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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Compromise Journal : Community Proffesional
Steven Tandiono
Universitas Sari Mutiara Indonesia
Health Professions Public Health

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Pemberdayaan Buah Asam Jawa (Tamarindus Indica L.) Menjadi Sediaan Gel Sistem Fitosom sebagai Antioksidan Devina Chandra; Cut Masyithah Thaib; Steven Tandiono; Manuppak Irianto Tampubolon
Compromise Journal Community Proffesional Service Journal Vol. 3 No. 1 (2025): Compromise Journal : Community Proffesional Service Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/compromisejournal.v3i1.561

Abstract

Empowering the community using one of the cooking spices to become something which has high selling power because of its effectiveness will increase people's enthusiasm for using it. Tamarind fruit has bioactive compounds which often used as natural antioxidants and will be made into phytosome system gel preparations which can improve better penetration of drugs into the skin. The aim of this service was that the community is expected to provide education about tamarind fruit in Klambir V Village, Medan, Indonesia. This community service method was carried out using leaflets, modules, power points and presentations to the community. The result of this service was an increase in public knowledge of tamarind fruit as an antioxidant by 87%.
Formulasi dan Uji Penetrasi In Vitro Sediaan Gel Sistem FitosomEkstrak Buah Asam Jawa (Tamarindus indica L.) Devina Chandra; Cut Masyithah Thaib; Steven Tandiono; Manuppak Irianto Tampubolon
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.559

Abstract

Tamarind fruit extract (Tamarindus indica L.) contained flavonoids such as quercetin as antioxidants. The hydrophilic nature of tamarind fruit (Tamarindus indica L.) led to poor penetration and low bioavailability. Research was conducted to address penetration issues by preparing a phytosome drug delivery system incorporated into tamarind fruit extract formulations. The study aimed to formulate a tamarind fruit extract gel with phytosome preparation to enhance the effectiveness of active ingredient penetration. Phytosome preparation was carried out using the thin layer hydration method with concentrations of 1.5%, 3%, and 4.5%. Evaluation of the gel preparations showed that the color of FI (1.5%) was yellowish-brown, F2 (3%) was light brown, and F3 (4.5%) was dark brown. All formulations had a distinctive odor, pH ranged from 4.3 to 5.2, viscosity ranged from 4,333 to 7,500 cPs, spreadability ranged from 5.2 to 5.8 cm, and they had good stability, were homogeneous, and did not cause irritation. Penetration tests using Franz diffusion cells were performed on male rabbit skin (Oryctolagus cuniculus). The penetration results were analyzed using UV-Vis spectrophotometry with a maximum wavelength of 435 nm. The cumulative amount penetrated was 13.2085 ppm for F1 (1.5%), 14.2142 ppm for F2 (3%), and 15.5136 ppm for F3 (4.5%). In contrast, the tamarind fruit extract gel without phytosomes had a cumulative penetration amount of 1.3684 ppm. The tamarind fruit extract's phytosome gel showed better penetration than the tamarind fruit extract gel without phytosomes.
Co-Authors Cut Masyithah Thaib Devina Chandra Manuppak Irianto Tampubolon