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All Journal Jurnal Ners Journal of Pharmaceutical and Sciences.
Yulia Kristyanti
universitas citra bangsa
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Uji efektivitas permen jelly ekstrak serai wangi (Cymbopogon nardus L.) terhadap pertumbuhan jamur Candida albicans Yulia Kristyanti; Yahya Febrianto; Evanisia More
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.54319

Abstract

Sariawan adalah suatu lesi atau luka kecil yang dimulai dengan sensasi terbakar atau menyengat di bagian rongga mulut seperti di dalam pipi, lidah maupun bibir. Penyebab sariawan bervariasi mulai dari pengaruh lingkungan, trauma, inflamasi, neuroplastik, degeneratif atau kongenital hingga infeksi bakteri, virus atau jamur. Infeksi jamur yang sering dijumpai adalah infeksi jamur Candida albicans. Candida albicans merupakan flora normal tubuh manusia yang sering dijumpai pada area rongga mulut dalam jumlah kecil, dan biasanya tidak menimbulkan masalah namun dlam kondisi tertentu jumur dapat tumbuh dalam optimal. Salah satu tanaman dengan potensi herbal yang tinggi dan mudah ditemukan di Indonesia adalah tanaman serai wangi. Kandungan kimia dalam tanaman sereh yang dapat menghambat pertumbuhan jamur Candida albicans yaitu saponin, flavonoid dan tanin. Tujuan penelitian ini untuk mengetahui formulasi yang optimal dari permen jelly ekstrak serai wangi (Cymbopogon nardus L.) 20%, 25%, atau 30% dalam menghambat pertumbuhan jamur Candida albicans penyebab sariawan. Metode penelitian ini adalah metode eksperimental yang terdiri dari empat kelompok uji. Penentuan aktivitas antijamur menggunakan metode difusi cakram dengan melihat adanya zona bening disekitar cakram. Hasil penelitian menuunjukkan sediaan permen jelly ekstrak serai wangi memiliki sifat fisik sediaan yang baik. Sediaan dengan konsentrasi 20%, 25%, 30% mampu menghambat pertumbuhan jamur Candida albicans dengan diameter rata-rata zona hambat sebesar 6.5 mm, 9.5 mm dan 12.66 mm. Konsentrasi yang paling optimal menghambat pertumbuhan jamur Candida albicans adalah 30%.
Uji Efektivitas Gel Ekstrak Buah Tomat (Solanum lycopersicum L.) Terhadap Staphylococcus aureus Yulia Kristyanti; Evanisia More
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1489

Abstract

Acne is an inflammatory condition of the sebaceous layer accompanied by blockage and accumulation of keratin, characterized by the appearance of blackheads, papules, pustules, nodules, and cysts, which are considered to damage appearance. In addressing this condition, people tend to use natural remedies because they have fewer side effects. One of the natural ingredients that is often used is tomatoes (Solanum lycopersicum L.). Tomatoes contain many components, including flavonoids, alkaloids, and saponins, which act as antibacterial agents. The purpose of this research is to determine the effectiveness of tomato fruit extract gel as an antibacterial and the most optimal dosage of the tomato fruit extract gel. The method used in this research is the evaluation of the antibacterial ability of tomato fruit extract gel based on organoleptic physical properties, homogeneity, pH, adhesion, spreadability, viscosity, and antibacterial testing of Staphylococcus aureus using the well diffusion method on Mueller Hinton Agar medium. Based on the results of One-Way ANOVA This study shows that 75%, 85%, 95%, and the control (+) tomato fruit extract gel have antibacterial activity. Formula I, with a gel extract concentration of 75%, has an inhibition zone of 18.02 mm, and Formula II, with a gel extract concentration of 85%, has an inhibition zone of 20.84 mm. Both formulas do not have a significant difference. Meanwhile, the gel Formula III with a 95% extract concentration has greater antibacterial activity, measuring 26.65 mm, which is the same as the control (+) or shows no significant difference p>0.05. The most effective dose as an antibacterial is the gel extract of tomato fruit (Solanum lycopersicum L.) with a concentration of 95%, with an inhibition diameter of 26.65 mm, categorized as very strong in inhibiting bacterial growth. Meanwhile, the 75% and 85% concentrations with inhibition diameters of 18.02 mm and 20.84 mm fall into the strong inhibition.
Co-Authors Evanisia More Novi Winda Lutsina Yahya Febrianto