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All Journal Nexus Kedokteran Translasional SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Respirologi Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Jurnal Dunia Gizi Jurnal Pengabdian Masyarakat Sasambo Proceedings of the International Conference on Nursing and Health Sciences Proceeding ISETH (International Summit on Science, Technology, and Humanity) Media Penelitian dan Pengembangan Kesehatan Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)
Dono Indarto
Universitas Sebelas Maret
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Application of Autodock Vina program version 1.1.2 for Exploring Indonesian Phytochemicals as an Activator of Adenosine Monophosphate-Activated Protein Kinase Farchan Azzumar; Dono Indarto; Balgis .
Nexus Kedokteran Translasional Vol 4, No 2 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Increased activity of Adenosine Monophosphate-Activated Protein Kinase (AMPK) can inhibit cell growth and biosynthetic pathwaysin some cancer cells. Recently, several endogenous ligands have been identified to activate AMPK including Adenosine Monophosphate (AMP).Virtual screening is one of the recent technique, which is used for drug discoveries.Therefore the aim of this study was to identify active compounds of Indonesian herbal plants that activate AMPK by using molecular docking. Methods: Samples used in this study wereall of active compounds which were derived from Indonesian herbal plantsand had three-dimensional structures. Molecular docking was performed by using AutodockVina version 1.1.2 to evaluate interaction between AMPK and active compounds. The AMP structure obtained from protein data bank (www.rcsb.org/pdb)was used as a molecule standard of AMPK interaction. Docking score indicated affinity of molecule interaction and was determined in Cal/mol. To visualize docking results that fit to the AMPK molecule, chimera software version 1.9 was used. Results: Curcumin has docking scores as same as docking score of AMP (-7.5 Cal/mol) and has hydrogen bound in ? subunit of AMPK (Thr86, Thr88, and Arg117). Conclusions: Curcumin might be an activator of AMPK. Another molecular docking which has a flexible substrate-enzyme algorithm is required for confirming the docking result. Keywords: AMPK, Herbal plant, Molecular Docking.
PEMBERDAYAAN YAYASAN SEBAGAI PELOPOR GERAKAN MASYARAKAT HIDUP SEHAT DALAM UPAYA PENCEGAHAN PENYAKIT HIPERTENSI Dono Indarto; Setyo Sri Rahardjo; Sinu Andhi Jusup; Sri Wulandari; Niniek Purwaningtyas; Heru Sulastomo; Ratna Kusumawati; Tri Nugraha Susilawati
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 6, No 1 (2022): Maret
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v6i1.7284

Abstract

ABSTRAKPenyakit Tidak Menular (PTM) merupakan penyebab kematian tertinggi di dunia, termasuk di Indonesia. Salah satu PTM yang cukup tinggi prevalensinya adalah hipertensi. Kabupaten Karanganyar merupakan salah satu kabupaten di provinsi Jawa Tengah dengan jumlah kasus hipertensi yang cukup tinggi dan prevalensinya terus meningkat dari tahun ke tahun. Pemerintah Indonesia dan pemerintah kabupaten setempat telah mencanangkan Gerakan Masyarakat Hidup Sehat (Germas) sebagai upaya pengendalian PTM. Yayasan Usaha Umat Karanganyar (YUUK), sebuah organisasi masyarakat yang berlokasi di Tasikmadu, Karanganyar, telah memiliki program kegiatan pendidikan dan pelatihan yang diperlukan oleh masyarakat setempat, namun program pendidikan dan pelatihan tersebut belum menjamah aspek kesehatan masyarakat. Untuk mengoptimalkan kesehatan masyarakat setempat melalui pemberdayaan organisasi kemasyarakatan, tim pengabdian masyarakat yang tergabung dalam grup riset Human Proteomics Fakultas Kedokteran Universitas Sebelas Maret (FK UNS) melakukan kegiatan penyuluhan dan konsultasi tentang hipertensi dan serta pelatihan penggunaan tensimeter digital dan oximeter. Kegiatan tersebut bertujuan untuk meningkatkan peran serta YUUK dalam pencegahan dan deteksi dini penyakit hipertensi. Sasaran kegiatan ini adalah para remaja di sekitar masjid Al Walidah Tasikmadu Karanganyar. Hasil dari kegiatan tersebut adalah meningkatnya pemahaman peserta mengenai hipertensi dan keterampilan memantau kesehatan kardiovaskuler melalui penggunaan tensimeter digital. Evaluasi kegiatan ini dilakukan dengan cara menghubungi pengurus YUUK untuk mendapatkan laporan tentang implementasi pemanfaatan 2 unit tensimeter digital dan 1 unit oximeter yang diberikan oleh tim pengabdi kepada pengelola Yayasan untuk dimanfaatkan sebaik-baiknya bagi masyarakat sekitar. Tim pengabdi juga terus memonitor prevalensi hipertensi dari tahun ke tahun di Kabupaten Karanganyar. Kata kunci: hipertensi; pemberdayaan masyarakat; penyakit tidak menular ABSTRACT Non-communicable diseases (NCD) are the major causes of mortality in the world, including in Indonesia. One of the most prevalent type of NCD is hypertension. Karanganyar is a district in Central Java province with high incidence of hypertension and its prevalence continues to rise over years. Both central and local governments have established "Gerakan Masyarakat Hidup Sehat (Germas)", a community-based movement to promote healthy lifestyle, to control NCD. "Yayasan Usaha Umat Karanganyar (YUUK)", a community organization located in Tasikmadu, Karanganyar, provides education and training for locals but their main focus has not reached health programs. To optimize the locals' health through empowerment of community organizations, we conducted education and counseling about hypertension as well as training on using digital sphygmomanometer and oxymeter. The activities aimed to increase YUUK's roles in the prevention and early detection of hypertension. The activities involved teenagers living in the catchment area of Al Walidah mosque, Tasikmadu, Karanganyar. The activites resulted in an increased understanding about hypertension and skills to monitor cardiovascular health by using a digital sphygmomanometer,  Evaluation was performed by contacting the YUUK manager who is responsible for reporting the use of 2 units of digital sphygmomanometers and 1 unit of oxymeter that were given during the occasion so that the equipment can be used by locals. We also continuosly monitor the annual prevalence of hypertension in Karanganyar district. Keywords:  hypertension; community empowerment; non-communicable diseases
The Test of DLCO Is A Valuable Predictor for Prognostic Determination of Patients with Chronic Obstructive Pulmonary Disease Dina Okfina Ria; Suradi Suradi; Jatu Aphridasari; Reviono Reviono; Dono Indarto
Jurnal Respirologi Indonesia Vol 38, No 2 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i2.162

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is characterized by permanent and progressive air way obstruction. In terms of morbidity, this disease is the first highest pulmonary disease in the world. DLCO is used for measurement of gas transfer from alveoli to blood capillary and Hb level is one of the main factors affecting the gas transfer. The aim of this study was to examine prognosis of patients with stable COPD using lung function, DLCO and Hb tets. Methods: Consecutive sampling was used to recruit 33 outward patients who suffered stable COPD and visited the Lung Clinic at Public Hospital dr. Moewardi Surakarta. Classification of COPD was determined using GOLD 2016. Airway and lung functions were examined using spirometry and single breath DLCO. Hb level was measured using cyamethemoglobin method. All collected data were analyzed using student t test and p value was set up P
Hubungan Berat Badan Dengan Kejadian Anemia Remaja Putri di Kabupaten Boyolali Yatty Destani Sandy; Didik Gunawan Tamtomo; Dono Indarto
Jurnal Dunia Gizi Vol 3, No 2 (2020): Edisi Desember
Publisher : Study Program of Nutrition, Public Health Faculty, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdg.v3i2.4744

Abstract

Latar Belakang; Masalah kesehatan global yang masih cukup tinggi pada remaja putri yaitu Anemia. Beberapa faktor penyebab anemia adalah usia menarche, obesitas, serta kurangnya asupan zat besi. Remaja putri yang memiliki berat badan lebih mengalami anemia karena penimbunan lemak di dalam jaringan adipose yang akan berpengaruh terhadap peningkatan kadar hepsidin sehingga mengganggu absorbsi besi di dalam tubuh. Tujuan; Menganalisis hubungan berat badan dengan kejadian anemia pada remaja putri di Kabupaten Boyolali. Metode; Observasional analitik dengan desain cross sectional. Populasi adalah seluruh remaja putri SMA di Boyolali. Sampel sebanyak 90 remaja putri dengan menggunakan teknik Multi Stage Sampling. Pengumpulan data berat badan diukur dengan antopometri dan pengukuran kadar hemoglobin menggunakan metode cyanmethemoglobin. Data di analisis menggunakan uji statistik chi square. Hasil; Sebanyak 51,1% remaja putri mengalami anemia dengan obesitas. Obesitas ditemukan  pada 87,8% remaja putri dengan berat badan lebih. Remaja putri dengan berat badan lebih berisiko untuk mengalami anemia sebanyak 6,273 kali (p = 0,013). Kesimpulan; Berat badan berhubungan positif dengan kejadian anemia. Remaja putri diharapkan dapat mengontrol berat badan dan mengkonsumsi makanan yang mengandung tinggi zat besi. Penyediaan suplementasi zat besi dimasukkan ke dalam program UKS.
PEMBERDAYAAN KLUB PERSATUAN DIABETES INDONESIA (PERSADIA) DALAM UPAYA PENCEGAHAN KOMPLIKASI KARDIOVASKULER PADA PENDERITA DIABETES MELLITUS Setyo Sri Rahardjo; Sinu Andhi Jusup; Dono Indarto; Sri Wulandari; Niniek Purwaningtyas; Tri Nugraha Susilawati
Jurnal Pengabdian Masyarakat Sasambo Vol 4, No 1 (2022): November
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jpms.v4i1.931

Abstract

Diabetes mellitus (DM) merupakan penyakit tidak menular (PTM) dengan prevalensi yang cukup tinggi di Kabupaten Karanganyar, Jawa Tengah. Pengendalian gula darah merupakan faktor utama untuk mencegah berbagai komplikasi penyakit DM. Tujuan dari pengabdian masyarakat ini adalah mengaktifkan gerakan masyarakat hidup sehat (Germas) dalam upaya pencegahan komplikasi kardiovaskuler pada penderita DM. Sasaran kegiatan ini adalah masyarakat yang tergabung dalam klub Persatuan Diabetes Indonesia (Persadia) Perumnas Palur, Kecamatan Jaten, Kabupaten Karanganyar, Jawa Tengah dimana kegiatan senam diabetes yang rutin diselenggarakan oleh klub tersebut sempat vakum dikarenakan pandemi Covid-19. Kegiatan pengabdian masyarakat berlangsung pada tanggal 7 Juni 2022 dan diikuti oleh 32 anggota klub. Metode pengabdian adalah edukasi, pelatihan, serta pemeriksaan tekanan darah dan gula darah sewaktu (GDS). Hasil dari kegiatan tersebut adalah meningkatnya pemahaman peserta mengenai penyakit DM dan keterampilan dalam memantau kesehatan melalui penggunaan tensimeter digital dan alat pengukur gula darah. Dari hasil pencatatan tekanan darah dan GDS didapatkan 1 kasus komorbid DM dan hipertensi, 14 kasus hipertensi, dan 2 kasus DM. Dapat disimpulkan bahwa kegiatan ini bermanfaat bagi klub Persadia dan masyarakat di sekitarnya dalam upaya pencegahan dan deteksi penyakit hipertensi dan DM.
The Biochemical and Kidney Histopathological Parameters in Hyperoxaluria Rats Treated with Breadfruit Leaf Extract Jatmiko Susilo; Siswanta Jaka Purnama; Ardianti Wahyuni; Bambang Purwanto; Muchsin Doewes; Dono Indarto
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

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Abstract

Purpose: This study was to analyze the administration of breadfruti leaf extract to changes in biochemical parameters and renal histology in hyperoxaluria rats.Methodology: The experimental study used 6 groups, each of 5 mice that are EG, Normal, Vitamin E, an ethanol extract of breadfruit 100, 200 and 400 mg/kg BW. Blood data for the analysis of biochemical parameters and kidney were taken at the end of the experiment for histological analysis of kidney changes. Results: Research shows that the purified ethanol extract of breadfruit leaf can prevent increases in MDA levels, reduce creatinine and BUN levels, increase body weight, prevent hypertrophy and kidney damage Conclusion: Purified ethanol extract of AA leaves has an antioxidant, nephroprotective activity, protect kidney inflammation, and kidney damage in nephrolithiasis rats and the effective dose is 400 mg/kg BW. The higher the extract dose, the more effective to reduce the biochemical and histopathological parameters in hyperoxaluria rats.Applications/Originality/Value: as a basis for futher studies of molecular biology in the prevention of kidney disorder.
Finding Airon Deficiency Anemia (IDA)at Young Women with Overweigth or Obesity Amelya Augusthina Ayusari; Shofura Azizah; Lilik Wijayanti; Dono Indarto; Yuliana Heri Suselo; Yusuf Ari Mashuri; Yunia Hastami; Dwi Rahayu
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2015: Proceeding ISETH (International Conference on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

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Abstract

Background: Young women can suffer from anemia due to monthly menstruation and by having many activities without adequate iron-filled nutrition. Otherproblems found on them are overweight and obesity. The data show that one with overweight or obesity can lead to iron deficiency anemia (IDA) along with increasingproinflammatory cytokines, which will cause the transcription of hepcidin. The increaseof hepcidin transcription will inhibit the absorption of iron from the intestine into the circulation, inhibiting spending iron reserves into circulation, and inhibitingthe release of iron recycled from splenic macrophages. This can cause IDA. The purpose of this study was to obtain the proportion of iron deficiency anemia in overweight or obese young women.Methods: The design of this study was cross sectional using purposive sampling. The subjects of this study were the student from fiveselected Senior high schools inBoyolali, Central Java, Indonesia. The determination of IDAis done by using hemoglobin and indexes of erythrocytes. Results: This study was the follow-upof the previous study, which was conducted to 14 obese and/or overweightyoung women withanemia From 14 subjects, there wasone subject suffered from other anemia and 13 subjects with IDA (using index erythrocytes examination). Their mean of MCV was 72.68±4.29fl, MCH was 23.08±2.63pg, and MCHC was 35.21±0.65 %.Conclusions: From this study, almost all overweight or obeseyoung women with anemia were indicated as IDA (92.8%).
Development of the Obesity Nutraceutical from Raja and Kepok Banana Peels Kezia Elian Devina; Dono Indarto; Tri Nugraha Susilawati
Proceedings of the International Conference on Nursing and Health Sciences Vol 4 No 1 (2023): January-June 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v4i1.1817

Abstract

Patients with obesity often fail to control their body weight through diet and physical activity, while the existing anti-obesity drugs have some side effects for long-term use. Banana is Indonesia's tropical fruits with the highest production, and the banana peel has become soil waste. This study aimed to analyze nutrients and active compounds of methanol extracts of raja and kepok banana peels (ERP and EKP respectively). Macro and micro-nutrient compositions of the ERP and EKP were determined using the proximate analysis, while Thin Layer Chromatography (TLC) was used to detect the ERP and EKP active compounds. The ERP contained 0.11% crude fibers, 4.44% fat, and 58.08% carbohydrates, different from the EKP (4.25% protein, 20.95% water, and 14.45% minerals). By contrast, both the ERP and EKP contained flavonoids, phenols, tannins, alkaloids, and saponins. In conclusion, ERP is potentially developed as a nutraceutical for obesity treatment in the future. Further study is needed to measure specific fat levels and to analyze specific active compounds in the ERP which can modulate gene expression and interact with protein targets in lipid metabolism.
Nutritional Analysis of Aqueous Extract of Snake Fruit Seeds (Salacca Edulis Reinw) for Development of Anemia Treatment Hani Fara Ayu Febyawati; Dono Indarto; Selfi Handayani
Proceedings of the International Conference on Nursing and Health Sciences Vol 4 No 1 (2023): January-June 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v4i1.1818

Abstract

Anemia remains a global nutritional problem, which prevalence continues to increase every year. Children, female adolescents, and pregnant women are more susceptible to anemia than other age groups. Prolonged anemia has negative impacts on their life such as premature birth, low birth weight (LBW) babies and intrauterine fetal death. Snake fruit Pondoh (Salacca edulis Reinw) is an original Indonesian fruit, which is well cultivated at the Sleman regency, Yogyakarta. Snake fruit seeds contribute to 25-30% of the total fruit, which has not been established their health effect. Therefore, this study aims to analyze the nutritional content of aqueous extract of snake fruit seeds (AES). The powder of snake fruit seeds was made using a previous method, which was adopted from our research group. The powder was then extracted using hot aqueous with 65°C. A proximate analysis was used to determine the AES nutritional content. A hundred g AES contained 21.92% water, 41.10% carbohydrates, 12.66% protein, 4.51% fat, 0.62% tannins, 32.8 mg Iron, 10.25 mg zinc, 276.42 mg magnesium, and 495.48 mg vitamin C. In conclusion, the AES has complete macronutrients and contains high levels of Iron, Magnesium, and vitamin C, which becomes a potential nutraceutical for anemia treatment. Further research is required to confirm the beneficial effect of AES administration in female rats with anemia.
The Comparative Effect Between Pellets and Porridge Made from Local Ingredients on Body Weight of Rats with Protein-Energy Deficiency Dandi Sanjaya; Dono Indarto; Ida Nurwati
Proceedings of the International Conference on Nursing and Health Sciences Vol 4 No 1 (2023): January-June 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v4i1.1819

Abstract

Protein-energy deficiency (PED) is a major infant health problem in developing countries with high mortality rate. Inadequate food intake and infectious diseases are the main factors for PED. In clinical setting, branded foods are commonly used to treat the PED but these foods are expensive. Canna (Canna edulis Ker.), catfish (Pangasius sp.), and red beans (Phaseolus vulgaris) are easily found in Indonesia and rich carbohydrates and protein. Therefore, this study aimed to compare the effect between pellets and porridge from canna, catfish, and red beans (GANIME) on the body weight (BW) of rats with PED.Ten male wistar rats, which aged 3 weeks and weighed 50-100 g, were used in this in vivo study. The rats model with PED was made by using the existing method through 40-60% gradual feed restriction for 14 days. Selected rats were randomly divided into 2 groups: G1 was given GANIME pellets and G2 was given GANIME porridge for 14 days. The rat BW each group routinely weighed every 7 days.The average BW of G1 rats was 78,00 ± 15,52 g, which was not significant different from the average BW of G2 rats was 70,50 ± 2,12 g (p= 0,64). In group G1 there was a greater increase than in group G2, namely 12.67 grams.Administration of GANIME pellets increases more body weight in rats with PED, compared to administration of GANIME porridge.
Co-Authors Ardianti Wahyuni Ayusari, Amelya Augusthina Balgis . Bambang Purwanto Dandi Sanjaya Didik Gunawan Tamtomo Diffah Hanim Dina Okfina Ria Dwi Rahayu Farchan Azzumar Fera Widyanti Ghina Widiasih Hani Fara Ayu Febyawati Hastami, Yunia Heru Sulastomo Ida Nurwati Isti Sundari Jatmiko Susilo Jatu Aphridasari Jusup, Sinu Andhi Kezia Elian Devina Kusnandar Kusnandar Lilik Wijayanti M Rizal Permadi Mashuri, Yusuf Ari Muchsin Doewes Niniek Purwaningtyas Paramasari Dirgahayu Ratna Kusumawati Reviono Reviono Selfi Handayani Setyo Sri Rahardjo Shofura Azizah Siswanta Jaka Purnama Sri Wulandari Suradi Suradi Tri Nugraha Susilawati Winda Rizki Pebrina Batubara Yatty Destani Sandy Yuliana Heri Suselo