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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Compromise Journal : Community Proffesional Jurnal Siti Rufaidah
Manuppak Irianto Tampubolon
Universitas Sari Mutiara Indonesia
Health Professions Nursing Public Health

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Formulasi Dan Pengujian Sediaan Deodorant Spray Yang Mengandung Ekstrak Daun Kemangi (Ocimum Basilicum L.) Terhadap Bakteri Staphylococcus Aureus Devina Chandra; Manuppak Irianto Tampubolon; Natanael Priltius
Jurnal Siti Rufaidah Vol. 1 No. 4 (2023): November : Jurnal Siti Rufaidah
Publisher : PPNI UNIMMAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jasira.v1i4.37

Abstract

Basil leaves are very rich in nutritious substances. Among them are beta carotene, vitamin C, macro minerals (calcium, phosphorus, magnesium). This plant is included in the Lamiaceae family which contains various chemical compounds, including phenols, saponins, alkaloids, flavonoids, tannins, and essential oils. The benefits of basil have been widely applied in people's lives as traditional medicine, for example, basil leaves are used to treat, cough, colds and so on. Body odor can be caused by several factors such as genetic factors, psychological conditions, food factors, obesity factors and clothing materials used.One of the triggers of body odor due to bacterial infection, namely Staphyloccous aureus bacteria.This study aims to formulate deodorant spray ethanol extract of basil leaves, test the physical properties of deodorant spray preparations, and determine whether the preparation of deodorant spray ethanol extract of basil leaves can inhibit staphylococcus aureus bacteria. Physical tests were carried out on days 0 (after manufacture) and 7 with the results of the organoleptical physical test of the preparation having a distinctive odor of basil, brownish yellow in color, It has a pH of 4 which corresponds to the pH of the skin, and experiencing an increase in viscosity on day 7 examination. The antibacterial test results of formulations 1, 2, and 3 showed inhibition of the banteri.
Formulasi Dan Evaluasi Sediaan Shampo Ekstrak Etanol Daun Cengkeh (Syzygium Aromaticum L) Sebagai Penumbuh Rambut Pada Tikus Putih Jantan Manuppak Irianto Tampubolon; Dhea Nur Fadhilah; Dumartina Hutauruk
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 3 (2024): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i3.332

Abstract

Clove leaves have the property of overcoming hair growth problems, where the eugenol compound contained in clove leaves is efficacious as a hair growth agent. This research was conducted to formulate a clove leaf extract shampoo preparation. The research method used was the experimental method. Tests were carried out on experimental animals, namely male white mice in various groups. The first group (without treatment), the second group (negative control), the third group (5% clove leaf extract shampoo), the fourth group (10% clove leaf ethanol extract shampoo), the fifth group (15% clove leaf ethanol extract shampoo) and groups sixth (positive control). The shampoo preparations were tested and evaluated, the results of the preparation evaluation test showed that the four shampoo preparations were homogeneous and had a pH ranging from 5.1-5.7, with a viscosity of 1700-3000 cps and a foam height of 9-11 cm. This shampoo preparation also does not irritate the skin. The results of the data analysis obtained showed that all data were normally distributed (p> 0.005) and homogeneous (p> 0.005). The results of the one way ANOVA test show that F1 (5% formula), F2 (10% formula) and F3 (15% formula) have significant differences. This research shows that clove leaf ethanol extract shampoo with a concentration of 15% is the most effective formulation in hair growth in male white rats. However, the ethanol extract of clove leaves shampoo is less effective than minoxidil 5% for hair growth.
Pemberdayaan Buah Asam Jawa (Tamarindus Indica L.) Menjadi Sediaan Gel Sistem Fitosom sebagai Antioksidan Devina Chandra; Cut Masyithah Thaib; Steven Tandiono; Manuppak Irianto Tampubolon
Compromise Journal Community Proffesional Service Journal Vol. 3 No. 1 (2025): Compromise Journal : Community Proffesional Service Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/compromisejournal.v3i1.561

Abstract

Empowering the community using one of the cooking spices to become something which has high selling power because of its effectiveness will increase people's enthusiasm for using it. Tamarind fruit has bioactive compounds which often used as natural antioxidants and will be made into phytosome system gel preparations which can improve better penetration of drugs into the skin. The aim of this service was that the community is expected to provide education about tamarind fruit in Klambir V Village, Medan, Indonesia. This community service method was carried out using leaflets, modules, power points and presentations to the community. The result of this service was an increase in public knowledge of tamarind fruit as an antioxidant by 87%.
Formulasi dan Uji Penetrasi In Vitro Sediaan Gel Sistem FitosomEkstrak Buah Asam Jawa (Tamarindus indica L.) Devina Chandra; Cut Masyithah Thaib; Steven Tandiono; Manuppak Irianto Tampubolon
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.559

Abstract

Tamarind fruit extract (Tamarindus indica L.) contained flavonoids such as quercetin as antioxidants. The hydrophilic nature of tamarind fruit (Tamarindus indica L.) led to poor penetration and low bioavailability. Research was conducted to address penetration issues by preparing a phytosome drug delivery system incorporated into tamarind fruit extract formulations. The study aimed to formulate a tamarind fruit extract gel with phytosome preparation to enhance the effectiveness of active ingredient penetration. Phytosome preparation was carried out using the thin layer hydration method with concentrations of 1.5%, 3%, and 4.5%. Evaluation of the gel preparations showed that the color of FI (1.5%) was yellowish-brown, F2 (3%) was light brown, and F3 (4.5%) was dark brown. All formulations had a distinctive odor, pH ranged from 4.3 to 5.2, viscosity ranged from 4,333 to 7,500 cPs, spreadability ranged from 5.2 to 5.8 cm, and they had good stability, were homogeneous, and did not cause irritation. Penetration tests using Franz diffusion cells were performed on male rabbit skin (Oryctolagus cuniculus). The penetration results were analyzed using UV-Vis spectrophotometry with a maximum wavelength of 435 nm. The cumulative amount penetrated was 13.2085 ppm for F1 (1.5%), 14.2142 ppm for F2 (3%), and 15.5136 ppm for F3 (4.5%). In contrast, the tamarind fruit extract gel without phytosomes had a cumulative penetration amount of 1.3684 ppm. The tamarind fruit extract's phytosome gel showed better penetration than the tamarind fruit extract gel without phytosomes.
Co-Authors Cut Masyithah Thaib Devina Chandra Dhea Nur Fadhilah Dumartina Hutauruk Natanael Priltius Steven Tandiono