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All Journal Cermin Dunia Kedokteran ACTIVE: Journal of Physical Education, Sport, Health and Recreation Cermin Dunia Kedokteran
Subandi
Universitas Sebelas Maret
Health Professions Medicine & Pharmacology Public Health Other

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Efek Terapi Citicoline terhadap Pemulihan Kognitif dan Motorik Pasien Stroke Iskemik Akut dengan Polimorfisme ApoE4 rs429358 dan rs7412 Faizal Muhammad; Afifah Syifaul Ummah; Farida Aisyah; Rivan Danuaji; Subandi; Diah Kurnia Mirawati
Cermin Dunia Kedokteran Vol 50 No 11 (2023): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i11.1016

Abstract

Citicoline has a neuroprotectant effect, especially in mild-to-moderate stroke. The presence of the ε4 allele in the ApoE gene is associated with a severe acute ischemic stroke (AIS) phenotype, in addition to neurodegenerative risk This study aims to determine the effect of citicoline on cognitive and motoric recovery in severe AIS biomolecularly, such as ApoE4 rs429358 and rs7412 polymorphisms. A 64-year-old woman was diagnosed with AIS with a 6-hour onset and with a NIHSS score of 25 and MMSE score of 21. The patient’s AIS was biomolecularly severe as proven by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) ApoE4 which yielded 482 bp at rs429358 (codon 112) and 249 bp 167 bp at rs7412 (codon 158) on electrophoretic visualization. The patient received 3x 500 mg intravenous citicoline for 4 days followed by another 1000 mg of citicoline intravenous during polyclinic control for 5 consecutive days. On the 9th day, the patient experienced improvement in cognitive function with an MMSE score of 29 and superior (4/5) and inferior (5/5) motoric strength. Citicoline is a neuroprotectant agent that is beneficial for the recovery of cognitive and motoric function in biomolecularly severe SIA (ApoE4, C/C, Arg112/Arg158) because it can save the penumbra area from infarction.
Efek Terapi Citicoline terhadap Pemulihan Kognitif dan Motorik Pasien Stroke Iskemik Akut dengan Polimorfisme ApoE4 rs429358 dan rs7412 Faizal Muhammad; Afifah Syifaul Ummah; Farida Aisyah; Rivan Danuaji; Subandi; Diah Kurnia Mirawati
Cermin Dunia Kedokteran Vol 50 No 11 (2023): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i11.1016

Abstract

Citicoline has a neuroprotectant effect, especially in mild-to-moderate stroke. The presence of the ε4 allele in the ApoE gene is associated with a severe acute ischemic stroke (AIS) phenotype, in addition to neurodegenerative risk This study aims to determine the effect of citicoline on cognitive and motoric recovery in severe AIS biomolecularly, such as ApoE4 rs429358 and rs7412 polymorphisms. A 64-year-old woman was diagnosed with AIS with a 6-hour onset and with a NIHSS score of 25 and MMSE score of 21. The patient’s AIS was biomolecularly severe as proven by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) ApoE4 which yielded 482 bp at rs429358 (codon 112) and 249 bp 167 bp at rs7412 (codon 158) on electrophoretic visualization. The patient received 3x 500 mg intravenous citicoline for 4 days followed by another 1000 mg of citicoline intravenous during polyclinic control for 5 consecutive days. On the 9th day, the patient experienced improvement in cognitive function with an MMSE score of 29 and superior (4/5) and inferior (5/5) motoric strength. Citicoline is a neuroprotectant agent that is beneficial for the recovery of cognitive and motoric function in biomolecularly severe SIA (ApoE4, C/C, Arg112/Arg158) because it can save the penumbra area from infarction.
Exercise for Dysphagia Pasca Stroke : A Literature Review Annisa Fitri Dewi; Umi Budi Rahayu; Subandi
ACTIVE: Journal of Physical Education, Sport, Health and Recreation Vol. 14 No. 1 (2025)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/active.v14i1.22880

Abstract

Stroke causes many complications, one of which is dysphagia which is common after a stroke. Medical complications of dysphagia include the risk of aspiration pneumonia which results in increased hospitalization and morbidity. Several approaches to treating dysphagia can be taken including exercise therapy interventions. The aim of this study was to examine the effects of exercise for stroke patients with dysphagia. The method of this research was to look for studies related to exercise in post-stroke dysphagia and review them using an electronic database. Search for articles to review using the keywords “exercise”, “dysphagia”, and “stroke” and their combinations. The results of data extraction found a total of five pieces of literature which were thoroughly reviewed in the form of resistance training combined with kinesiology taping, group-based training, lingual strengthening exercise, Inspiratory and Expiratory Respiratory Muscle Training (IEMT), and McNeill Dysphagia Therapy Program (MDTP) exercises, showing that training for post-stroke dysphagia not only improves swallowing ability but can also improve mood, quality of life, and swallowing efficiency and reduce the cost of post-stroke dysphagia treatment. The conclusion of the review study was that in general exercise can overcome post-stroke dysphagia.
Co-Authors Afifah Syifaul Ummah Annisa Fitri Dewi Diah Kurnia Mirawati Faizal Muhammad Farida Aisyah Rivan Danuaji Umi Budi Rahayu