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All Journal Biomedical Journal of Indonesia Jurnal Ners Nusantara Hasana Journal AMMA : Jurnal Pengabdian Masyarakat
Roland Helmizar
Universitas Baiturrahmah
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing

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EFEKTIVITAS DOSIS MODIFIKASI SORAFENIB TERHADAP KESINTASAN PASIEN KARSINOMA SEL HATI STADIUM LANJUT: SUATU LAPORAN KASUS BERBASIS BUKTI Roland Helmizar
Nusantara Hasana Journal Vol. 2 No. 9 (2023): Nusantara Hasana Journal, February 2023
Publisher : Yayasan Nusantara Hasana Berdikari

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Abstract

Background: Sorafenib is a multi-tyrosine kinase inhibitor that has been shown to improve survival in patients with advanced stage hepatocellular carcinoma (HCC). Based on the search to date, there are quite number of studies evaluating the effectiveness and safety of sorafenib dose modification on the survival of patients with advanced HCC; however, the previous studies have showed varying results. Method: A comprehensive literature search was conducted using three electronic databases: PubMed, Cochrane and EBSCohost. Meta-analyses, randomized controlled trials (RCTs), and cohort studies were selected based on inclusion and exclusion criteria. The quality of selected studies was evaluated using critical appraisal tools developed by the Center for Evidence-Based Medicine. Results: Three cohort studies were included in this report. In general, of the three studies that have been reviewed, show that reducing the dose of sorafenib from 800 mg/day to 400 mg/day does not affect the mean or median survival of patients with advanced HCC. Conclusion: Administration of sorafenib with initial dose of 400 mg/day or decreasing the dose from 800 mg/day to 400 mg/day has good tolerance, with not significantly difference on overall survival. But more evidence is required before they can be widely recommended in clinical practice for this indication.
VARICOSE ULCERS OF THE LOWER LEGS Dessy Abdullah; Khomeini Khomeini; Adetetivani Adetetivani; Nadia Purnama Dewi; Roland Helmizar
Jurnal Ners Vol. 7 No. 1 (2023): APRIL 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v7i1.12793

Abstract

Disorders that are often found in the lower extremities are vascular disorders. Varicose veins are very common, especially in women due to venous insufficiency due to poor blood circulation such as reflux and obstructive and can be inherited. The chronic phase of varicose veins can manifest as venous ulcers which is the development of wound below the knee. The lesions appear irregular in shape with clear boundaries, these ulcers can be prevented as early as possible by treating the trigger factor first before referring to the chronic direction. Physical examination is a medical process that must be undertaken when diagnosing a disease. The results are recorded in the medical record which is used to make a diagnosis and plan further treatment. Physical examination will be carried out systematically, starting from head to toe which is carried out in four ways, namely inspection, palpation, auscultation, and percussion. Varicose ulcers are a manifestation of chronic venous insufficiency. Patients with varicose ulcers have a history of varicose veins which, if treated, prevent the occurrence of varicose ulcers.
The Role of Probiotics as An Adjuvant Therapy for Sepsis Against Multidrug-Resistant Bacteria Ruhsyahadati Ajisman; Rinita Amelia; Rahma Triyana; Roland Helmizar; Sri Nani Jelmila; Nana Liana; Dian Puspita; Letvi Mona
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.170

Abstract

The role of probiotics on sepsis, particularly when induced by multidrug-resistant (MDR) bacteria, is mediated through complex biochemical pathways. Probiotics demonstrate a capacity to effectively combat infections and reduce mortality rates in sepsis cases. A significant contributor to this efficacy is attributed to the short-chain fatty acids (SCFAs) produced by these probiotics. SCFAs play a critical role in modulating the immune system, primarily by influencing the production of inflammatory cytokines, fortifying the integrity of intestinal epithelium, preventing cellular apoptosis, and maintaining the balance of gut microbiota. Moreover, probiotics are instrumental in counteracting the detrimental impacts of excessive antibiotic use, which is a major contributing factor to the emergence of MDR bacterial strains. The integration of probiotics with conventional therapeutic approaches offers a viable and potentially effective strategy in the management of sepsis caused by MDR bacteria, suggesting a promising direction for future clinical interventions.
Pelayanan Kesehatan Bagi Masyarakat Dalam Rangka Kegiatan Pengabdian Kepada Masyarakat Rifkind Malik; Irma Primawati; Roland Helmizar; Annisa Lidra Maribeth; Yahdian Rasyadi; Relin Yesika
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 4 (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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The economy and education are important aspects of the community but the other most important is health because health can affect economy and social productivity. Health can be imbalanced due to a poor lifestyle, diet, and lack of physical activity which will trigger various non-communicable diseases. The aim of this service community is to provide understanding on disease, good diet and daily physical activity. The method used is leaflets, posters, and short lectures. The result of this service is that many respondents are elderly. With this service we hope that in the future the elderly can begin to increase their physical activity, consume healthy food and routine health checks to increase the quality of life.
GAMBARAN KLINIKOPATOLOGI KARSINOMA PAYUDARA DI RSUP DR. M. DJAMIL PADANG TAHUN 2023 Muhammad Rifki; Nana Liana; Irwan Triansyah; Roland Helmizar; Lismawati Lismawati; Desi Aliefia; Muhammad Rizki Saputra; Ruhsyahadati Ruhsyahadati; Rahma Triyana
Nusantara Hasana Journal Vol. 5 No. 12 (2026): Nusantara Hasana Journal, May 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i12.2046

Abstract

Background: Breast cancer is a malignancy originating from epithelial cells of the breast ducts or lobules. Clinicopathological characteristics are important in determining prognosis and treatment. Understanding these features is essential to support early detection and improve management strategies. Objective: This study aimed to describe the clinicopathological features of breast cancer patients at RSUP Dr. M. Djamil Padang in 2023. Methods: This descriptive observational study used a cross-sectional design with secondary data. A total of 114 samples were collected using the total sampling technique. Data were analyzed using univariate analysis with Statistical Product and Service Solution (SPSS) version 25. Results: Among 114 breast cancer patients, the most common age group was 35–44 years, accounting for 37 patients (32.5%). The predominant histopathological subtype was Mixed Infiltrating Duct NST with Lobular Carcinoma in 37 patients (32.5%). Histopathological grading was most commonly grade 2 in 79 patients (69.3%). Positive lymphovascular invasion was identified in 76 patients (66.7%). The most frequent molecular subtype was Luminal B, found in 51 patients (44.7%). Conclusion: Breast cancer was most prevalent in patients aged 35–44 years. The dominant histopathological subtype was Mixed Infiltrating Duct NST with Lobular Carcinoma, with grade 2 and positive lymphovascular invasion most frequently observed. Luminal B was the predominant molecular subtype. Increasing awareness of early detection through breast self-examination is recommended.
EDUKASI 10 PESAN GIZI SEIMBANG SEBAGAI UPAYA PENINGKATAN PENGETAHUAN MASYARAKAT DI PUSKESMAS KOTO PANJANG IKUA KOTO KOTA PADANG Muhammad Rizki Saputra; Bun Yurizali; Rahma Triyana; Ruhsyahadati Ruhsyahadati; Nana Liana; Rifkind Malik; Roland Helmizar; Suharni Suharni; Sri Wahyuni; Alif Dhuha
Nusantara Hasana Journal Vol. 6 No. 1 (2026): Nusantara Hasana Journal, June 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v6i1.2177

Abstract

Nutritional problems remain one of the major public health challenges in Indonesia. Limited public knowledge regarding healthy eating patterns can increase the risk of various health problems among both children and adults. This community service activity aimed to improve community knowledge regarding the 10 Messages of Balanced Nutrition through health education. The activity was conducted at Koto Panjang Ikua Koto Primary Health Center, Padang City, involving 45 participants consisting of fathers, mothers, and children. The methods used included educational presentations and interactive question-and-answer sessions. The results showed that participants were highly enthusiastic throughout the activity. The high level of participation during discussions indicated increased interest and awareness of the importance of implementing balanced nutrition principles. This educational intervention successfully enhanced participants’ understanding of diverse food consumption, physical activity, clean and healthy living behaviors, and regular nutritional status monitoring. This community service activity is expected to contribute to improving healthy lifestyle behaviors and the overall health quality of the community.
COMMUNITY-ACQUIRED PNEUMONIA OLEH KLEBSIELLA PNEUMONIAE DI RSUP DR. M. DJAMIL PADANG TAHUN 2024: GAMBARAN MORTALITAS TINGGI DAN TANTANGAN KLINIS Ruhsyahadati Ruhsyahadati; Nana Liana; Rahma Triyana; Dian Puspita; Muhammad Rizki Saputra; Roland Helmizar; Rifkind Malik; Aulia Akbar
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1859

Abstract

Community-acquired pneumonia (CAP) caused by Klebsiella pneumoniae is frequently associated with severe clinical courses and high mortality, particularly among elderly patients and those with comorbidities. The increasing rate of antimicrobial resistance has further limited the effectiveness of standard empirical therapy. This was a retrospective descriptive observational study using secondary data from medical records of hospitalized CAP patients at Dr. M. Djamil General Hospital, Padang, from January 2022 to December 2023. Subjects were adults (≥18 years) diagnosed with CAP and with positive cultures for K. pneumoniae. Variables included demographic characteristics, length of hospital stay, clinical outcomes, and antibiotic susceptibility patterns. Data were analyzed using univariate descriptive analysis. A total of 50 patients were included, predominantly male (58%) and aged over 65 years (40%). The most frequent comorbidities were hypertension (60%) and diabetes mellitus (36%). The mean length of hospital stay was 14 days. Mortality was high, reaching 56%. Antibiotic susceptibility testing showed the highest sensitivity to meropenem (96%) and amikacin (92%), while commonly used first-line agents such as ceftriaxone, ampicillin–sulbactam, and ciprofloxacin demonstrated low sensitivity (<15%). CAP due to Klebsiella pneumoniae at Dr. M. Djamil General Hospital is associated with very high mortality and widespread resistance to first-line antibiotics. Empirical therapy should be guided by local antibiogram data and supported by strong antimicrobial stewardship programs.
Co-Authors Adetetivani Adetetivani Alif Dhuha Annisa Lidra Maribeth Aulia Akbar Bun Yurizali Desi Aliefia Dessy Abdullah Dian Puspita Dian Puspita Irma Primawati Irwan Triansyah Khomeini Khomeini Letvi Mona Lismawati Lismawati Malik, Rifkind Muhammad Rifki Muhammad Rizki Saputra Nadia Purnama Dewi Nana Liana Nana Liana Rahma Triyana Rahma Triyana Relin Yesika Rinita Amelia Ruhsyahadati Ajisman Ruhsyahadati Ruhsyahadati Sri Nani Jelmila Sri Wahyuni Suharni Suharni Yahdian Rasyadi