Umi Yuniarni
Prodi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Islam Bandung

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Antibacterial Activity of Pluchea indica and Piper betle Ethanol Extract on Staphylococcus epidermidis and Pseudomonas aeruginosa Simanjuntak, Nela; Yuniarni, Umi; Prayugo, Diki
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.448 KB) | DOI: 10.15416/pcpr.v1i2.15202

Abstract

Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonasaeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 mm of inhibition zone on 1 mg/ml concentration, respectively. There was no increased effect from the combination of these two extracts against these bacteria. When comparing the antibacterial activity of these extract with tetracycline asthe standard, we found that antibacterial activity of P. indica at the concentration of 0.9 mg/ ml was comparable with that of tetracycline at concentration of 12.52 μg/ml, while P. betle needed 0.3 mg/ml concentration to had similar activity with 10.51 μg/ml of tetracycline. In conlusion, the antibacterial activity of ethanol extracts of P. indica and P. betle indicated that these extract had sufficient potential to warrant further examination and development as a new antibacterial agent.Keywords: Pluchea indica, Piper betle, antibacterial, agar disk diffusion
AKTIVITAS ANTIFUNGI EKSTRAK DAUN BELUNTAS, JAWER KOTOK, DAN SIRIH SERTA KOMBINASINYA TERHADAP Candida albicans Yuniarni, Umi; Lukmayani, Yani
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.757 KB) | DOI: 10.12928/pharmaciana.v6i1.2684

Abstract

Piper betle, Coleus scutellarioides and Pluchea indica have been used empirically to overcome vaginal discharge and scientifically proven to inhibit the growth of Candida albicans. The goal of this research was to search for a combined extract with effective antimicrobial activity against Candida albicans. Single extract,combination of two and three extracts evaluated antimicrobial activity against Candida albicans using agar diffusion method. Inhibitory effect of Piper betle showed the greatest activity against Candida albicans compared to other single extract. Combination of Piper betle and Pluchea indica (26.57±0.56 mm) gave greater inhibition than two other  combination extracts (Piper betle and Coleus scutellarioides (25.17±0.96 mm); Coleus scutellarioides and Pluchea indica (22.73±0.95 mm).The combination of Piper betle, Pluchea indica and Coleus scutellarioides gave inhibition of 27.53±1.10 mm. extracts did not give a better diameter compared to the betle extract.
SKRINING POTENSI ANTIBAKTERI EKSTRAK ETANOL BUAH NANGKA MUDA (ARTOCARPUS HETEROPHYLLUS LAMK.) TERHADAP BAKTERI PENYEBAB DIARE Yuniarni, Umi
JURNAL FARMASI GALENIKA Vol 1 No 02 (2014): JURNAL FARMASI GALENIKA
Publisher : Sekolah Tinggi Farmasi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.589 KB)

Abstract

Secara empiris buah nangka muda dapat mengobati diare akut. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antibakteri eksrak etanol buah nangka muda terhadap bakteri Escherichia coli dan Shigella dysentriae yang menyebabkan diare. Pengujian aktivitas antibakteri dilakukan dengan metode difusi agar pada konsentrasi 50, 75, 100 dan 125 mg/mL dan tetrasiklin digunakan sebagai standar. Kromatografi lapis tipis dilakukan untuk mengetahui senyawa marker dari buah nangka muda. Nilai Konsentrasi Hambat Minimum (KHM) ekstrak etanol buah nangka muda terhadap E. Coli yaitu 1,25 mg/mL dan 2,5 mg/mL terhadap S. dysentriae. Ekstrak etanol buah nangka muda pada konsentrasi 50 mg/mL sebanding dengan tetrasiklin pada konsentrasi 36,30 µg/mL terhadap E. coli dan 35,48 µg/mL terhadap S. dysentriae. Ekstrak etanol buah nangka muda memberikan hasil positif terhadap senyawa golongan fenolat yang berflouresensi merah muda dibawah sinar UV 366 nm dan memberikan warna hitam dengan penampak bercak FeCl3 dengan nilai Rf 0,77. Ekstrak etanol buah nangka muda mempunyai aktivitas antibakteri terhadap E. coli dan Shigella dysentriaeserta menunjukkan kandungan senyawa fenolat dengan nilai Rf 0,77.
AKTIVITAS ANTIFUNGI EKSTRAK DAUN BELUNTAS, JAWER KOTOK, DAN SIRIH SERTA KOMBINASINYA TERHADAP Candida albicans Umi Yuniarni; Yani Lukmayani
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.757 KB) | DOI: 10.12928/pharmaciana.v6i1.2684

Abstract

Piper betle, Coleus scutellarioides and Pluchea indica have been used empirically to overcome vaginal discharge and scientifically proven to inhibit the growth of Candida albicans. The goal of this research was to search for a combined extract with effective antimicrobial activity against Candida albicans. Single extract,combination of two and three extracts evaluated antimicrobial activity against Candida albicans using agar diffusion method. Inhibitory effect of Piper betle showed the greatest activity against Candida albicans compared to other single extract. Combination of Piper betle and Pluchea indica (26.57±0.56 mm) gave greater inhibition than two other  combination extracts (Piper betle and Coleus scutellarioides (25.17±0.96 mm); Coleus scutellarioides and Pluchea indica (22.73±0.95 mm).The combination of Piper betle, Pluchea indica and Coleus scutellarioides gave inhibition of 27.53±1.10 mm. extracts did not give a better diameter compared to the betle extract.
Antibacterial Activity of Pluchea indica and Piper betle Ethanol Extract on Staphylococcus epidermidis and Pseudomonas aeruginosa Nela Simanjuntak; Umi Yuniarni; Diki Prayugo
Pharmacology and Clinical Pharmacy Research Vol 1, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.448 KB) | DOI: 10.15416/pcpr.v1i2.15202

Abstract

Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonasaeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 mm of inhibition zone on 1 mg/ml concentration, respectively. There was no increased effect from the combination of these two extracts against these bacteria. When comparing the antibacterial activity of these extract with tetracycline asthe standard, we found that antibacterial activity of P. indica at the concentration of 0.9 mg/ ml was comparable with that of tetracycline at concentration of 12.52 μg/ml, while P. betle needed 0.3 mg/ml concentration to had similar activity with 10.51 μg/ml of tetracycline. In conlusion, the antibacterial activity of ethanol extracts of P. indica and P. betle indicated that these extract had sufficient potential to warrant further examination and development as a new antibacterial agent.Keywords: Pluchea indica, Piper betle, antibacterial, agar disk diffusion
Kajian Pustaka Aktivitas Antijamur Tanaman Kayu Manis (Cinnamomum burmanii) terhadap Candida albicans Syahla Alpia Rachman; Lanny Mulqie; Umi Yuniarni
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.163 KB) | DOI: 10.29313/bcsp.v2i2.3580

Abstract

Abstract. Indonesia is a country with a tropical climate and has high humidity, so this can be a factor causing fungal infections of the skin. Cinnamon (Cinnamomum burmanii) is one of the plants from the family Lauraceae which is known to have potential as an antifungal causing candidiasis such as Candida albicans. The purpose of this study was to determine the part of the plant that has antifungal activity from the cinnamon plant (Cinnamomum burmanii) against Candida albicans and determine the content of active compounds and the mechanism of action of compounds that act as antifungals found in cinnamon. The method used in this research is a literature review with relevant data sources, both national and international journals, with the criteria for publication in the last 10 years. The observed parameter of the antifungal activity was the diameter of the inhibition zone. Cinnamon plants, including wood, bark, and leaves, have antifungal activity, and the strongest activity as antifungal is water extract and essential oil with inhibition zone diameter > 20 mm, active compounds and groups of compounds, namely cinnamaldehyde, eugenol, tanins, alkaloids, flavonoids, and saponins. The mechanism of action is by inhibiting cell walls, inhibiting colonization, inhibiting chitin synthesis, inhibiting cell wall synthesis, and lowering surface tension. Abstrak. Indonesia merupakan negara dengan iklim tropis dan memiliki kelembaban yang tinggi sehingga hal ini dapat menjadi faktor penyebab terjadinya infeksi jamur pada kulit. Kayu manis (Cinnamomum burmanii) merupakan salah satu tanaman dari famili Lauraceae yang diketahui mempunyai potensi sebagai antijamur penyebab kandidiasis seperti Candida albicans. Tujuan penelitian adalah untuk mengetahui bagian tanaman yang memiliki aktivitas antijamur dari tanaman kayu manis (Cinnamomum burmanii) terhadap Candida albicans serta mengetahui kandungan senyawa aktif dan mekanisme kerja senyawa yang berperan sebagai antijamur yang terdapat pada kayu manis. Metode yang dilakukan pada penelitian ini adalah kajian pustaka dengan sumber data yang relevan baik jurnal nasional maupun internasional dengan kriteria terbitan 10 tahun terakhir. Parameter yang diamati dari adanya aktivitas antijamur yaitu diameter zona hambat. Tanaman kayu manis meliputi kayu, kulit batang dan daun memiliki aktivitas antijamur dan aktivitas yang paling kuat sebagai antijamur adalah ekstrak air dan minyak atsiri dengan diameter zona hambat > 20 mm, senyawa aktif dan golongan senyawa yaitu sinamaldehid, eugenol, tanin, alkaloid, flavonoid dan saponin. Mekanisme kerja dengan menghambat dinding sel, menghambat kolonisasi, menghambat sintesis kitin, menghambat sistesis dinding sel dan menurunkan tegangan permukaan.
Evaluasi Data Demografi dan Antihipertensi yang Digunakan pada Pasien Klinik 24 Medika Tanjungsari Nabila Khaerunnisa; Umi Yuniarni; Sri Peni Fitrianingsih
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.467 KB) | DOI: 10.29313/bcsp.v2i2.4010

Abstract

Abstract. Hypertension is a condition where the systolic blood pressure is more than 140 mmHg and the diastolic pressure is more than 90 mmHg. This study was conducted at Clinic 24 Medika Tanjungsari which aims to determine the use of antihypertensive drugs in patients at Clinic 24 Medika Tanjungsari. This study uses a descriptive method with a retrospective research design, namely by reviewing information or processing past data. For sampling using the slovin method with an error rate of 10% so that the sample used was 95 recipes. The data collected came from the prescription of hypertension patients at Clinic 24 Medika Tanjungsari for the period January – December 2021, which had met the inclusion criteria and exclusion criteria. The results showed that hypertension was mostly experienced by women (65%), and for the age category that experienced hypertension, namely the elderly (55%), while the antihypertensive drug that was widely used as amlodipine (55%). Abstrak. Hipertensi adalah suatu kondisi dimana tekanan darah sistolik lebih dari 140 mmHg dan tekanan diastolic lebih dari 90 mmHg. Penelitian ini dilakukan di Klinik 24 Medika Tanjungsari yang bertujuan untuk mengetahui penggunaan obat antihipertensi pada pasien di Klinik 24 Medika Tanjungsari. Penelitian ini menggunakan metode deskriptif dengan racancangan penelitian retrospektif yaitu dengan mengkaji informasi atau mengolah data yang telah lalu. Untuk pengambilan sampel dengan menggunakan metode slovin dengan tingkat kesalahan 10% sehingga sampel yang digunakan sebanyak 95 resep. Data yang dikumpulkan berasal dari resep pasien hipertensi Klinik 24 Medika Tanjungsari periode Januari – Desember 2021 yang telah memenuhi kriteria inklusi dan kriteria eksklusi. Hasil penelitian menunjukkan bahwa hipertensi banyak dialami oleh perempuan sebesar (65%), dan untuk kategori usia yang banyak mengalami hipertensi yaitu lanjut usia sebesar (55%), sedangkan untuk obat antihipertensi yang banyak digunakan yaitu amlodipine sebesar (55%).
Studi Kepatuhan Penggunaan Obat Antihiperglikemik Oral pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Cikutra Lama 1 Bandung Diva Rachmadita Kusumawardani; Fetri Lestari; Umi Yuniarni
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.225 KB) | DOI: 10.29313/bcsp.v2i2.4106

Abstract

Abstract. Diabetes mellitus is a lifelong metabolic illness that can occur in all levels of society, and causes the rising of glucose levels in the bloodstream. Normalizing the glucose levels can be done either by therapy of changing the lifestyle or ingesting oral antihyperglycemic medicine. The patient using oral antihyperglycemic medicine has to take the medicine regularly and cannot miss any of it, thus the adherence of the patient is important. This study was done to depict adherence and reasons of disobedience on ingesting oral hyperglycemic medicine of Type 2 Diabetes Mellitus patients in Puskesmas Cikutra Lama Bandung using MMAS-8 type questionnaire on 25 adults as subjects with criteria such as man or woman, in the range of 18-65 year old, and is treated with oral antihyperglycemic on January 2021-May 2022. This study was carry out on May 2022 with interview method. MMAS-8 is used because of its objectiveness and can be used to both identify and measure how the patients adhere to ingesting oral hyperglycemic medicine. From 25 subjects, 36% has "high adherence", 16% has "medium adherence", and 48% has "low adherence". There are several factors that promote low adherence such as forgetting or being lazy to take the medicine and also the minimal knowledge of the patient's ongoing treatment. Abstrak. Diabetes melitus merupakan penyakit metabolik seumur hidup yang dapat ditemui di berbagai kalangan masyarakat dan menyebabkan meningkatnya kadar glukosa dalam tubuh. Untuk mengembalikan kadar glukosa dalam tubuh menjadi normal, dilakukan terapi dengan mengubah gaya hidup atau pun dengan obat antihiperglikemik oral. Pasien yang menggunakan obat antihiperglikemik oral harus menggunakannya secara teratur dan tidak boleh terlewat, sehingga kepatuhan pasien menjadi hal yang sangat penting. Pada penelitian ini, dilakukan studi gambaran kepatuhan dan faktor yang mempengaruhi ketidakpatuhan pasien Diabetes Melitus Tipe 2 di Puskesmas Cikutra Lama 1 Bandung dengan menggunakan kuesioner MMAS-8 kepada 25 subjek dewasa dengan kriteria wanita atau pria, berumur 18-65 tahun, dan sedang menjalankan pengobatan antihiperglikemik oral pada periode Januari 2021-Mei 2022 di Puskesmas Cikutra Lama 1 Bandung. Penelitian ini dilakukan pada bulan Mei 2022 dengan metode wawancara. MMAS-8 digunakan karena sifatnya yang objektif dan dapat digunakan untuk identifikasi masalah kepatuhan pasien juga dapat digunakan untuk memantau kepatuhan pasien. Dari 25 subjek, sebanyak 36% memiliki tingkat kepatuhan tinggi, 16% memiliki tingkat kepatuhan sedang,dan 48% memiliki tingkat kepatuhan yang rendah. Ketidakpatuhan pasien dapat disebabkan karena adanya beberapa faktor yang mempengaruhi, seperti lupa, adanya rasa resah dan malas, dan juga minimnya pengetahuan dalam pengobatan yang dijalani pasien.
Pengetahuan Masyarakat Desa Cikole Lembang Kecamatan Kabupaten Bandung Barat pada Swamedikasi dalam Mengatasi Penyakit Gastritis Shifa Fadillah Indreswari Puja; Suwendar; Umi Yuniarni
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (336.351 KB) | DOI: 10.29313/bcsp.v2i2.4170

Abstract

Abstract. Public knowledge of disease is important for achieving a better quality of life so that they will care and comply with drug identification, so that errors do not occur, in dealing with health problems or medication errors. Understanding of performing an act of self-medication of disease is very necessary because the slightest mistake made by the patient will be fatal and even death. Based on the survey results, in general, people are more likely to do self-medication if they feel a health symptom. Such as, influenza, fever, diarrhea, ulcers (gastritis) and others, with only minimal educational knowledge and information. light. The perceived benefits of self-medication include drugs that are easy to obtain because they are sold freely in stalls, pharmacies and drug stores. Without having to attach a doctor's prescription. Thus, the cost of treatment is cheaper. According to information, disease data from the Cikole Community Health Center in Lembang District shows that the disease occupies the top 6 every month (Cikole Public Health Center, 2021). The purpose of this study was to determine the extent of understanding of the community in Cikole Village, Lembang District in identifying the right drug, using descriptive research methods through questionnaires. which are often used are Antacids (91.1%), tablet dosage forms (66.6%) and in the use of gastritis drugs and their storage are in the good category (86.43%). Abstrak. Pengetahuan masyarakat terhadap penyakit merupakan hal penting untuk tercapainya kualitas kehidupan yang lebih baik sehingga akan peduli dan patuh terhadap identifikasi obat, agar tidak terjadi kesalahan dalam menangani masalah kesehatan atau medication error. Pemahaman melakukan suatu tindakan swamedikasi penyakit sangatlah diperlukan karena kesalahan sedikit saja yang dilakukan penderita akan berakibat fatal bahkan kematian. Berdasarkan hasil survei pada umumnya masyarakat lebih cenderung melakukan swamedikasi apabila merasakan suatu gejala kesehatan. Seperti, influenza, demam, diare, maag (gastritis) dan lainnya, dengan hanya berbekal pengetahuan edukasi dan informasi yang minim. swamedikasi merupakan penggunaan obat oleh seseorang untuk pengobatan diri sendiri berdasarkan diagnosa gejala sendiri, tanpa berkonsultasi dengan dokter biasanya dilakukan dalam mengatasi keluhan penyakit ringan. keuntungan yang dirasakan dari swamedikasi obat mudah didapat karena dijual bebas diwarung, Apotek dan toko obat. tanpa harus dilampirkan resep dokter. Sehingga, biaya berobatpun lebih murah. Menurut informasi data penyakit dari Puskesmas Cikole Kecamatan lembang bahwa penyakit gastritis setiap bulannya menempati 6 besar (Puskesmas Cikole, 2021). Tujuan penelitian ini untuk mengetahui sejauh mana pemahaman masyarakat Desa Cikole Kecamatan lembang dalam mengidentifikasi obat yang tepat, dengan menggunakan metode penelitian deskriptif. dan penyebaran melalui kuesioner, dari hasil penelitian disimpulkan bahwa pengetahuan masyarakat Desa Cikole pada swamedikasi penyakit gastritis termasuk kategori baik (90,79%) obat yang sering digunakan adalah golongan Antasida (91,1%), bentuk sediaan tablet (66,6%) dan dalam penggunaan obat gastritis dan penyimpanannya termasuk kategori baik (86,43%).
Studi Literatur Aktivitas Antelmintik pada Tanaman Pepaya (Carica papaya L.) terhadap Cacing Gelang Babi (Ascaris suum Goeze) Marshanda Reiya Hanafiah; Umi Yuniarni; Ratu Choesrina
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.134 KB) | DOI: 10.29313/bcsp.v2i2.4210

Abstract

Abstract. Nowadays, worm infection is disease that is still faced by society. Diseases caused by these worms occur partly because sanitation in the vicinity is poorly maintained, especially among people with densely populated areas. For preventing or treat these worm infection, anthelmintic are needed that can kill the worms. Using of anthelmintic was sourced from natural materials can be used as an alternative. Indonesia have many types of nutritious plants which are a source of medicinal ingredients, one of which is papaya. This study literature to determine the parts of the papaya plant that have anthelmintic activity, the contained class of secondary metabolites and their mechanism of action as anthelmintics. Based on the results of the study literature, it can be concluded that some parts of the papaya plant are leaves, seeds and stems have the potential as anthelmintics because they can cause death in roundworm on pig. The secondary metabolite compounds that have anthelmintic activity in papaya plant are alkaloid, flavonoid, tannin, saponin, triterpenoid and phenol. The mechanism action of alkaloid is through suppression of the central nervous system. The mechanism action of flavonoid and saponin is by inhibiting the enzyme acetylcholinesterase which will affect the worm muscles. Tannin work by causing the binding of enzymes produced by roundworm pig for nutrient absorption. Triterpenoid with a polar neutralizing mechanism of action. Phenol work by causing interference with glycoprotein on the surface of worm cells. Abstrak. Infeksi cacing merupakan masalah kesehatan yang masih dihadapi oleh masyarakat saat ini. Penyakit yang disebabkan oleh cacing ini terjadi antara lain karena sanitasi di sekitarnya kurang terpelihara, terutama pada kalangan masyarakat dengan tempat tinggal padat penduduk. Untuk dapat mencegah atau mengobati infeksi cacing tersebut, diperlukan antelmintik yang dapat membunuh cacing. Penggunaan antelmintik yang bersumber dari bahan alam dapat digunakan sebagai alternatif. Indonesia diketahui memiliki banyak jenis tanaman berkhasiat yang merupakan sumber bahan obat, salah satunya tanaman papaya. Tujuan dari dilakukannya studi literatur ini adalah untuk mengetahui bagian dari tanaman papaya yang memiliki aktivitas antelmintik, golongan senyawa metabolit sekunder yang terkandung dan mekanisme kerjanya sebagai antelmintik. Berdasarkan hasil studi literatur dapat disimpulkan bahwa beberapa bagian tanaman pepaya yaitu daun, biji dan batang berpotensi sebagai antelmintik karena dapat menyebabkan kematian pada cacing gelang babi. Golongan senyawa metabolit sekunder yang memiliki aktivitas antelmintik pada tanaman pepaya adalah alkaloid, flavonoid, tanin, saponin, triterpenoid dan fenol. Mekanisme kerja alkaloid dengan melalui penekanan sistem saraf pusat. Mekanisme kerja flavonoid dan saponin dengan menghambat enzim asetilkolinesterase yang akan berpengaruh terhadap otot-otot cacing. Tanin bekerja dengan cara menyebabkan terikatnya enzim-enzim yang dihasilkan oleh cacing gelang babi untuk penyerapan nutrisi. Triterpenoid dengan mekanisme kerja penetralan keadaan polar. Fenol bekerja dengan cara menyebabkan terjadinya gangguan pada glikoprotein di permukaan sel cacing.