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All Journal Biomedical Journal of Indonesia
Nana Liana
Faculty of Medicine, Universitas Baiturrahmah, Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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The Role of Probiotics as An Adjuvant Therapy for Sepsis Against Multidrug-Resistant Bacteria Ruhsyahadati Ajisman; Rinita Amelia; Rahma Triyana; Roland Helmizar; Sri Nani Jelmila; Nana Liana; Dian Puspita; Letvi Mona
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.170

Abstract

The role of probiotics on sepsis, particularly when induced by multidrug-resistant (MDR) bacteria, is mediated through complex biochemical pathways. Probiotics demonstrate a capacity to effectively combat infections and reduce mortality rates in sepsis cases. A significant contributor to this efficacy is attributed to the short-chain fatty acids (SCFAs) produced by these probiotics. SCFAs play a critical role in modulating the immune system, primarily by influencing the production of inflammatory cytokines, fortifying the integrity of intestinal epithelium, preventing cellular apoptosis, and maintaining the balance of gut microbiota. Moreover, probiotics are instrumental in counteracting the detrimental impacts of excessive antibiotic use, which is a major contributing factor to the emergence of MDR bacterial strains. The integration of probiotics with conventional therapeutic approaches offers a viable and potentially effective strategy in the management of sepsis caused by MDR bacteria, suggesting a promising direction for future clinical interventions.
Co-Authors Dian Puspita Letvi Mona Rahma Triyana Rinita Amelia Roland Helmizar Ruhsyahadati Ajisman Sri Nani Jelmila