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All Journal Pharmaciana: Jurnal Kefarmasian Human Care Journal
Oryza Sativa Fitriani
Universitas Fort De Kock
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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EFEKTIVITAS PEMBERIAN EKSTRAK ETANOL BAWANG MERAH (Allium cepa L) TERHADAP PENURUNAN JUMLAH MIKROORGANISME UDARA Hary Ade Saputra; Fidri Fahmi Febriani; Oryza Sativa Fitriani; Shantrya Dhelly Susanty; Yulia Yesti; Rido Farnandi
HUMAN CARE JOURNAL Vol 8, No 1 (2023): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v8i1.2353

Abstract

Udara yang kotor banyak mengandung mikroorganisme seperti bakteri, jamur, virus dan lainnya yang dapat menimbulkan penyakit menular salah satunya infeksi nosokomial. bahan alam yang memiliki senyawa yang bersifat sebagai desinfektan adalah bawang merah. Tujuan penelitian ini adalah untuk  mengetahui efektivitas pemberian ekstrak etanol bawang merah (Allium cepa L) terhadap penurunan jumlah mikroorganisme udara. Penelitian ini merupakan penelitian eksperimental menggunakan post test only design. Pengujian  dilakukan dengan mendispersikan ekstrak menggunakan diffuser selama 15 menit dalam ruang terbatas dengan konsentrasi  0,4%, 0,8% dan 1,2%. Pengambilan sampel dilakukan dengan menggunakan metode settle plate. Rata–rata jumlah koloni bakteri setelah didispersikan ekstrak bawang merah konsentrasi 0,4%, 0,8% dan 1,2% berturut-turut yaitu 49,3CFU/15 menit, 35,6CFU/15 menit dan 24,6CFU/15 menit. Rata–rata jumlah koloni jamur setelah didispersikan ekstrak bawang merah dengan konsentrasi 0,4%, 0,8% dan 1,2% berturut-turut yaitu 28CFU/15 menit, 21CFU/15 menit dan 5,3CFU/15 menit. Hasil uji statistic menggunakan uji one way ANOVA, didapatkan  adanya perbedaan jumlah mikroorganisme udara setelah diberikan perlakuan, dimana nilai p-value ˂ 0,05. Dimana  p-value koloni bakteri 0,006 dan p-value koloni jamur 0,002. Kesimpulan adanya perbedaan jumlah mikroorganisme udara setelah didispersikan ekstrak bawang merah dengan konsentrasi 0,4%, 0,8% dan 1,2%. Perlunya pengujian lebih lanjut menggunakan ruang dan konsentrasi yang lebih besar.
The effect of the ethyl acetate extract of Eleutherine bulbosa on reducing cholesterol in male white rats Miming Andika; Haliza Diny Fauzia; Oktavianis; Rizqa Hasanah; Nanda Hasanah; Oryza Sativa Fitriani; Fajrian Aulia Putra; Nur Rahmi; Taufit Julianto
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.28893

Abstract

Heart disease and stroke are more likely to occur in people with high cholesterol. Hypercholesterolemia is the cause of one-third of ischemic heart disease worldwide. One of the plants cultivated by communities for traditional medicine is Eleutherine bulbosa, which is used to treat cardiovascular conditions. E. bulbosa has antioxidants, which can lower cholesterol levels by competitively inhibiting the enzyme HMG-CoA reductase, thereby reducing cholesterol formation in the liver. E. bulbosa also contains flavonoids, whose role in lowering hypercholesterolemia is by reducing HMG-CoA reductase activity and increasing lecithin cholesterol acyl transferase (LCAT) activity, which accelerates the reaction of cholesterol ester formation from free cholesterol in high-density lipoprotein (HDL) molecules during the process of cholesterol uptake from cells or tissues, and decreases liver HMG-CoA reductase enzyme levels. This study aimed to examine the effects of administering the ethyl acetate fraction of E. bulbosa and test its ability to reduce total cholesterol, LDL, VLDL, and triglycerides, while increasing HDL. The test animals were fed a high-fat diet for 22 days to increase their cholesterol levels. A Dumolab DC20 photometer was used to measure cholesterol levels. Histopathological examination of the aorta was performed using paraffin blocks and stained with hematoxylin and eosin. The preparations were observed under a microscope (magnification of 100x and 400x). Observations included the diameter of the aorta. The results showed that the treatment groups differed significantly (P < 0.05). According to Duncan's test, there was a difference in reduction, in the hypercholesterolemia + extract group, the decrease in cholesterol levels was lower compared to the hypercholesterolemia + simvastatin group. The most effective dose group was 400 mg/kgBW, which was close to the results of the hypercholesterolemia + simvastatin group. Administration of the ethyl acetate fraction of E. bulbosa can normalize cholesterol levels. Also, histopathological results showed that the diameter of the aorta was larger after administration of 400 mg/kgBW of E. bulbosa extract compared to the hypercholesterolemia group.
Co-Authors Fajrian Aulia Putra Fidri Fahmi Febriani Haliza Diny Fauzia Hary Ade Saputra Miming Andika Nanda Hasanah Nur Rahmi Oktavianis Rido Farnandi Rizqa Hasanah Shantrya Dhelly Susanty Taufit Julianto Yulia Yesti