Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

p-Index From 2021 - 2026

P-Index

This Author published in this journals

All Journal Journal of Applied Pharmaceutical Research

Teotia, U. V. S

Unknown Affiliation

Author-ID : 1560304

Medicine & Pharmacology

Published : 5 Documents Claim Missing Document

Claim Missing Document

Articles

Investigation of novel penetration enhancer Lawsonia inermis for drug delivery through nail plate Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.847 KB)

Nail fungus infections may be very painful and can seriously harm through systemic circulation if untreated. In this study we try to find out and formulate the natural penetration enhancer(PEs). Lawsonia Inermis leafs were used as a penetration enhancer. To extract the penetration enhancer extraction was done with methanol and dried, which shows hundred percent penetrations across the nail plate. Human cadaver nail plate (dry weight 45.8 mg, thickness 220 µm) defatted with chloroform: methanol (2:1) was used for penetration study. Diffusion study with the help of franz diffusion cell with phosphate buffer saline. The transungual film F32 evaluated for the physical properties – %Drug Content 97.1±0.03, Weight variation 180±2.10, Thickness 0.21±0.01, Flatness 99%, Folding endurance 180±3, WVTR 3.143±0.436, %Moisture content3.823±0.23. The drug moved across the nail plate in near to first order manner and support by the pepass “n” value i.e. 0.87. The formulation with the Lawsonia Inermis’s extract penetrates the 2.09% more drug through nail plate. The present study can claim that the Lawsonia Inermis as a potent penetration enhancer for transungual delivery for which the penetration is a limiting factor.

Subduing the nail barrier with novel herbal penetration enhancers for transungual delivery system Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.188 KB)

Nail fungal infections are very common and also very difficult to treat because of nail morphology, deep penetrability of infectious agent inside nail plate and poor permeability of the nail plate. Transungual delivery shall be the first choice for treatment of nail infection if we get the effective penetration enhancers without causing the serious problem. In this study we tried to scanning some extracts penetration potency through the human cadaver nail plate. Five plants selected for the purpose acacia catechu, rosa hybrid, hibiscus rose-sinensis, tagetes patula, tagetes erecta. For penetration potency first defatted the nail plate with chloroform : methanol (2:1) mixture. Extracts of tagetes erecta, acacia catechu shows 100%, tagetes patula 60% and rosa hybrid 40% from dorsal side of plate. Those extracts were stable by it only. That proves that they may be used as a penetration enhancer to increase the penetration of drug

Screening of poly vinyl chloride degrading bacteria from plastic contaminated area of Baddi Kumar, Sahni; Teotia, U. V. S; Singh, Yogendra
Journal of Applied Pharmaceutical Research Vol. 5 No. 3 (2017)
Publisher : Creative Pharma Assent

Plastic wastes are posing ever increasing environmental concerns. Recent research works have shown that most of the constituents of plastics can be degraded by microbes and the film plastics can be treated by microbial systems. In this study, poly vinyl chloride (PVC), degrading bacteria’s were isolate and characterize from soil dumped with plastics. The PVC degradating bacterial were identified as E.Coli, Staphylococcus, Pseudomonas and Klebsiella. It was observed that maximum degradation by Pseudomonas and degradation after 10 months was 40.53%, 23.06%, 10.92% and 5.32% for Pseudomonas, Klebsiella, Staphylococcus and E.Coli respectively.This work concluded that soil contains bacteria’s that have ability to carry degradation of poly vinyl chloride (PVC)

A comprehensive review on microbial degradation of plastic waste Kumar, Sahni; Teotia, U. V. S; Singh, Yogendra
Journal of Applied Pharmaceutical Research Vol. 5 No. 4 (2017)
Publisher : Creative Pharma Assent

Plastic is a broad name given to different polymers with high molecular weight, which can be degraded by various processes. However, considering their abundance in the environment and their specificity in attacking plastics, biodegradation of plastics by microorganisms and enzymes seems to be the most effective process. When plastics are used as substrates for microorganisms, evaluation of their biodegradability should not only be based on their chemical structure, but also on their physical properties (melting point, glass transition temperature, crystallinity, storage modulus etc.). In this review, microbial and enzymatic biodegradation of plastics and some factors that affect their biodegradability are discussed. Plastics have become an important part of modern life and are used in different sectors of applications like packaging, building materials, consumer products and much more. Each year about 100 million tons of plastics are produced worldwide. Degradation is defined as reduction in the molecular weight of the polymer. The Degradation types are (a). Chain end degradation/de-polymerization (b).Random degradation/reverse of the poly condensation process. Biodegradation is defined as reduction in the molecular weight by naturally occurring microorganisms such as bacteria, fungi, and actinomycetes. That is involved in the degradation of both natural and synthetic plastics.

Effect of primary packaging on microbiological status of oral solid dosage form Khana, Meenal; Teotia, U. V. S; Siingh, Yogendra
Journal of Applied Pharmaceutical Research Vol. 6 No. 1 (2018)
Publisher : Creative Pharma Assent

The emergence of microbial contaminants in non-sterile drugs caused not only the degradation of many products, but also proved to be a potential risk to consumer health. The aim of this study was to test microbial load of non sterile solid pharmaceutical product and investigate the effects of different packaging system on microbial status of pharmaceutical product. A total of 18 sample of solid dosage form packaged in different packaging were procured from market. All samples have been tested for the presence of specific microorganisms, Total aerobic microbial counts (TAMC) and Total yeast and mold counts (TYMC) using compendial procedures. Out of 18 sample 72.22 % (n=13) had shown microbial growth and only 16 % (n=3) of samples were non-compliant. Sample containing herbal ingredients, were the most heavily contaminated, showing a bacterial load > 104 CFU/g. The result showed that all the tested samples were free from E. coli. There was no significant difference (p>0.05) in microbial load of product packaged in different primary packaging

Co-Authors Khana, Meenal R. D. Gupta, R. D. Sahni Kumar, Sahni Siingh, Yogendra Vikram Singh, Vikram Yogendra Singh, Yogendra

Title

Found 5 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 5 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 5 Documents
Search