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All Journal Jurnal Health Sains Medical Scope Journal (MSJ) Jurnal Sehat Indonesia (JUSINDO)
Denny Saleh
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Liposarcoma of the Thyroid Gland: A Case Report Christian Manginstar; Marselus Merung; Denny Saleh; Leise Limpeleh; Enika Tilaar; Ridel Torar
Medical Scope Journal Vol. 6 No. 1 (2024): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v6i1.51654

Abstract

Abstract: Liposarcoma is one of the most common soft tissue tumors in adults. Liposarcoma is usually found in retroperitoneal organs and extremities, but rarely in the thyroid gland. We presented a case of dedifferentiated liposarcoma in the thyroid gland. A 56-year-old woman with a history of a lump in her neck for ten years. Malignancy was suspected due to the local extension of the tumor, therefore, complete resection of the tumor was performed. Histopathological examination showed a dedifferentiated liposarcoma. Two months post-surgery, the patient suffered from lung and brain metastases and was treated with lenvatinib. The complaints reduced and there was no significant side effect during therapy. The treatments for liposarcoma are surgery, radiotherapy, chemotherapy, and targeted therapy. Surgery followed by radiotherapy and chemotherapy is the option in the treatment of liposarcoma. This patient underwent surgery with the histopathological result of dedifferentiated thyroid liposarcoma. In the nine-month follow-up of therapy, there were no complaint of the patient. In this case, dedifferentiated liposarcoma in the thyroid gland with metastases was treated surgically followed by lenvatinib administration gave satisfactory result. Keyword: liposarcoma; thyroid gland; dedifferentiated liposarcoma; malignant tumor
Faktor Prediktor Terjadinya Delayed Hemothorax pada Pasien dengan Riwayat Trauma Tumpul Toraks di RSUP Prof Dr. R.D. Kandou Manado Gufi George Stefanus; Wega Sukanto; Adrian Tangkilisan; F. L. Fredrik G. Langi; Eko Prasetyo; Christha Tamburian; Denny Saleh
Jurnal Sehat Indonesia (JUSINDO) Vol. 6 No. 02 (2024): Jurnal Sehat Indonesia (JUSINDO)
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v6i02.133

Abstract

Trauma toraks merupakan penyebab signifikan dari morbiditas dan mortalitas, terutama dalam konteks multitrauma, dengan dampak kematian berkisar antara 20% hingga 25%. Penelitian ini bertujuan untuk mengetahui faktor prediktor terjadinya delayed hemothorax pada pasien dengan riwayat trauma tumpul toraks di RSUP Prof. Dr. R.D. Kandou Manado. Metode yang di guanakan metode penelitian dengan pendekatan kohort retrospektif, dengan cara consecutive sampling, analisis data dengan analisis deskriptif. Adapun hasil penelitian, ditemukan bahwa faktor prediktor yang signifikan adalah adanya fraktur tulang iga, jumlah fraktur iga 3 atau lebih, dan lokasi fraktur tulang iga. Usia dan kejadian kontusio paru tidak ditemukan sebagai faktor prediktor yang signifikan. Hasil penelitian juga menunjukkan bahwa pasien yang memiliki fraktur pada tulang iga ke 10-12, 6-9, dan 3-5 memiliki risiko lebih tinggi untuk mengalami delayed hemothorax.
A Comparison of Recist 1.1 and the Side Effects of Neoadjuvant Chemotherapy Based on Anthracyclines and Taxane in Patients with Advanced Local-Stage Breast Cancer at Prof. Dr. R.D. Kandou General Hospital Toby Hadinata Wiranegara; Marselus Merung; Denny Saleh
Jurnal Health Sains Vol. 7 No. 8 (2026): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v7i8.2870

Abstract

Breast cancer remains a major cause of cancer-related morbidity and mortality among women, and locally advanced disease continues to pose significant therapeutic challenges. Neoadjuvant chemotherapy is commonly administered to reduce tumor burden and improve surgical operability, with anthracycline- and taxane-based regimens being widely used. This study aimed to compare the effectiveness and adverse effects of anthracycline-based and taxane-based neoadjuvant chemotherapy in patients with locally advanced breast cancer at Prof. Dr. R. D. Kandou General Hospital. An observational analytic study with a prospective cohort design was conducted involving 27 female patients, comprising 11 patients who received anthracycline-based chemotherapy and 16 patients who received taxane-based chemotherapy. Tumor response was assessed using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, while adverse events were evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE). The results showed that partial response was the predominant outcome in both groups, occurring in 81.82% of patients in the anthracycline group and 75% of patients in the taxane group. The Mann–Whitney test revealed no significant difference in treatment effectiveness between the two regimens (p = 0.708). Most adverse effects were mild to moderate, although toxicity patterns differed between the groups. In conclusion, both regimens demonstrated comparable effectiveness, while treatment selection should consider patient characteristics, organ function, tolerability, and regimen-specific adverse-effect risks. These findings support individualized regimen selection based on therapeutic efficacy and anticipated toxicity profiles.
Co-Authors Adrian Tangkilisan Christha Tamburian Christian Manginstar Eko Prasetyo Enika Tilaar F. L. Fredrik G. Langi Gufi George Stefanus Leise Limpeleh Marselus Merung Ridel Torar Toby Hadinata Wiranegara Wega Sukanto