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All Journal Journal of Applied Pharmaceutical Research International Journal of Humanities, Management, and Social Science (IJ-HuMaSS) International Journal Education and Computer Studies jes
Vikram Singh, Vikram
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Aerospace Engineering Humanities Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Education Electrical & Electronics Engineering Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Social Sciences Other

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Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS Kumar, Amrendra; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 2 No 4 (2014)
Publisher : Creative Pharma Assent

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Abstract

The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system. 
Design and in vitro evaluation of mouth dissolving tablets olanzapine Sharma, Vivek Kumar; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 3 No 1 (2015)
Publisher : Creative Pharma Assent

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The purpose of this research was to design and evaluate the olanzapine fast dissolving tablets.  The variable formulation of Olanzapine having challenging methodology. Olanzapine practically insoluble in water so used different polymers and superdisintigrant to make formulation. Direct compression are most desired method for preparation of mouth dissolving tablets. The tablets were evaluated for disintegration and dissolution properties of the formulation. In formulation of mouth dissolving tablet evaluate the precompression parameter and post compression parameter and after evaluation found satisfactory
Naringin a potent antioxidant used as bioavailibility enhancer for terbinafine hydrochloride Singh, Akanksha; Juyal, Divya; Singh, Vikram; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 2 No 3 (2014)
Publisher : Creative Pharma Assent

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The poor bioavailability of drugs has been identified as the single most important challenge in oral drug delivery. Prominent among the factors responsible for this are the oxidative metabolic activity of the intestinal and hepatic cytochrome P450 enzyme family. Naringin and naringenin which are the major phytochemical component of grapefruit juice, a well-known cytochrome P450 3A4 inhibitor and flavone glycoside, is antioxidant in nature and occurs naturally in the pericarp of citrus fruit, and particularly of grapefruit (Citrus paradisii) where it is the predominant flavonoid found and is responsible for the bitter taste associated with the fruit. CYP3A4 which is a class of CYP – 450 (microsomal enzyme) is responsible for the oxidative metabolic reaction of various substrates which decreases the bioavailability of drug. 
Solubility enhancement of biperidine hcl by complexation with hydroxypropyl β-cyclodextrin Dubey, Amit; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol 3 No 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Oral route is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, and cheap cost of production, accurate dosage and easy process, solid oral dosage forms have several advantages over other dosage forms. All the poor water soluble drugs after oral administrations are not well absorbed and thus leads to decrease in inherent efficiency of drugs. Therefore, for oral drug delivery system the improvement of drug solubility thereby its oral bio-availability is the most important aspect of drug development process. Biperiden HCl is a potent drug (Maximum daily dose is 16mg/day), having extensive first pass metabolism resulting in poor Bioavailability. The pharmacokinetic profile of this drug showed 33±5 % Bioavailability and 18-24 hours elimination half-life (t1/2). In the present study attempt has been made to prepare and characterize inclusion complex of Biperiden HCl with Hydroxypropyl β-Cyclodextrin. The inclusion complexes prepared by different methods i.e. Physical mixture, Kneading and Solvent evaporation methods. The prepared complexes were characterized using FT-IR. The inclusion complex prepared by Kneading method exhibited greatest enhancing in solubility and faster dissolution (93.98% drug release in 60 min) of Biperiden HCl.
Inspection of a novel penetration enhancer for transungual drug delivery system: Pelargonium hortorum Singh, Vikram; Chandrul, Kaushal Kishore
Journal of Applied Pharmaceutical Research Vol 3 No 1 (2015)
Publisher : Creative Pharma Assent

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This study was to search some natural penetration enhancer and formulate them in  a transungual drug delivery formulation. This natural penetration enhancer helps to overcome the main problem in front of success of transungual drug delivery system. We selected to formulate fluconazole as a model drug  for the nail fungal infection treatment with extracted penetration enhancer (PE). Model drug i.e. fluconazole was formulated with the natural extracted penetration enhancer with different deigned formula. The solvent for PE extraction was methanol and that extracts were air dried. 
Subduing the nail barrier with novel herbal penetration enhancers for transungual delivery system Singh, Vikram; Gupta, R. D.; Teotia, U. V. S.
Journal of Applied Pharmaceutical Research Vol 3 No 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Nail fungal infections are very common and also very difficult to treat because of nail morphology, deep penetrability of infectious agent inside nail plate and poor permeability of the nail plate. Transungual delivery shall be the first choice for treatment of nail infection if we get the effective penetration enhancers without causing the serious problem. In this study we tried to scanning some extracts penetration potency through the human cadaver nail plate. 
Development and characterization of surface solid dispersion of curcumin for solubility enhancement Singh, Mahendra Vikram; Juyal, Divya; Singh, Vikram; Rawat, Geeta; Tiwari, Akhilesh
Journal of Applied Pharmaceutical Research Vol 2 No 4 (2014)
Publisher : Creative Pharma Assent

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Surface solid dispersion (SSD) of curcumin was developed and characterized with purview to overcome solubility hurdle in its pharmacokinetic and pharmacodynamic performance. SSDs were prepared by co-evaporation method using polyplasdone XL, croscarmelose sodium, and silicone dioxide and polyethlene glycol 6000 as carrier. The optimized SSD (F9) was characterized using FE-SEM and XRD as an analytical tool. The formulation of modified Curcumin shows better drug release profile as compared to the natural Curcumin. Formulation F9 released more than 90% of the loaded Curcumin within 30 minutes where marketed formulations shows 90% drug only after 60 minutes.  
Investigation of novel penetration enhancer lawsonia inermis for drug delivery through nail plate Singh, Vikram; Gupta, R. D.; Teotia, U. V. S.
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

Nail fungus infections may be very painful and can seriously harm through systemic circulation if untreated. In this study we try to find out and formulate the natural penetration enhancer(PEs). Lawsonia Inermis leafs were used as a penetration enhancer. To extract the penetration enhancer extraction was done with methanol and dried, which shows hundred percent penetrations across the nail plate. Human cadaver nail plate (dry weight 45.8 mg, thickness 220 µm) defatted with chloroform: methanol (2:1) was used for penetration study. Diffusion study with the help of franz diffusion cell with phosphate buffer saline. The transungual film F32 evaluated for the physical properties – %Drug Content 97.1±0.03, Weight variation 180±2.10, Thickness 0.21±0.01, Flatness 99%, Folding endurance 180±3, WVTR 3.143±0.436, %Moisture content3.823±0.23. The drug moved across the nail plate in near to first order manner and support by the pepass “n” value i.e. 0.87. The formulation with the Lawsonia Inermis’s extract penetrates the 2.09% more drug through nail plate. The present study can claim that the Lawsonia Inermis as a potent penetration enhancer for transungual delivery for which the penetration is a limiting factor.
Investigation of novel penetration enhancer Lawsonia inermis for drug delivery through nail plate Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

Nail fungus infections may be very painful and can seriously harm through systemic circulation if untreated. In this study we try to find out and formulate the natural penetration enhancer(PEs). Lawsonia Inermis leafs were used as a penetration enhancer. To extract the penetration enhancer extraction was done with methanol and dried, which shows hundred percent penetrations across the nail plate. Human cadaver nail plate (dry weight 45.8 mg, thickness 220 µm) defatted with chloroform: methanol (2:1) was used for penetration study. Diffusion study with the help of franz diffusion cell with phosphate buffer saline. The transungual film F32 evaluated for the physical properties – %Drug Content 97.1±0.03, Weight variation 180±2.10, Thickness 0.21±0.01, Flatness 99%, Folding endurance 180±3, WVTR 3.143±0.436, %Moisture content3.823±0.23. The drug moved across the nail plate in near to first order manner and support by the pepass “n” value i.e. 0.87. The formulation with the Lawsonia Inermis’s extract penetrates the 2.09% more drug through nail plate. The present study can claim that the Lawsonia Inermis as a potent penetration enhancer for transungual delivery for which the penetration is a limiting factor.
Naringin a potent antioxidant used as bioavailibility enhancer for terbinafine hydrochloride Singh, Akanksha; Juyal, Divya; Singh, Vikram; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol. 2 No. 3 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (750.5 KB)

Abstract

The poor bioavailability of drugs has been identified as the single most important challenge in oral drug delivery. Prominent among the factors responsible for this are the oxidative metabolic activity of the intestinal and hepatic cytochrome P450 enzyme family. Naringin and naringenin which are the major phytochemical component of grapefruit juice, a well-known cytochrome P450 3A4 inhibitor and flavone glycoside, is antioxidant in nature and occurs naturally in the pericarp of citrus fruit, and particularly of grapefruit (Citrus paradisii) where it is the predominant flavonoid found and is responsible for the bitter taste associated with the fruit. CYP3A4 which is a class of CYP – 450 (microsomal enzyme) is responsible for the oxidative metabolic reaction of various substrates which decreases the bioavailability of drug.
Co-Authors Akanksha Singh, Akanksha Akhilesh Tiwari, Akhilesh Amit Dubey, Amit Amrendra Kumar, Amrendra Chandrul , Kaushal Kishore Divya Juyal, Divya Geeta Rawat, Geeta Gupta, Ananya Harrison, Liam Kaushal Kishore Chandrul, Kaushal Kishore Kumar, Arjun Kumari, Priya Mahendra Vikram Singh, Mahendra Vikram Patel, Ravi R. D. Gupta, R. D. Rawat, Geet Sharma, Priya Teotia, U. V. S U. V. S. Teotia, U. V. S. Vivek Kumar Sharma, Vivek Kumar