepass “n” value i.e. 0.87. The formulation with the Lawsonia Inermis’s extract penetrates the 2.09% more drug through nail plate. The present study can claim that the Lawsonia Inermis as a potent penetration enhancer for transungual delivery for which the penetration is a limiting factor.
Investigation of novel penetration enhancer Lawsonia inermis for drug delivery through nail plate Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.847 KB)

Abstract

Nail fungus infections may be very painful and can seriously harm through systemic circulation if untreated. In this study we try to find out and formulate the natural penetration enhancer(PEs). Lawsonia Inermis leafs were used as a penetration enhancer. To extract the penetration enhancer extraction was done with methanol and dried, which shows hundred percent penetrations across the nail plate. Human cadaver nail plate (dry weight 45.8 mg, thickness 220 µm) defatted with chloroform: methanol (2:1) was used for penetration study. Diffusion study with the help of franz diffusion cell with phosphate buffer saline. The transungual film F32 evaluated for the physical properties – %Drug Content 97.1±0.03, Weight variation 180±2.10, Thickness 0.21±0.01, Flatness 99%, Folding endurance 180±3, WVTR 3.143±0.436, %Moisture content3.823±0.23. The drug moved across the nail plate in near to first order manner and support by the pepass “n” value i.e. 0.87. The formulation with the Lawsonia Inermis’s extract penetrates the 2.09% more drug through nail plate. The present study can claim that the Lawsonia Inermis as a potent penetration enhancer for transungual delivery for which the penetration is a limiting factor.
Subduing the nail barrier with novel herbal penetration enhancers for transungual delivery system Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.188 KB)

Abstract

Nail fungal infections are very common and also very difficult to treat because of nail morphology, deep penetrability of infectious agent inside nail plate and poor permeability of the nail plate. Transungual delivery shall be the first choice for treatment of nail infection if we get the effective penetration enhancers without causing the serious problem. In this study we tried to scanning some extracts penetration potency through the human cadaver nail plate. Five plants selected for the purpose acacia catechu, rosa hybrid, hibiscus rose-sinensis, tagetes patula, tagetes erecta. For penetration potency first defatted the nail plate with chloroform : methanol (2:1) mixture. Extracts of tagetes erecta, acacia catechu shows 100%, tagetes patula 60% and rosa hybrid 40% from dorsal side of plate. Those extracts were stable by it only. That proves that they may be used as a penetration enhancer to increase the penetration of drug
Co-Authors Teotia, U. V. S U. V. S. Teotia, U. V. S. Vikram Singh, Vikram