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All Journal International Journal of Medicine and Health Duta Pharma Journal Jurnal Kesehatan Amanah International Journal of Health, Engineering and Technology Journal of Innovative and Creativity Jurnal Pengabdian Ilmu Kesehatan
Niken Luthfiyanti
Program Studi S1 Farmasi Fakultas Ilmu Kesehatan, Universitas Duta Bangsa Surakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pendampingan Program Stimulasi Ibu-Anak Cegah Stunting di Posyandu Ngadi Asih Surakarta Darah Ifalahma; Ana yuliana; Niken Luthfiyanti
Jurnal Pengabdian Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Pengabdian Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jpikes.v5i3.5863

Abstract

Integrated Health Post (Posyandu) Ngadi Asih Surakarta implements Integrated Primary Services (ILP) services targeting pregnant women, toddlers, and breastfeeding mothers in support of the zero new stunting program. So far, the implementation has been limited to weighing and measuring. Problems have been identified, including the lack of health services and health education on stunting prevention. This is due to the limited knowledge and skills of cadres. The solution is an innovative Mother-Child Stimulation Program to Prevent Stunting (Prosiacting) at the Ngadi Asih Surakarta Posyandu. The activities carried out are Prosiacting Activation and Capacity Building for cadres in the form of training in Pregnancy Exercises, Baby Massage, and Oxytocin Massage. The implementation method has 6 stages: preparation, apperception, application of science and technology, mentoring, evaluation, and termination. The results of the Mother-Child Stimulation Program Innovation to Prevent Stunting (Prosiacting) have been well implemented at the Ngadi Asih Surakarta Integrated Health Post (Posyandu). Capacity Building activities for cadres were carried out well. The knowledge and skills of cadres have increased after the training, namely Pregnancy Gymnastics skills in the good category (75%), Baby Massage skills in the good category (80%), and Oxytocin Massage skills in the good category (90%). The Mother-Child Stimulation Program to Prevent Stunting (Prosiacting) has been activated. Cadres are committed to implementing the results of the training and Prosiacting routinely once a month during the Toddler Family Development activity. With the stunting prevention stimulation skills possessed by cadres, it is hoped that cadres will be able to independently accompany pregnant women, mothers of infants and toddlers, and postpartum mothers. It is hoped that this program will be routinely implemented at the Ngadi Asih Surakarta Integrated Health Post (Posyandu) as an effort to independently prevent Stunting in the Community.
Evaluasi Kesesuaian Rekonstitusi Sediaan Steril di Bangsal Anak RS Universitas Sebelas Maret Ayu Cahyani Abidin; Hidayah Apriliawan; Niken Luthfiyanti
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

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Abstract

Reconstitution of injectable drugs involved mixing sterile drug powders with appropriate sterile solvents prior to parenteral administration. This critical pharmacy practice was particularly vital in pediatrics where dosing errors and contamination posed significant risks. Reconstitution errors could lead to chemical instability, therapeutic failure, and serious adverse effects including toxicity or nosocomial infections. This study aimed to evaluate the appropriateness of sterile injectable drug reconstitution procedures in the Pediatric Ward of Universitas Sebelas Maret Hospital across five parameters: dosage calculation, solvent selection, solvent volume, post-reconstitution storage temperature, and Beyond Use Date (BUD) assignment. A descriptive observational study with prospective design was conducted among pediatric inpatients from December 2025 to January 2026. Seventy cases of pediatric injectable drug administrations were sampled using saturated (total) sampling technique. Primary data were collected through direct pharmacist reconstitution observations while secondary data came from medical records and sterile preparation worksheets. Compliance was benchmarked against gold standards: Pediatric Injectable Drugs 10th edition and Handbook on Injectable Drugs 17th edition. Perfect compliance (100%) was achieved for dosage, solvent selection (NaCl 0.9%, sterile water), and reconstitution volumes. However, storage temperature compliance (2-8°C for light-sensitive drugs) was only 68%, while BUD documentation aligned with post-reconstitution stability in 70% of cases, leaving 2% critical non-compliance posing patient safety risks. While reconstitution technical execution was excellent, cold chain monitoring and BUD documentation required systemic improvements through regular training, real-time temperature tracking, and stricter Standard Operating Procedures to ensure pediatric pharmacotherapy safety.
Analisis Kadar Flavonoid Total dan Aktivitas Antioksidan dari Ekstrak Etanol Serta Fraksi dari Gagang Cengkeh (Syzygium Aromaticum (L)). Intan Oktaviana Putri; Niken Luthfiyanti; Danang Raharjo
Jurnal Kesehatan Amanah Vol. 9 No. 2 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i2.989

Abstract

Antioxidants are substances that can inhibit oxidation caused by free radicals. Flavonoids are effective natural antioxidants due to their unique chemical structure. Both have a hydroxyl group (-OH) attached to an aromatic ring. This hydroxyl group can donate hydrogen or electrons to free radicals. Clove stems (Syzygium aromaticum (L.)) are known to possess bioactive compounds, including flavonoids like quercetin and kaempferol, which act as antioxidants in protecting cells from free radicals. Maceration is a commonly used extraction method to obtain therapeutic compounds from plants. The process involves soaking the finely or coarsely ground plant material in a solvent (liquid thinner) in a closed container. Fractionation is a method for separating chemical components in an extract based on differences in their polarity or solubility. This process uses two immiscible solvents. This study is an experimental research aimed at determining the total flavonoid content (TFC) and the IC50​ value of the antioxidant activity present in the ethanol extract and fractions of clove stems (Syzygium aromaticum (L.)) using the ABTS method. The tests utilized maceration extraction with 96% ethanol as the solvent, and liquid-liquid fractionation using N-hexane, ethyl acetate, and water as solvents, along with UV-Vis spectrophotometry analysis. The results showed that the highest flavonoid content was in the ethanol extract, with a TFC value of 51.000 mgQE/g, and the highest antioxidant activity was in the ethyl acetate fraction, with an IC50​ value of 23.716 µg/mL, indicating a strong potential as a source of natural antioxidants.
The Relationship Between ARV Therapy Adherence And Clinical Outcomes in HIV Patients at Dr Moewardi Hospital Putri Eka Prasetya; Niken Luthfiyanti; Vivin Marwiyati Rohmana; Angelina da Costa Fernandes
Duta Pharma Journal Vol. 6 No. 1 (2026): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/s04wca81

Abstract

Background: Human immunodeficiency virus (HIV) remains a major global public health problem with the number of people living with HIV continuing to increase, including in Indonesia. Antiretroviral therapy (ART) is the main treatment to suppress viral replication and improve immune function, however its success is highly dependent on patient adherence. Objective: This study aimed to determine the level of adherence to ART, evaluate clinical outcomes and analyze the relationship between ART adherence and clinical outcomes among HIV patients at Dr. Moewardi Hospital. Methods: This study employed a quantitative analytical design with a cross-sectional approach. A total of 83 patients (n=83) undergoing ART were included in this study. Data were collected using the Morisky Medication Adherence Scale (MMAS-8) and medical records. Data analysis was performed using univariate and bivariate methods. Results: The majority of patients demonstrated high adherence to ART (60.2%), followed by moderate adherence (34.9%) and low adherence (4.8%). Most patients achieved favorable clinical outcome with 89.2% having undetectable viral load and 10.8% having detectable viral load. CD4 levels were categorized as good (51.8%), very good (33.7%) and poor (14.5%). Bivariate analysis showed a significant relationship between ARV adherence and CD4 outcomes (p = 0.007) as well as viral load outcomes (p < 0.000). Conclusion: There is a significant relationship between ART adherence and clinical outcomes in HIV patients. Higher adherence is associated with improved CD4 levels and viral load suppression.
Relationship of Medication Adherence to Clinical Outcome in Patients Type 2 Diabetes with Modified Morisky Adherence Scale 8 (MMAS 8) Niken Luthfiyanti; Ardi Setyawan; Kharisma Jayak Pratama
International Journal of Medicine and Health Vol. 3 No. 4 (2024): Desember : International Journal of Medicine and Health (IJMH)
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v3i4.4547

Abstract

Diabetes melitus is a chronic condition desease that requires continued use of medication. High adherence to treatment will produce good clinical results and play a role in improving the quality of life of diabetes melitus sufferers. The following research aims to assess the relationship between adherence to medication use and clinical outcomes for patients with type 2 diabetes mellitus at RSUD DR. Moewardi Surakarta which was conducted in the period April – June 2024. This research used a cross sectional method with a total of 98 patients as respondents who met the inclusion and exclusion criteria. Adherence data was assessed using the Modified Morisky Adherence Scale 8 (MMAS 8) questionnaire, and clinical outcomes were assessed from fasting or fasting blood glucose values ​​and %HbA1C from medical record data. Analysis of the relationship between adherence and clinical outcomes using chi-square. The results of the level of treatment compliance can be divided into 3 categories, namely: high treatment compliance has a percentage of 24.5%, moderate treatment compliance has a percentage of 46.9%, and low treatment compliance has a percentage of 28.6%. Clinical outcomes were achieved by 38.8% and not achieved by 62.2%. There is a relationship between adherence medication and therapeutic outcomes in type 2 diabetes melitus patients with a Pearson chi square value of 0.011. Based on these data, pharmacist professionals need to place greater emphasis on adherence with medication use in type 2 diabetes mellitus patients to obtain good clinical outcomes.
Evaluation Of The Rationality Of Antibiotic Use In Hospitalized Adult Patients With UTI Diagnosis On Clinical Outcome At Dr. Moewardi Regional Hospital Malinda Apriliani; Kharisma Jayak Pratama; Niken Luthfiyanti
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.651

Abstract

Urinary Tract Infection (UTI) is a common infection with high antibiotic resistance due to irrational use.  To assess the rationality of antibiotics in adult inpatients with UTI at Dr. Moewardi Regional General Hospital using the Gyssens method, ATC/DDD patterns, and their relationship with clinical outcomes. A retrospective descriptive observational study of medical records of 50 acute pyelonephritis patients (population 270, Slovin sample e=10%, consecutive sampling), collected in December 2025. LPD medical records; analysis: Gyssens (qualitative Permenkes 28/2021), ATC/DDD (quantitative), Fisher's Exact (p<0.05). 64% female, 52% >60 years; ciprofloxacin 90%; rationality 46% (Gyssens category 0), 54% irrational (mainly short duration 44%); ATC/DDD: ciprofloxacin 47.2%, ceftriaxone 52.8%; outcome improved 94%; p=0.090 (not significant). Rationale was low, especially for duration, with no significant association with outcome; stewardship is recommended to prevent resistance.
Predictors Of Antiretroviral Therapy Failure In HIV/AIDS Patients At Dr. Moewardi Regional Hospital, Surakarta Fachry Harbipero; Niken Luthfiyanti; Vivin Marwiyati
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.680

Abstract

Antiretroviral (ARV) therapy failure remains a significant issue in HIV/AIDS control as it contributes to disease progression and drug resistance. This study aims to analyze predictors of ARV therapy failure based on demographic and clinical characteristics of HIV/AIDS patients. This study used a retrospective quantitative descriptive analytical design with medical records of HIV outpatients at Dr. Moewardi Regional General Hospital from November 2024 to November 2025 as the data source. The study population was all HIV patients receiving ARV therapy, with a sample of 100 patients selected using accidental sampling. The research instrument was a medical record-based observation sheet, covering demographic, clinical, CD4, viral load, and clinical stage characteristics. Data analysis was performed univariately and bivariately using the Chi-square test with a significance level of p<0.05. The results showed that the majority of patients were male, productive age, married, had secondary or higher education, had a normal BMI, were in the early clinical stage, and did not experience opportunistic infections or side effects of therapy. No significant associations were found between demographic and clinical variables and CD4 count, viral load, or clinical stage. In conclusion, the immunological, virological, and clinical status of HIV patients is multifactorial and is not solely determined by the demographic and clinical characteristics studied.
Co-Authors Ana Yuliana Angelina da Costa Fernandes Ardi Setyawan Ayu Cahyani Abidin Darah Ifalahma Fachry Harbipero Hidayah Apriliawan Intan Oktaviana Putri Kharisma Jayak Pratama Malinda Apriliani Putri Eka Prasetya Rohmana, Vivin Marwiyati Vivin Marwiyati