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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Sehat Mandiri Innovative: Journal Of Social Science Research
Dia Septiani
Universitas Singaperbangsa Karawang
Humanities Computer Science & IT Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Other

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Formulasi Dan Pengujian Nilai Spf Losion Ekstrak Etanol Batang Cendana (Santalum Album L.) Devi Ratnasari; Dia Septiani; Dinda Shafira Rahmawati
Innovative: Journal Of Social Science Research Vol. 3 No. 4 (2023): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v3i4.4542

Abstract

Di Indonesia, cendana (Santalum album L.) adalah tumbuhan yang terkenal dengan banyak manfaat. Salah satu manfaatnya adalah sebagai antioksidan alami yang melindungi kulit dari paparan sinar ultraviolet dan radikal bebas yang merusak kulit. Fokus penelitian ini adalah untuk mengevaluasi potensi Cendana sebagai bahan dalam tabir surya, yang dapat diukur dengan nilai Sun Protection Factor (SPF). Penelitian melibatkan ekstraksi etanol dari batang Cendana menggunakan metode Soxhlet. Hasil penelitian menunjukkan bahwa kandungan flavonoid, fenol, dan terpenoid dalam ekstrak batang cendana menunjukkan tingkat antioksidan yang kuat, dengan nilai IC50 sebesar 89,05 ppm. Berikutnya, empat formulasi losion tabir surya (F0, F1, F2, dan F3) disiapkan dan diuji menggunakan spektrofotometer UV-Vis untuk menentukan nilai SPF-nya. Hasil penelitian mengungkap bahwa losion tabir surya dengan ekstrak batang Cendana menunjukkan tingkat efektivitas yang tergolong rendah, walaupun rendemen ekstrak mencapai 2%. Secara keseluruhan, dapat disimpulkan bahwa Cendana memiliki potensi sebagai bahan tabir surya, meskipun efektivitasnya relatif rendah.
Enzyme-assisted extraction (EAE): efficient and effective green extraction on turmerik (Curcuma longa L.) and temulawak (Curcuma xanthorriza Roxb.) rhizomes for higher yield and content of curcumin Dia Septiani; Marsah Rahmawati Utami; Mally Ghinan Sholih; Tiara Nurayuni; Syifa Khairunnisa
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.29314

Abstract

Curcumin, as the main active compound in Zingiberaceae plants, turmeric and temulawak, with various health benefits. That active compound generally exists in low concentrations, thus an effective and efficient method is needed to extract these compounds, such as Enzyme Assisted Extraction (EAE), one of which involves cellulase enzyme. This study aims to use the Enzyme Assisted-Extraction (EAE) method with cellulase enzyme in the extraction of curcumin from turmeric and temulawak plants, and to evaluate the extraction yield and efficiency of extract, comparing the curcumin content in turmeric and temulawak extracts between EAE and conventional maceration extraction method. The research was conducted using a Randomized Block Design (RBD) experiment with variations in temperature (45°, 50°, 55℃), time (1 hour, 2 hours, 3 hours), and enzyme concentration of 6%. The research stages included determining the water and ash content in the raw materials, water content in the extracts, extraction using maceration and EAE methods, determination of extract yield, extract purification, phenol screening, analysis of curcumin content using UV-Vis Spectrophotometry, and statistical analysis using the Mann-Whitney test. The results showed that the use of cellulase enzyme in the extraction process of turmeric and temulawak successfully increased the extract yield and curcumin content. The highest yield was obtained in turmeric at 34.24%± 0.038, and the highest curcumin content was achieved at a temperature of 45˚C for 2 hours, reaching 56.86% ± 0.090. Meanwhile, in temulawak, the highest yield was 53.11%± 0.385, and the highest curcumin content was obtained at a temperature of 50˚C for 2 hours, reaching 54.10% ± 0.100. There was an increase in curcumin content in turmeric and temulawak EAE extract compared to the conventional maceration extraction method. Statistical analysis using the Mann-Whitney test (p < 0.05,) indicating a significant difference between the EAE and conventional maceration extraction method.
Efektivitas Ekstrak Stevia (Stevia Rebaudiana) dalam Menurunkan Kadar Glukosa Darah: Suatu Tinjauan Literatur Okta Piola; Dia Septiani
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1743

Abstract

Diabetes Mellitus (DM) is a chronic disease with a steadily increasing global prevalence, creating an urgent need for effective blood glucose management strategies. One potential alternative is stevia (Stevia rebaudiana) leaf extract, which contains the main components stevioside and rebaudioside. This review aims to evaluate the effectiveness of stevia as an antidiabetic agent based on current literature analysis. Data were obtained through searches on Google Scholar and PubMed using inclusion criteria: original articles, published within the last 10 years, and focusing on the antidiabetic effects of stevia. The results indicate that stevia extract significantly reduces blood glucose levels, improves insulin sensitivity, and exhibits antioxidant properties through mechanisms involving genetic regulation, enhanced enzymatic activity, and reduced inflammation. In conclusion, stevia shows potential as a natural sweetener as well as a complementary therapy in diabetes management, offering additional benefits for lipid profile improvement and cardiovascular protection with minimal side effects. To ensure its long-term safety and efficacy, further human clinical trials with adequate design, extended follow-up periods, and the development of innovative formulations such as nano-stevia are recommended to enhance bioavailability.
Co-Authors Devi Ratnasari Dinda Shafira Rahmawati Mally Ghinan Sholih Marsah Rahmawati Utami Okta Piola Syifa Khairunnisa Tiara Nurayuni