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All Journal Jurnal Biologi Tropis Journal of Social Science
Dinda Salsabila
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Physics Social Sciences

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Understanding and Addressing the Challenges of Gastrointestinal Stromal Tumor (GIST): Towards Improved Diagnosis and Treatment Strategies Ali Ramzi; Alma Dyah Perwita; Dinda Salsabila; Trisna Ayu Kurnia Putri; Ulul Azmi
Journal of Social Science Vol. 4 No. 5 (2023): Journal of Social Science
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jss.v4i5.705

Abstract

Gastrointestinal stromal tumor (GIST) is a prevalent mesenchymal tumor affecting the digestive tract, with the stomach being the most common location. While some GIST cases are sporadic with no known risk factors, certain factors like age and genetic abnormalities increase the risk. Early diagnosis of GIST remains challenging due to atypical symptoms, leading to late diagnoses and reduced survival rates. This research aims to identify specific risk factors related to local populations, develop accurate early diagnosis methods, and formulate more effective treatment strategies. The study involves a retrospective observational approach, collecting data from medical records of GIST patients and analyzing risk factors and treatment outcomes. The results highlight the increasing prevalence of GIST globally, emphasizing the need for increased awareness and early diagnosis. Challenges in early diagnosis and treatment underscore the importance of public awareness, medical education, and collaborative efforts for better GIST management. This research offers implications for the development of diagnostic guidelines and more effective treatment approaches, ultimately improving the prognosis and quality of life for GIST patients.
Cerebral Malaria Dinda Salsabila; Alifia Mawadddah; Athalitha Andhera Nabil; Baiq Ramdhani Amelia Negara; Herdiana Nurul Utami; Indri Setiawati; Ni Nyoman Geriputri
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.5810

Abstract

Cerebral malaria is the worst complication of malaria caused by Plasmodium spp. This disease is spread in tropical and subtropical countries and can attack all age groups and genders. The peak incidence occurs in preschool children and very often causes death in children. The endemic areas of malaria in Indonesia include NTT, Maluku, West Papua and Papua. Every year, as much as 40% of the total global population lives in or visits endemic areas every year. Cerebral malaria can cause long-term neurocognitive complications that can reduce quality of life. The speed of treatment determines the patient's prognosis. Therefore, it is necessary to understand the signs of malaria and the complications that can arise. This article was written to discuss cerebral malaria as a whole based on existing literature.
Giant Cell Tumor: Pathogenesis and Clinical Manifestation Adinda Ilsa Maulida; Ali Ramzi; Amrullah Muliawan H; Baiq Ghassani Kayla; Clara Nadila; Dinda Salsabila; Febbi Anggy; Herodya Lajunee Fesmia; Jihan Alifa Rahma; Trisna Ayu Kurnia Putri; Wina Aryslia Fakar; Zulfa Hasyimiyyah Ihtisyam; Nurhidayati Nurhidayati
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i4b.5831

Abstract

A giant cell tumor of bone (GCTB) as known as a benign bone tumor (neoplasm) is aggressive locally and frequently recurs, and it is characterized by the growth of mononuclear stromal cells and datia cells that resemble osteoclasts. GCTB has varying incidence rates and has been shown to have high mortality. GCTB patients have several treatment options, but the majority of patients still experience recurrence and even metastasis to other organs. This literature review aims to explain more deeply about Giant Cell Tumor (GCT) starting from the definition, etiology, epidemiology, pathogenesis, clinical manifestations and treatment options so that patients get a better prognosis. This literature review was conducted using the keywords "Giant Cell Tumor AND pathogenesis AND clinical manifestation" from PubMed dan Google Scholar. The results of the literature review carried out are that the molecular and biological pathogenesis of GCTB consists of 4 processes, namely tumorigenesis of neoplastic mononuclear stromal cells, generation of reactive multinucleated giant cells, bone resorption/migration, and bone matrix remodeling for angiogenesis, invasiveness, and metastasis. Besides, the histological picture of GCTB contains "reactive" osteoclasts such as multinucleated giant cells (Giant Cells/GC), round cells such as macrophages and spindle stromal cells such as "neoplastic" fibroblasts (mononuclear stromal cells/SC) which are important findings in establishing the diagnosis. In conclusion, staging and management are very important to produce a better prognosis and reduce recurrence rates in GCTB patients.
Co-Authors Adinda Ilsa Maulida Ali Ramzi Alifia Mawadddah Alma Dyah Perwita Amrullah Muliawan H Athalitha Andhera Nabil Baiq Ghassani Kayla Baiq Ramdhani Amelia Negara Clara Nadila Febbi Anggy Herdiana Nurul Utami Herodya Lajunee Fesmia Indri Setiawati Jihan Alifa Rahma Ni Nyoman Geriputri Nurhidayati Nurhidayati Trisna Ayu Kurnia Putri Ulul Azmi Wina Aryslia Fakar Zulfa Hasyimiyyah Ihtisyam