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All Journal SRIWIJAYA JOURNAL OF MEDICINE
Rita Khairani
Internal Medicine Department, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Importance of Exercise in Mitigating Age-Related Cardiac Apoptosis: English Mustika Anggiane Putri; Patwa Amani; Donna Adriani; Rita Khairani
Sriwijaya Journal of Medicine Vol. 6 No. 3 (2023): Vol 6, No. 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i3.208

Abstract

Aging causes a progressive decline in heart function. Loss of cardiomyocytes through programmed cell death or apoptosis is a critical factor contributing to this age-related damage. As we age, the heart undergoes structural changes, such as loss of cardiomyocytes, cardiomyocyte hypertrophy, and increased connective tissue with changes in heart geometry. It is widely known that mitochondria are vital sites of apoptosis. Mitochondrial-mediated apoptotic pathways are important regulators of apoptosis with aging. Mitochondrial dysfunction and oxidative stress also contribute to the cardiac remodeling and apoptosis associated with the aging process. On the other hand, exercise can improve heart function and reduce the risk of heart disease. Recent studies suggest that aging increases apoptotic signaling in the left ventricle. However, chronic exercise reduces this mitochondrial-mediated apoptotic signaling pathway in the aging heart. This review will describe the impacts of aging and exercise on cardiac apoptosis, highlighting the importance of exercise in reducing age-related cardiac apoptosis.
Co-Authors Donna Adriani Patwa Amani Putri, Mustika Anggiane