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All Journal Jurnal Ilmu dan Teknologi Hasil Ternak Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Journal of Innovation and Applied Technology Jurnal Teknologi Pertanian JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Journal of Tropical Biodiversity and Biotechnology Sari Pediatri Padjadjaran Journal of Dentistry JMM (Jurnal Masyarakat Mandiri) Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat E-Prodenta Journal of Dentistry Lingua Rima: Jurnal Pendidikan Bahasa dan Sastra Indonesia Indian Journal of Forensic Medicine & Toxicology
Miftakhul Cahyati
Faculty Of Dentistry, Universitas Brawijaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Complication risks of invasive dental procedures in HIV/AIDS patients Cahyati, Miftakhul; Rahmayanti, Febrina
Padjadjaran Journal of Dentistry Vol 20, No 3 (2008): November
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.331 KB) | DOI: 10.24198/pjd.vol20no3.14128

Abstract

A total number of people living with HIV reached since it was first reported. Indonesia is on the brink of rapidly worsening AIDS epidemic. Oral health was a frequent problem among HIV-infected person. Opportunistic oral lesions and infections were often one of the first manifestations of HIV. The aim of this literature review was to discuss complication risks and management undergoing invasive dental procedures. Thereby, dentists have been expected to increase awareness of dental treatment needs for HIV-infected patients by pay attention to applied standard procedure. The complications of HIV-infected patients were reported minor, self-limiting, non-life threatening and readily treated. Treatment planning for the patient with HIV follows the same sequences as with other patients priorities are to assuage pain, restore function, prevent further disease and consider esthetic results. We concluded that no different complication risks between HIV-infected and non-infected. Dentists can provide care for HIV-infected patients with assessing the current immunosuppression stage, intake systemic medications, opportunistic infection potential and minimize contagion possibility to dental care professional or other patients.
PEMANFAATAN ANTIOKSIDAN (GLUTATHIONE) TERIPANG EMAS LAUT (GOLDEN STICHOUPUS VARIEGATUS) BERBASIS NANOTEKNOLOGI DALAM APOPTOSIS SEL SKUAMOSA KANKER MULUT Cahyati, Miftakhul; Aprilia Rahmawati, Priska Anindhita; Kusuma, Nabilah; Adam, Sakinah Azzahra
E-Prodenta Journal of Dentistry Vol 2, No 2 (2018)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (241.192 KB) | DOI: 10.21776/ub.eprodenta.2018.002.02.2

Abstract

Kanker mulut adalah penyakit yang jarang diteliti dan kurangnya pendeteksian dini.. Antioksidan terbesar ada pada Teripang Emas Laut (Golden stichoupus variegatus) dengan bantuan Glutathione, memberikan elektron pada radikal bebas mampu menekan adanya kerusakan sel. Tujuan: untuk mengetahui dosis pemberian ekstrak Teripang Emas Laut (Golden stichoupus variegatus) yang paling efektif terhadap sel skuamosa kanker mulut. Metode: Tikus putih sebanyak 25 ekor: Tikus tanpa perlakuan, Tikus dengan induksi DMBA, Tikus dengan paparan DMBA (Dimethylbenz 7,12-  anthracene) 20mg/kg BB diinduksi ekstrak teripang emas laut dosis 0,33 g/kg BB, 0,66 g/kg BB, dan 0,99 g/kg BB dengan analisa data One Way Anova. Hasil: K1 adalah perlakuan paling efektif. Hasil anova menunjukkan perlakuan K1 tidak berbeda signifikan dengan perlakuan K2, dan K3, maka ketiga perlakuan ini yaitu perlakuan K1, K2, dan K3 adalah perlakuan sama efektif. Kesimpulan: Tidak ada perbedaan signifikan diantara ketiga kelompok perlakuan. Kata kunci: Sel skuamosa, Kanker Mulut, Teripang Emas Laut, Antioksidan.
Potential Effect of Djambal Catfish (Pangasius djambal) Gelatin as Biomaterial Product on Healing Socket after Tooth Extraction in Rats Fredy Mardiyantoro; Nenny Prasetyaningrum; Miftakhul Cahyati; Zefry Zainal Abidin; Norifumi Nakamura
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14728

Abstract

Purpose: Adequate wound healing after a tooth extraction is significant because the oral cavity has amasticatory function and plays a role in nutrient intake. Various scientific studies have been conducted tofind the ideal biomaterial to support wound healing. This study aims to determine the wound healing activityusing Djambal Catfish (Pangasius djambal) gelatin after tooth extraction.Method: Gelatin was obtained from Djambal Catfish (Pangasius djambal). The sample was selected byrandom sampling, divided into 6 groups, namely the control group on the 3rd day (n=6), the control groupon the 5th day (n=6), the control group on the 7th day (n=6), the treatment group on the 3rd day (n=6), thetreatment group on the 5th day (n=6), and the treatment on the 7th day (n=6). Wound healing was examinedby evaluating wound healing marker such as macrophages, fibroblasts, epithelialization, angiogenesis, andcollagen. Data were processed using statistical analysis.Results: The treatments had a positive result in wound healing as compared with the control groups.Histological assessment showed a remarkable sign of an increased number of macrophage, fibroblast,epithelialization, and collagen deposition.Conclusion: Gelatin derived from Djambal Catfish (Pangasius djambal) can accelerate the wound healingprocess thus could be a component therapeutic potential product that may be beneficial in wound healing inthe future.
Pengenalan Acquired Immunodeficiency Syndrome pada Pasien Anak Ditinjau dari Bidang Kedokteran Gigi Anak Essie Octiara; Miftakhul Cahyati; Virmala Indah Aulia
Sari Pediatri Vol 8, No 3 (2006)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp8.3.2006.231-7

Abstract

Acquired Immunodeficiency Syndrome (AIDS) merupakan kumpulan gejala penyakityang disebabkan infeksi Human Immunodeficiency Virus (HIV). 1 Di dunia pada tahun2002 sebanyak 3,2 juta anak telah terinfeksi HIV. Penularan HIV/AIDS pada anakdapat terjadi antara lain melalui tranfusi darah serta oleh ibu yang terinfeksi kepada bayiyang dikandungnya. Manifestasi pada rongga mulut merupakan salah satu gejala yangpertama kali timbul dan paling dapat dipercaya akan adanya infeksi HIV pada anak, danhal ini penting dalam mendiagnosis awal infeksi HIV serta dalam memberikan upayaintervensi dini. Manifestasi oral pada pasien anak dengan infeksi HIV berupa infeksijamur, virus, bakteri, neoplasma ataupun lesi idiopatik. Peran dokter gigi anak dalampreventif kesehatan mulut bagi pasien anak HIV antara lain melakukan supervisi semuapemberian makanan dengan botol, managemen medikasi yang kariogenik, sertamelakukan sealant dan pemberian fluor secara sistemik dan topikal.
Optimization of East Java Propolis Extraction as Anti SARS-Cov-2 by Molecular Docking Study Sofia Aulia Hidayat; Agus Susilo; Khothibul Umam Al Awwaly; Miftakhul Cahyati
Jurnal Ilmu dan Teknologi Hasil Ternak (JITEK) Vol. 17 No. 2 (2022)
Publisher : Faculty of Animal Science Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitek.2022.017.02.7

Abstract

The purpose of this research is to obtain the optimum propolis extraction method using microwave extraction so as to produce anti-SARS CoV-2 compounds. The research method used was experimental with a completely randomized factorial design consisting of 2 factors namely extraction time and power level, 9 treatments and 3 replications. The extraction using microwave assisted extraction was carried out according to treatment factors, namely low power level (A1), medium (A2), high (A3) and the length of treatment time was 10 minutes (B1), 20 minutes (B2), and 30 minutes (B3). The results of statistical analysis showed that the interaction between the two had a high significant effect (p<0.01) on the alkaloid content which is ranged from 0.665 to 1.452 mg/g and had no effect on color L*a*b* and antioxidant activity which is ranged from 1.533 to 1.553. The percentage of hexadecane in East Java propolis extract was 0.280 %, octadecane was 0.775%, and pentacosane was 6.716%. The results of druglikeness analysis showed that hexadecane, octadecane and pentacosane compounds had potential as antivirals with a probability to be active value of 0.68. The binding affinity value produced by enzalutamide as a native ligand is -6.7 kcal/mol while the highest inhibitory value is octadecane and pentacosane of -5.9 kcal/mol and followed by hexadecane at -5.8 kcal/mol. The conclusion of this research is that the most optimal extraction method using microwave assisted extraction is done with a medium microwave power level for 30 minutes in terms of the alkaloid content and antioxidant activity produced. This method is able to produce extracts with good antiviral bioactive components, although the binding affinity has not been able to exceed the native ligand's ability in terms of the molecular docking approach.
EVALUATION ON ANTIOXIDANT ACTIVITY AND ACTIVE COMPONENTS OF TRIGONA ITAMA PROPOLIS EXTRACT AND ITS POTENTIAL AS SARS-CoV2 INFECTION INHIBITORS Elma Putri Primandasari; Agus Susilo; Khothibul Umam Al Awwaly; Miftakhul Cahyati; Dewi Masyithoh
Jurnal Teknologi Pertanian Vol. 24 No. 2 (2023)
Publisher : Fakultas Teknologi Pertanian Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtp.2023.024.02.6

Abstract

          Propolis Trigona itama  has a blackish brown color and has a bitter taste. Propolis contains immunomodulator, antibacterial, antifungal and antiviral. Efforts made to determine the potential of propolis require an extraction process. The extraction process aims to obtain propolis ready for consumption. Propolis has thermostable properties with a melting point of 60oC – 65oC, so it does not require high temperatures in the extraction process. The extraction process using MAE requires a faster time because the pressure and temperature can be controlled. This study used a factorial completely randomized design with 2 factors with 9 treatments and 3 replications. The data obtained were analyzed by analysis of variant (ANOVA). If there is a difference, it is continued with the DUNCAN multiple distance test. The results of the extraction using the MAE method of propolis have antioxidant activity using the DPPH method of 1,460µg/ml to 1,413 µg/ml which is expressed in IC50. Trigona itama  propolis extract had an average antioxidant value of 0.22 µg/ml to 0.57 µg/ml using the FRAP method.There is a unique component in the GCMS results of Trigona itama propolis extract called bisalcofen.Bisalcofen is an active component which has antioxidant properties. The results of the bisalcofen docking score of -7.6 on the ACE2 protein. Bisalcofen has a stronger potency than umifenovir which can be used as an inhibitor of SARS-CoV2 infection.
PENGARUH GEL EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP EKSPRESI VEGF PADA PENYEMBUHAN LUKA PASCA PENCABUTAN GIGI TIKUS (Rattus norvegicus) Miftakhul Cahyati; Sari, Dyah Ayu Wulan
E-Prodenta Journal of Dentistry Vol 8 No 1 (2024)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2024.008.01.8

Abstract

Latar belakang: Pencabutan gigi idealnya yakni tanpa menimbulkan rasa sakit dengan trauma sekecil mungkinpada jaringan penyangga, sehingga nantinya luka bekas pencabutan gigi akan dapat sembuh dengan normal.Pembentukan pembuluh darah baru pada proses penyembuhan luka merupakan hal yang sangat penting,prosesnya dirangsang oleh faktor pertumbuhan angiogenik yakni vascular endothelial growth factor (VEGF).VEGF merupakan perangsang angiogenesis yang kuat dan juga dikenal sebagai faktor yang mengaturpermeabilitas pembuluh darah. Tujuan: untuk mengetahui pengaruh gel ekstrak daun kersen terhadap ekspresiVEGF pada proses penyembuhan luka pasca pencabutan gigi tikus. Metode: penelitian ini menggunakan desaineksperimen murni (True experimental) dengan menggunakan rancangan penelitian “Post Test Only RandomizedControl Design” di Laboratorium secara in-vivo. Hewan coba tikus (Rattus norvegicus) yang digunakan sebanyak30 ekor dibagi kedalam 2 kelompok, yaitu kelompok yang tidak diberi gel ekstrak daun kersen/kelompok kontrol(K3, K5, K7) dan kelompok yang diberi gel ekstrak daun kersen/kelompok perlakuan (P3, P5, P7), dilakukandekaputasi pada hari ke-3, ke-5, dan ke-7. Dilakukan pengambilan jaringan keras dan pembuatan preparat,selanjutnya preparat dilakukan pewarnaan Imunohistokimia indirect. Ekspresi VEGF diamati menggunakanmikroskop cahaya dengan perbesaran 400x pada 5 lapang pandang. Hasil: Uji One way ANOVA menunjukkanterdapat perbedaan jumlah ekspresi VEGF antara kelompok kontrol dengan kelompok perlakuan. Uji Post HocHSD Tukey membuktikan terdapat perbedaan yang bermakna antara kelompok kontrol dan kelompok perlakuan.Ekspresi VEGF pada kelompok perlakuan terjadi peningkatan yang signifikan pada hari ke-3 (P3). Pada hari yangsama tiap kelompok selalu terjadi peningkatan jumlah rata-rata ekspresi VEGF, yaitu kelompok perlakuan selalulebih tinggi dari kelompok kontrol. Kesimpulan: Pemberian gel ekstrak daun kersen (Muntingia calabura L.)berpengaruh terhadap ekspresi VEGF pada penyembuhan luka pasca pencabutan gigi tikus (Rattus norvegicus).
Chrysin Inhibits Indonesian Serotype Foot-and-Mouth-Disease Virus Replication: Insights from DFT, Molecular Docking and Dynamics Analyses Susilo, Agus; Cahyati, Miftakhul; Nurjannah, Nurjannah; Pranowo, Dodyk; Hermanto, Feri Eko; Primandasari, Elma Putri
Journal of Tropical Biodiversity and Biotechnology Vol 9, No 1 (2024): March
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.83140

Abstract

Chrysin, a predominant compound in Propolis, possesses diverse bioactivities, including antiviral properties. However, its antiviral efficacy against the Indonesian Foot-and-Mouth Disease Virus (FMDV) serotype remains unexplored. This study investigates Chrysin's inhibitory potential against FMDV Indonesian serotype by targeting the 3C Protease (3CP), a vital enzyme for viral replication. Multiple sequence alignment was used to reveal unique characteristics of the Indonesian serotype's 3CP compared to global serotypes. Density Functional Theory (DFT) calculations assessed Chrysin's interaction with 3CP based on electronegativity. Molecular docking and molecular dynamics analyses evaluated Chrysin's inhibitory activity against 3CP, using homology modeling for the Indonesian serotype's 3CP structure. Luteolin, a known FMDV 3CP inhibitor with a similar structure to Chrysin, served as a reference. Results showed distinct 3CP sequences in the Indonesian serotype compared to O serotypes and others. Chrysin exhibited potential electron-donor activity with lower HOMO and LUMO values than Luteolin, but they had similar energy gaps, i.e., 4.016 and 4.044 eV, respectively. Molecular docking indicated similar binding affinities, with Chrysin (-6.365 kcal/mol) and Luteolin (-6.864 kcal/mol) bound to active site residues. Molecular dynamics analysis demonstrated stable 3CP-Chrysin and 3CP-Luteolin complexes, with minor differences in Radius of gyration (Rg) and Root-Mean-Square Fluctuation (RMSF) below 1 Å. From the ligand stability point of view, Chrysin had comparable stability with Luteolin. However, Chrysin formed fewer hydrogen bonds and displayed greater free-binding energy than Luteolin during simulation periods. These findings suggest that Chrysin holds promise as an inhibitor of the Indonesian serotype's FMDV 3C Protease. 
Use of Propolis Extract as an Ingredient for Skin Cancer Cell Apoptosis Transfersome Cream with Gelatin as an Emulgator Puspa, Galuh Wilujeng; Susilo, Agus; Cahyati, Miftakhul; Nurjannah, Nurjannah; Pranowo, Dodyk
Jurnal Ilmu dan Teknologi Peternakan Tropis Vol 10, No 1 (2023): JITRO, January
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/jitro.v10i1.28659

Abstract

Transfersome has been commonly used to increase the penetration of drugs derived from natural ingredients. Propolis is a natural ingredient with many benefits, such as antimicrobial, antiviral, anti-inflammatory, antitumor, antioxidant, and anticancer. In various in vitro studies, propolis showed proapoptotic activity in cancer cells. Gelatin is a chemical compound that can be used as an emulsifier because it has a hydrophobic part in the peptide chain. This study aimed to determine the optimal gelatin content based on physical tests as an emulsifier in the manufacture of emulsions for transfersome cream ingredients. The research method used was an experimental laboratory with 6 gelatin concentration treatments, namely 1% (P1), 2% (P2), 3% (P3), 4% (P4), 5% (P5), and 6% (P6) with 3 replicates. To make the emulsion, 5% propolis extract was added. The results of statistical analysis showed that the manufacture of emulsions using different concentrations of gelatin had a very significant effect (p
Utilization of Apple Cider Vinegar By-Products Into Zero Waste Based Functional Food Ingredients at CV Sinar Tirta Indonesia Nurjannah; Miftakhul Cahyati; Dedes Amertaningtyas; Khothibul Umam Al Awwaly; Agus Susilo; Indha Fitria Pangesti; Ahmad Yuda Ihwanudin
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 8 No. 1 (2025): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/abdimas.v8i1.5542

Abstract

In Indonesia, apples are one of the types of fruit that are widely cultivated and widely consumed as processed foods, such as apple cider vinegar CV Sinar Tirta Indonesia, a producer of apple cider vinegar, consistently yields apple pulp as a by-product. In addition to apple cider vinegar, the processing process produces apple pulp by-products. Apple pulp by-products, which consist of pulp and skin that has extraordinary nutrition, make it very suitable to be processed into useful food. Innovation is needed so that apple pulp by-products are not only used for animal feed mixtures that have low selling value. To realize the processing of waste-based products, it must be able to change the by-product into a product that has the maximum possible economic value, as shown in this community service activity, namely changing the by-product of apple vinegar into flour and ingredients for making cookies that were attended by the surrounding community, students, employees, and business actors. This training provides direct benefits to participants, namely gaining new knowledge about how to process apple pulp into functional food ingredients. This training proves that processing apple pulp with current technology is easy to do and produces a high-value product.
Co-Authors Abdul Razaq Komarruzaman Adam, Sakinah Azzahra Agus Susilo Agus Susilo Agus Susilo Agustine Hanafi Putri Ahmad Imron Rozuli Ahmad Yuda Ihwanudin Ahmad Yuda Ihwanudin Aprilia Rahmawati, Priska Anindhita Asep Awaludin Prihanto Astika Swastirani Dedes Amertaningtyas Dedes Amertaningtyas Dedes Amertaningtyas Devan Maulana Firdaus Dewi Masyithoh Dodyk Pranowo Elma Putri Primandasari Essie Octiara Febrina Rahmayanti Fredy Mardiyantoro, Fredy Hermanto, Feri Eko Ihwanudin, Ahmad Yuda Indha Fitria Pangesti Indha Fitria Pangesti Khothibul Umam Al Awwaly Khothibul Umam Al Awwaly Khothibul Umam Al Awwaly Khuluq, Muhammad Husnul Kusuma, Nabilah Lukman Hakim Hidayat Meilia Aquina Hakim Muhammad Alvaro Riandi Muhammad Fathur Rouf Hasan Nenny Prasetyaningrum Norifumi Nakamura Nurjannah Nurjannah Nurjannah Nurjannah Pangesti, Indha Fitria Prastyo, Redy Eko Primandasari, Elma Putri Puspa, Galuh Wilujeng Sari, Dyah Ayu Wulan Sofia Aulia Hidayat Virmala Indah Aulia Zefanya Nicko Sukadi Zefry Zainal Abidin