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All Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY ARTERI : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat Sasambo
Jusup, Sinu Andhi
Fakultas Kedokteran Universitas Sebelas Maret Surakarta
Agriculture, Biological Sciences & Forestry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PEMBERDAYAAN YAYASAN SEBAGAI PELOPOR GERAKAN MASYARAKAT HIDUP SEHAT DALAM UPAYA PENCEGAHAN PENYAKIT HIPERTENSI Dono Indarto; Setyo Sri Rahardjo; Sinu Andhi Jusup; Sri Wulandari; Niniek Purwaningtyas; Heru Sulastomo; Ratna Kusumawati; Tri Nugraha Susilawati
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 6, No 1 (2022): Maret
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v6i1.7284

Abstract

ABSTRAKPenyakit Tidak Menular (PTM) merupakan penyebab kematian tertinggi di dunia, termasuk di Indonesia. Salah satu PTM yang cukup tinggi prevalensinya adalah hipertensi. Kabupaten Karanganyar merupakan salah satu kabupaten di provinsi Jawa Tengah dengan jumlah kasus hipertensi yang cukup tinggi dan prevalensinya terus meningkat dari tahun ke tahun. Pemerintah Indonesia dan pemerintah kabupaten setempat telah mencanangkan Gerakan Masyarakat Hidup Sehat (Germas) sebagai upaya pengendalian PTM. Yayasan Usaha Umat Karanganyar (YUUK), sebuah organisasi masyarakat yang berlokasi di Tasikmadu, Karanganyar, telah memiliki program kegiatan pendidikan dan pelatihan yang diperlukan oleh masyarakat setempat, namun program pendidikan dan pelatihan tersebut belum menjamah aspek kesehatan masyarakat. Untuk mengoptimalkan kesehatan masyarakat setempat melalui pemberdayaan organisasi kemasyarakatan, tim pengabdian masyarakat yang tergabung dalam grup riset Human Proteomics Fakultas Kedokteran Universitas Sebelas Maret (FK UNS) melakukan kegiatan penyuluhan dan konsultasi tentang hipertensi dan serta pelatihan penggunaan tensimeter digital dan oximeter. Kegiatan tersebut bertujuan untuk meningkatkan peran serta YUUK dalam pencegahan dan deteksi dini penyakit hipertensi. Sasaran kegiatan ini adalah para remaja di sekitar masjid Al Walidah Tasikmadu Karanganyar. Hasil dari kegiatan tersebut adalah meningkatnya pemahaman peserta mengenai hipertensi dan keterampilan memantau kesehatan kardiovaskuler melalui penggunaan tensimeter digital. Evaluasi kegiatan ini dilakukan dengan cara menghubungi pengurus YUUK untuk mendapatkan laporan tentang implementasi pemanfaatan 2 unit tensimeter digital dan 1 unit oximeter yang diberikan oleh tim pengabdi kepada pengelola Yayasan untuk dimanfaatkan sebaik-baiknya bagi masyarakat sekitar. Tim pengabdi juga terus memonitor prevalensi hipertensi dari tahun ke tahun di Kabupaten Karanganyar. Kata kunci: hipertensi; pemberdayaan masyarakat; penyakit tidak menular ABSTRACT Non-communicable diseases (NCD) are the major causes of mortality in the world, including in Indonesia. One of the most prevalent type of NCD is hypertension. Karanganyar is a district in Central Java province with high incidence of hypertension and its prevalence continues to rise over years. Both central and local governments have established "Gerakan Masyarakat Hidup Sehat (Germas)", a community-based movement to promote healthy lifestyle, to control NCD. "Yayasan Usaha Umat Karanganyar (YUUK)", a community organization located in Tasikmadu, Karanganyar, provides education and training for locals but their main focus has not reached health programs. To optimize the locals' health through empowerment of community organizations, we conducted education and counseling about hypertension as well as training on using digital sphygmomanometer and oxymeter. The activities aimed to increase YUUK's roles in the prevention and early detection of hypertension. The activities involved teenagers living in the catchment area of Al Walidah mosque, Tasikmadu, Karanganyar. The activites resulted in an increased understanding about hypertension and skills to monitor cardiovascular health by using a digital sphygmomanometer,  Evaluation was performed by contacting the YUUK manager who is responsible for reporting the use of 2 units of digital sphygmomanometers and 1 unit of oxymeter that were given during the occasion so that the equipment can be used by locals. We also continuosly monitor the annual prevalence of hypertension in Karanganyar district. Keywords:  hypertension; community empowerment; non-communicable diseases
Hubungan Volume Oksigen Maksimal dengan Denyut Nadi Istirahat Fase Pertumbuhan Dewasa Muda Ilham Ramadhan; Rizki Amalia Nurfitriani; Sinu andhi jusup; Lukman aryoseto
ARTERI : Jurnal Ilmu Kesehatan Vol 3 No 4 (2022): Agustus
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v3i4.237

Abstract

Maximal oxygen uptake is a measure of cardiorespiratory capacity that shows human body fitness. Resting heart rate shows the ability of the heart to pump blood throughout the body thus resting heart rate related to the maximum oxygen volume. The young adult is an important phase of human in determining the productivity of the level of life. Maximum oxygen volume can be related to resting heart rate, but this has not been studied in detail regarding the relationship between maximal oxygen volume and resting heart rate in young adults. The purpose of this study was to determine the relationship between maximal oxygen volume and resting heart rate of young adults. This research uses cross sectional method. The number of research samples was 38 students from the Faculty of Medical Education, Sebelas Maret University (UNS). The dependent variable tested in this study was resting pulse rate and the independent variable was maximal oxygen volume. The research was conducted at the Physiology Laboratory of Sebelas Maret University, Surakarta. Resting heart rate was calculated by sleeping position in the supine position for 15 minutes then measured by pulse oximetry and maximal oxygen volume was calculated by Astrand-Rhyming Step Test. The results showed that the data were normally distributed so that the Pearson correlation test could be performed. The results of the correlation test showed that the value of p = 0.000 (p < 0.05) which indicated there was a significant correlation between the two variables tested and the Pearson correlation value of - 0.612 which indicated a negative correlation with a strong correlation strength. This study concludes that there is a significant correlation between maximal oxygen volume and heart rate of young adults with a negative correlation.
PEMBERDAYAAN KLUB PERSATUAN DIABETES INDONESIA (PERSADIA) DALAM UPAYA PENCEGAHAN KOMPLIKASI KARDIOVASKULER PADA PENDERITA DIABETES MELLITUS Setyo Sri Rahardjo; Sinu Andhi Jusup; Dono Indarto; Sri Wulandari; Niniek Purwaningtyas; Tri Nugraha Susilawati
Jurnal Pengabdian Masyarakat Sasambo Vol 4, No 1 (2022): November
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jpms.v4i1.931

Abstract

Diabetes mellitus (DM) merupakan penyakit tidak menular (PTM) dengan prevalensi yang cukup tinggi di Kabupaten Karanganyar, Jawa Tengah. Pengendalian gula darah merupakan faktor utama untuk mencegah berbagai komplikasi penyakit DM. Tujuan dari pengabdian masyarakat ini adalah mengaktifkan gerakan masyarakat hidup sehat (Germas) dalam upaya pencegahan komplikasi kardiovaskuler pada penderita DM. Sasaran kegiatan ini adalah masyarakat yang tergabung dalam klub Persatuan Diabetes Indonesia (Persadia) Perumnas Palur, Kecamatan Jaten, Kabupaten Karanganyar, Jawa Tengah dimana kegiatan senam diabetes yang rutin diselenggarakan oleh klub tersebut sempat vakum dikarenakan pandemi Covid-19. Kegiatan pengabdian masyarakat berlangsung pada tanggal 7 Juni 2022 dan diikuti oleh 32 anggota klub. Metode pengabdian adalah edukasi, pelatihan, serta pemeriksaan tekanan darah dan gula darah sewaktu (GDS). Hasil dari kegiatan tersebut adalah meningkatnya pemahaman peserta mengenai penyakit DM dan keterampilan dalam memantau kesehatan melalui penggunaan tensimeter digital dan alat pengukur gula darah. Dari hasil pencatatan tekanan darah dan GDS didapatkan 1 kasus komorbid DM dan hipertensi, 14 kasus hipertensi, dan 2 kasus DM. Dapat disimpulkan bahwa kegiatan ini bermanfaat bagi klub Persadia dan masyarakat di sekitarnya dalam upaya pencegahan dan deteksi penyakit hipertensi dan DM.
Potential of Cocoa Flavanols in Improving Cardiovascular Adaptation and Exercise: A Scoping Review Arya Dwi Handana; Yulia Lanti Retno Dewi; Sinu Andhi Jusup
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6468

Abstract

Cardiovascular fitness, quantified as maximal oxygen consumption (VO₂Max), is a significant indicator of exercise tolerance and cardiovascular health. Sedentary behavior and aging are determinants that contribute to endothelial dysfunction, arterial stiffness, and reduced cardiac output, leading to a decline in VO₂Max. Cocoa Flavanols (CFs), rich in (−)-epicatechin, have been found to enhance endothelial function, nitric oxide bioavailability, and reduce blood pressure and hence might be beneficial for cardiovascular adaptation and VO₂Max improvement. This scoping review explores the potential of CFs to enhance cardiovascular function and exercise tolerance. Method: Two randomized controlled trials were employed in this scoping review. The first trial examined the effect of 30-day CF supplementation (1000 mg/day) on cardiorespiratory fitness in healthy elderly adults. The second trial examined the effect of 7-day CF supplementation (400 mg/day) on pulmonary oxygen uptake kinetics and exercise tolerance in middle-age sedentary adults. Results: In older adults, CF supplementation improved VO₂peak, oxygen pulse, exercise capacity, and endothelial function and lowered blood pressure in middle-aged sedentary adults, CFs improved VO₂ kinetics during moderate-intensity exercise, indicating enhanced oxygen delivery, but not exercise tolerance during severe-intensity exercise. Such results highlight CFs' positive effects on vascular health and efficiency of moderate-intensity exercise. Conclusion: Cocoa flavanols may enhance cardiovascular adaptation and exercise performance by improving endothelial function, reducing arterial stiffness, and optimizing oxygen uptake during exercise. Further studies are required to evaluate their effect on maximal exercise performance and long-term cardiovascular outcomes.
The baseline levels of receptors and cytokines in phorbol 12-myristate 13-acetate-induced THP-1 monocyte to macrophage cells Sri Wulandari; Tri Agusti Sholikah; Sinu Andhi Jusup
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.7917

Abstract

Monocyte-derived macrophages regulate various aspects of inflammation. Phorbol 12-myristate 13-acetate (PMA)-induced THP-1 monocytes are widely used as monocyte-derived macrophage models suitable for studying the pathophysiology of inflammation and developing therapies. However, there is insufficient data concerning the baseline expression of pro-inflammatory receptors and the associated cytokine levels in THP-1-derived macrophage-like cells compared with their monocyte precursors. In this study, PMA-treated THP-1 cells were employed as models for monocyte-derived macrophage-like cells (M0). The mRNA levels of Toll-like receptors (TLR)4, receptor for advanced glycation end-product (RAGE), and TLR7 in THP-1 cells, both with and without PMA treatment, were evaluated using quantitative real-time polymerase chain reaction (RT-qPCR). ELISA was performed to quantify IL-6, TNF-α, and IL-18 levels in the THP-1 culture supernatant. The mRNA expression of TLR4, RAGE, and TLR7 was increased twofold in PMA-induced THP-1-derived macrophage-like cells compared to monocytes. IL-6 (p = 0.0277) and TNF-α (p = 0.0105) levels were significantly elevated in the culture supernatants of THP-1-derived macrophages. However, IL-18 levels did not show a significant increase. The upregulation of TLR4, RAGE, and TLR7 transcription was accompanied by elevated secretion of IL-6 and TNF-α during PMA-induced differentiation of THP-1-derived macrophage-like cells (M0), highlighting the polarization state and the specific role of macrophages in producing pro-inflammatory cytokines. This study provides baseline data on pro-inflammatory receptor expression and cytokine production in the THP-1-derived macrophage-like cells model for inflammatory research.
Co-Authors Arya Dwi Handana Bhisma Murti Dono Indarto ENDANG LISTYANINGSIH Fikri, Aulia Muhammad Ilham Ramadhan Iryawan, Andri Jarot Subandono Lukman Aryoseto Nanang Wiyono Niniek Purwaningtyas Pratiaksa, Ardian Randita, Amandha Boy Timor Ratna Kusumawati Ratri, Lely Amedia Rizki Amalia Nurfitriani Rosida, Lulut Khoridatur Setyo Sri Rahardjo SETYO SRI RAHARJO Sri Wulandari SULASTOMO, HERU Tri Agusti Sholikah Tri Nugraha Susilawati Yulia Lanti Retno Dewi