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All Journal Biomedical Journal of Indonesia Jurnal Ners Nusantara Hasana Journal
Roland Helmizar
Universitas Baiturrahmah
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing

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EFEKTIVITAS DOSIS MODIFIKASI SORAFENIB TERHADAP KESINTASAN PASIEN KARSINOMA SEL HATI STADIUM LANJUT: SUATU LAPORAN KASUS BERBASIS BUKTI Roland Helmizar
Nusantara Hasana Journal Vol. 2 No. 9 (2023): Nusantara Hasana Journal, February 2023
Publisher : Yayasan Nusantara Hasana Berdikari

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Abstract

Background: Sorafenib is a multi-tyrosine kinase inhibitor that has been shown to improve survival in patients with advanced stage hepatocellular carcinoma (HCC). Based on the search to date, there are quite number of studies evaluating the effectiveness and safety of sorafenib dose modification on the survival of patients with advanced HCC; however, the previous studies have showed varying results. Method: A comprehensive literature search was conducted using three electronic databases: PubMed, Cochrane and EBSCohost. Meta-analyses, randomized controlled trials (RCTs), and cohort studies were selected based on inclusion and exclusion criteria. The quality of selected studies was evaluated using critical appraisal tools developed by the Center for Evidence-Based Medicine. Results: Three cohort studies were included in this report. In general, of the three studies that have been reviewed, show that reducing the dose of sorafenib from 800 mg/day to 400 mg/day does not affect the mean or median survival of patients with advanced HCC. Conclusion: Administration of sorafenib with initial dose of 400 mg/day or decreasing the dose from 800 mg/day to 400 mg/day has good tolerance, with not significantly difference on overall survival. But more evidence is required before they can be widely recommended in clinical practice for this indication.
VARICOSE ULCERS OF THE LOWER LEGS Dessy Abdullah; Khomeini Khomeini; Adetetivani Adetetivani; Nadia Purnama Dewi; Roland Helmizar
Jurnal Ners Vol. 7 No. 1 (2023): APRIL 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v7i1.12793

Abstract

Disorders that are often found in the lower extremities are vascular disorders. Varicose veins are very common, especially in women due to venous insufficiency due to poor blood circulation such as reflux and obstructive and can be inherited. The chronic phase of varicose veins can manifest as venous ulcers which is the development of wound below the knee. The lesions appear irregular in shape with clear boundaries, these ulcers can be prevented as early as possible by treating the trigger factor first before referring to the chronic direction. Physical examination is a medical process that must be undertaken when diagnosing a disease. The results are recorded in the medical record which is used to make a diagnosis and plan further treatment. Physical examination will be carried out systematically, starting from head to toe which is carried out in four ways, namely inspection, palpation, auscultation, and percussion. Varicose ulcers are a manifestation of chronic venous insufficiency. Patients with varicose ulcers have a history of varicose veins which, if treated, prevent the occurrence of varicose ulcers.
The Role of Probiotics as An Adjuvant Therapy for Sepsis Against Multidrug-Resistant Bacteria Ruhsyahadati Ajisman; Rinita Amelia; Rahma Triyana; Roland Helmizar; Sri Nani Jelmila; Nana Liana; Dian Puspita; Letvi Mona
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.170

Abstract

The role of probiotics on sepsis, particularly when induced by multidrug-resistant (MDR) bacteria, is mediated through complex biochemical pathways. Probiotics demonstrate a capacity to effectively combat infections and reduce mortality rates in sepsis cases. A significant contributor to this efficacy is attributed to the short-chain fatty acids (SCFAs) produced by these probiotics. SCFAs play a critical role in modulating the immune system, primarily by influencing the production of inflammatory cytokines, fortifying the integrity of intestinal epithelium, preventing cellular apoptosis, and maintaining the balance of gut microbiota. Moreover, probiotics are instrumental in counteracting the detrimental impacts of excessive antibiotic use, which is a major contributing factor to the emergence of MDR bacterial strains. The integration of probiotics with conventional therapeutic approaches offers a viable and potentially effective strategy in the management of sepsis caused by MDR bacteria, suggesting a promising direction for future clinical interventions.
Co-Authors Adetetivani Adetetivani Dessy Abdullah Dian Puspita Khomeini Khomeini Letvi Mona Nadia Purnama Dewi Nana Liana Rahma Triyana Rinita Amelia Ruhsyahadati Ajisman Sri Nani Jelmila