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All Journal Berkala Ilmiah Kedokteran Duta Wacana Archives Pharmacia AKSONA Occupational and Environmental Medicine Journal of Indonesia Indonesian Journal of Pharmacology and Therapy
Yacobus Christian Prasetyo
Department Of Pharmacology, Faculty Of Medicine, Universitas Kristen Duta Wacana, Yogyakarta
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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CARA MUDAH MERAWAT LUKA (AN EASY WAY TO CARE FOR WOUNDS) Yacobus Christian Prasetyo
Berkala Ilmiah Kedokteran Duta Wacana Vol. 6 No. 2 (2021): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v6i2.461

Abstract

Merupakan resensi buku Cara Mudah Merawat Luka.
Brominated Flame Retardants: A Literature Review of The Toxicity Mechanisms, Clinical Manifestations, And Current Treatments Prasetyo, Yacobus Christian; Sholikhah, Eti Nurwening
Occupational and Environmental Medicine Journal of Indonesia Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Brominated flame retardants (BFRs) are organohalogen compounds that can inhibit fire formation and delay its spread in manufacturing materials. BFRs are known to be toxic for the environment and humans. BFRs could persist for years prolonging potential exposure and toxicity to living beings. Indonesia had begun to reduce the use, even though some of toxic BFRs are still illegally circulating. This review aims to describe some aspects of BFRs toxicity including the mechanism, its clinical manifestations, and the current possible treatments. Toxicity after BFRs exposure includes endocrine, neurodevelopmental, and genotoxicity. The toxicity is manifested into some clinical conditions such as hypothyroidism, gonadal disturbance, or neurological disorders. Currently no definitive specific treatment is available, so the treatment is focused on primary survey as well as surface decontamination with running water and gastrointestinal decontamination with activated charcoal of some dose if the ingestion is less than 1 hour.
CIPLUKAN’S ANTI-INFLAMMATORY EFFECTS: MECHANISMS UNCOVERED Prasetyo, Yacobus Christian; Purwanti, Noerlina
Berkala Ilmiah Kedokteran Duta Wacana Vol. 9 No. 1 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v9i1.656

Abstract

Background: Ciplukan (Physalis angulata Linn) is a native American plant widely distributed in tropical regions including Indonesia. This herb has been used as a traditional ingredient to treat inflammation as well as other diseases. Ciplukan’s anti-inflammatory effects are thought to be triggered by the active compounds in the various parts of the herb. Objective: This review aims to describe the herb’s anti-inflammatory effects and its mechanisms. Methods: PubMed and Google Scholar databases were searched for articles using Boolean operations with keywords related to Physalis angulata and inflammatory components. We included literature in English and Indonesian without limiting the publication time range. Results: Ciplukan has an anti-inflammatory effect by regulating inflammatory mediators, inhibiting immune signaling pathways, and the genes associated with the immune system.
Current pharmacological treatments for COVID-19: A narrative review Sudi Indra Jaya; Yacobus Christian Prasetyo
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021): Special Issue: COVID-19
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.2881

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has lasted more than one year. The number of daily cases and the number of deaths is still changing dynamically. As of this writing, specific drugs for COVID-19 are not yet available. This review aims to describe the key clinical evidence in pharmacological treatments for COVID-19. The article search process was carried out on the PubMed database with a combination of keywords ((“COVID-19”) OR (“SARS-CoV-2”)) AND ((“treatment”) OR (“therapy”)). In this article, there were six drugs reviewed that is corticosteroids, remdesivir, lopinavir-ritonavir, hydroxychloroquine, ivermectin, and interleukin-6 (IL-6) receptor blockers. Hydroxychloroquine, lopinavir-ritonavir, remdesivir, and ivermectin were not recommended for COVID-19 treatments regardless of disease severity and duration of symptoms. Therefore, they were excluded from the list of drugs for the treatment of COVID-19 by World Health Organization (WHO) stated strong recommendations in favor of two drugs, namely systemic corticosteroids and IL-6 receptor blockers namely tocilizumab or sarilumab. Both of them are recommended for the treatment of patients with severe and critical covid-19 so they are included in the list of COVID-19 therapeutic drugs by WHO.
Tamarindus indica increases the stability of jamu kunyit-asam herbal suspension over Citrus aurantifolia arko jatmiko wicaksono; rita Rakhmawati; Mae Sri Hartati Wahyuningsih; Rul Afiyah Syarif; Yacobus Christian Prasetyo
Indonesian Journal of Pharmacology and Therapy Vol 5 No 2 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11818

Abstract

Rapid shelf-life of traditional supplementary drink still becomes major issue for herbal production in household industries. In this study the stability formula of an herbal suspension, so called as jamu kunyit-asam, was investigated. The jamu kunyit-asam Formula-1 (F1) contains combination of Citrus aurantifolia and Curcuma longa. While the Formula-2 (F2) is consisted by mixture of Tamarindus indica and C. longa. The two formulas were compared to justify better stability between preparations. No preservatives were added, in order to comply with the local regulation. To simulate the real situation, all samples were stored in 4 different conditions: opened bottle (room temperature), closed bottle (room temperature), closed bottle (refrigerator), and freeze-thaw condition. To evaluate the stability profile, an organoleptic testing and pH alteration were frequently checked for 12 consecutive days. Several parameters including color changing, sting odor, and microscopic appearance were looked over. As the results, mold, precipitation and pungent odor were formed faster from the F1 (C. aurantifolia combined with C. longa). These findings indicates that jamu kunyit-asam herbal drink suspensions containing C. longa has less stability in combination with the C. aurantifolia (F1) compared to the T. indica (F2).
Evaluasi Peresepan Obat berdasarkan Metode WHO/INRUD: Studi Potong Lintang pada Klinik Pratama di Yogyakarta Prasetyo, Yacobus Christian; Lestari, Dewi; Ignatya, Ratma Inggrid; Panjaitan, Ambar Gita Soraya; Panjaitan, Elvira Ruth Mahardika
Archives Pharmacia Vol 7, No 1 (2025): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/ap.v7i1.9040

Abstract

Penggunaan obat yang rasional memungkinkan pasien mendapatkan pengobatan yang sesuai dengan kebutuhannya seperti dosis dan waktu pengobatan yang tepat, serta biaya yang paling rendah. Indikator peresepan obat WHO/INRUD dan Index of Rational Drug Prescribing adalah metode yang bermanfaat untuk mengukur penggunaan obat berdasarkan beberapa komponen peresepan. Tujuan penelitian ini adalah mengidentifikasi peresepan obat di sebuah klinik swasta non-profit di Yogyakarta berdasarkan indikator peresepan obat dan IRDP. Penelitian ini adalah observasional, potong lintang, retrospektif yang dilaksanakan di sebuah klinik pratama di Yogyakarta. Diteliti 355 resep obat yang sesuai kriteria inklusi dan tidak tereksklusi. Resep obat dianalisis secara deskriptif menggunakan indikator peresepan obat WHO/INRUD dan dilanjutkan dengan IRDP. Ditemukan rata-rata jumlah obat diresepkan per kunjungan adalah 3,1 ± 1. Persentase peresepan nama generik (74,7%) dan kunjungan dengan injeksi (0,3%). Persentase kunjungan dengan antibiotik adalah 35,2%. Persentase obat pada formularium setempat adalah 99,9%, mendekati nilai rujukan. Nilai indeks non-polifarmasi (0,58), antibiotik rasional (0,76), dan nama generik (0,75) lebih rendah dari nilai optimal. Indeks penggunaan sesuai formularium (0,99) mendekati nilai optimal, indeks penggunaan injeksi rasional optimal (>1). Peresepan obat perlu diteliti lebih lanjut terkait peresepan banyak obat, penggunaan antibiotik, maupun peresepan dengan nama generik.
Profile of Motoric and Non-Motoric Symptoms Using the Indonesian Version of the Wearing-Off Questionnaire-19 in Parkinson’s Patients Muktiarini, Bernadetha; Pinzon, Rizaldy Taslim; Prasetyo, Yacobus Christian
AKSONA Vol. 5 No. 2 (2025): JULY 2025
Publisher : Universitas Airlangga

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Abstract

Highlight: Tremors are the most common motor symptom in patients with Parkinson's disease. Abdominal discomfort is a prevalent non-motor symptom of Parkinson's disease. Comprehensive symptom management is essential for patients with Parkinson's disease.   ABSTRACT Introduction: Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor symptoms. The prolonged administration of levodopa in patients may induce the wearing-off phenomenon, where symptoms recur before the next dose. Studies on the symptom profile of Parkinson's disease, especially in wearing-off conditions, are crucial for further management. Objective: This study aimed to determine the motor and non-motor symptom profile of patients with Parkinson's disease. Methods: conducted. The Indonesian version of the Wearing-Off Questionnaire-19 (WOQ-19) was used to identify motor and non-motor symptoms. Data were collected from 30 Parkinson’s patients at Bethesda Yogyakarta Hospital from October to December 2023 using a purposive sampling technique. The sample size was calculated using OpenEpi V3.01. Results: The most prevalent motor symptom among patients with Parkinson's disease was tremor (100%), followed by bradykinesia (93.33%) and rigidity (86.67%). The most common non-motor symptoms reported were abdominal discomfort (56.67%) and body aches (50%). Conclusion:Patients have a variety of Parkinson's disease symptoms. Parkinson's patients most commonly experienced motor symptoms such as tremors, bradykinesia, and rigidity, along with non-motor symptoms like abdominal discomfort and body aches. The significant percentage of wearing-off seen in this study underscores its common occurrence and highlights the importance of early identification and management.  
Co-Authors Arko Jatmiko Wicaksono, Arko Jatmiko Dewi Lestari Eti Nurwening Sholikhah Ignatya, Ratma Inggrid Mae Sri Hartati Wahyuningsih Muktiarini, Bernadetha Panjaitan, Ambar Gita Soraya Panjaitan, Elvira Ruth Mahardika Purwanti, Noerlina rita Rakhmawati Rizaldy Pinzon Rul Afiyah Syarif Sudi Indra Jaya