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Dodi Iskandar
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IN SILICO ANALYSIS OF ACTIVE LIGANDS OF MITRAGYNA SPECIOSA KORTH PLANT AS ANTICOCEPTIVE: ANALISIS IN SILICO LIGAND AKTIF TANAMAN MITRAGYNA SPECIOSA KORTH SEBAGAI ANTIOSISEPTIF Donor Utomo Muhammad Susilo; Dodi Iskandar; Mhd Syamsu Bahri
ROCE : Jurnal Pertanian Terapan Vol. 2 No. 1 (2025): JPT ROCE 3, 2025
Publisher : PT. ROCE WISDOM ACEH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71275/roce.v2i1.73

Abstract

Mitragyna speciosa Korth (MSK) plant or known as Kratom is a leading export commodity from West Kalimantan Province. The leaves of this plant are processed by farmers into crumbs and flour to be sold to collectors and exported abroad, especially to the United States. The leaves of this plant have long been used by local people as a traditional herbal medicine to relieve pain and provide a calming effect if the boiled water is drunk. The purpose of this study was to evaluate the content of Kratom as an Antinociceptive, Analgesic, General Anesthetic, Vasodilator, and 5 Hydroxytryptamine Release Stimulant (5HRS). Active metabolites and most of the simplified molecular input line entry (SMILE) codes of the MSK plant were obtained from the Knapsack database. The relationship between active metabolites and proteins in the human body was analyzed using STITCH software computationally. There are 23 active metabolites in MSK leaves. Isomitraphylline, Isopaynantheine, and Paynantheine have the highest Antinociceptive bioactivity (82.8). Corynoxine and Corynoxine B have higher Analgesic bioactivity (81.5) compared to other ligands. Isomitrafoline and Speciophylline show the strongest general Anesthetic (92.2) compared to other ligands.
ANTIFUNGAL STUDY AGAINST CURVULARIA SP. FROM UNCARIAGAMBIR ROXB LEAF EXTRACT: STUDI ANTIFUNGAL TERHADAP CURVULARIA SP. DARI EKSTRAKDAUN UNCARIA GAMBIR ROXB Rexi Iswanto; Dodi Iskandar; Zaenal Mutaqin; Muliani; Danie Indra Yama
ROCE : Jurnal Pertanian Terapan Vol. 2 No. 1 (2025): JPT ROCE 3, 2025
Publisher : PT. ROCE WISDOM ACEH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71275/roce.v2i1.79

Abstract

Isomitrafoline and Speciophylline show the strongest general Anesthetic (92.2) compared to other ligands. This study aims to determine the effect of gambir leaf extract on the growth of Curvularia sp. fungus and the concentration of extract that can inhibit 50% of the growth of fungal colonies. The research method used was a Completely Randomized Design (CRD) with 4 variations of extract concentration (0%, 5%, 10%, and 15%), each repeated 6 times. The results showed that the highest concentration of gambir leaf extract in inhibiting fungal growth was at a concentration of 15%. LC 50% analysis revealed that the concentration required to achieve 50% inhibition was 118.16%, indicating that the effectiveness of the extract against Curvularia sp. fungus is low or less toxic
ANTIOXIDANT OF n-HEXANE EXTRACT OF Uncaria gambir RoxbFROM PONTIANAK: ANTIOKSIDAN EKSTRAK n-HEXANE Uncaria Gambir Roxb DARIPONTIANAK Susana; Dodi Iskandar
ROCE : Jurnal Pertanian Terapan Vol. 2 No. 2 (2025): JPT ROCE 4, 2025
Publisher : PT. ROCE WISDOM ACEH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71275/roce.v2i2.128

Abstract

The n-hexane extract of dried UGR leaves was obtained with a yield of 8.0 grams (16%). Phytochemicalscreening revealed the presence of secondary metabolites, including phenolics, steroids, and terpenes.The antioxidant activity was evaluated using the DPPH assay, yielding an IC50 value of 53.654 ppm,which classified the extract as strong, falling within the 50–100 ppm range. However, n-hexane extractsgenerally exhibit weaker antioxidant activity due to the nonpolar nature of the solvent, which limits theextraction of polar antioxidant compounds such as polyphenols and flavonoids. Consequently, n-hexane extracts contain higher amounts of lipids, terpenes, and other nonpolar compounds, which are less effective at scavenging DPPH radicals compared to polar extracts like ethanol or methanol.
Analysis of the Antioxidant and Anticancer Bioactivity of Gamal Plants with Basic In Silico Methods: ANALISIS BIOAKTIVITAS ANTIOKSIDAN DAN ANTIKANKERTANAMAN GAMAL METODE IN SILICO DASAR Dodi Iskandar
ROCE : Jurnal Pertanian Terapan Vol. 1 No. 2 (2024): JPT ROCE 2, 2024
Publisher : PT. ROCE WISDOM ACEH

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Abstract

In silico research has been carried out to analyze the antioxidant and anticancer bioactivity of the Gliricidiasepium plant. The software used includes knapsackfamily, pubchem, chemdraw, swissadme, passonline and MS excel. The result is that all compounds in the Gliricidia sepium plant have antioxidant and anticancer probability values ​​above 0.500. Sepinol has the highest probability value of 0.873 for antioxidant, 0.869 for free radical scavenger, 0.784 for anticarcinogenic and 0.745 for chemopreventive. As for TP53, the strongest expression enhancer is robinetin with a probability value of 0.920.
Co-Authors Danie Indra Yama Donor Utomo Muhammad Susilo Mhd Syamsu Bahri Muliani Muliani Rexi Iswanto Susana Zaenal Mutaqin