Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal The Journal of Pure and Applied Chemistry Research
Ridho Firmansyah
Department of Mechanical Engineering, Faculty of Engineering, Universitas Brawijaya, Malang, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Effects of Preparation Temperature and Liquid-Solid Lipid Composition to Curcumin-Nanostructured Lipid Carrier Characteristics Fabricated by Microfluidic Technique Ridho Arief Al Rasyid; Diah Mardiana; Ridho Firmansyah; Zubaidah Ningsih
The Journal of Pure and Applied Chemistry Research Vol 12, No 2 (2023): May-August 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.02.3317

Abstract

Nanostructured Lipid Carriers (NLC) are lipid-based carrier that uses a combination of liquid and solid lipids which is believed to deliver a higher amount of active substance to the human body. This study aimed to obtain the best formulation and evaluate the stability of curcumin-loaded NLC (C-NLC) using microfluidic technique at temperature of 40oC and 60oC with the ratios of liquid:solid lipids were 2 : 1 ; 3.5 : 1 ; 4 : 1 ; 6 : 1% w/w. Our results showed that the increase of process temperature and liquid lipid concentration reduced particle size. There was a non-linear relationship between lipid ratio and temperature to encapsulation percentage. At ratio of soybean oil:stearic acid 6 : 1 and, at 40°C, particles size (PS) obtained was 143.87 ± 3.36 nm, polydispersity index (PDI) obtained was 0.44 ± 0.01, zeta potential (ZP) obtained was -33.3 ± 6.53 mV with encapsulation percentage of 20.62%. At the same ratio at 60°C, the PS obtained was 60.21 ± 2.55 nm, PDI obtained was 0.72 ± 0.03, ZP obtained was -26.10 ± 1.83 mV and encapsulation percentage of 31.45%. Stability test showed that C-NLC produced at 60°C was more stable since the change of particle size and pH were lower than C-NLC produced at 40°C.
Co-Authors Diah Mardiana Ridho Arief Al Rasyid Zubaidah Ningsih