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THE POTENTIAL OF CELL-FREE DNA METHYLATION BIOMARKER AS AN EARLY DETECTION FOR LUNG CANCER Muhammad Yusuf; Nasim Amar; Shintya Octaviana Baliulina
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.369

Abstract

Background: Lung cancer is still the leading cause of cancer deaths. Current screening methods still have many limitations in diagnosing lung cancer, thus a more precise and applicable screening method is needed in diagnosing individuals with lung cancer. One of the screening methods that has the potential to help diagnose lung cancer is DNA methylation which is thought to have an advantage as a biomarker in lung cancer. Method: This literature review was conducted by including validated studies extracted through PubMed, ScienceDirect, and Cochrane Library databases. A total of 13 studies fulfilled the inclusion criteria. Discussion: DNA methylation could occur in the early stages of cancer development and was specific to different tumor types. In lung cancer, DNA methyltransferase (DNMT) regulation and ten-eleven translocation (TET) enzymes were disrupted resulting in tumor suppressor gene inactivation and cancer development. Overall, DNA methylation in the genes HOXD10 / PAX9 / PTPRN2 / STAG3, SHOX2 / PTGER4 / FOXL2, SOX17 / TAC1 / HOXA7 / CDO1 / HOXA9 / ZFP42, and CDO1 / SOX17 / HOXA7 had a sensitivity above 90%. Several other DNA methylation panels such as DCC, TMEM196, SHOX2 / PTGER4, and CDO1 / SOX17 / HOXA7 had a high specificity of up to 90-100%. AUC scores were above 0.80 in the majority of studies. DNA methylation as a support for screening methods could increase the effectiveness of early detection and reduce the rate of false positives. Conclusion: DNA methylation biomarker is an effective method for an early detection of lung cancer.
Sosialisasi hasil pemetaan potensi sumber air tanah sebagai upaya mitigasi kekeringan Desa Selobanteng, Kabupaten Situbondo Muhammad Fathur Rouf Hasan; Adi Susilo; Rochman Hidayat; Muhammad Husnul Khuluq; Miftakhul Cahyati; Redy Eko Prastyo; Hari W. Wijayanto; Abdul Khodir Jaelani; Juzaili S. Alam; Muhammad Lubab; Nurlaily Lavianti; Muhammad Yusuf; Totok Widianto; Reska Pragusta
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 10, No 5 (2026): October (In Progress)
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v10i5.43023

Abstract

AbstrakKetersediaan sumber air tanah menjadi masalah utama setiap daerah di Indonesia ketika memasuki musim kemarau, peningkatan jumlah populasi berbanding lurus dengan jumlah kebutuhan air. Kebutuhan ini akan teratasi jika suatu daerah memiliki cadangan sumber air tanah yang dapat dimanfaatkan setiap waktu. Kegiatan pengabdian bertujuan untuk memberikan pemahaman kepada masyarakat Desa Selobanteng tentang teknologi investigasi air tanah dan lokasi yang berpotensi sebagai sumber air tanah. Mitra kegiatan yaitu Corporate Social Responsibility (CSR) PT Paiton Energy dan Pemerintah Desa Selobanteng, Kabupaten Situbondo. Sasaran sosialisasi adalah 23 dari warga Desa Selobanteng; metode pelaksanaan sosialisasi yaitu ceramah dan diskusi, materi disampaikan dalam kemasan yang sederhana agar mudah dipahami oleh peserta. Berdasarkan hasil evaluasi, peserta memahami materi yang disampaikan, hal ini ditunjukkan oleh persentase jawaban pada keempat butir pertanyaan yang diberikan; skala jawaban "sangat setuju" sebesar 88,04% dan jawaban ”cukup setuju” sebesar 11,96%. Hal ini menunjukkan bahwa peserta memiliki persepsi pengetahuan tentang metode investigasi air tanah dan lokasi potensi air tanah pada daerah mereka. Adapun lokasi yang direkomendasikan untuk pengeboran adalah titik VES 1 dengan target kedalaman 40-42 meter, titik tersebut berada disebelah timur laut gudang mebel. Rekomendasi kegiatan pengabdian serupa perlu dilakukan di daerah lain yang mengalami kekeringan dengan validasi pengeboran. Kata kunci: air tanah; CSR; Desa Selobanteng; mitigasi kekeringan; sosialisasi. AbstractThe availability of groundwater resources is a major issue for every region in Indonesia during the dry season, as the growing population leads to a proportional increase in water demand. This need can be addressed if a region possesses groundwater reserves that can be utilized at any time. This community service activity aims to provide the residents of Selobanteng Village with an understanding of groundwater investigation technology and locations with potential as groundwater sources. The project partners are the Corporate Social Responsibility (CSR) division of PT Paiton Energy and the Selobanteng Village Government, Situbondo Regency. The outreach activity targeted 23 residents of Selobanteng Village; the session was conducted through lectures and discussions, with the material presented in a simple format to ensure easy understanding by the participants. Based on the evaluation results, participants understood the material presented; this is evidenced by the response percentages for the four questions asked, with 88.04% selecting "strongly agree" and 11.96% selecting " somewhat agree". This indicates that the evaluation based on participants' perceived knowledge following the dissemination session is high. The recommended location for drilling is the VES 1 point, targeting a depth of 40–42 meters; this point is situated northeast of the furniture warehouse. Similar community service activities should be carried out in other drought-affected areas, accompanied by validation through drilling. Keywords: groundwater; CSR; selobanteng village; drought mitigation; outreach.