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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Medisains Kesehatan
Fajrian Aulia Putra
Universitas Sumatera Barat
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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The effect of the ethyl acetate extract of Eleutherine bulbosa on reducing cholesterol in male white rats Miming Andika; Haliza Diny Fauzia; Oktavianis; Rizqa Hasanah; Nanda Hasanah; Oryza Sativa Fitriani; Fajrian Aulia Putra; Nur Rahmi; Taufit Julianto
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.28893

Abstract

Heart disease and stroke are more likely to occur in people with high cholesterol. Hypercholesterolemia is the cause of one-third of ischemic heart disease worldwide. One of the plants cultivated by communities for traditional medicine is Eleutherine bulbosa, which is used to treat cardiovascular conditions. E. bulbosa has antioxidants, which can lower cholesterol levels by competitively inhibiting the enzyme HMG-CoA reductase, thereby reducing cholesterol formation in the liver. E. bulbosa also contains flavonoids, whose role in lowering hypercholesterolemia is by reducing HMG-CoA reductase activity and increasing lecithin cholesterol acyl transferase (LCAT) activity, which accelerates the reaction of cholesterol ester formation from free cholesterol in high-density lipoprotein (HDL) molecules during the process of cholesterol uptake from cells or tissues, and decreases liver HMG-CoA reductase enzyme levels. This study aimed to examine the effects of administering the ethyl acetate fraction of E. bulbosa and test its ability to reduce total cholesterol, LDL, VLDL, and triglycerides, while increasing HDL. The test animals were fed a high-fat diet for 22 days to increase their cholesterol levels. A Dumolab DC20 photometer was used to measure cholesterol levels. Histopathological examination of the aorta was performed using paraffin blocks and stained with hematoxylin and eosin. The preparations were observed under a microscope (magnification of 100x and 400x). Observations included the diameter of the aorta. The results showed that the treatment groups differed significantly (P < 0.05). According to Duncan's test, there was a difference in reduction, in the hypercholesterolemia + extract group, the decrease in cholesterol levels was lower compared to the hypercholesterolemia + simvastatin group. The most effective dose group was 400 mg/kgBW, which was close to the results of the hypercholesterolemia + simvastatin group. Administration of the ethyl acetate fraction of E. bulbosa can normalize cholesterol levels. Also, histopathological results showed that the diameter of the aorta was larger after administration of 400 mg/kgBW of E. bulbosa extract compared to the hypercholesterolemia group.
Formulasi Dan Uji Stabilitas Sediaan Stick Moisturizer Dari Ekstrak Pagagan (Centella Asiatica) Ardi Yurlanda; Fajrian Aulia Putra
Jurnal Medisains Kesehatan Vol. 7 No. 1 (2026): Jurnal Medisains Kesehatan
Publisher : Universitas Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59963/jmk.v7i1.563

Abstract

 Centella asiatica, also known as gotu kola, contains triterpenoids and flavonoids that function as natural antioxidants and moisturizers. This study formulated three stick moisturizer preparations F0 as a control without extract, F1 containing 3% extract, and F2 containing 5% extract to evaluate the effect of active ingredient concentration on product quality. The formulations were assessed over six storage cycles through organoleptic testing, homogenity, pH, irritation, skin hydration, and hedonic evaluation. The results showed that F0, F1, and F2 maintained a stable light-green color, soft texture, and consistent aroma without significant changes during storage. The pH values of all three formulas remained within the safe range for skin (5.6–6.9) and did not cause irritation. Hydration testing indicated that both F1 and F2 increased skin moisture levels, with F2 producing the highest improvement. Hedonic evaluation also revealed that panelists preferred F2 in terms of aroma and texture. Overall, the three formulas demonstrated good physical stability and were well accepted, with F2 showing the best performance.
Co-Authors Ardi Yurlanda Haliza Diny Fauzia Miming Andika Nanda Hasanah Nur Rahmi Oktavianis Oryza Sativa Fitriani Rizqa Hasanah Taufit Julianto