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Korelasi Kadar Plasminogen Activator Inhibitor-1 (PAI-1) Plasma dengan Enzim Transaminase Serum pada Demam Berdarah Dengue Budi Santosa; Kisdjamiatun RMD; Tatty Ermin; Ni Putu Aniek Mahayani
Sari Pediatri Vol 12, No 1 (2010)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp12.1.2010.6-10

Abstract

Latar belakang. Plasminogen activator inhibitor-1 (PAI-1) adalah inhibitor fibrinolisis yang berperan padapatogenesis demam berdarah dengue (DBD). Peningkatan PAI-1 akan menyebabkan peningkatan statusprokoagulasi yang menyebabkan terbentuknya mikrotrombi dan menyebabkan gagal multi organ dan kematian.Serum SGOT dan SGPT digunakan sebagai penanda kerusakan hepatoselular. Peningkatan kadar keduapenanda ini dapat menjadi indikator keparahan penyakit DBD.Tujuan. Mengetahui korelasi antara PAI-1 plasma terhadap SGOT dan SGPT serumMetode. Penelitian observasional analitik dengan cross sectional time series. Subjek adalah pasien DBD yangdirawat di bangsal anak RSUP Dr. Karyadi selama bulan Juli 2005 –Juli 2006, berusia 3-14 tahun yangbersedia berpartisipasi secara tertulis. Dilakukan pemeriksaan kadar PAI-1 dan SGOT, SGPT pada hari ke0 dan 2, di Lab Patologi Klinik RSDK menggunakan alat Dade Behring seri Dimension RXL. Dilakukanuji korelasi Spearman untuk mengetahui hubungan PAI-1 dengan SGOT dan SGPTHasil. Jumlah subjek penelitian 49 orang. Sebagian besar berjenis kelamin perempuan dengan rerata umur(7,3±2,7) tahun, rerata kadar PAI-1 hari 0 (98,8±142,60 ng/ml) lebih tinggi daripada hari ke 2 (55,1±29,59ng/ml) ; p=0,001. Kadar SGOT hari ke 0 (173,3 ± 159,11) U/L lebih tinggi daripada hari ke 2 (132,3 ±110,78) U/L p<0, sedangkan serum SGPT hari ke 2 (72,4 ± 68,92 U/L) lebih tinggi daripada hari ke 0(65,1 ± 49,35 U/L) p=0,8 .Uji korelasi kadar PAI-1 dengan serum SGOT dan SGPT hari ke 0 (r=0,33,p=0,02)dan (0,49 p<0,001); hari ke 2 (r=0,30 p=0,03) dan (r=0,35, p=0,01)Kesimpulan. Terdapat korelasi positif derajat lemah antara kadar PAI-1 plasma dengan kadar SGOT danSGPT serum pada pemeriksaan hari ke-0 dan ke-2. (
PENYULUHAN ASI EKSKLUSIF DALAM RANGKA MENINGKATKAN PENGETAHUAN IBU DAN PELAKSANAAN ASI EKSKLUSIF DALAM RANGKA MENURUNKAN ANGKA KEJADIAN INFEKSI DAN ANGKA KEMATIAN BAYI DI RUANG BAYI SEHAT RUMAH SAKIT UMUM DAERAH TABANAN Ni Putu Aniek Mahayani; Sri Utami
JURNAL SEWAKA BHAKTI Vol 8 No 1 (2022): Sewaka Bhakti
Publisher : UNHI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/jsb.v8i1.2234

Abstract

Breast milk (ASI) is a liquid that comes out of a mother’s breast who has just given birth which is specially created for her baby. Exclusive breast milk (ASI) is breastfeeding the baby for 6 months without any additional fluids except drugs. There are some factors that affect the success of exclusive breastfeeding both internal and external factors of the mother, also influenceable and non-influenceable factors. Mother’s internal factors are nutritional status, education level, and age, as for external factors consist of the influence of the mass media, knowledge of exclusive breastfeeding, and whether there is guidance from health workers. the mother's knowledge factor plays a major role in a success breast-feed. Mothers who have sufficient knowledge about the benefits of breastfeeding will feel more convinced and confident to exclusively breastfeed their babies. This PKM activity aims to increase mother's knowledge about breastfeeding and the benefits of exclusive breastfeeding. The activity begins with socialization to mothers who has given birth, and pregnant women who carry out the pregnancy control to the obstetrics poly, implementation and evaluation of activities in the form of pretest and posttest. From the results of PKM activities, it is found that there are 85% increase of mother's knowledge about breastfeeding and the benefits of exclusive breastfeeding. The activity outcome of exclusive breastfeeding is 60% after 6 months evaluation.
Karakteristik Penderita Kusta di Kabupatjen Tabanan Periode Tahun 2016 Sampai dengan Tahun 2021 Amukty, I Nyoman Fidry Octora Young; Mahayani, Ni Putu Aniek; Puspasari, Ni Made Indah
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i9.16105

Abstract

Berdasarkan WHO pada tahun 2016 terdapat 200.000 kasus baru. Prevalensi kusta di Indonesia pada tahun 2017 sebesar 0,7 kasus per 10.000 dengan kasus baru sebesar 6,08 per 100.000 dan Bali di tahun yang sama Bali terlapor 70 kasus baru. Kabupaten Tabanan memiliki laporan 2 kasus baru dengan angka temuas sebesar 0.0446 kasus per 100.000 penduduk. Penelitian ini bertujuan untuk mendeskripsikan penderita kusta dan melibatkan seluruh data sekunder di kabupaten Tabanan. Penelitian ini merupakan studi retrospektif dengan 31 pasien dari seluruh faskes di Tabanan tahun 2016 sampai dengan tahun 2021. Hasil dari studi di dominasi oleh laki – laki (67,74%) dan kelompok usia dewasa awal (35.48%). Tipe kusta yang paling umum adalah tipe multi basiler (MB) (83,87%) dan eritema nodosum leprosum (ENL) sebagai reaksi kusta terbanyak (66,67%). Lama pengobatan pasien dengan kusta di dapatkan pada rentang 6 sampai 12 bulan (59,26%). Kasus kusta di Indonesia di derita terbanyak oleh laki – laki dewasa awal. Tipe kusta terbanyak ada MB dengan reaksi kusta tipe ENL sebagai reaksi tersering. Rata – rata pasien dengan kusta berobat selama 6 sampai 12 bulan.
Hubungan Vaksinasi Rotavirus Pentavalent dengan Kejadian Diare pada Anak Usia 6-24 Bulan di Denpasar I Made Dwiky Vinandyanata; Ni Putu Aniek Mahayani; Anak Agung Ayu Lila Paramasatiari
Aesculapius Medical Journal Vol 1 No 1 (2021): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.1.1.2021.20-26

Abstract

Abstrak Diare adalah penyakit yang banyak menimpa serta menjadi sebab kematian kedua tertinggi secara global pada anak yang berumur < 5 tahun. Prevalensi diare pada balita di Indonesia terus meningkat tiap tahunnya. Kota Denpasar adalah kabupaten dengan kasus diare tertinggi kedua di Provinsi Bali. Infeksi rotavirus menjadi sebab diare banyak menjangkiti bayi dan anak-anak di Indonesia bahkan dunia. WHO memiliki 7 poin pedoman yang paling efektif untuk mencegah diare pada anak, salah satunya adalah pemberian vaksin rotavirus. Maksud kajian ini ialah guna memahami kaitan vaksinasi rotavirus pentavalent terhadap kasus diare anak umur 6-24 bulan di Kota Denpasar. Kajian ini merupakan observasional analitik melalui desain penelitian case control. Peserta penelitian dipilih mempergunakan teknik consecutive sampling dengan jumlah 72 anak berusia 24-36 bulan yang datang ke praktik dokter spesialis anak wilayah Denpasar. Data penelitian didapatkan menggunakan instrumen kuesioner yang berikutnya akan dianalisis menggunakan aplikasi SPSS memakai uji chi-square dan regresi logistik. Kajian ini memperlihatkan pada kelompok yang tidak mengalami kejadian diare sebagian besar mendapatkan vaksin rotavirus pentavalent (66,7%). Pada uji chi-square diketahui bahwa adanya kaitan yang bermakna antara vaksinasi rotavirus pentavalent dengan kejadian diare dan vaksin rotavirus pentavalent mempunyai dampak protektif pada kasus diare anak (OR = 0,318, IK 95% = 0,121-0,843, dan nilai p = 0,018). Kata kunci: anak, diare, rotavirus, vaksin, pentavalent Abstract Diarrhea is a disease that afflicts many and is the second leading cause of death globally in children aged < 5 years. The prevalence of diarrhea in children under five in Indonesia continues to increase every year. Denpasar City is the district with the second highest diarrhea case in Bali Province. Rotavirus infection is the cause of diarrhea in many infants and children in Indonesia and even the world. WHO has 7 points of the most effective guidelines for preventing diarrhea in children, one of which is the provision of rotavirus vaccine. The purpose of this study is to understand the relationship between pentavalent rotavirus vaccination on cases of diarrhea in children aged 6-24 months in Denpasar City. This study is an analytic observational through case control research design. The study participants were selected using a consecutive sampling technique with a total of 72 children aged 24-36 months who came to the pediatrician's practice in the Denpasar area. Research data obtained using a questionnaire instrument which will then be analyzed using the SPSS application through chi-square test and logistic regression. The results of this study showed that in the group that did not experience diarrhea, most of them received pentavalent rotavirus vaccine (66.7%). In the chi-square test, it was found that there was a significant association between pentavalent rotavirus vaccination and the incidence of diarrhea and the pentavalent rotavirus vaccine had a protective effect on pediatric diarrhea cases (OR = 0.318, 95% CI = 0.121-0.843, and p value = 0.018). Keywords: children, diarrhea, rotavirus, vaccine, pentavalent
Hubungan Kadar Trombosit, Hematokrit, dan Hemoglobin dengan Derajat Demam Berdarah Dengue pada Pasien Anak yang Rawat Inap di BRSU Tabanan Ni Made Dwinda Handayani; Desak Putu Citra Udiyani; Ni Putu Aniek Mahayani
Aesculapius Medical Journal Vol 2 No 2 (2022): Agustus
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.2.2.2022.130 - 136

Abstract

Dengue Hemorrhagic Fever (DHF) is the top ten causes of hospitalization in pediatrics. Indonesia is a country with the highest dengue cases in Southeast Asia and Bali is among the top five highest dengue cases in Indonesia. Tabanan Regency is the district with the highest Case Fatality Rate (CFR) in Bali, which is 0.6%. Early and accurate diagnosis can determine the patient's prognosis, but the WHO classification of DHF has not been able to provide a definite value for the degree of DHF based on the results of an examination of platelets, hematocrit, and hemoglobin. The existence of a definite value from the examination of platelets, hematocrit, and hemoglobin for each degree of DHF is expected to determine the prognosis of DHF. This type of research is an analytical research method with cross-sectional study design. The data collection method used secondary data from medical records. The research sample was all DHF pediatric patients aged 0-18 years at BRSU Tabanan who met the inclusion and exclusion criteria obtained using a consecutive sampling technique with a total sample of 84 children. Data analyses are univariate and bivariate. The results of this study showed that there was a significant relationship between platelet levels and the degree of DHF (p = 0.023 and r = 0.248), there was a significant relationship between hematocrit levels and the degree of DHF (p = 0.045 and r = 0.219), and there was no significant relationship between hemoglobin values. with the degree of DHF (p=0.073 and r=0.196).
Hubungan BBLR dengan Stunting pada Anak Usia 2-5 Tahun di Desa Sidan Gianyar Tahun 2019 Putu Kania Ayu Kirana; Ni Putu Aniek Mahayani; Anak Agung Gede Indraningrat
Aesculapius Medical Journal Vol 3 No 3 (2023): October
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.3.3.2023.409-413

Abstract

Stunting is a condition that fails to grow in children under five so that the child becomes too short for his age. The standard stunting measurement is based on the body length index compared to age (PB / U) or height compared to age (TB / U) with a limit (z-score) less than -2 SD from the WHO child growth nutritional status table. Stunting events are influenced by several factors, one of which is Low Birth Weight (LBW). The purpose of this study was to find out if there is a LBW relationship with stunting events in children aged 2-5 years in Sidan Village of Health Center Gianyar I Working Area in 2019. This study is a analitic study with a case control approach. The sample in this study was all children aged 2-5 years in sidan village. This research sampling technique is a total sampling with a sample number of 58 respondents who meet the criteria of inclusion and exclusion. Data collection using observation sheets and mother and child health (KIA) books. Data analysis using the Chi-square test with α=0.05. In this study obtained the results: the frequency of stunting the most in the age range of 24-36 months as many as 12 children. Of the 58 children, there were 26 children with a history of LBW, including in the stunting group as many as 21 children and in the group of not stunting as many as 5 children. From this study, it was concluded that there is a historical relationship between LBW and stunting events in children aged 2-5 years in Sidan Village of Health Center Gianyar I Working Area in 2019 (p: 0.000; OR: 12,000; 95% CI: 3,569-44,488).