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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Biologi Tropis Jurnal Sehat Mandiri Innovative: Journal Of Social Science Research
Dia Septiani
Universitas Singaperbangsa Karawang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Other

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Formulasi Dan Pengujian Nilai Spf Losion Ekstrak Etanol Batang Cendana (Santalum Album L.) Devi Ratnasari; Dia Septiani; Dinda Shafira Rahmawati
Innovative: Journal Of Social Science Research Vol. 3 No. 4 (2023): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v3i4.4542

Abstract

Di Indonesia, cendana (Santalum album L.) adalah tumbuhan yang terkenal dengan banyak manfaat. Salah satu manfaatnya adalah sebagai antioksidan alami yang melindungi kulit dari paparan sinar ultraviolet dan radikal bebas yang merusak kulit. Fokus penelitian ini adalah untuk mengevaluasi potensi Cendana sebagai bahan dalam tabir surya, yang dapat diukur dengan nilai Sun Protection Factor (SPF). Penelitian melibatkan ekstraksi etanol dari batang Cendana menggunakan metode Soxhlet. Hasil penelitian menunjukkan bahwa kandungan flavonoid, fenol, dan terpenoid dalam ekstrak batang cendana menunjukkan tingkat antioksidan yang kuat, dengan nilai IC50 sebesar 89,05 ppm. Berikutnya, empat formulasi losion tabir surya (F0, F1, F2, dan F3) disiapkan dan diuji menggunakan spektrofotometer UV-Vis untuk menentukan nilai SPF-nya. Hasil penelitian mengungkap bahwa losion tabir surya dengan ekstrak batang Cendana menunjukkan tingkat efektivitas yang tergolong rendah, walaupun rendemen ekstrak mencapai 2%. Secara keseluruhan, dapat disimpulkan bahwa Cendana memiliki potensi sebagai bahan tabir surya, meskipun efektivitasnya relatif rendah.
Enzyme-assisted extraction (EAE): efficient and effective green extraction on turmerik (Curcuma longa L.) and temulawak (Curcuma xanthorriza Roxb.) rhizomes for higher yield and content of curcumin Dia Septiani; Marsah Rahmawati Utami; Mally Ghinan Sholih; Tiara Nurayuni; Syifa Khairunnisa
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.29314

Abstract

Curcumin, as the main active compound in Zingiberaceae plants, turmeric and temulawak, with various health benefits. That active compound generally exists in low concentrations, thus an effective and efficient method is needed to extract these compounds, such as Enzyme Assisted Extraction (EAE), one of which involves cellulase enzyme. This study aims to use the Enzyme Assisted-Extraction (EAE) method with cellulase enzyme in the extraction of curcumin from turmeric and temulawak plants, and to evaluate the extraction yield and efficiency of extract, comparing the curcumin content in turmeric and temulawak extracts between EAE and conventional maceration extraction method. The research was conducted using a Randomized Block Design (RBD) experiment with variations in temperature (45°, 50°, 55℃), time (1 hour, 2 hours, 3 hours), and enzyme concentration of 6%. The research stages included determining the water and ash content in the raw materials, water content in the extracts, extraction using maceration and EAE methods, determination of extract yield, extract purification, phenol screening, analysis of curcumin content using UV-Vis Spectrophotometry, and statistical analysis using the Mann-Whitney test. The results showed that the use of cellulase enzyme in the extraction process of turmeric and temulawak successfully increased the extract yield and curcumin content. The highest yield was obtained in turmeric at 34.24%± 0.038, and the highest curcumin content was achieved at a temperature of 45˚C for 2 hours, reaching 56.86% ± 0.090. Meanwhile, in temulawak, the highest yield was 53.11%± 0.385, and the highest curcumin content was obtained at a temperature of 50˚C for 2 hours, reaching 54.10% ± 0.100. There was an increase in curcumin content in turmeric and temulawak EAE extract compared to the conventional maceration extraction method. Statistical analysis using the Mann-Whitney test (p < 0.05,) indicating a significant difference between the EAE and conventional maceration extraction method.
Efektivitas Ekstrak Stevia (Stevia Rebaudiana) dalam Menurunkan Kadar Glukosa Darah: Suatu Tinjauan Literatur Okta Piola; Dia Septiani
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1743

Abstract

Diabetes Mellitus (DM) is a chronic disease with a steadily increasing global prevalence, creating an urgent need for effective blood glucose management strategies. One potential alternative is stevia (Stevia rebaudiana) leaf extract, which contains the main components stevioside and rebaudioside. This review aims to evaluate the effectiveness of stevia as an antidiabetic agent based on current literature analysis. Data were obtained through searches on Google Scholar and PubMed using inclusion criteria: original articles, published within the last 10 years, and focusing on the antidiabetic effects of stevia. The results indicate that stevia extract significantly reduces blood glucose levels, improves insulin sensitivity, and exhibits antioxidant properties through mechanisms involving genetic regulation, enhanced enzymatic activity, and reduced inflammation. In conclusion, stevia shows potential as a natural sweetener as well as a complementary therapy in diabetes management, offering additional benefits for lipid profile improvement and cardiovascular protection with minimal side effects. To ensure its long-term safety and efficacy, further human clinical trials with adequate design, extended follow-up periods, and the development of innovative formulations such as nano-stevia are recommended to enhance bioavailability.
Comparison of the Antibacterial Effectiveness of Kersen Leaf Extract and Cassava Leaf Extract Against Escherichia coli and Staphylococcus aureus: A Literature Review Muhammad Rofif Albukhori; Dia Septiani; Hilmah Ayu Mardhiyya
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.13009

Abstract

Staphylococcus aureus and Escherichia coli are among the most common bacterial pathogens responsible for various infectious diseases, prompting the search for alternative antibacterial agents from medicinal plants. Cassava (Manihot esculenta Crantz) and cherry (Muntingia calabura L.) leaves contain bioactive compounds, including flavonoids, tannins, and saponins, that exhibit antibacterial properties. This study aimed to compare the antibacterial effectiveness of cassava and cherry leaf extracts against S. aureus and E. coli through a systematic literature review. Articles were retrieved from the Google Scholar and PubMed databases following predefined inclusion and exclusion criteria. Of the 1,072 records identified, 12 eligible studies were included in the final synthesis. The reviewed studies consistently demonstrated that both plant extracts inhibited the growth of S. aureus and E. coli. However, cherry leaf extract generally exhibited stronger and more consistent antibacterial activity than cassava leaf extract, both as crude extracts and in topical formulations. The superior activity of cherry leaves was associated with their higher abundance of antibacterial phytochemicals and broader inhibitory spectrum. These findings suggest that cherry leaf extract has greater potential as a natural antibacterial agent, although further in vivo studies and clinical evaluations are required to confirm its efficacy and safety for therapeutic applications.
Comparison of Antioxidant Effectiveness of Papaya Leaf Extract and Bidara Leaf Extract Using the DPPH Method: A Literature Review Hilmah Ayu Mardhiyya; Dia Septiani; Muhammad Rofif Albukhori
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.13010

Abstract

Natural antioxidants have gained increasing attention as safer alternatives to synthetic antioxidants for preventing oxidative stress caused by free radicals. Papaya (Carica papaya L.) and bidara (Ziziphus sp.) leaves are rich in bioactive compounds, including flavonoids, phenolics, vitamin C, and vitamin E, which exhibit antioxidant properties. This study aimed to compare the antioxidant activity of papaya and bidara leaf extracts based on evidence from published studies using the DPPH assay. A systematic literature review was conducted by searching the Google Scholar and PubMed databases using predefined keywords and inclusion criteria. A total of 989 records were identified, and 13 eligible articles were included in the final synthesis. The reviewed studies consistently demonstrated that papaya leaf extract exhibited very strong antioxidant activity, particularly in topical formulations such as creams and emulgels, with lower IC₅₀ values indicating greater free-radical scavenging capacity. In contrast, bidara leaf extract showed moderate to strong antioxidant activity, with IC₅₀ values ranging from 90 to 263 ppm, depending on the extraction solvent and method employed. Overall, papaya leaf extract demonstrated a stronger and more consistent antioxidant profile than bidara leaf extract. These findings suggest that papaya leaves have greater potential as a natural antioxidant source, while further in vivo and clinical studies are needed to validate their therapeutic applications.
Co-Authors Devi Ratnasari Dinda Shafira Rahmawati Hilmah Ayu Mardhiyya Hilmah Ayu Mardhiyya Mally Ghinan Sholih Marsah Rahmawati Utami Muhammad Rofif Albukhori Muhammad Rofif Albukhori Okta Piola Syifa Khairunnisa Tiara Nurayuni