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All Journal Jurnal Farmanesia Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Compromise Journal : Community Proffesional Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Siti Rufaidah
Manuppak Irianto Tampubolon
Universitas Sari Mutiara Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health Other

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Formulasi Dan Pengujian Sediaan Deodorant Spray Yang Mengandung Ekstrak Daun Kemangi (Ocimum Basilicum L.) Terhadap Bakteri Staphylococcus Aureus Devina Chandra; Manuppak Irianto Tampubolon; Natanael Priltius
Jurnal Siti Rufaidah Vol. 1 No. 4 (2023): November : Jurnal Siti Rufaidah
Publisher : PPNI UNIMMAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jasira.v1i4.37

Abstract

Basil leaves are very rich in nutritious substances. Among them are beta carotene, vitamin C, macro minerals (calcium, phosphorus, magnesium). This plant is included in the Lamiaceae family which contains various chemical compounds, including phenols, saponins, alkaloids, flavonoids, tannins, and essential oils. The benefits of basil have been widely applied in people's lives as traditional medicine, for example, basil leaves are used to treat, cough, colds and so on. Body odor can be caused by several factors such as genetic factors, psychological conditions, food factors, obesity factors and clothing materials used.One of the triggers of body odor due to bacterial infection, namely Staphyloccous aureus bacteria.This study aims to formulate deodorant spray ethanol extract of basil leaves, test the physical properties of deodorant spray preparations, and determine whether the preparation of deodorant spray ethanol extract of basil leaves can inhibit staphylococcus aureus bacteria. Physical tests were carried out on days 0 (after manufacture) and 7 with the results of the organoleptical physical test of the preparation having a distinctive odor of basil, brownish yellow in color, It has a pH of 4 which corresponds to the pH of the skin, and experiencing an increase in viscosity on day 7 examination. The antibacterial test results of formulations 1, 2, and 3 showed inhibition of the banteri.
Formulasi Dan Evaluasi Sediaan Shampo Ekstrak Etanol Daun Cengkeh (Syzygium Aromaticum L) Sebagai Penumbuh Rambut Pada Tikus Putih Jantan Manuppak Irianto Tampubolon; Dhea Nur Fadhilah; Dumartina Hutauruk
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 3 (2024): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i3.332

Abstract

Clove leaves have the property of overcoming hair growth problems, where the eugenol compound contained in clove leaves is efficacious as a hair growth agent. This research was conducted to formulate a clove leaf extract shampoo preparation. The research method used was the experimental method. Tests were carried out on experimental animals, namely male white mice in various groups. The first group (without treatment), the second group (negative control), the third group (5% clove leaf extract shampoo), the fourth group (10% clove leaf ethanol extract shampoo), the fifth group (15% clove leaf ethanol extract shampoo) and groups sixth (positive control). The shampoo preparations were tested and evaluated, the results of the preparation evaluation test showed that the four shampoo preparations were homogeneous and had a pH ranging from 5.1-5.7, with a viscosity of 1700-3000 cps and a foam height of 9-11 cm. This shampoo preparation also does not irritate the skin. The results of the data analysis obtained showed that all data were normally distributed (p> 0.005) and homogeneous (p> 0.005). The results of the one way ANOVA test show that F1 (5% formula), F2 (10% formula) and F3 (15% formula) have significant differences. This research shows that clove leaf ethanol extract shampoo with a concentration of 15% is the most effective formulation in hair growth in male white rats. However, the ethanol extract of clove leaves shampoo is less effective than minoxidil 5% for hair growth.
Pemberdayaan Buah Asam Jawa (Tamarindus Indica L.) Menjadi Sediaan Gel Sistem Fitosom sebagai Antioksidan Devina Chandra; Cut Masyithah Thaib; Steven Tandiono; Manuppak Irianto Tampubolon
Compromise Journal Community Proffesional Service Journal Vol. 3 No. 1 (2025): Compromise Journal : Community Proffesional Service Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/compromisejournal.v3i1.561

Abstract

Empowering the community using one of the cooking spices to become something which has high selling power because of its effectiveness will increase people's enthusiasm for using it. Tamarind fruit has bioactive compounds which often used as natural antioxidants and will be made into phytosome system gel preparations which can improve better penetration of drugs into the skin. The aim of this service was that the community is expected to provide education about tamarind fruit in Klambir V Village, Medan, Indonesia. This community service method was carried out using leaflets, modules, power points and presentations to the community. The result of this service was an increase in public knowledge of tamarind fruit as an antioxidant by 87%.
Formulasi dan Uji Penetrasi In Vitro Sediaan Gel Sistem FitosomEkstrak Buah Asam Jawa (Tamarindus indica L.) Devina Chandra; Cut Masyithah Thaib; Steven Tandiono; Manuppak Irianto Tampubolon
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.559

Abstract

Tamarind fruit extract (Tamarindus indica L.) contained flavonoids such as quercetin as antioxidants. The hydrophilic nature of tamarind fruit (Tamarindus indica L.) led to poor penetration and low bioavailability. Research was conducted to address penetration issues by preparing a phytosome drug delivery system incorporated into tamarind fruit extract formulations. The study aimed to formulate a tamarind fruit extract gel with phytosome preparation to enhance the effectiveness of active ingredient penetration. Phytosome preparation was carried out using the thin layer hydration method with concentrations of 1.5%, 3%, and 4.5%. Evaluation of the gel preparations showed that the color of FI (1.5%) was yellowish-brown, F2 (3%) was light brown, and F3 (4.5%) was dark brown. All formulations had a distinctive odor, pH ranged from 4.3 to 5.2, viscosity ranged from 4,333 to 7,500 cPs, spreadability ranged from 5.2 to 5.8 cm, and they had good stability, were homogeneous, and did not cause irritation. Penetration tests using Franz diffusion cells were performed on male rabbit skin (Oryctolagus cuniculus). The penetration results were analyzed using UV-Vis spectrophotometry with a maximum wavelength of 435 nm. The cumulative amount penetrated was 13.2085 ppm for F1 (1.5%), 14.2142 ppm for F2 (3%), and 15.5136 ppm for F3 (4.5%). In contrast, the tamarind fruit extract gel without phytosomes had a cumulative penetration amount of 1.3684 ppm. The tamarind fruit extract's phytosome gel showed better penetration than the tamarind fruit extract gel without phytosomes.
Tinjauan Literatur: Hubungan Tingkat Kepercayaan Masyarakat Terhadap Obat Tradisional Dalam Mendukung Pelayanan Kesehatan Manuppak Irianto Tampubolon; Devina Chandra; Syukur Berkat Waruwu; Febriana Rianti Siagian; Fanny Asdian; Muhammad Ridha Taftanzani; Sefin Simanihuruk
Jurnal Intelek Dan Cendikiawan Nusantara Vol. 2 No. 6 (2025): Desember 2025 - Januari 2026
Publisher : PT. Intelek Cendikiawan Nusantara

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Abstract

Sistem Pelayanan kesehatan di berbagai negara masih menghadapi masalah seperti akses yang sulit, biaya mahal, dan layanan yang tidak merata, terutama di negara berkembang. Obat tradisional sudah digunakan masyarakat sejak lama sebagai cara mencegah dan mengobati penyakit. Walaupun banyak masyarakat yang menggunakan obat tradisional, belum banyak penelitian yang membahas mengapa masyarakat terus memilih obat tradisional. Kepercayaan masyarakat diduga menjadi alasan utama, tetapi masih sedikit kajian yang meneliti hubungan antara kepercayaan dengan penggunaan obat tradisional dalam sistem pelayanan kesehatan. Tujuan: Meninjau tingkat kepercayaan masyarakat terhadap obat tradisional sebagai pendukung pelayanan kesehatan. Metode: Penelitian ini menggunakan metode tinjauan literatur sistematis dengan panduan PRISMA. Pencarian artikel dilakukan di Google Scholar dan PubMed dari Januari 2020 sampai Juli 2025. Dari 2.850 artikel yang ditemukan, setelah menghapus duplikat dan melakukan skrining, didapatkan 10 artikel yang sesuai untuk dianalisis. Hasil: Hasil menunjukkan bahwa kepercayaan masyarakat terhadap obat tradisional cukup tinggi, yaitu berkisar antara 60%-94,3%. Masyarakat percaya karena pengalaman keluarga yang turun-temurun, dianggap aman dan efektif, mudah didapat, serta harganya terjangkau. Sebagian besar pengguna obat tradisional (60%-94,3%) tidak mengalami efek samping. Ada hubungan yang jelas antara kepercayaan dengan penggunaan obat tradisional, dan pengetahuan tentang obat tradisional menjadi faktor terkuat yang membuat orang lebih percaya dan menggunakannya. Kesimpulan: Kepercayaan masyarakat adalah faktor penting yang membuat penggunaan obat tradisional terus berlanjut dalam pelayanan kesehatan. Obat tradisional dipilih karena harganya murah, mudah didapat, dan sesuai dengan budaya masyarakat. Untuk meningkatkan pemanfaatan obat tradisional yang aman, perlu dilakukan edukasi berdasarkan penelitian ilmiah, standarisasi produk dan praktik pengobatan tradisional, serta penggabungan sistem pengobatan tradisional dan modern dalam kebijakan kesehatan
MEMBANDINGKAN EFEKTIVITAS PEMBERSIH LANTAI SEBAGAI DESINFEKTAN MENGGUNAKAN UJI KOEFISIEN FENOL TERHADAP Salmonella typhi Muhammad Irianto Napitupulu; Audi T.A. Hutasoit; Fajar Pebriyandi; Eva Diansari Marbun; Manuppak Irianto Tampubolon
Jurnal Farmanesia Vol 12 No 1 (2025): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Latar belakang: Salmonella typhi masih menjadi penyebab utama demam tifoid di berbagai wilayah endemis. Permukaan lantai yang terkontaminasi dapat menjadi media penyebaran bakteri ini, terutama di fasilitas umum dan rumah tangga. Oleh karena itu, pemilihan pembersih lantai yang efektif sebagai desinfektan sangat penting untuk upaya pencegahan. Tujuan: Penelitian ini bertujuan untuk mengevaluasi dan membandingkan efektivitas desinfektan dari sepuluh merek pembersih lantai terhadap Salmonella typhi menggunakan metode Koefisien Fenol (KF). Metode: Uji dilakukan dengan menginokulasikan suspensi S. typhi ke dalam larutan pembersih lantai dan fenol 5% pada berbagai pengenceran. Pertumbuhan bakteri diamati setelah inkubasi selama 48 jam pada suhu 30 °C. Nilai KF dihitung berdasarkan rasio efektivitas masing-masing produk terhadap fenol sebagai standar. Hasil: Dari sepuluh merek yang diuji, hanya dua produk menunjukkan nilai KF di atas 1, yang berarti lebih efektif dibandingkan fenol 5%. Sebagian besar produk lainnya memiliki efektivitas lebih rendah atau setara dengan fenol. Simpulan: Hanya sebagian kecil pembersih lantai yang efektif sebagai desinfektan terhadap Salmonella typhi. Hasil ini menunjukkan pentingnya sosialisasi pemilihan produk yang terbukti efektif secara ilmiah dalam rangka mengurangi risiko penyebaran infeksi di lingkungan.
Co-Authors Audi T.A. Hutasoit Cut Masyithah Thaib Devina Chandra Dhea Nur Fadhilah Dumartina Hutauruk Fajar Pebriyandi Fanny Asdian Febriana Rianti Siagian Marbun, Eva Diansari Muhammad Irianto Napitupulu Muhammad Ridha Taftanzani Natanael Priltius Sefin Simanihuruk Steven Tandiono Syukur Berkat Waruwu